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公开(公告)号：WO2009042962A3
公开(公告)日：2009-06-04
申请号：PCT/US2008078014
申请日：2008-09-26
Applicant: PORTOLA PHARM INC , LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
CPC classification number: A61K38/4846 , A61K38/00 , A61K38/4826 , A61K38/4833 , A61K38/4853 , A61K39/00 , A61K47/60 , C07K14/435 , C12N9/6432 , C12Y304/21006
Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
Abstract translation: 本发明涉及解毒剂靶向因子Xa的抗凝血剂。 解毒剂是因子Xa蛋白衍生物，其与因子Xa抑制剂结合，从而基本上中和它们但不组装成凝血酶原酶复合物。 本文描述的衍生物缺乏或降低了内在凝固剂活性。 本文公开了停止或预防正在用Xa因子抑制剂进行抗凝血剂治疗的患者出血的方法。
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2.发明申请DEVICE AND METHODS FOR IDENTIFYING AND TREATING ASPIRIN NON-RESPONSIVE PATIENTS 审中-公开鉴定和治疗ASPIRIN非反应性患者的装置和方法
公开(公告)号：WO2006066008A2
公开(公告)日：2006-06-22
申请号：PCT/US2005045445
申请日：2005-12-14
Applicant: PORTOLA PHARM INC , PHILLIPS DAVID R , ANDRE PATRICK , STEPHENS GILLIAN
Inventor： PHILLIPS DAVID R , ANDRE PATRICK , STEPHENS GILLIAN
IPC: C12Q1/56
CPC classification number: G01N33/9486 , G01N33/86
Abstract: The present invention relates to methods and compositions for identifying and treating subjects in need of antithrombotic therapies but who are not responsive to aspirin.
Abstract translation: 本发明涉及用于鉴定和治疗需要抗血栓治疗但是对阿司匹林不敏感的受试者的方法和组合物。
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公开(公告)号：WO2009042962A2
公开(公告)日：2009-04-02
申请号：PCT/US2008078014
申请日：2008-09-26
Applicant: PORTOLA PHARM INC , LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
IPC: A61P7/02 , A61K31/4545 , A61K31/5377 , A61K31/715 , A61K31/727 , A61K38/36 , A61K38/48 , A61K39/395 , A61K47/48 , A61P7/04 , C07H21/00 , C07K14/00 , C07K16/00 , C12N5/10 , C12P21/00
CPC classification number: A61K38/4846 , A61K38/00 , A61K38/4826 , A61K38/4833 , A61K38/4853 , A61K39/00 , A61K47/60 , C07K14/435 , C12N9/6432 , C12Y304/21006
Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
Abstract translation: 本发明涉及靶向因子Xa的抗凝剂的解毒剂。 解毒剂是与因子Xa抑制剂结合的因子Xa蛋白衍生物，从而基本上中和它们，但不组装到凝血酶原酶复合物中。 本文所述的衍生物缺乏或具有降低的内在凝结剂活性。 本文公开了在目前正在进行使用因子Xa抑制剂进行抗凝治疗的患者中停止或预防出血的方法。
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4.发明申请COMBINATION THERAPY WITH A COMPOUND ACTING AS A PLATELET ADP RECEPTOR INHIBITOR 审中-公开作为平板ADP受体抑制剂的化合物治疗的组合治疗
公开(公告)号：WO2008137787A3
公开(公告)日：2009-02-05
申请号：PCT/US2008062561
申请日：2008-05-02
Applicant: PORTOLA PHARM INC , CONLEY PAMELA B , ANDRE PATRICK , SINHA UMA
Inventor： CONLEY PAMELA B , ANDRE PATRICK , SINHA UMA
IPC: A61K31/235 , A61K31/422 , A61K31/435 , A61K31/517 , A61K45/06 , A61P7/00 , A61P7/02 , A61P9/00
CPC classification number: A61K31/422 , A61K31/235 , A61K31/435 , A61K31/4545 , A61K31/517 , A61K38/4846 , A61K45/06 , A61K2300/00
Abstract: The present invention is directed to pharmaceutical compositions and methods of using combination therapies containing [4 (6-fluoro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea, or a pharmaceutically acceptable salt thereof, for the treatment of thrombosis diseases.
Abstract translation: 本发明涉及药物组合物和使用含有[4（6-氟-7-甲基氨基-2,4-二氧代-1,4-二氢-2H-喹唑啉-3-基） - 苯基] - 5-氯 - 噻吩-2-基 - 磺酰脲或其药学上可接受的盐，用于治疗血栓形成疾病。
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5.发明申请INTRAVENOUS AND ORAL DOSING OF A DIRECT-ACTING AND REVERSIBLE P2Y12 INHIBITOR 审中-公开直接作用和可逆的P2Y12抑制剂的口服和口服剂量
公开(公告)号：WO2008137753A2
公开(公告)日：2008-11-13
申请号：PCT/US2008062518
申请日：2008-05-02
Applicant: PORTOLA PHARM INC , SCARBOROUGH CARROLL ANNA CREW , GRETLER DANIEL D , CONLEY PAMELA B , ANDRE PATRICK , HUTCHALEELAHA ATHIWAT , PHILLIPS DAVID R , PANDEY ANJALI , WOLIN HUANG
Inventor： GRETLER DANIEL D , CONLEY PAMELA B , ANDRE PATRICK , HUTCHALEELAHA ATHIWAT , PHILLIPS DAVID R , PANDEY ANJALI , WOLIN HUANG , SCARBOROUGH ROBERT M
IPC: A61K31/216 , A61K31/517 , A61P7/02
CPC classification number: A61K31/517 , A61K31/216 , A61K2300/00
Abstract: The invention provides methods and compositions for rapid and reversible inhibition of platelet aggregation in human subjects in need thereof by administering compounds of the formula: (I) alone or in combination with a second agent which can be aspirin or a thrombolytic agent.
Abstract translation: 本发明提供了在需要的人类受试者中快速和可逆地抑制血小板聚集的方法和组合物，其通过单独给予式（I）化合物或与可以是阿司匹林或溶栓剂的第二药剂组合施用。
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Patent Agency Ranking6.发明公开UNIT DOSE FORMULATIONS AND METHODS OF TREATING AND PREVENTING THROMBOSIS WITH THROMBOXANE RECEPTOR ANTAGONISTS 审中-公开单位剂量制剂并用于治疗和血栓形成预防WITH A THROMBOXANREZEPTORHEMMER方法
公开(公告)号：EP2146573A4
公开(公告)日：2012-11-21
申请号：EP08747595
申请日：2008-05-02
Applicant: PORTOLA PHARM INC
Inventor： STEPHENS GILLIAN , GAO DACAO , ANDRE PATRICK , PHILLIPS DAVID R
IPC: A61K31/444 , A61K45/06 , A61P9/00
CPC classification number: A61K31/422 , A61K31/20 , A61K31/405 , A61K31/4406 , A61K31/444 , A61K45/06
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公开(公告)号：EP1737386A4
公开(公告)日：2012-01-04
申请号：EP05736870
申请日：2005-04-18
Applicant: PORTOLA PHARM INC
Inventor： ANDRE PATRICK , PHILLIPS DAVID R , HOMCY CHARLES
IPC: A61F2/02 , A61K31/473 , A61K31/4745 , A61K31/52 , A61L31/10 , A61L31/16
CPC classification number: A61K31/473 , A61K31/4745 , A61K31/52 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L2300/434
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8.发明公开USE OF TP MODULATORS FOR THE TREATMENT OF CARDIOVASCULAR DISORDERS IN ASPIRIN SENSITIVE AND OTHER POPULATIONS 审中-公开TP调节剂用于治疗心血管疾病的阿司匹林敏感数据和其它人群治疗
公开(公告)号：EP2144999A4
公开(公告)日：2010-06-16
申请号：EP08747593
申请日：2008-05-02
Applicant: PORTOLA PHARM INC
Inventor： PHILLIPS DAVID R , ANDRE PATRICK , HOMCY CHARLES J
CPC classification number: A61K31/422 , A61K31/20 , A61K31/405 , A61K31/4406 , A61K31/444 , A61K45/06
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公开(公告)号：PL2193196T3
公开(公告)日：2017-07-31
申请号：PL08834136
申请日：2008-09-26
Applicant: PORTOLA PHARM INC
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
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公开(公告)号：LT2193196T
公开(公告)日：2016-12-12
申请号：LT08834136
申请日：2008-09-26
Applicant: PORTOLA PHARM INC
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
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