公开(公告)号：PL1639352T3

公开(公告)日：2019-03-29

申请号：PL04755635

申请日：2004-06-18

Applicant: HOFFMANN LA ROCHE

Inventor： WILSEY CHRISTOPHER D ,  MOSOIU DAN

IPC: G01N27/30 ,  B05C5/02 ,  C12Q1/00 ,  G01N27/26 ,  G01N31/22 ,  G01N33/00 ,  G01N33/487 ,  G01N33/558

公开(公告)号：AU2012242252B2

公开(公告)日：2015-04-16

申请号：AU2012242252

申请日：2012-04-12

Applicant: HOFFMANN LA ROCHE

Inventor： BUCILLI SERGIO ,  JOSEPH ABNER D ,  WILSEY CHRISTOPHER D

IPC: B05D1/26 ,  B05C5/02 ,  B05C11/10

Abstract: Systems, apparatuses, techniques and processes for applying a wet film (18) to a substrate (16) using a slot die (22) are provided. In one form, the air pressure around at least a portion of the discharge end of the slot die is adjustable by the application of a vacuum force (23) in order to control the width and thickness of the wet film being applied to the substrate. In one aspect of this form, the wet film is a narrow, continuous stripe of reagent material applied to a moving web of the substrate from which a plurality of test elements will be obtained. However, different forms and applications are also envisioned.

公开(公告)号：CA2886162A1

公开(公告)日：2014-05-08

申请号：CA2886162

申请日：2013-10-31

Applicant: HOFFMANN LA ROCHE

Inventor： WILSEY CHRISTOPHER D

IPC: C12Q1/00

Abstract: Reagent materials and associated test elements are provided. In one embodiment, a test element having dual functionality includes a first coenzyme-dependent enzyme or a substrate for the first enzyme, a second coenzyme-dependent enzyme or a substrate for the second enzyme, and a coenzyme selected from the group consisting of thio-NAD, thio-NADP, and a compound according to formula (I). In one aspect, the first analyte is hydroxybutyrate and the first enzyme is a hydroxybutyrate dehydrogenase, and the second analyte is glucose and the second enzyme is a glucose dehydrogenase or a glucose oxidase. Other aspects of the subject application are directed to unique reagent materials. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description and drawings.

公开(公告)号：CA2529378C

公开(公告)日：2014-04-15

申请号：CA2529378

申请日：2004-06-18

Applicant: HOFFMANN LA ROCHE

Inventor： WILSEY CHRISTOPHER D ,  MOSOIU DAN

IPC: G01N27/30 ,  B05C5/02 ,  C12Q1/00 ,  G01N27/26 ,  G01N31/22 ,  G01N33/00 ,  G01N33/487 ,  G01N33/558

Abstract: The present application concerns a reagent coating mass which can be used in slot-die-coating of flat support materials in the manufacturing processes of test strips. Advantageously, the reagent mass of the invention exhibits certain superior rheological properties such as viscosity, surface tension and thixotropy. The reagent typically comprises an enzyme, a redox radiator and viscosity modifiers and thickeners, eg. Xanthan gum, silica, caboxy methyl cellulose, and surfactants to yield between 70 and 130 mPa.s and a surface tension between 30 and 50 nM/m. The reagent mass is preferably used to coat thin, narrow and homogeneous stripes of reagent material onto flat web material.

公开(公告)号：CA2831068A1

公开(公告)日：2012-10-18

申请号：CA2831068

申请日：2012-04-12

Applicant: HOFFMANN LA ROCHE

Inventor： BUCILLI SERGIO ,  JOSEPH ABNER D ,  WILSEY CHRISTOPHER D

IPC: B05D1/26 ,  B05C5/02 ,  B05C11/10

Abstract: Systems, apparatuses, techniques and processes for applying a wet film (18) to a substrate (16) using a slot die (22) are provided. In one form, the air pressure around at least a portion of the discharge end of the slot die is adjustable by the application of a vacuum force (23) in order to control the width and thickness of the wet film being applied to the substrate. In one aspect of this form, the wet film is a narrow, continuous stripe of reagent material applied to a moving web of the substrate from which a plurality of test elements will be obtained. However, different forms and applications are also envisioned.

公开(公告)号：HK1157413A1

公开(公告)日：2012-08-24

申请号：HK11111829

申请日：2011-11-02

Applicant: HOFFMANN LA ROCHE

Inventor： WILSEY CHRISTOPHER D ,  GHOSHAL MITALI ,  WIEDER HERBERT

IPC: C12Q20060101 ,  G01N20060101

Abstract: A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.

公开(公告)号：ES2378528T3

公开(公告)日：2012-04-13

申请号：ES01123622

申请日：2001-10-02

Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE

Inventor： BHULLAR RAGHBIR SINGH ,  WILSEY CHRISTOPHER D ,  HILL BRIAN S

IPC: C12Q1/00 ,  G01N27/327 ,  G01N27/28 ,  G01N27/30 ,  G01N27/416 ,  G01N33/483 ,  G01N33/487 ,  G01N33/49 ,  G01N33/543

Abstract: Biosensor (10) que comprende: un elemento de placa inferior (14) que comprende una primera superficie (22), un área de reacción predeterminada (42) sobre la primera superficie (22) y, como mínimo, un rebaje (34) formado en la primera superficie (22) y que circunscribe, como mínimo, una parte del área de reacción (42); y un reactivo (20) posicionado sobre el área de reacción; un elemento de placa superior (12) y un separador (15) formando un subconjunto, incluyendo dicho separador (15) una primera y segunda partes (70, 72), incluyendo cada una de las partes extremos (60, 62) y bordes (64, 66) que se extienden entre los extremos (60, 62), estando situado dicho subconjunto sobre el elemento de placa inferior (14) cubriendo el reactivo (20) y cooperando con el elemento de placa inferior (14), definiendo los bordes (64) de las partes (70, 72) del separador (15) un intersticio (68) en el biosensor montado (10), en el que el rebaje (34) está dispuesto en el intersticio (68).

公开(公告)号：CA2530297C

公开(公告)日：2011-04-12

申请号：CA2530297

申请日：2004-06-18

Applicant: HOFFMANN LA ROCHE

Inventor： BURKE DAVID W ,  MARQUANT MICHAEL ,  ZAPF UDO ,  FRITZ MICHAEL ,  MOSOIU DAN ,  WILSEY CHRISTOPHER D

IPC: G01N27/30 ,  C12Q1/00 ,  G01N27/26 ,  G01N31/22 ,  G01N33/00 ,  G01N33/487 ,  G01N33/558

Abstract: A test strip (10) having a small sample-receiving chamber on the order of less than 1 microliter includes a reagent layer (33) that extends across the width of the test strip and also extends to the sample-receiving end (36), such that the edges of the reagent layer are aligned with the side and dose receiving edges of the test strip. The hydrophilic reagent extending to the dosing edge of the strip promotes wicking of the sample into the test strip. The end and side edges of the reagent layer are preferably formed as part of a cutting process that forms individual test strips from a larger web, which results in a smooth and thin reagent layer with a uniform thickness, substantially covering the entire floor of the sample-receiving chamber. The inventive mass production process helps improve the reproducibility of the quantity, location, thickness and other properties of the reagent layer, which in turn improves the accuracy of the test result.

公开(公告)号：CA2467775C

公开(公告)日：2009-03-17

申请号：CA2467775

申请日：2002-11-18

Applicant: HOFFMANN LA ROCHE

Inventor： WILSEY CHRISTOPHER D ,  SURRIDGE NIGEL A

IPC: G01N27/327 ,  G01N27/416 ,  C12Q1/00 ,  G01N27/00 ,  G01N27/30 ,  G01N27/403 ,  G01N27/42 ,  G01N33/487 ,  G01N33/66

Abstract: Described are micro-arrays of electrodes disposed proximal to a flexible substrate, electronic components and sensors comprising such arrays, and methods of use for such arrays.

公开(公告)号：AT378419T

公开(公告)日：2007-11-15

申请号：AT02011230

申请日：2002-05-22

Applicant: HOFFMANN LA ROCHE

Inventor： BHULLAR RAGHBIR S ,  WILSEY CHRISTOPHER D ,  AUSTERA JOHN T ,  REISER WOLFGANG O L

IPC: C12Q1/00 ,  G01N33/483 ,  G01N27/30 ,  G01N27/327 ,  G01N27/403 ,  G01N27/416 ,  G01N33/487

Abstract: The present invention relates to a biosensor. The biosensor includes a support substrate having first and second ends, electrodes positioned on the support substrate, the electrodes cooperating with one another to define electrode arrays situated adjacent to the first end, a spacer substrate positioned on the support substrate, and a cover positioned on the spacer substrate. The cover cooperates with the support substrate to define a channel. The channel includes an inlet adjacent to the first end and opposite ends. Each electrode array is positioned in the channel adjacent to one of the ends.