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公开(公告)号：AU2013205326A1
公开(公告)日：2013-05-09
申请号：AU2013205326
申请日：2013-04-11
Applicant: PORTOLA PHARM INC
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
IPC: A61P7/02 , A61K31/4545 , A61K31/5377 , A61K31/715 , A61K31/727 , A61K38/36 , A61K38/48 , A61K39/00 , A61K39/395 , A61K47/48 , A61P7/04 , C07H21/00 , C07K14/00 , C07K16/00 , C12N5/10 , C12N9/64 , C12P21/00
Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or 5 have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
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公开(公告)号：MX2011004907A
公开(公告)日：2011-07-29
申请号：MX2011004907
申请日：2009-11-11
Applicant: PORTOLA PHARM INC
Abstract: La presente invención se refiere a los antídotos de los anticoagulantes dirigidos contra el factor Xa los cuales son usados en combinación con agentes de coagulación de sangre u otros antídotos tipo heparina para prevenir o reducir el sangrado en un sujeto. Los antídotos aquí descritos tienen o no reducida su actividad anticoagulante intrínseca. Aquí se manifiestan métodos para detener o prevenir el sangrado en un paciente que es o será sometido a terapia de anticoagulantes con un inhibidor del factor Xa.
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公开(公告)号：AU2009314153A1
公开(公告)日：2010-05-20
申请号：AU2009314153
申请日：2009-11-11
Applicant: PORTOLA PHARM INC
Abstract: The present invention relates to antidotes of anticoagulants targeting factor Xa which antidotes are used in combination with blood coagulating agents or other heparin antidotes to prevent or reduce bleeding in a subject. The antidotes described herein have reduced or no intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is or will be undergoing anticoagulant therapy with a factor Xa inhibitor.
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公开(公告)号：AU2008304192A2
公开(公告)日：2010-04-08
申请号：AU2008304192
申请日：2008-09-26
Applicant: PORTOLA PHARM INC
Inventor： PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA , LU GENMIN
IPC: A61P7/02 , A61K31/4545 , A61K31/5377 , A61K31/715 , A61K31/727 , A61K38/36 , A61K38/48 , A61K39/00 , A61K39/395 , A61K47/48 , A61P7/04 , C07H21/00 , C07K14/00 , C07K16/00 , C12N5/10 , C12N9/64 , C12P21/00
Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa.The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
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公开(公告)号：AU2008304192A1
公开(公告)日：2009-04-02
申请号：AU2008304192
申请日：2008-09-26
Applicant: PORTOLA PHARM INC
Inventor： PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA , LU GENMIN
IPC: A61P7/02 , A61K31/4545 , A61K31/5377 , A61K31/715 , A61K31/727 , A61K38/36 , A61K38/48 , A61K39/00 , A61K39/395 , A61K47/48 , A61P7/04 , C07H21/00 , C07K14/00 , C07K16/00 , C12N5/10 , C12N9/64 , C12P21/00
Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa.The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
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Patent Agency Ranking
公开(公告)号：AU2017283720B2
公开(公告)日：2022-11-17
申请号：AU2017283720
申请日：2017-06-19
Applicant: PORTOLA PHARM INC
Inventor： KARBARZ MARK , CONLEY PAMELA B , LU GENMIN
Abstract: The present disclosure provides methods for manufacturing a fXa derivative protein at large scale leading to high yield of highly pure protein product. The method may include adding a detergent to a sample that contains a polynucleotide construct encoding the protein and purifying the protein through a soybean trypsin inhibitor (STI)-based affinity chromatograph, an ion exchange and mixed mode chromatograph and a hydrophobic interaction.
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公开(公告)号：EA037815B1
公开(公告)日：2021-05-25
申请号：EA201990052
申请日：2017-06-19
Applicant: PORTOLA PHARM INC
Inventor： KARBARZ MARK , CONLEY PAMELA B , LU GENMIN
IPC: A61K38/00 , A61K38/36 , A61K38/48 , C07K14/745
Abstract: Изобретениепредлагаетспособыкрупномасштабногопроизводствапроизводногобелка fXa, которыеприводятк высокомувыходувысокочистогобелковогопродукта. Способможетвключатьдобавлениедетергентак образцу, которыйсодержитполинуклеотиднуюконструкцию, кодирующуюбелок, иочисткубелкас помощьюхроматографадляаффиннойхроматографиинаосновеингибиторатрипсинасои (STI), хроматографас ионнымобменоми смешаннымрежимоми хроматографас гидрофобнымвзаимодействием.
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公开(公告)号：HUE050063T2
公开(公告)日：2020-11-30
申请号：HUE16167534
申请日：2008-09-26
Applicant: PORTOLA PHARM INC
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
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公开(公告)号：LT3078743T
公开(公告)日：2020-09-25
申请号：LT16167534
申请日：2008-09-26
Applicant: PORTOLA PHARM INC
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
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公开(公告)号：CA2876361C
公开(公告)日：2020-06-30
申请号：CA2876361
申请日：2013-06-12
Applicant: PORTOLA PHARM INC
Abstract: Disclosed herein are methods and kits for purifying a serine protease. The methods entail loading the serine protease to a soybean trypsin inhibitor (STI) based affinity chromatograph, and eluting the serine protease with an elution buffer comprising an agent that disrupts interaction between the STI and the serine protease
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