公开(公告)号：DK449680A

公开(公告)日：1981-04-27

申请号：DK449680

申请日：1980-10-24

Applicant: BASF AG

Inventor： FRICKEL F F ,  THIEME P C ,  FRANKE A ,  THEOBALD H ,  LENKE D ,  GRIES J

IPC: A61K31/42 ,  A61P9/00 ,  A61P9/12 ,  A61P25/02 ,  C07C43/12 ,  C07C45/61 ,  C07C45/64 ,  C07C45/70 ,  C07D261/08 ,  C07F9/653 ,  C07D

Abstract: Novel aminopropanol derivatives of 5-(2-hydroxystyryl)-isoxazole and their addition salts with acids, their preparation, pharmaceutical formulations containing these compounds, and their use in the treatment of hypertonia, coronary heart disease and cardiac arrhythmias.

公开(公告)号：ZA796789B

公开(公告)日：1980-12-31

申请号：ZA796789

申请日：1979-12-14

Applicant: BASF AG

Inventor： GRIES J ,  THYES M ,  LENKE D ,  LEHMANN H ,  KUNZE J

IPC: A61K31/395 ,  A61K31/502 ,  A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07C62/38 ,  C07C205/56 ,  C07D231/54 ,  C07D237/26 ,  A61K ,  C07C

Abstract: 2-Aryl-3,4-diaza-bicyclo-[4.1.0]hept-2-en-5-ones, substituted in the phenyl ring, of the general formula their preparation, and therapeutic agents, containing these compounds, which may be used for the treatment of hypertension or of thrombo-embolic disorders.

公开(公告)号：ZA795716B

公开(公告)日：1980-11-26

申请号：ZA795716

申请日：1979-10-25

Applicant: BASF AG

Inventor： TREIBER H ,  WORSTMANN W ,  LENKE D

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/00 ,  C07D267/12 ,  C07D267/14 ,  C07D ,  A61K

Abstract: PCT No. PCT/EP79/00080 Sec. 371 Date Jun. 26, 1980 Sec. 102(e) Date Jun. 16, 1980 PCT Filed Oct. 22, 1979 PCT Pub. No. WO80/00838 PCT Pub. Date May 1, 1980. The invention relates to novel 1,4-cycloalkano-oxazepines of the general formula where R1 is hydrogen, hydroxyl or alkoxy or acyloxy of 1 to 4 carbon atoms, R2 is a hydrocarbon radical of 1 to 3 carbon atoms, n is 1, 2 or 3 and x is 0 or 1, and of its salts with physiologically acceptable acids; processes for their preparation, and their use in therapy. The novel substances are suitable for the pharmacotherapy of pains of various origins.

公开(公告)号：ZA793667B

公开(公告)日：1980-07-30

申请号：ZA793667

申请日：1979-07-19

Applicant: BASF AG

Inventor： LENKE D ,  BLIESENER J ,  MUELLER C ,  GEISS K

IPC: A61K31/40 ,  A61K31/4025 ,  A61P7/10 ,  C07D207/48 ,  C07D307/68 ,  C07D333/28 ,  C07D333/38 ,  C07D405/12 ,  C07D409/10 ,  C07D ,  A61K

公开(公告)号：ZA7903667B

公开(公告)日：1980-07-30

申请号：ZA7903667

申请日：1979-07-19

Applicant: BASF AG

Inventor： LENKE D ,  BLIESENER J ,  MUELLER C ,  GEISS K

IPC: A61K31/40 ,  A61K31/4025 ,  A61P7/10 ,  C07D207/48 ,  C07D307/68 ,  C07D333/28 ,  C07D333/38 ,  C07D405/12 ,  C07D409/10 ,  C07D ,  A61K

CPC classification number: C07D307/68 ,  C07D207/48 ,  C07D333/28 ,  C07D333/38

公开(公告)号：DK175179A

公开(公告)日：1979-10-30

申请号：DK175179

申请日：1979-04-27

Applicant: BASF AG

Inventor： THIEME P C ,  FRICKEL F F ,  THEOBALD H ,  FRANKE A ,  LENKE D ,  GRIES J

IPC: A61K31/41 ,  A61K31/42 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  A61P25/02 ,  C07D261/08 ,  C07D

Abstract: Alkylamino-propanol derivatives of 3-alkyl-5-(2-hydroxystyryl)-isoxazole, of the general formula where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cycloalkyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and R' is alkyl of 1 to 4 carbon atoms, and their addition salts with physiologically acceptable acids, their preparation, and pharmaceutical formulations which contain these compounds and which can be used as valuable drugs in the treatment of hypertonia, coronary diseases of the heart and cardiac arrhythmias.

公开(公告)号：ZA7801552B

公开(公告)日：1979-04-25

申请号：ZA7801552

申请日：1978-03-16

Applicant: BASF AG

Inventor： LENKE D ,  PHILIPSBORN G ,  BOELL W

IPC: A61C8/00 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4415 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/455 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  C07D213/127 ,  C07D213/65 ,  C07D213/66 ,  C07D213/67 ,  C07D213/79 ,  C07D213/80 ,  C07D221/04 ,  C07D263/32 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/056

CPC classification number: C07D213/80 ,  A61C8/0018 ,  C07D213/65 ,  C07D263/32 ,  C07D491/04

公开(公告)号：ZA78652B

公开(公告)日：1979-01-31

申请号：ZA78652

申请日：1978-02-03

Applicant: BASF AG

Inventor： GRIES J ,  OHNSORGE U ,  FRICKEL F ,  HAGEN H ,  FRANKE A ,  LENKE D ,  LEHMANN H

IPC: A61K31/428 ,  C07D275/04 ,  A61K31/425

Abstract: New aminopropanol derivatives of 4-hydroxy-1,2-benzisothiazole and their addition salts with acids, their preparation, and pharmaceutical formulations which contain the said compounds and may be used for the treatment and prophylaxis of cardiac and circulatory disorders.

公开(公告)号：SE7801303A

公开(公告)日：1978-08-06

申请号：SE7801303

申请日：1978-02-03

Applicant: BASF AG

Inventor： FRICKEL F-F ,  HAGEN H ,  OHNSORGE U ,  FRANKE A ,  LENKE D ,  GREIS J ,  LEHMANN H-D

IPC: A61K31/428 ,  C07D275/04

CPC classification number: C07D275/04

公开(公告)号：YU41016B

公开(公告)日：1986-10-31

申请号：YU225282

申请日：1982-10-07

Applicant: BASF AG

Inventor： PHILIPSBORN G ,  BOELL W ,  LENKE D

IPC: A61C8/00 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4415 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/455 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  C07D213/127 ,  C07D213/65 ,  C07D213/66 ,  C07D213/67 ,  C07D213/79 ,  C07D213/80 ,  C07D221/04 ,  C07D263/32 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/056

Abstract: New pyridinyl aminoalkyl ethers, their N-oxides and their physiologically acceptable addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.