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公开(公告)号：WO2009042962A3
公开(公告)日：2009-06-04
申请号：PCT/US2008078014
申请日：2008-09-26
Applicant: PORTOLA PHARM INC , LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
CPC classification number: A61K38/4846 , A61K38/00 , A61K38/4826 , A61K38/4833 , A61K38/4853 , A61K39/00 , A61K47/60 , C07K14/435 , C12N9/6432 , C12Y304/21006
Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
Abstract translation: 本发明涉及解毒剂靶向因子Xa的抗凝血剂。 解毒剂是因子Xa蛋白衍生物，其与因子Xa抑制剂结合，从而基本上中和它们但不组装成凝血酶原酶复合物。 本文描述的衍生物缺乏或降低了内在凝固剂活性。 本文公开了停止或预防正在用Xa因子抑制剂进行抗凝血剂治疗的患者出血的方法。
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公开(公告)号：WO2009042962A2
公开(公告)日：2009-04-02
申请号：PCT/US2008078014
申请日：2008-09-26
Applicant: PORTOLA PHARM INC , LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
IPC: A61P7/02 , A61K31/4545 , A61K31/5377 , A61K31/715 , A61K31/727 , A61K38/36 , A61K38/48 , A61K39/395 , A61K47/48 , A61P7/04 , C07H21/00 , C07K14/00 , C07K16/00 , C12N5/10 , C12P21/00
CPC classification number: A61K38/4846 , A61K38/00 , A61K38/4826 , A61K38/4833 , A61K38/4853 , A61K39/00 , A61K47/60 , C07K14/435 , C12N9/6432 , C12Y304/21006
Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
Abstract translation: 本发明涉及靶向因子Xa的抗凝剂的解毒剂。 解毒剂是与因子Xa抑制剂结合的因子Xa蛋白衍生物，从而基本上中和它们，但不组装到凝血酶原酶复合物中。 本文所述的衍生物缺乏或具有降低的内在凝结剂活性。 本文公开了在目前正在进行使用因子Xa抑制剂进行抗凝治疗的患者中停止或预防出血的方法。
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3.发明申请COMBINATION THERAPY WITH A COMPOUND ACTING AS A PLATELET ADP RECEPTOR INHIBITOR 审中-公开作为平板ADP受体抑制剂的化合物治疗的组合治疗
公开(公告)号：WO2008137787A3
公开(公告)日：2009-02-05
申请号：PCT/US2008062561
申请日：2008-05-02
Applicant: PORTOLA PHARM INC , CONLEY PAMELA B , ANDRE PATRICK , SINHA UMA
Inventor： CONLEY PAMELA B , ANDRE PATRICK , SINHA UMA
IPC: A61K31/235 , A61K31/422 , A61K31/435 , A61K31/517 , A61K45/06 , A61P7/00 , A61P7/02 , A61P9/00
CPC classification number: A61K31/422 , A61K31/235 , A61K31/435 , A61K31/4545 , A61K31/517 , A61K38/4846 , A61K45/06 , A61K2300/00
Abstract: The present invention is directed to pharmaceutical compositions and methods of using combination therapies containing [4 (6-fluoro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea, or a pharmaceutically acceptable salt thereof, for the treatment of thrombosis diseases.
Abstract translation: 本发明涉及药物组合物和使用含有[4（6-氟-7-甲基氨基-2,4-二氧代-1,4-二氢-2H-喹唑啉-3-基） - 苯基] - 5-氯 - 噻吩-2-基 - 磺酰脲或其药学上可接受的盐，用于治疗血栓形成疾病。
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4.发明申请ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME IN COMBINATION WITH BLOOD COAGULATING AGENTS 审中-公开用于因子XA抑制剂的抗体及其与血液凝结剂组合使用的方法
公开(公告)号：WO2010056765A3
公开(公告)日：2010-08-05
申请号：PCT/US2009064060
申请日：2009-11-11
Applicant: PORTOLA PHARM INC , LU GENMIN , SINHA UMA
CPC classification number: A61K38/36 , A61K35/16 , A61K38/16 , A61K38/37 , A61K38/482 , A61K38/4826 , A61K38/4833 , A61K38/4846 , A61K38/4853 , A61K45/06 , A61K2300/00
Abstract: The present invention relates to antidotes of anticoagulants targeting factor Xa which antidotes are used in combination with blood coagulating agents or other heparin antidotes to prevent or reduce bleeding in a subject. The antidotes described herein have reduced or no intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is or will be undergoing anticoagulant therapy with a factor Xa inhibitor.
Abstract translation: 本发明涉及靶向凝血因子Xa的抗凝剂的解毒剂，其中解毒剂与凝血剂或其他肝素解毒剂组合使用以预防或减少受试者的出血。 本文所述的解毒剂具有降低的或不具有内在凝固剂活性。 本文公开了停止或预防正在或将要用Xa因子抑制剂进行抗凝血剂治疗的患者出血的方法。
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公开(公告)号：ES2796623T3
公开(公告)日：2020-11-27
申请号：ES16167534
申请日：2008-09-26
Applicant: PORTOLA PHARM INC
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
Abstract: Una composición farmacéutica que comprende un transportador y un polipéptido para uso en terapia donde el polipéptido comprende una secuencia de aminoácidos que tiene al menos el 80% de homología con la SEQ ID NO. 12, donde el polipéptido: (i) tiene actividad catalítica reducida; (ii) es capaz de unirse a un inhibidor del factor Xa; y (iii) no puede ensamblarse en el complejo de protrombinasa.
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Patent Agency Ranking
公开(公告)号：PL3078743T3
公开(公告)日：2020-11-02
申请号：PL16167534
申请日：2008-09-26
Applicant: PORTOLA PHARM INC
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
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公开(公告)号：HRP20201071T1
公开(公告)日：2020-10-30
申请号：HRP20201071
申请日：2020-07-08
Applicant: PORTOLA PHARM INC
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
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公开(公告)号：DK3078743T3
公开(公告)日：2020-08-10
申请号：DK16167534
申请日：2008-09-26
Applicant: PORTOLA PHARM INC
Inventor： LU GENMIN , PHILLIPS DAVID R , SINHA UMA , ANDRE PATRICK
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公开(公告)号：CA2743496C
公开(公告)日：2018-03-27
申请号：CA2743496
申请日：2009-11-11
Applicant: PORTOLA PHARM INC
Abstract: The present invention relates to antidotes of anticoagulants targeting factor Xa which antidotes are used in combi-nation with blood coagulating agents or other heparin antidotes to prevent or reduce bleeding in a subject. The antidotes described herein have reduced or no intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a pa-tient that is or will be undergoing anticoagulant therapy with a factor Xa inhibitor.
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公开(公告)号：HRP20161255T1
公开(公告)日：2016-12-02
申请号：HRP20161255
申请日：2016-10-03
Applicant: PORTOLA PHARM INC
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
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