公开(公告)号：DE10154180A1

公开(公告)日：2003-05-15

申请号：DE10154180

申请日：2001-11-05

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C07K14/34 ,  C12N1/21 ,  C12N9/00 ,  C12P13/08 ,  C12N15/11 ,  C12N15/77 ,  C12P13/04

Abstract: The invention relates to novel nucleic acid molecules, to the use thereof in the construction of genetically improved microorganisms and to a method for producing fine chemical products, in particular amino acids, by means of said genetically improved microorganisms.

公开(公告)号：DE10154175A1

公开(公告)日：2003-05-15

申请号：DE10154175

申请日：2001-11-05

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C07K14/34 ,  C12N1/21 ,  C12P13/08 ,  C12N15/11 ,  C12N15/77 ,  C12P13/04

Abstract: The invention relates to novel nucleic acid molecules, to their use for constructing genetically improved microorganisms and to methods for producing fine chemicals, in particular, amino acids by using these genetically modified microorganisms.

公开(公告)号：DE1246922T1

公开(公告)日：2003-03-20

申请号：DE00942322

申请日：2000-06-27

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: G01N33/53 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/31 ,  C12N15/54 ,  C12N15/77 ,  C12P1/04 ,  C12P13/04 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/16 ,  G01N33/566 ,  G01N33/569

公开(公告)号：CA2456828A1

公开(公告)日：2003-03-06

申请号：CA2456828

申请日：2002-08-21

Applicant: BASF AG

Inventor： REVUELTA DOVAL JOSE L ,  KAROS MARVIN ,  KROEGER BURKHARD ,  ALTHOEFER HENNING

IPC: C12N15/09 ,  A61K31/7052 ,  A61K38/00 ,  A61P43/00 ,  C07K14/37 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P19/32 ,  C12Q1/02 ,  C12N15/31 ,  C07H21/00 ,  C12P25/00 ,  C12N15/11 ,  C12P17/12 ,  C07K14/39 ,  C12N15/63

Abstract: The invention relates to novel polynucleotides from Ashbya gossypii; oligonucleotides hybridised therewith; expression cassettes and vectors, containing said polynucleotide; microorganism transformed therewith; polypeptides coded by said polynucleotides and the use of the novel polypeptides and polynucleotides as targets for modulation of the cell wall or cytoskeletion construction and in particular for improving the production of vitamin B2 in microorganisms of the species Ashbya.

公开(公告)号：HU0203340A2

公开(公告)日：2003-01-28

申请号：HU0203340

申请日：2000-06-23

Applicant: BASF AG

Inventor： HABERHAUER GREGOR ,  KIM HYUNG-JOON ,  KROEGER BURKHARD ,  LEE HEUNG-SHICK ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  ZELDER OSKAR

IPC: G01N33/53 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/18 ,  C12N15/09 ,  C12N15/31 ,  C12P20060101 ,  C12P1/04 ,  C12P13/04 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/15 ,  C12R1/16 ,  G01N33/569 ,  G01N37/00 ,  C12N15/00

Abstract: Isolated nucleic acid molecules, designated SRT nucleic acid molecules, which encode novel SRT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SRT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SRT proteins, mutated SRT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SRT genes in this organism.

公开(公告)号：DE10133372A1

公开(公告)日：2003-01-23

申请号：DE10133372

申请日：2001-07-10

Applicant: BASF AG

Inventor： KAROS MARVIN ,  ALTHOEFER HENNING ,  KROEGER BURKHARD ,  REVUELTA DOVAL JOSE L

IPC: C07K14/37 ,  C07K14/47 ,  C12N1/15 ,  C07H21/00 ,  C12N15/52 ,  C12N15/80

Abstract: Polynucleotide (I) that encodes a protein (II) of the stress response and isolatable from Ashbya gossypii. Independent claims are also included for the following: (1) Oligonucleotides (ON) that hybridize to (I), particularly under stringent conditions; (2) Polynucleotides (Ia) that hybridize to ON, particularly under stringent conditions, and encode a gene product from the genus Ashbya or its functional equivalent; (3) Polypeptides (IIa) encoded by (I), or its fragments, or (Ib), or having an amino acid (aa) sequence that includes at least 10 consecutive aa from any of 10 sequences reproduced, or their functional equivalents; (4) Expression cassettes (EC) containing (I), ON or (Ia) linked to regulatory sequences; (5) Recombinant vector containing at least one EC; (6) Prokaryotic or eukaryotic host transformed with at least one vector of (5), or in which at least one gene encoding (IIa) is modulated, or in which the biological activity of (IIa) is altered; (7) Method for identifying effector targets for modulating microbial production of Vitamin B2 or its precursors or derivatives; (8) Method for modulation microbial production of Vitamin B2 or its precursors or derivatives by treatment with an effector that interacts with (IIa) or nucleic acid encoding it; (9) Effectors (X) for (IIa) or nucleic acid encoding it; and (10) Microbial production of Vitamin B2 or its precursors or derivatives using a host cell of (6).

公开(公告)号：ES2178979T1

公开(公告)日：2003-01-16

申请号：ES00940687

申请日：2000-06-23

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: G01N33/53 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/12 ,  C12N9/18 ,  C12N9/88 ,  C12N15/09 ,  C12N15/31 ,  C12N15/55 ,  C12P20060101 ,  C12P13/04 ,  C12P13/08 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/68 ,  C12R1/15 ,  G01N33/566 ,  G01N33/569

Abstract: Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.

公开(公告)号：SK18912001A3

公开(公告)日：2002-10-08

申请号：SK18912001

申请日：2000-06-23

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: G01N33/53 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/18 ,  C12N15/09 ,  C12N15/31 ,  C12N15/52 ,  C12P20060101 ,  C12P1/04 ,  C12P13/04 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/15 ,  C12R1/16 ,  G01N33/569

Abstract: Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCT genes in this organism.

公开(公告)号：BR0012038A

公开(公告)日：2002-07-02

申请号：BR0012038

申请日：2000-06-27

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: G01N33/53 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/31 ,  C12N15/54 ,  C12P1/04 ,  C12P13/04 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/16 ,  G01N33/566 ,  G01N33/569 ,  C12N15/77

Abstract: Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. Glutamicum based on genetic engineering of PTS genes in this organism.

公开(公告)号：HU0103190A2

公开(公告)日：2001-12-28

申请号：HU0103190

申请日：1999-06-04

Applicant: BASF AG

Inventor： HOEGER THOMAS ,  KOCK MICHAEL ,  KROEGER BURKHARD ,  LEMAIRE HANS-GEORG ,  LUBISCH WILFRIED ,  OTTERBACH BERND

IPC: A01K67/027 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  A61K49/00 ,  A61P43/00 ,  C07K14/455 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12Q1/68 ,  G01N33/53

Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD+ binding domain and b) no zinc finger sequence motif of the general formula CX2CXmHX2C in which m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.