公开(公告)号：CA2355251A1

公开(公告)日：2000-06-29

申请号：CA2355251

申请日：1999-12-09

Applicant: BASF AG

Inventor： RASCHACK MANFRED ,  UNGER LILIANE ,  HERGENRODER STEFAN ,  BAUMANN ERNST ,  JANSEN ROLF ,  RIECHERS HARTMUT ,  KETTSCHAU GEORG ,  AMBERG WILHELM

IPC: C07D251/24 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P15/10 ,  A61P35/00 ,  A61P43/00 ,  C07C229/34 ,  C07C233/87 ,  C07C235/52 ,  C07D239/34 ,  C07D251/22 ,  C07D401/12 ,  C07D491/048 ,  C07D239/60

Abstract: The invention relates to carboxylic acid derivatives of formula (I), in whic h the substituents have the following meanings: R1 is tetrazol or a group (a); W and Z, can be identical or different and are nitrogen or methine, provided that if W and Z are methine, then Q is nitrogen; X is nitrogen or CR9; Y is nitrogen or CR10; Q is nitrogen or CR11, provided that if Q is nitrogen then X is CR5 and Y is CR10; R2 and R3 are identical or different and are possibly substituted phenyl or naphthyl or phenyl or naphthyl which are linked in an ortho position via a direct bond, a methlyene, ethylene or ethenylene group, an oxygen or sulfur atom or a SO2-, NH- or N-alkyl group or possibly substituted C5-C6-cycloalkyl; R4 is a rest (b) or (c); and R5 is hydrogen, C 1- C4-alkyl. The invention further relates to their preparation and their use a s endothelin receptor antagonists. The invention also relates to compounds of formula (II) and a structural fragment of formula (d) in which the rests R1, R2, R3, R4 and R5 have the meanings given in claim no. 1 and to their use as structural elements in an endothelin receptor antagonist.

公开(公告)号：CA2340167A1

公开(公告)日：2000-02-24

申请号：CA2340167

申请日：1999-08-07

Applicant: BASF AG

Inventor： RASCHACK MANFRED ,  UNGER LILIANE ,  AMBERG WILHELM ,  JANSEN ROLF ,  HERGENRODER STEFAN ,  KETTSCHAU GEORG

IPC: C07D251/22 ,  A61K31/505 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K45/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P35/00 ,  A61P43/00 ,  C07D239/34 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D251/52 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D491/048 ,  C07D495/04

Abstract: The invention relates to new carboxylic acid derivatives of the formula (I), where the substituents have the meaning given in the description, their production and their use as endothelin-receptor antagonists.

公开(公告)号：AU711293B2

公开(公告)日：1999-10-07

申请号：AU2636497

申请日：1997-04-04

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  BAUMANN ERNST ,  UNGER LILIANE ,  RASCHACK MANFRED ,  HERGENRODER STEFAN ,  SCHULT SABINE

IPC: A61K31/00 ,  A61K31/47 ,  A61K31/505 ,  A61P9/00 ,  A61P9/12 ,  A61P13/00 ,  A61P13/12 ,  C07D215/22 ,  C07D215/227 ,  C07D239/34 ,  C07D239/60 ,  C07D401/12 ,  C07D403/12

Abstract: PCT No. PCT/EP97/01687 Sec. 371 Date Oct. 8, 1998 Sec. 102(e) Date Oct. 8, 1998 PCT Filed Apr. 4, 1997 PCT Pub. No. WO97/38982 PCT Pub. Date Oct. 23, 1997Carboxylic acid derivatives of the formula I where the radicals have the meanings stated in the description, and the preparation of these agreements [sic] and their use as drugs are described.

公开(公告)号：AU3027199A

公开(公告)日：1999-09-06

申请号：AU3027199

申请日：1999-02-05

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENRODER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: A61K31/505 ,  A61K31/506 ,  A61P5/14 ,  A61P9/02 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/12 ,  A61P35/00 ,  A61P43/00 ,  C07D239/34 ,  C07D239/46 ,  C07D239/52 ,  C07D239/60 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D239/36

Abstract: The invention relates to carboxylic acid derivatives of formula (I), wherein the substituents have the following meanings; R = tetrazole or a group (1); R = a radical OR (2), (3), a 5-membe red heteroaromatic bonded by a nitrogen atom such a pyrrolyl, pyrazolyl, imidazolyl and trizolyl; R , R = hydrogen, hydroxy, NH2, NH(C1-C4-alkyl), N(C1-C4-alkyl)2, halogen, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkinyl, C1-C4-hydroxyalkyl, C1-C4-alkoxy, C1-C4-halogen alkyl, C1-C4-alkoxy, C1-C4-halogen alkoxy or C1-C4-alkythio; X = halogen, C1-C4-halogen alkyl, hydroxy; R and R = phenyl or naphthyl, C3-C7-cycloalkyl, phenyl or naphthyl which are bonded in ortho position by a direct bond, a methylene, ethylene or ethenylene group, an oxygen or sulfur atom or an SO2-NH or an N-alkyl group or a 5-membered or 6-membered heteroaromatic; R = hydrogen, phenyl or naphthyl, a five or six-membered heteroaromatic, C1-C8-alkyl, C3-C6-alkenyl, C3-C6-alkinyl or C3-C8-cycloalkyl, whereby said radicals can be substituted once or many times, with the proviso that R can only stand for hydrogen if Z does not represent a single bond; Z = sulfur, oxygen or a single bond, in addition to the physiologically compatible salts and the enantiomeric-pure and diastereomeric-pure forms. The novel compounds are suitable for combating diseases, especially as endothelin antagonists.

公开(公告)号：TR9901416T2

公开(公告)日：1999-08-23

申请号：TR9901416

申请日：1997-12-04

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENRODER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: C07D253/06 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61K31/53 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/08 ,  C07D237/14 ,  C07D237/16 ,  C07D241/18 ,  C07D253/07 ,  C07D253/075 ,  C07D253/10 ,  C07D403/12 ,  C07D491/04

CPC classification number: C07D403/12 ,  C07D237/14 ,  C07D237/16 ,  C07D241/18 ,  C07D253/07 ,  C07D253/075 ,  C07D253/10 ,  C07D491/04

公开(公告)号：TR199901416T2

公开(公告)日：1999-08-23

申请号：TR9901416

申请日：1997-12-04

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENRODER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: C07D253/06 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61K31/53 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/08 ,  C07D237/14 ,  C07D237/16 ,  C07D241/18 ,  C07D253/07 ,  C07D253/075 ,  C07D253/10 ,  C07D403/12 ,  C07D491/04

Abstract: The present invention relates to carboxylic acid derivatives of the formula Iwhere the substituents have the meanings explained in the description, and to preparation and use as endothelin receptor antagonists.

公开(公告)号：AU9626498A

公开(公告)日：1999-05-03

申请号：AU9626498

申请日：1998-09-18

Applicant: BASF AG

Inventor： PUHL MICHAEL ,  AMBERG WILHELM ,  HILLEN HEINZ ,  KLING ANDREAS ,  HERGENRODER STEFAN ,  MARKERT CLAUS OTTO

IPC: A61K38/00 ,  A61P1/00 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/08 ,  A61P13/12 ,  A61P25/06 ,  A61P35/00 ,  A61P43/00 ,  C07K1/06 ,  C07K5/065 ,  C07K5/078 ,  A61K38/05

公开(公告)号：AU1023599A

公开(公告)日：1999-05-03

申请号：AU1023599

申请日：1998-09-18

Applicant: BASF AG

Inventor： PUHL MICHAEL ,  ZECHEL JOHANN-CHRISTIAN ,  DITRICH KLAUS ,  HILLEN HEINZ ,  KOHL TANJA ,  ERHARDT MELANIE ,  HERGENRODER STEFAN ,  MARKERT CLAUS OTTO

IPC: C07D333/40 ,  A61K31/198 ,  A61K31/27 ,  A61K31/381 ,  A61K31/4704 ,  A61K31/498 ,  A61P1/04 ,  A61P1/18 ,  A61P7/02 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P25/06 ,  A61P35/00 ,  C07C271/12 ,  C07C271/20 ,  C07C323/56 ,  C07D215/48 ,  C07D241/44 ,  C07D333/38 ,  C07D333/16 ,  C07D241/42 ,  C07C271/22 ,  C07D215/14 ,  A61K31/38 ,  A61K31/47 ,  A61K31/495

Abstract: Pharmaceutically active compounds are prepared as described and used to produce pharmaceutical preparations for treating diseases.

公开(公告)号：CA2305499A1

公开(公告)日：1999-04-22

申请号：CA2305499

申请日：1998-09-18

Applicant: BASF AG

Inventor： ERHARDT MELANIE ,  PUHL MICHAEL ,  KOHL TANJA ,  HERGENRODER STEFAN ,  HILLEN HEINZ ,  ZECHEL JOHANN-CHRISTIAN ,  MARKERT CLAUS OTTO ,  DITRICH KLAUS

IPC: C07D333/40 ,  A61K31/198 ,  A61K31/27 ,  A61K31/381 ,  A61K31/4704 ,  A61K31/498 ,  A61P1/04 ,  A61P1/18 ,  A61P7/02 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P25/06 ,  A61P35/00 ,  C07C271/12 ,  C07C271/20 ,  C07C323/56 ,  C07D215/48 ,  C07D241/44 ,  C07D333/38 ,  C07D333/16 ,  C07D215/14 ,  C07C271/22 ,  A61K31/38 ,  C07D241/42 ,  A61K31/47 ,  A61K31/495

Abstract: Novel pharmaceutically active compounds of general formula (I), their preparation and use for producing pharmaceutical compositions for the treatment of diseases are disclosed. (Endothelin conversion enzyme inhibitors (=ECE)).

公开(公告)号：NZ316940A

公开(公告)日：1999-01-28

申请号：NZ31694096

申请日：1996-08-29

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  UNGER LILIANE ,  RASCHACK MANFRED ,  HERGENRODER STEFAN ,  ELGER BERND ,  SCHULT SABINE

IPC: A61K31/00 ,  A61K31/19 ,  C07D317/02 ,  A61K31/192 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/35 ,  A61K31/352 ,  A61K31/357 ,  A61K31/36 ,  A61K31/435 ,  A61K31/44 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  C07C53/134 ,  C07C57/30 ,  C07C57/32 ,  C07C57/38 ,  C07C59/64 ,  C07C69/616 ,  C07C69/734 ,  C07C255/00 ,  C07D213/55 ,  C07D213/64 ,  C07D221/04 ,  C07D239/26 ,  C07D239/34 ,  C07D239/52 ,  C07D239/70 ,  C07D257/04 ,  C07D307/79 ,  C07D317/50 ,  C07D317/60 ,  C07D319/02 ,  C07D319/18

Abstract: PCT No. PCT/EP96/03793 Sec. 371 Date Feb. 24, 1998 Sec. 102(e) Date Feb. 24, 1998 PCT Filed Aug. 29, 1996 PCT Pub. No. WO97/09294 PCT Pub. Date Mar. 13, 1997Carboxylic acid derivatives of the formula I here R1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the meaning explained in the description.