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公开(公告)号：CA2111083A1
公开(公告)日：1993-01-07
申请号：CA2111083
申请日：1992-06-17
Applicant: BASF AKTIENESELLSCHAFT , BASF AG
Inventor： EMLING FRANZ , HAUPT ANDREAS , KLUGE MICHAEL , KRONER MATTHIAS , HAAS GERHARD , SCHMIDT ULRICH , GRIESSER HELMUT , RIEDL BERND
Abstract: 2111083 9300362 PCTABS00019 Described are peptides of formula (I), in which R1, R2, R3, R4, R5, X1 and X2 are as defined in the description, as well as their preparation. The new peptides are suitable for use in the treatment of illnesses.
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公开(公告)号：CA2005058A1
公开(公告)日：1990-06-12
申请号：CA2005058
申请日：1989-12-11
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , DAUM LOTHAR , HAUPT ANDREAS , SCHMIED BERNHARD , WALKER NIGEL , ZECHEL JOHANN-CHRISTIAN
IPC: A61K38/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07K1/04 , C07K7/06 , C07K7/08 , C07K7/64 , C07K14/52 , C07K14/525 , A61K38/08 , A61K38/10 , A61K38/12 , A61K38/19 , C07K7/50
Abstract: Peptides of the formula X-A-Gly-Asp-Y, where A, X and Y are defined in the description, and the preparation thereof are described. The novel peptides are suitable for controlling diseases.
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公开(公告)号：CA2219819C
公开(公告)日：2008-05-20
申请号：CA2219819
申请日：1996-06-03
Applicant: BASF AG
Inventor： EMLING FRANZ , ROMERDAHL CYNTHIA A , HAUPT ANDREAS
Abstract: Novel dolasstatin derivatives of the formula (I): R1R2N-CHX-CO-A-B-D-E-(F)t K, in which R1, R2, A, B, D, E, F, K, X and t have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
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公开(公告)号：CA2219818C
公开(公告)日：2008-05-20
申请号：CA2219818
申请日：1996-06-03
Applicant: BASF AG
Inventor： ROMERDAHL CYNTHIA A , HAUPT ANDREAS , EMLING FRANZ
Abstract: Novel dolastatin derivatives of the formula (I): R1R2N-CHX-CO-A- B-D-E-(F)t-K in which R1, R2, A, B, D, E, F, K, X and t have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
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公开(公告)号：CA2237721C
公开(公告)日：2008-01-29
申请号：CA2237721
申请日：1996-12-11
Applicant: BASF AG
Inventor： RITTER KURT , ZIERKE THOMAS , BARLOZZARI TERESA , KLING ANDREAS , BUSCHMANN ERNST , BERNARD HARALD , HAUPT ANDREAS , HEGE HANS-GUENTHER , WEYMANN JURGEN , JANSSEN BERND , ULLRICH MARTINA , LIETZ HELMUT , AMBERG WILHELM
IPC: A61K38/00 , C07K7/06 , A61K31/00 , A61K38/07 , A61K38/08 , A61P35/00 , A61P35/02 , C07K1/00 , C07K5/10
Abstract: Novel peptides of the following formula (I): R1R2N-CHX-CO-A-B-D-E-(G)s-K in which R1, R2, A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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Patent Agency Ranking
公开(公告)号：BG64563B1
公开(公告)日：2005-07-29
申请号：BG10247998
申请日：1998-05-22
Applicant: BASF AG
Inventor： AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JUERGEN , ZIERKE THOMAS
Abstract: The invention relates to new peptides with the formula R1R2N-CHX-CO-A-B-D-E-(G)s-K, where R1, R2, A, B, D, E, G, K, X and s have the meanings listed in the description. The invention also relates to methods for the preparation of the above peptides having antineoplastic properties.
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公开(公告)号：MY119042A
公开(公告)日：2005-03-31
申请号：MYPI9602155
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , ROMERDAHL CYNTHIA A , EMLING FRANZ
Abstract: NOVEL COMPOUNDS OF THE FORMULA :R1R2N-CHX-CO-A-B-D-E-(F)T-K IIN WHICH R1, R2, A, B, D, E, F, K, X, AND T HAVE THE MEANINGS STATED IN THE DESCRIPTION, AND THE PREPARATION THEREOF ARE DESCRIBED. THE NOVEL SUBSTANCES HAVE AN ANTINEOPLASTIC EFFECT.
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公开(公告)号：RO119783B1
公开(公告)日：2005-03-30
申请号：RO9702254
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: The invention relates to dolastatine derivatives having the chemical structure corresponding to the general formula: R1R2N-CHK-CO-A-B-D-E-(F)t-K to a pharmaceutical composition comprising a therapeutically efficient quantity of dolastatine derivative and a pharmaceutically acceptable carrier and to the use of a dolastatine derivative for preparing a pharmaceutical composition for treating a tumour in a mammal.
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公开(公告)号：DE69815100D1
公开(公告)日：2003-07-03
申请号：DE69815100
申请日：1998-03-09
Applicant: BASF AG
Inventor： BARLOZZARI TERESA , HAUPT ANDREAS
IPC: A61K38/00 , A61K31/337 , A61K38/07 , A61K38/08 , A61K38/15 , A61P35/00 , C07K5/08 , C07K5/10 , C07K7/00 , A61K38/04
Abstract: The present invention provides compositions and methods for the treatment of cancer in a subject wherein compounds of Formula I as defined herein in combination with paclitaxel, taxotere or modified taxane or taxoid analogs provide enhanced anticancer effects over the effects achieved with the individual compounds.
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公开(公告)号：SK282467B6
公开(公告)日：2002-02-05
申请号：SK165497
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: Peptides of formula R1R2N-CHX-CO-A-B-D-E-(F)t-K (I) and their salts with acids are new. In the formula, R1 = Me, Et or iPr; R2 = H, Me or Et; or NR1R2 = a pyrrolidine ring; A = a valyl, isoleucyl, leucyl, 2-tert-butylglycyl, 2-ethylglycyl, norleucyl or norvalyl residue; B = a N-methyl-valyl, -leucyl, -isoleucyl, -norvalyl, -norleucyl, -2-tert-butylglycyl, -3-tert-butylalanyl or -2-ethylglycyl residue; D = a prolyl, 3,4-dehydroprolyl, 4-fluoroprolyl, 4,4-difluoroprolyl, azetidine-2-carbonyl, homoprolyl, thiazolidine-4-carbonyl or 3-, 4- or 5-methylprolyl residue; E = a 3,4-dehydroprolyl, 4-fluoroprolyl, 3- or 4-methylprolyl, 4,4-difluoroprolyl or azetidine-2-carbonyl residue; F = a valyl, 2-tert-butylglycyl, isoleucyl, leucyl, 2-cyclohexylglycyl, norleucyl, norvalyl, neopentylglycyl, alanyl, ~b-alanyl or aminoisobutyroyl residue; X = alkyl (pref. 2-5C alkyl), cyclopropyl or cyclopentyl; t = 0 or 1; and K = alkoxy (pref. 1-4C alkoxy), benzyloxy or opt. substd. amino.
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