中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

152 records (took 0.076 seconds)

    62.
    发明专利
    未知

    公开(公告)号：TR200103545T2

    公开(公告)日：2002-06-21

    申请号：TR200103545

    申请日：1998-07-07

    Applicant: BASF AG

    Inventor： JANSSEN BERND ,  BARLOZZARI TERESA ,  HAUPT ANDREAS ,  ZIERKE THOMAS ,  KLING ANDREAS

    IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K7/06 ,  C12P19/34

    Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L  (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

    63.
    发明专利
    未知

    公开(公告)号：BR9911932A

    公开(公告)日：2001-10-16

    申请号：BR9911932

    申请日：1999-06-23

    Applicant: BASF AG

    Inventor： RITTER KURT ,  JANSSEN BERND ,  HAUPT ANDREAS ,  KLING ANDREAS ,  BARLOZZARI TERESA ,  AMBERG WILHELM

    IPC: A61K38/00 ,  A61K35/56 ,  A61P35/00 ,  C07K5/103 ,  C07K5/117 ,  C07K7/02 ,  A61K38/07 ,  A61K38/08

    Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula IA-B-D-E-F-G(I)and acid salts thereof, wherein A, D, and E are alpha -amino acid residues, B is an alpha -amino acid residue or an alpha -hydroxy acid residue, F is an aminobenzoic acid residue or an aminocycloalkanecarboxylic acid residue, and G is a monovalent radical, such as, for example, a hydrogen atom, an amino group, an alkyl group, an alkylene alkyl ether, an alkylene alkyl thioether, an alkylene aldehyde, an alkylene amide, a beta -hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, an oximato group, an alkylene aryl group, an alkylene ester, an alkylene sulfoxide or an alkylene sulfone. Another aspect of the present invention includes pharmaceutical compositions comprising a compound of Formula I and a pharmaceutically acceptable carrier. An additional embodiment of the present invention is a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

    DERIVADOS DE DOLASTATINA 15 CON FUNCIONALIDADES CARBONILO Y HETEROCICLICAS EN EL C-TERMINAL
    68.
    发明专利
    DERIVADOS DE DOLASTATINA 15 CON FUNCIONALIDADES CARBONILO Y HETEROCICLICAS EN EL C-TERMINAL 未知

    公开(公告)号：CO4950525A1

    公开(公告)日：2000-09-01

    申请号：CO98012757

    申请日：1998-03-09

    Applicant: BASF AG

    Inventor： RITTER KURT ,  AMBERG WILHELM ,  BARLOZZARI TERESA ,  HAUPT ANDREAS ,  JANSSEN BERND ,  KLING ANDREAS

    IPC: A61K38/00 ,  A61P35/00 ,  A61P35/02 ,  C07K5/10 ,  C07K5/103 ,  C07K7/02

    Abstract: Un compuesto, CARACTERIZADO PORQUE presenta la siguientefórmula general A-B-D-E-F-G, donde A, B, D y E son, cada uno, un residuo de un a-aminoácido; F es un residuo del ácido azacicloalcancarboxílico y G es un radical monovalente seleccionado del grupo formado por hidrógeno, alquilo, cicloalquilo, cicloalquilalquilo, amincarbonilalquilo, arilalquilo, alcoxicarbonilalquilo, ariloxicarbonilalquilo, alquilsulfinilalquilo, alquilsulfonilalquilo, arilsulfinilalquilo, arilsulfonilalquilo, alquil- o arilsulfinilo y alquil- o arilsulfonilo; o F es un grupo azacicloalquilo y G es un grupo heteroarilo; o una sal ácido de los mismos. El compuesto de la cláusula 1, CARACTERIZADO PORQUE el ácido es seleccionado del grupo formado por: ácido clorhídrico, ácido cítrico, ácido tartárico, ácido láctico, ácido fosfórico, ácido metansulfónico, ácido acético, ácido fórmico, ácido maléico, ácido fumárico, ácido málico, ácido succínico, ácido malónico, ácido sulfúrico, ácido L- glutámico, ácido L-aspártico, ácido pirúvico, ácido múcico, ácido benzóico, ácido glucurónico, ácido oxálico, ácido ascórbico o N-acetilglicina. El compuesto de la cláusula 1, CARACTERIZADO PORQUE A es un derivado de prolina de Fórmula IIa, na es 0, 1, 2 ó 9 3; Ra es un átomo de hidrógeno o un grupo metilo, etilo, propilo normal, isopropilo o ciclopropilo no sustituido o sustituido con flúor, R1 a es un átomo de hidrógeno o un grupo metilo, etilo, propilo, fenilo o grupo fenilo sustituido, donde los sustituyentes de fenilo comprenden uno o más grupos alquilo, alcoxi, trifluorometilo o ...

    69.
    发明专利
    未知

    公开(公告)号：BR9810911A

    公开(公告)日：2000-08-01

    申请号：BR9810911

    申请日：1998-07-07

    Applicant: BASF AG

    Inventor： JANSSEN BERND ,  BARLOZZARI TERESA ,  HAUPT ANDREAS ,  ZIERKE THOMAS ,  KLING ANDREAS

    IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K7/06 ,  C12P19/34

    Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L  (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

Patent Agency Ranking