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    INTEGRATED FUNCTIONAL AND MOLECULAR PROFILING OF CELLS
    61.
    发明公开
    INTEGRATED FUNCTIONAL AND MOLECULAR PROFILING OF CELLS 审中-公开

    公开(公告)号：US20240175870A1

    公开(公告)日：2024-05-30

    申请号：US18235751

    申请日：2023-08-18

    Applicant: University of Houston System

    Inventor： Navin Varadarajan ,  Gabrielle Romain ,  Ivan Liadi ,  Victor G. Sendra ,  Badrinath Roysam

    IPC: G01N33/569 ,  C12Q1/68 ,  C12Q1/6869 ,  G01N33/50

    CPC classification number: G01N33/56966 ,  C12Q1/68 ,  C12Q1/6869 ,  G01N33/5005 ,  G01N2570/00

    Abstract: Presented herein are methods of evaluating cellular activity by: placing a cell population on an area; assaying for a dynamic behavior of the cell population as a function of time; identifying cell(s) of interest based on the dynamic behavior; characterizing a molecular profile of the cell(s); and correlating the obtained information. The assayed dynamic behavior can include cellular activation, cellular inhibition, cellular interaction, protein expression, protein secretion, cellular proliferation, changes in cellular morphology, motility, cell death, cell cytotoxicity, cell lysis, and combinations thereof. Sensors associated with the area may be utilized to facilitate assaying. Molecular profiles of the cell(s) can then be characterized by various methods, such as DNA analysis, RNA analysis, and protein analysis. The dynamic behavior and molecular profile can then be correlated for various purposes, such as predicting clinical outcome of a treatment, screening cells, facilitating a treatment, diagnosing a disease, and monitoring cellular activity.

    BIOSENSOR FOR DETECTING A SINGLE MAGNETIC LABEL
    67.
    发明公开
    BIOSENSOR FOR DETECTING A SINGLE MAGNETIC LABEL 审中-公开

    公开(公告)号：US20240019398A1

    公开(公告)日：2024-01-18

    申请号：US18372558

    申请日：2023-09-25

    Applicant: UNIVERSITY OF HOUSTON SYSTEM

    Inventor： Dmitri Litvinov ,  Long Chang ,  Richard Willson

    IPC: G01N27/74 ,  G01N33/543

    CPC classification number: G01N27/745 ,  G01N33/54326 ,  G01N33/54346 ,  G01N33/54373

    Abstract: A biosensor may provide a magnetoresistive (MR) film comprising a nonmagnetic layer may be sandwiched between the two ferromagnetic layers. The MR film may be positioned on a substrate, where the edges of the MR film are in contact with leads. The leads may be in contact with pads. The sensors may provide quasi-digital readout that enable greatly enhanced sensitivity. In some embodiments, biosensors may be arranged as array of sensors. The array of sensors may be arranged as a symmetric or asymmetric N1×N2 array, where N1 and N2 are integers, N1 represents the number of sensors linked together in series, and N2 represents the number of sensor sets in parallel, where each sensor set may comprise one or more sensors. Further, the array of sensors may be coupled to a voltmeter, which may be a single voltmeter in that allows the sensors to all be probed simultaneously.

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