公开(公告)号：NO912848L

公开(公告)日：1992-01-22

申请号：NO912848

申请日：1991-07-19

Applicant: HOECHST AG

Inventor： HENNING RAINER ,  WAGNER ADALBERT ,  GERHARDS HERMANN ,  SCHOELKENS BERNWARD

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/495 ,  A61K31/505 ,  A61P1/16 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P43/00 ,  C07D233/56 ,  C07D233/90 ,  C07D403/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: Substd. azole derivs. of formula (I) and their physiologically acceptable salts are new. In (I) X, Y and Z are each N or CR2 R1 is 2-10C alkyl, 3-10C alkenyl, 3-10C alkynyl, -(CH2)mB(CH2nR4 (these 4 gps. opt. monosubstd. with CO2R3 and opt. have 1-all H atoms replaced by F), OR3, 3-8C cycloalkyl, 5-10C cycloalkylalkynyl, or benzyl (opt. mono or disubstd. on the Ph ring with halogen, 1-4C alkoxy and/or NO2), R2 = H, halogen, CvF2v+1, SF5, pentafluoro phenyl CN, phenyl, -(CH2)nF, -(CH2)nONO2, -CH2N3, -(CH2)nNO2, phthalimido (CH2)n-, R3 = H, 1-8C alkyl (in which 1 to all H are replaced by F), 3-8C cycloalkyl, Ph or benzyl, R4 = H, 1-6C alkyl, 3-8C cycloalkyl, 2-4C alkenyl, or 2-4C alkynyl, A = a mono or bicyclic unsatd. or partially hydrogenated heterocycle gp. with 5-10 ring atom of which up to 9 are C, and opt. substd. with up to 3 opt. different R14 gps. or -(CH2)n-1-(CHR6CH2)0-1, R14 where R14 = halogen, oxo, nitroso, NO2, amino, CN, OH, 1-6C alkyl, 1-4C alkanoyl, 1-4C alkanoyloxy. B = O, NR7 or S, W = O or S, L = 1-3C alkanediyl, R26 and R27 are each H, halogen, NO2, 1-4C alkyl or 1-2C alkoxy, n = 1-5, o = 1-10, q = 0-1.

公开(公告)号：NO920048D0

公开(公告)日：1992-01-03

申请号：NO920048

申请日：1992-01-03

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  ENGLERT HEINRICH ,  KLEEMANN HEINZ-WERNER ,  GERHARDS HERMANN ,  SCHOELKENS BERNWARD ,  BECKER REINHARD ,  LINZ WOLFGANG

IPC: A61K31/415 ,  A61K31/40 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00 ,  C07D233/00

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.

公开(公告)号：AU7401391A

公开(公告)日：1991-10-10

申请号：AU7401391

申请日：1991-04-03

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  HENNING RAINER ,  GERHARDS HERMANN ,  SCHOLKENS BERNWARD

IPC: A61K31/415 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4164 ,  A61K31/423 ,  A61K31/437 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/495 ,  A61K31/505 ,  A61K31/519 ,  A61P9/12 ,  A61P29/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/84 ,  C07D233/90 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D471/04 ,  C07D487/04 ,  C07D405/10 ,  C07D409/10 ,  C07D403/10 ,  C07D413/04

Abstract: The invention relates to compounds of the formula in which X, Y and Z are identical or different and are N or CR , R and R are as defined in the description, L is an alkylene radical, q = 0 or 1, and A is the radical of a fused heterobicycle. The invention furthermore relates to a method for the preparation of the abovementioned compounds, to compositions containing them, and to their use.

公开(公告)号：IE911098A1

公开(公告)日：1991-10-09

申请号：IE109891

申请日：1991-04-03

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  HENNING RAINER ,  GERHARDS HERMANN ,  SCHOELKENS BERNWARD ,  CAILLE JEAN-CLAUDE ,  VEVERT JEAN-PAUL

IPC: A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4164 ,  A61K31/423 ,  A61K31/415 ,  A61K31/437 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/495 ,  A61K31/505 ,  A61K31/519 ,  A61P9/12 ,  A61P29/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/84 ,  C07D233/90 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D471/04 ,  C07D487/04

Abstract: The invention relates to compounds of the formula in which X, Y and Z are identical or different and are N or CR , R and R are as defined in the description, L is an alkylene radical, q = 0 or 1, and A is the radical of a fused heterobicycle. The invention furthermore relates to a method for the preparation of the abovementioned compounds, to compositions containing them, and to their use.

公开(公告)号：PL286188A1

公开(公告)日：1991-04-22

申请号：PL28618890

申请日：1990-07-23

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ WERNER ,  URBACH HANSJORG ,  WAGNER ADALBERT ,  RUPPERT DIETER ,  LINZ WOLFGANG ,  KRAMER WERNER

IPC: C12N9/99 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/445 ,  A61K31/535 ,  A61K38/55 ,  A61P9/12 ,  C07C237/08 ,  C07C237/22 ,  C07D211/26 ,  C07D211/58 ,  C07D233/54 ,  C07D233/64 ,  C07D295/20 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D521/00 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81 ,  C07C233/34

Abstract: The present invention relates to compounds of the formula I in which A, R , R , R and n are defined as indicated in the description, to processes for the preparation thereof, to the use thereof as medicines and to pharmaceutical compositions containing these.

公开(公告)号：FI911584A0

公开(公告)日：1991-04-02

申请号：FI911584

申请日：1991-04-02

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  HENNING RAINER ,  GERHARDS HERMANN ,  SCHOELKENS BERNHARD

IPC: A61K31/38 ,  A61K31/415 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4164 ,  A61K31/423 ,  A61K31/437 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/495 ,  A61K31/505 ,  A61K31/519 ,  A61P9/12 ,  A61P29/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/84 ,  C07D233/90 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D471/04 ,  C07D487/04 ,  C07D

Abstract: The invention relates to compounds of the formula in which X, Y and Z are identical or different and are N or CR , R and R are as defined in the description, L is an alkylene radical, q = 0 or 1, and A is the radical of a fused heterobicycle. The invention furthermore relates to a method for the preparation of the abovementioned compounds, to compositions containing them, and to their use.

公开(公告)号：PT94798A

公开(公告)日：1991-03-20

申请号：PT9479890

申请日：1990-07-24

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER ,  URBACH HANSJOERG ,  WAGNER ADALBERT ,  RUPPERT DIETER ,  LINZ WOLFGANG ,  KRAMER WERNER

IPC: C12N9/99 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/445 ,  A61K31/535 ,  A61K38/55 ,  A61P9/12 ,  C07C237/08 ,  C07C237/22 ,  C07D211/26 ,  C07D211/58 ,  C07D233/54 ,  C07D233/64 ,  C07D295/20 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D521/00 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81 ,  C07C235/06 ,  C07D211/00 ,  C07D233/00 ,  A61K31/16 ,  A61K31/40

Abstract: The present invention relates to compounds of the formula I in which A, R , R , R and n are defined as indicated in the description, to processes for the preparation thereof, to the use thereof as medicines and to pharmaceutical compositions containing these.

公开(公告)号：AU5971990A

公开(公告)日：1991-01-31

申请号：AU5971990

申请日：1990-07-24

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER ,  URBACH HANSJORG ,  WAGNER ADALBERT ,  RUPPERT DIETER ,  LINZ WOLFGANG ,  KRAMER WERNER

IPC: C12N9/99 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/445 ,  A61K31/535 ,  A61K38/55 ,  A61P9/12 ,  C07C237/08 ,  C07C237/22 ,  C07D211/26 ,  C07D211/58 ,  C07D233/54 ,  C07D233/64 ,  C07D295/20 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D521/00 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81 ,  C07K15/06 ,  C12N9/64 ,  C12P21/02 ,  A61K37/02

Abstract: The present invention relates to compounds of the formula I in which A, R , R , R and n are defined as indicated in the description, to processes for the preparation thereof, to the use thereof as medicines and to pharmaceutical compositions containing these.

公开(公告)号：PT93797A

公开(公告)日：1990-11-20

申请号：PT9379790

申请日：1990-04-19

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  RUPPERT DIETER ,  LINZ WOLFGANG ,  NICKEL WOLF-ULRICH ,  URBACH HANSJORG

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  A61K37/64

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, and W, R , R , R and R are as defined in the description, to processes for the preparation thereof, to the use thereof and to pharmaceutical compositions containing them.

公开(公告)号：FI903701A0

公开(公告)日：1990-07-23

申请号：FI903701

申请日：1990-07-23

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER ,  URBACH HANSJOERG ,  WAGNER ADALBERT ,  RUPPERT DIETER ,  LINZ WOLFGANG ,  KRAMER WERNER

IPC: C12N9/99 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/445 ,  A61K31/535 ,  A61K38/55 ,  A61P9/12 ,  C07C237/08 ,  C07C237/22 ,  C07D211/26 ,  C07D211/58 ,  C07D233/54 ,  C07D233/64 ,  C07D295/20 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D521/00 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81 ,  C07K

Abstract: The present invention relates to compounds of the formula I in which A, R , R , R and n are defined as indicated in the description, to processes for the preparation thereof, to the use thereof as medicines and to pharmaceutical compositions containing these.