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    61.
    发明专利
    未知

    公开(公告)号：DE4308073A1

    公开(公告)日：1994-09-15

    申请号：DE4308073

    申请日：1993-03-13

    Applicant: BASF AG

    Inventor： RITTINGER STEFAN DR ,  RIEBER NORBERT DR

    IPC: C07D239/26 ,  C07D239/36 ,  C07D239/40 ,  C07D239/42 ,  C07D295/104 ,  C07D239/32 ,  C07C225/14

    Abstract: Process for the preparation of 4-methylpyrimidines of the general formula I in which R is C1- to C20-alkyl, C3- to C8-cycloalkyl, aryl, C7- to C12-phenalkyl, C7- to C12-alkylphenyl, NH2, NHCN, OH or SH, by reacting 1-aminovinyl methyl ketones of the general formula II in which R and R are C1- to C20-alkyl, C3- to C8-cycloalkyl, aryl, C 7- to C12-phenylalkyl, C7- to C12-alkylphenyl, C1- to C20-hydroxyalkyl, or together are a C2- to C7-alkylene chain which is optionally monosubstituted to tetrasubstituted by C1- to C4-alkyl and optionally interrupted by oxygen, nitrogen or sulphur, with carboxamides or amidines of the general formula III in which R has the abovementioned meanings and X represents oxygen or NH, at temperatures from 20 to 200@C and pressures from 0.01 to 50 bar.

    Ethylene oxide, propylene oxide and butylene oxide prodn. from glycol mixt. - by conversion to cyclic carbonate ester mixt., catalytic decarboxylation and distn.
    62.
    发明专利
    Ethylene oxide, propylene oxide and butylene oxide prodn. from glycol mixt. - by conversion to cyclic carbonate ester mixt., catalytic decarboxylation and distn. 未知

    公开(公告)号：DE4213010A1

    公开(公告)日：1993-10-28

    申请号：DE4213010

    申请日：1992-04-21

    Applicant: BASF AG

    Inventor： SCHUSTER LUDWIG DR ,  RIEBER NORBERT DR ,  TELES JOAQUIM HENRIQUE DR

    IPC: C07D301/02 ,  C07D303/04 ,  C07C27/04 ,  C07C29/132 ,  C07C31/20 ,  C07D301/32 ,  C07D317/36

    Abstract: Prodn. of ethylene oxide (IA), propylene oxide (IB) and 1,2-butylene oxide (IC) comprises (a) conversion of a mixt. (II) of ethylene glycol (IIA), 1,2-propylene glycol (IIB) and 1,2-butylene glycol (IIC) into a mixt. (III) of the corresp. cyclic carbonate esters; (b) decarboxylation of (III) to epoxides (I) in the presence of catalysts; and (c) sepn. of (I) into (IA), (IB) and (IC) by distn. Pref. (II) contains 10-20 (wt.)% (IIA), 60-80% (IIB) and 5-15% (IIC) and pref. is obtd. by catalytic hydrogention of a sugar and distn. of the prod. USE/ADVANTAGE - (II) is converted into valuable prods., which can be sepd. more easily than (II) into the individual components, so that (II) is utilised economically. (IA), (IB) and (IC) are obtd. in good yields. (I) are valuable intermediate for the prodn. of polyalkylene oxides used in the mfr. of polyesters and polyurethanes. In an example a mixt. of 16% (IIA), 71% (IIB), 9% (IIC) and 4% unidentified cpds. was obtd. by catalytic hydrogenation of aq. sucrose soln. on a Co-Cu-Mn catalyst, followed by distn. 136 g this mixt. and 181.2 g CuCl were treated at 110 deg.C and 5 bar with 100 ml/min. gas contg. 80 mole-% CO and 20 mole-% 02. Distn. gave a practically quantitative yield of (III). 1.11 kg (III) were heated to 180 deg.C with 10 g KI, when 488 g (I) distilled off. This was distilled, giving 7.4% (IA), 70.7% (IB), 10.6% (IC) and 11.3% unidentified cpds. The total (I) yield was 76% w.r.t. (II).

    69.
    发明专利
    未知

    公开(公告)号：DE3532880A1

    公开(公告)日：1987-03-26

    申请号：DE3532880

    申请日：1985-09-14

    Applicant: BASF AG

    Inventor： OSTERSEHLT BERND DR ,  RIEBER NORBERT DR ,  GRIES JOSEF DR MED

    IPC: A61K31/415 ,  A61K31/505 ,  A61P1/04 ,  A61P43/00 ,  C07D231/12 ,  C07D317/00 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D417/14 ,  C07D401/06 ,  A61K31/445 ,  C07D403/14 ,  C07D413/14 ,  A61K31/535

    Abstract: 1,4-disubstituted pyrazole derivatives of the formula I I where R1 and R2 independently of one another are each hydrogen, lower alkyl or benzyl, or R1 and R2, together with the nitrogen atom to which they are bonded, may be a pyrrolidino, piperidino or morpholino radical, n is an integer from 2 to 5 and Z is a radical of the formula or QNR1R2 where R1 and R2 have the same meanings as above, Q is A is CHR3 or NR3 in which R3 is CN, NO2, SO2-aryl or SO2-lower alkyl and m may be 0 or 1, and their pharmaceutically tolerated salts, processes for their preparation, pharmaceutical compositions containing the compounds of formula I, the use of such compositions and an intermediate of the formula III III where R1, R2 and n have the same meanings as above, in the preparation of the compounds of the formula I. The compounds are useful to block histamine H2- receptors.

    METHOD FOR PRODUCING AN EPOXIDE
    70.
    发明专利
    METHOD FOR PRODUCING AN EPOXIDE 未知

    公开(公告)号：MY139320A

    公开(公告)日：2009-09-30

    申请号：MYPI20020334

    申请日：2002-01-30

    Applicant: BASF AG

    Inventor： TELES JOAQUIM HENRIQUE DR ,  REHFINGER ALWIN DR ,  BERG ANNE ,  RUDOLF PETER DR ,  RIEBER NORBERT DR ,  BASLER PETER DR

    IPC: C07D301/12 ,  C07D301/19 ,  C07D301/32

    Abstract: AN ORGANIC COMPOUND HAVING AT LEAST ONE C-C DOUBLE BOND IS EPOXIDIZED BY MEANS OF HYDROGEN PEROXIDE IN THE PRESENCE OF AT LEAST ONE CATALYTICALLY ACTIVE COMPOUND AND AT LEAST ONE SOLVENT, WHEREIN A PRODUCT MIXTURE COMPRISING -HYDROPEROXYALCOHOLS IS REDUCED USING AT LEAST ONE REDUCING AGENT. THE PROCESS ADVANTAGEOUSLY COMPRISES AT LEAST THE FOLLOWING STEPS: (I) REACTING AN ORGANIC COMPOUND HAVING AT LEAST ONE C-C DOUBLE BOND WITH HYDROGEN PEROXIDE IN THE PRESENCE OF AT LEAST ONE CATALYTICALLY ACTIVE COMPOUND AND AT LEAST ONE SOLVENT TO GIVE A PRODUCT MIXTURE P1 COMPRISING A-HYDROPEROXYALCOHOLS; (II) SEPARATING AN EPOXIDE FORMED IN THE REACTION IN STEP (I) AND THE UNREACTED ORGANIC COMPOUND HAVING AT LEAST ONE C-C DOUBLE BOND FROM P1 OR P1' TO GIVE A PRODUCT MIXTURE P2 OR P2', WHERE P2 COMPRISES THE -HYDROPEROXYALCOHOLS FORMED AS BY-PRODUCT IN THE REACTION IN STEP (I) AND P2' IS LARGELY FREE OF -HYDROPEROXYALCOHOLS; (III) TREATING P1 AND/OR P2 WITH AT LEAST ONE REDUCING AGENT SO THAT THE -HYDROPEROXYALCOHOLS ARE CONVERTED INTO CORRESPONDING GLYCOLS TO GIVE A PRODUCT MIXTURE P1' OR P3.

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