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公开(公告)号：KR101761697B1
公开(公告)日：2017-07-26
申请号：KR1020150124393
申请日：2015-09-02
Applicant: 재단법인대구경북과학기술원
IPC: C08G69/42 , C08G69/04 , A61K47/34 , A61K31/337 , A61K31/704 , A61K31/282 , A61K31/138
Abstract: 본발명은양친매성멀티제미니고분자, 이를포함하는약물전달체, 이의제조방법및 양친매성멀티제미니고분자조성물에관한것으로서, 좀더 구체적으로설명하면, 이황화결합(-S-S-)을포함하는양친매성멀티제미니고분자를약물전달체로사용함으로써, 약물전달체내 약물이타켓세포에흡수된후 신속하게마이셀분열이이루어져약물이타겟세포에흡수되는속도를향상시킬수 있는발명에관한것이다.
Abstract translation: 本发明两亲多双子聚合物，药物递送系统，制造方法，其包括相同的，并且所述两亲多双子涉及一种聚合物组合物，更具体地，两亲多双子含聚合物的二硫键（-SS-） 一个是作为药物载体，药物递送使用，包括一个主体的药物迅速地在靶细胞的吸收根据可以提高吸收速度在靶细胞中的本发明所述药物后胶束裂解。
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62.发明授权나노 섬유 웹 및 섬유 부직포의 복합 지지체로 이루어진 건식 스킨 케어 팩의 제조 방법, 상기 방법에 의해 제조되는 건식 스킨 케어 팩 및 상기 건식 스킨 케어 팩을 이용한 스킨 케어 방법 有权干型护肤品的制备方法由纳米纤维网和无纺布干式护肤品组成，采用相同的护肤方法，并使用干性护肤品
公开(公告)号：KR101643814B1
公开(公告)日：2016-07-28
申请号：KR1020140124059
申请日：2014-09-18
Applicant: 재단법인대구경북과학기술원 , 박주현
Abstract: 본발명은나노섬유웹 및섬유부직포의복합지지체로이루어진건식스킨케어팩의제조방법, 상기방법에의해제조되는건식스킨케어팩 및상기건식스킨케어팩을이용한스킨케어방법에관한것으로서, 더욱상세하게는건식스킨케어팩을적용하여외부에서에센스를스프레이하여적용함에있어서피부와의밀착성과사용감이우수한동시에에센스의확산및 피부로의흡수가용이하게진행될수 있는건식스킨케어팩을제조하는기술을제공한다. 본발명에따르면, 생체적합성고분자용액만을전기방사하여스킨케어팩을제조하고기능성성분은스킨케어팩과분리하여외부에서분사하여적용하는방식의건식스킨케어팩을제조하되, 기능성성분으로인해생체적합성고분자용액이용해되어피막을형성하는것을방지하기위해상기제조되는스킨케어팩을고온열처리하여생체적합성고분자로이루어진나노섬유웹의결정성을향상시켜용해성을제어함으로써투여되는기능성성분의피부로의투입및 확산속도를향상시켜스킨케어효과를높일수 있다.
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63.发明公开나노 섬유 웹 및 섬유 부직포의 복합 지지체로 이루어진 건식 스킨 케어 팩의 제조 방법, 상기 방법에 의해 제조되는 건식 스킨 케어 팩 및 상기 건식 스킨 케어 팩을 이용한 스킨 케어 방법 有权由纳米纤维网和非织造织物制成的干燥型皮肤护理组合物的制备方法，以及使用干燥型皮肤护理包装的皮肤护理方法
公开(公告)号：KR1020160033384A
公开(公告)日：2016-03-28
申请号：KR1020140124059
申请日：2014-09-18
Applicant: 재단법인대구경북과학기술원 , 박주현
Abstract: 본발명은나노섬유웹 및섬유부직포의복합지지체로이루어진건식스킨케어팩의제조방법, 상기방법에의해제조되는건식스킨케어팩 및상기건식스킨케어팩을이용한스킨케어방법에관한것으로서, 더욱상세하게는건식스킨케어팩을적용하여외부에서에센스를스프레이하여적용함에있어서피부와의밀착성과사용감이우수한동시에에센스의확산및 피부로의흡수가용이하게진행될수 있는건식스킨케어팩을제조하는기술을제공한다. 본발명에따르면, 생체적합성고분자용액만을전기방사하여스킨케어팩을제조하고기능성성분은스킨케어팩과분리하여외부에서분사하여적용하는방식의건식스킨케어팩을제조하되, 기능성성분으로인해생체적합성고분자용액이용해되어피막을형성하는것을방지하기위해상기제조되는스킨케어팩을고온열처리하여생체적합성고분자로이루어진나노섬유웹의결정성을향상시켜용해성을제어함으로써투여되는기능성성분의피부로의투입및 확산속도를향상시켜스킨케어효과를높일수 있다.
Abstract translation: 本发明涉及一种由纳米纤维网和纤维无纺布的复合载体制成的干式护肤品的制造方法，其制造的干式护肤品以及使用干燥型护肤品的护肤方法 型皮肤护理包。 更具体地，提供了一种用于制造干性护肤品的技术，其具有优异的皮肤粘附性，提供优异的使用感，并且包括能够容易地扩散和吸收在皮肤中的本质。 根据本发明，通过仅静电纺生物相容的聚合物溶液和从皮肤护理包中喷出来自外部的功能成分来制造皮肤护理包装。 为了防止生物相容的聚合物溶液被功能成分溶解并形成薄膜，在高温下用热处理制成的护肤品，以通过提高由生物相容性聚合物制成的纳米纤维网的结晶度来控制溶解度。 因此，通过增加注射的功能成分进入皮肤的穿透速度和扩散速度，可以增加护肤效果。
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公开(公告)号：KR1020160007125A
公开(公告)日：2016-01-20
申请号：KR1020140087327
申请日：2014-07-11
Applicant: 재단법인대구경북과학기술원
CPC classification number: C08K3/38 , C08J3/24 , C08K5/29 , C08K5/5415 , C08K5/55 , C08K2201/003 , C08L83/06 , C08L101/02
Abstract: 복합체조성물및 상기복합체조성물의제조방법에관한것이다.
Abstract translation: 本发明涉及复合组合物和复合组合物的制备方法。 复合组合物包括：颗粒物; 羟基端聚合物; 第一交联剂; 和第二交联剂。 此外，复合组合物的制备方法通过使颗粒物质，羟基端聚合物，第一交联剂和第二交联剂反应获得复合组合物。
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公开(公告)号：KR1020150091857A
公开(公告)日：2015-08-12
申请号：KR1020140012604
申请日：2014-02-04
Applicant: 대한민국(농촌진흥청장) , 재단법인대구경북과학기술원
CPC classification number: C08J7/06
Abstract: 본 발명은 일광견뢰도가 향상된 플라스틱을 제조하는 방법에 관한 것으로서, 보다 상세하게는 (a) 수수(
Sorghum
bicolor )의 잎, 줄기 및 이의 혼합물로 구성된 군으로부터 선택된 어느 하나의 추출물을 플라스틱 성형재료에 혼입하여 플라스틱 성형물을 제조하는 단계; 및 (b) 상기에서 제조된 플라스틱 성형물을 금속염이 포함된 용액으로 처리하는 단계를 포함한다.
본 발명은 수수 부산물로부터 항균 및 항산화 활성을 갖는 천연색소를 추출하여 플라스틱과 혼합하는 방법을 제공하고 있으며, 이에 의해 생산된 플라스틱을 이용하여 천연색소를 함유한 인체친화적이고 위생적인 제품을 개발할 수 있다.
특히, 본 발명은 수수에서 추출한 색소로 착색된 플라스틱 사출물 제조를 위한 최적 가공법을 제공함에 있어, 천연색소의 문제점인 일광에 대한 낮은 안정도를 높이기 위해 금속염과의 최적 가공조건을 확립함으로써 천연색소로 착색된 제품의 완성도를 높일 수 있다.Abstract translation: 本发明涉及一种制造具有改善的耐光性的塑料材料的制造方法，更具体地说，涉及一种方法，该方法包括：（a）通过将塑料模具成分与从叶子中选出的一种提取物和 高粱茎及其混合物; 和（b）用含有金属盐的溶液处理制造的塑料模制材料的步骤。 本发明提供一种通过从高粱副产品中提取着色剂来混合具有抗菌和抗氧化活性的天然着色剂的塑料的方法，并且可以开发含有天然着色剂的产品，并且对人体来说是安全和卫生的 使用由此制造的塑料。 特别是，为了提供用于制造由高粱提取的着色剂着色的注射成型塑料的优化方法，可以通过建立金属盐加工的优化条件来提高由天然着色剂着色的产品的完成率，以增强 耐光性的稳定性低，这是天然色素的缺点。
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Patent Agency Ranking66.发明公开셀룰로오스-그라프트-폴리락타이드계 양친매성 중합체에 기반한 고분자 마이셀-약물 복합체 및 이의 제조 방법 无效基于纤维素 - 聚酰胺的聚合物的聚合物MICELLE-MEDICINE复合物及其制备方法
公开(公告)号：KR1020140102456A
公开(公告)日：2014-08-22
申请号：KR1020130015768
申请日：2013-02-14
Applicant: 재단법인대구경북과학기술원
IPC: A61K47/48 , A61K47/38 , A61K9/127 , A61K31/573
CPC classification number: A61K47/61 , A61K9/127 , A61K31/573 , A61K2121/00
Abstract: The present invention relates to a polymer micelle-medicine complex based on a cellulose-graft-polylactide-based amphiphilic polymer and to a method for producing the same. More specifically, the polymer micelle-medicine complex includes an amphiphilic copolymer having a hydrophilic block including cellulose and a hydrophobic block including polylactide and is formed in a core-shell structure consisting of a hydrophobic core unit and a hydrophilic shell unit. Prednisolone acetate which is a refractory drug is encapsulated in the core unit of the core-shell structure so as to constitute the polymer micelle-medicine complex. The polymer micelle-medicine complex according to the present invention effectively solubilizes the refractory drug and changes the molecular variants of the amphiphilic copolymer so that a micelle having improved stability is produced. Accordingly, the encapsulation efficiency of the refractory drug is maximized and releasing behavior can be easily controlled.
Abstract translation: 本发明涉及基于纤维素接枝聚丙交酯的两亲聚合物的聚合物胶束 - 药物复合物及其制备方法。 更具体地，聚合物胶束 - 药物复合物包括具有包含纤维素的亲水性嵌段和包含聚丙交酯的疏水性嵌段的两亲共聚物，并且形成在由疏水性核心单元和亲水性壳单元组成的核 - 壳结构中。 作为难治性药物的醋酸泼尼松龙被封装在芯 - 壳结构的核心单元中，以构成聚合物胶束 - 药物复合物。 根据本发明的聚合物胶束 - 药物复合物有效地溶解耐火药物并改变两亲性共聚物的分子变体，从而产生具有改善的稳定性的胶束。 因此，耐火药物的包封效率最大化，并且可以容易地控制释放行为。
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公开(公告)号：KR1020130139671A
公开(公告)日：2013-12-23
申请号：KR1020120063335
申请日：2012-06-13
Applicant: 재단법인대구경북과학기술원 , 주식회사 삼양사
Abstract: The present invention relates to a device for forming homogeneous monomer droplets and, more specifically, to a device for forming homogeneous monomer droplets, which forms droplets with uniform shapes for making polymer particles in a bead type such as polystyrene beads, thereby improving uniformity in shapes and sizes of polymer beads. According to the present invention, the device collects a monomer solution with low viscosity at one point using a distribution plate and separately transfers the collected monomer solution to each droplet hole formed at a multi-hole distribution plate when the monomer solution is transferred, thereby forming monomer droplets with improved uniformity.
Abstract translation: 本发明涉及一种用于形成均匀单体液滴的装置，更具体地说，涉及一种用于形成均匀单体液滴的装置，其形成具有均匀形状的液滴，以使聚合物颗粒形成诸如聚苯乙烯珠的珠粒，从而改善形状的均匀性 和聚合物珠粒的尺寸。 根据本发明，该装置使用分配板在一点收集低粘度的单体溶液，并且当单体溶液转移时，将收集的单体溶液分别转移到形成在多孔分布板上的每个液滴孔，由此形成 具有改善均匀性的单体液滴。
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公开(公告)号：KR1020130054676A
公开(公告)日：2013-05-27
申请号：KR1020110120209
申请日：2011-11-17
Applicant: 재단법인대구경북과학기술원
IPC: C08F290/06 , C08G83/00 , A61K9/127 , A61K47/48
CPC classification number: C08F226/10 , A61K47/69 , C08F220/56 , C08G63/08 , C08G65/32
Abstract: PURPOSE: A core cross-linked polymer micelle composition is provided to improve biostability, to minimize side effect due to toxicity of chemicals, and to be used as a drug carrier. CONSTITUTION: A core cross-linked polymer micelle composition is represented by chemical formula 1. In the chemical formula 1, P is an aqueous polymer, X is a fat-soluble polymer, Y is a connection ring, and Z is polycysteine with 3-20 cysteine. The aqueous polymer P is one or more linear, block, graft, or dendrimer polymer selected form polyethylene glycol, polyvinylpyrrolidone, and poly[N-2-(hydroxypropyl)methacrylamide]. The molecular weight of the aqueous polymer P is 500-20,000 Dalton.
Abstract translation: 目的：提供核心交联聚合物胶束组合物以改善生物稳定性，以最小化由于化学药物毒性引起的副作用，并用作药物载体。 构成：核心交联聚合物胶束组合物由化学式1表示。在化学式1中，P为水性聚合物，X为脂溶性聚合物，Y为连接环，Z为多元半胱氨酸， 20半胱氨酸。 水性聚合物P是选自聚乙二醇，聚乙烯吡咯烷酮和聚[N-2-（羟丙基）甲基丙烯酰胺]的一种或多种线性，嵌段，接枝或树枝状聚合物聚合物。 水性聚合物P的分子量为500〜20,000道尔顿。
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公开(公告)号：KR1020120050190A
公开(公告)日：2012-05-18
申请号：KR1020100111577
申请日：2010-11-10
Applicant: 재단법인대구경북과학기술원
CPC classification number: G01N33/6803 , B82Y5/00 , B82Y15/00 , B82Y40/00
Abstract: PURPOSE: A magnetic nanoparticles which are surface modified with phosphocholine, a formation method thereof, and a protein isolation method using thereof are provided to simplify isolating process in order to easily isolate using magnetic nano particles which is surface modified with the choline phosphate and a magnet. CONSTITUTION: A magnetic nanoparticles which are surface modified with phosphocholine comprises magnetic nano particles and materials having choline phosphate group. The choline phosphate is combined with magnetic nano particle surface and is exposed. A formation method of material having choline phosphate comprises a step of radical polymerizing monomers having choline phosphate groups which is represented by the following structural formula at surfaces of the magnetic nano particles. The structural formula 1 is Choline phosphate -X-R. A isolation method of C-reactive protein comprises next steps: adding magnetic nanoparticles which are surface modified with choline phosphate to sample solution containing the C-reactive protein; forming a complex of the C-reactive proteins and magnetic nano particles; isolating the composite from the sample solution by using the magnet; and isolating the C-reactive protein from the isolated composite by using a dissociating agent.
Abstract translation: 目的：提供用磷酸胆碱表面改性的磁性纳米颗粒，其形成方法和使用其的蛋白质分离方法，以简化隔离过程，以便使用磷酸胆碱和磁体表面改性的磁性纳米颗粒容易地分离 。 构成：用磷酸胆碱表面改性的磁性纳米颗粒包括磁性纳米颗粒和具有磷酸胆碱基团的材料。 磷酸胆碱与磁性纳米颗粒表面结合并暴露。 具有磷酸胆碱的材料的形成方法包括在磁性纳米颗粒的表面上自由基聚合由下列结构式表示的具有磷酸胆碱基团的单体的步骤。 结构式1是胆碱磷酸酯-X-R。 C-反应蛋白的分离方法包括以下步骤：将含有磷酸胆碱的表面改性的磁性纳米颗粒加入到含有C-反应蛋白的样品溶液中; 形成C-反应蛋白和磁性纳米颗粒的复合物; 通过使用磁体从样品溶液中分离出复合物; 并通过使用离解剂从分离的复合物中分离C反应蛋白。
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公开(公告)号：KR1020120048348A
公开(公告)日：2012-05-15
申请号：KR1020100109942
申请日：2010-11-05
Applicant: 재단법인대구경북과학기술원
IPC: G01N33/68 , G01N33/553
Abstract: PURPOSE: A chip for detecting C-reactive proteins is provided to improve binding constant to the C-reactive proteins and detection effect. CONSTITUTION: A chip for detecting C-reactive proteins comprises: a metal substrate; and a molecularly imprinted layer which is formed on a metal substrate and contains phospho choline groups. The metal substrate contains gold, silver, copper, palladium, or combination thereof. The molecularly imprinted layer contains a monomolecular layer of HS-CnH2n+1-phospho choline or HC≡C-CH2-CmH2m+1-phospho choline. The chip also has a blocking layer on the metal substrate.
Abstract translation: 目的：提供用于检测C反应蛋白的芯片，以提高C-反应蛋白的结合常数和检测效果。 构成：用于检测C反应蛋白的芯片包括：金属底物; 以及形成在金属基板上并含有磷酸胆碱基团的分子印迹层。 金属基底含有金，银，铜，钯或其组合。 分子印迹层含有HS-CnH2n + 1-磷酸胆碱或HC≡C-CH2-CmH2m + 1-磷酸胆碱的单分子层。 芯片还在金属基板上具有阻挡层。
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