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公开(公告)号：KR101602797B1
公开(公告)日：2016-03-11
申请号：KR1020150146629
申请日：2015-10-21
Applicant: 대한민국(농촌진흥청장)
CPC classification number: A61L31/047 , A61F2/02 , A61L27/36
Abstract: 본발명은평면견을이용한인공생체막및 이의제조방법에관한것이다. 본발명의평면견을이용한인공생체막은, 누에에의하여생산된제 1두께의평면견(Silk Matrix)을이용하여, 상기제 1두께의단면을갖는상기평면견이두 개이상의적절한형태로평면분할된상기제 1두께의평면견의조각인것이특징이다. 본발명에의해, 제조과정이상대적으로간단하여통상의인공생체막의단가와대비하여훨씬절감이가능함과동시에세포배양능이우수하며생체적합성을갖는평면견을이용한인공생체막및 이의제조방법이제공된다. 또한, 인공생체막으로의우수한인장강도와연신율을갖는평면견을이용한생체막및 이의제조방법이제공된다.
Abstract translation: 本发明涉及使用丝织物的人造生物膜及其制造方法。 使用丝质基质的人造生物膜是具有第一厚度的横截面的丝状基质片，该第一厚度通过使用丝基体被平分成具有第一厚度的两个或更多个丝基质，以具有适当的形状 第一厚度由蚕生产。 本发明提供了使用丝素基质的人造生物膜，其通过相对简化的方法制造，与常规人造生物膜的成本相比大大节省成本，同时具有优异的细胞增殖和 生物兼容性。 本发明还提供其制造方法。 此外，本发明提供使用具有优异的拉伸强度和伸长率的丝线基质的人造生物膜及其制造方法。
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公开(公告)号：KR101582202B1
公开(公告)日：2016-01-05
申请号：KR1020140152646
申请日：2014-11-05
Applicant: 대한민국(농촌진흥청장)
CPC classification number: A61L27/3637 , A61F2/0063 , A61K9/70 , A61K35/63 , A61L27/3604 , A61L27/3691 , A61L27/44 , A61L27/507 , A61L27/56
Abstract: 본발명은누에고치를이용한혈관용패치및 이의제조방법에관한것이다. 본발명의누에고치를이용한혈관용패치는제 1두께의단면을갖는누에고치에서두 개이상의적절한형태로평면분할된상기누에고치편으로제조되는것이특징이다. 본발명에의해, 제조과정이상대적으로간단하여통상의혈관용패치의단가와대비하여훨씬절감이가능함과동시에세포배양능이우수하며생체적합성을갖는누에고치를이용한혈관용패치및 이의제조방법이제공된다.
Abstract translation: 本发明涉及使用茧的血管贴片及其制造方法。 使用茧的血管贴片由茧片制成，其中茧片是通过将具有第一厚度的横截面的茧分成基于横截面切片的两个或更多个适当形状的片而获得的。 提供使用茧的血管贴片及其制造方法，其能够通过相对简化的制造方法与常规血管贴片的单位成本相比显着降低成本，同时具有优异的细胞增殖能力和生物相容性。
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公开(公告)号：KR1020150136360A
公开(公告)日：2015-12-07
申请号：KR1020140063757
申请日：2014-05-27
Applicant: 강릉원주대학교산학협력단 , 대한민국(농촌진흥청장)
Abstract: 본발명은혈관의수복을위한혈관용패치에관한것으로, 구체적으로는손상된혈관의결손부에정밀하게봉합되어, 혈관벽이재생되는동안피가새지않게하며, 외부환경으로부터손상된혈관의재생이방해받지않도록보호하고, 혈행의감소및 혈관내경의감소를최소화하는동시에, 혈관결손부위로새로운혈관벽을재생시키기위한혈관용패치에관한것이다.
Abstract translation: 本发明涉及一种用于修复血管的血管补片，更具体地，涉及一种通过精确地附着在损伤的血管的受影响区域上而在血管壁再生时防止血液泄漏的血管补片。 本发明的血管贴片还保护受损的血管免受外部环境的影响，以防止再生中断。 此外，血管贴片最小化血液循环的减少和血管的内半径，同时诱导血管中受影响区域上的新血壁的再生。
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公开(公告)号：KR1020150053033A
公开(公告)日：2015-05-15
申请号：KR1020130134701
申请日：2013-11-07
Applicant: 대한민국(농촌진흥청장)
Abstract: 본발명은뽕잎배양물을포함하는비육돈용사료첨가제및 이를함유하는비육돈용사료에관한것이다. 본발명의비육돈용사료첨가제는뽕잎을차가버섯배양체로배양하여얻은뽕잎배양물을포함하는것이특징이다. 본발명에의해, 항생제를사용하지않으면서비육돈의생산성을높이기위해다양한종류의생리활성물질을함유하고있음에도불구하고제대로활용되지못하고폐기되어왔던뽕잎을차가버섯으로배양하여베타글루칸의함량을증가시킴으로인해, 이를이용하여비육돈의성장율과면역력을향상시키고비육돈의품질을개선시킬수 있는비육돈용사료첨가제및 이를함유하는비육돈용사료가제공된다.
Abstract translation: 本发明涉及一种用于猪肉的饲料添加剂，其包括桑叶的培养物和含有该桑叶的猪肉的饲料。 本发明的猪肉饲料添加剂的特征在于其中含有的桑叶的培养物，其通过用辣椒蘑菇培养培养桑叶而获得。 根据本发明，提供了一种用于猪肉的饲料添加剂和含有该饲料的猪肉的饲料添加剂，其可以通过增加β-葡聚糖的含量来提高猪肉的生长速率和免疫力并提高猪肉的质量 用沙加蘑菇栽培桑叶，以提高猪肉的生产力，而不使用抗生素，其中桑叶已经没有被适当利用，即使含有各种生物活性物质也被丢弃。
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65.发明授权히알루론산―도파민 컨쥬게이트로 표면이 개질된 하이드록시아파타이트 나노입자를 포함하는 실크피브로인 나노섬유 및 이를 이용한 지지체 有权包含用羟丙酸/多巴胺结合物修饰的羟基磷酸酯的纳米纤维素和使用其的SCAFFOLD
公开(公告)号：KR101313898B1
公开(公告)日：2013-09-30
申请号：KR1020120044954
申请日：2012-04-27
Applicant: 대한민국(농촌진흥청장) , 서울대학교산학협력단
CPC classification number: D01F4/02 , A61F2/2846 , A61L24/00 , A61L27/3604 , D01D5/0015 , D01D10/06 , D01F1/10
Abstract: PURPOSE: The complex nanofiber of hydroxyapatite and silk fibroin, a two dimensional structure and a three dimensional structure supporter using the same is provided to easily facilitate the uniformity and guarantee of reappearance, is able to electrospinning for a long time, and useful for cell formation, bond tissue regeneration and supporter as its mechanical property is satisfied. CONSTITUTION: The complex nanofiber uniformly disperses the hydroxyapatite nano particle which surface is reformed with the hyaluronic acid-dopamine conjugate inside the silk fibroin nanofiber. Conjugate of the hyaluronic acid-dopamine is the formation of amide bond by combining the carboxyl group of hyaluronic acid and amine group of dopamine. The hydroxyapatite which surface is reformed with the hyaluronic acid-dopamine conjugate is the combination of two hydroxyl radicals of dopamine to the surface of the hydroxyapatite. The diameter of the complex nanofiber is 100-1000 nm.
Abstract translation: 目的：提供复合纳米纤维的羟基磷灰石和丝素蛋白，二维结构和三维结构支持体，使其易于均匀，保证再现，能长时间静电纺丝，可用于细胞形成 ，粘合组织再生和支持体作为其机械性能得到满足。 构成：复合纳米纤维将丝氨蛋白纳米纤维内透明质酸 - 多巴胺缀合物表面的羟基磷灰石纳米粒子均匀分散。 透明质酸 - 多巴胺的结合物是通过将透明质酸的羧基和多巴胺的胺基组合而形成酰胺键。 表面用透明质酸 - 多巴胺缀合物重整的羟基磷灰石是多巴胺的两个羟基自由基与羟基磷灰石表面的组合。 复合纳米纤维的直径为100-1000nm。
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Patent Agency Ranking
公开(公告)号：KR1020130051602A
公开(公告)日：2013-05-21
申请号：KR1020110116838
申请日：2011-11-10
Applicant: 한림대학교 산학협력단 , 대한민국(농촌진흥청장) , 서울대학교산학협력단
CPC classification number: A61L27/60 , A61L27/22 , A61L2430/34 , D01D5/0007
Abstract: PURPOSE: A 3 dimensional silk nano fiber film and a manufacturing method thereof are provided to control biodegradation speed by having similar structure with human skin in size and thickness. CONSTITUTION: A manufacturing method of 3 dimensional silk nano filber film for skin substitute comprises a process for preparing nano fiber undiluted solution, salt adding process and applying voltage and diffusing prepared nano fiber undiluted solution at the same time, and salt removing process from the diffused nano fiber film. On the salt adding process with the electro-spinning, the supply quantity and particle size controlled salt is sprayed on the nano fiber film to form an air gap. The size of the air gap is 10-100 micrometer and the thickness is 1-5 millimeters.
Abstract translation: 目的：提供一种三维丝纳米纤维膜及其制造方法，以通过与人体皮肤的尺寸和厚度相似的结构来控制生物降解速度。 构成：用于皮肤代用品的三维丝纳米薄膜的制造方法包括同时制备纳米纤维未稀释溶液，加盐过程和施加电压并扩散制备的纳米纤维未稀释溶液的方法，以及从扩散的脱盐过程 纳米纤维膜。 在电纺丝的加盐过程中，将供给量和粒度控制盐喷洒在纳米纤维膜上形成气隙。 气隙的大小为10-100微米，厚度为1-5毫米。
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公开(公告)号：KR1020130031193A
公开(公告)日：2013-03-28
申请号：KR1020120068594
申请日：2012-06-26
Applicant: 대한민국(농촌진흥청장) , 차의과학대학교 산학협력단
CPC classification number: A61L15/325 , A61F13/0266 , A61F2013/00089 , A61F2013/00217 , A61L15/16 , A61L15/22
Abstract: PURPOSE: A medical dressing material using a silk grand-derived hydrolysate and a method for manufacturing the same are provided to ensure excellent wound healing and moisturizing effects. CONSTITUTION: A method for manufacturing a medical dressing material using a silk gland-derived hydrolysate comprises: a step of dissolving a silk-derived hydrolysate and preparing a hydrolysate solution; a step of adding a crosslinking agent to the hydrolysate solution and stirring at 15-30 deg. C for 0.5-2 hours; and a step of quickly freeze-drying.
Abstract translation: 目的：提供使用丝绸来源的水解产物的医用敷料及其制造方法，以确保良好的伤口愈合和保湿效果。 构成：使用丝腺衍生的水解产物制造医用敷料的方法包括：将丝衍生的水解产物溶解并制备水解产物溶液的步骤; 将交联剂加入到水解液中并在15-30℃搅拌的步骤。 C为0.5-2小时; 和快速冷冻干燥的步骤。
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公开(公告)号：KR101219736B1
公开(公告)日：2013-01-11
申请号：KR1020100030566
申请日：2010-04-02
Applicant: 대한민국(농촌진흥청장)
Abstract: 본 발명은 상족과정 중에 있는 누에의 건조분말을 활성성분으로 함유하는 남성호르몬 분비 촉진용 조성물에 관한 것으로 본 발명에 따른 조성물은 천연소재를 이용하여 부작용이 없으며 혈액내 테스토스테론의 분비를 촉진시켜 남성의 생식능력을 증진시키는 식품조성물 내지 약제학적 조성물로서 이용될 수 있다.
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公开(公告)号：KR1020120108637A
公开(公告)日：2012-10-05
申请号：KR1020110026779
申请日：2011-03-25
Applicant: 대한민국(농촌진흥청장)
IPC: A23L21/20 , A23L3/40 , A23L3/3418
CPC classification number: A23L21/27 , A23L3/40 , A23V2002/00 , A23V2200/30
Abstract: PURPOSE: Royal jelly capable of enabling users to easily storing and eating, and a producing method thereof are provided to enable users to store the royal jelly at room temperature. CONSTITUTION: A producing method of royal jelly capable of enabling users to easily storing and eating comprises the following steps: preparing raw royal jelly, and injecting liquid nitrogen to the raw royal jelly before drying; and crushing the dried royal jelly. The liquid nitrogen is injected into the royal jelly for 20-40 minutes.
Abstract translation: 目的：提供能够使用户容易存储和进食的蜂王浆及其制造方法，以使用户能够在室温下储存蜂王浆。 构成：能够使用户容易储存和进食的蜂王浆的生产方法包括以下步骤：制备生蜂蜜，并在干燥前向生蜂蜜注射液氮; 并粉碎干燥的蜂王浆。 液氮注入蜂王浆20-40分钟。
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公开(公告)号：KR101060910B1
公开(公告)日：2011-08-30
申请号：KR1020090040200
申请日：2009-05-08
Applicant: 한림대학교 산학협력단 , 대한민국(농촌진흥청장)
CPC classification number: A61L27/3641 , A61F2/18 , A61F11/00 , A61F2002/183 , A61L27/3604 , A61L27/38 , A61L2430/14
Abstract: Provided are an artificial eardrum using silk protein and a method of fabricating the same. The artificial eardrum is fabricated in the form of a silk membrane by desalinating and drying silk protein (or silk fibroin) or a silk protein complex solution obtained after removal of sericin from a silkworm cocoon or silk fiber. Thus, regeneration of an eardrum perforated due to disease or a sudden accident is stimulated, a boundary of the regenerated eardrum is clean and biocompatibility and transparency are increased. In addition, the artificial eardrum may be fabricated using the silk protein or silk protein complex solution obtained from a silkworm cocoon alone or mixed with collagen, alginic acid, PEG or pluronic 127.
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