公开(公告)号：DE3600275A1

公开(公告)日：1987-07-09

申请号：DE3600275

申请日：1986-01-08

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ DR ,  SCHMIED BERNHARD DR ,  KROPP RUDOLF ,  BALDINGER VERENA DR ,  GRIES JOSEF DR MED ,  LEHMANN HANS DIETER PROF DR ,  RUEBSAMEN KLAUS DR ,  TRAUT MARTIN DR

IPC: C07D237/00 ,  A61K31/50 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D403/04 ,  C07D403/10 ,  A61K31/40

公开(公告)号：DE3436550A1

公开(公告)日：1985-04-25

申请号：DE3436550

申请日：1984-10-05

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  KROPP RUDOLF ,  REICHENEDER FRANZ DR ,  GRIES JOSEF DR MED ,  HOFMANN HANS PETER DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  TRAUT MARTIN DR

IPC: C07D237/20 ,  A61K31/50

Abstract: 1-Phenyl-4(1H)-pyridazinone imines substituted on the imine nitrogen atom, of the formula (I) and their acid addition salts with a physiologically tolerated acid, process for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs, especially as antidepressants, antiparkinson drugs and antihypotensives.

公开(公告)号：DE3209159A1

公开(公告)日：1983-09-15

申请号：DE3209159

申请日：1982-03-13

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DIPL CHEM DR ,  THYES MARCO DIPL CHEM DR ,  FRANKE ALBRECHT DIPL CHEM DR ,  KOENIG HORST PROF DIPL CHEM DR ,  GRIES JOSEF DR MED ,  LEHMANN HANS DIETER DR MED ,  LENKE DIETER PROF DR

IPC: A61K31/50 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/26 ,  C07D237/14

Abstract: 6-Aryl-4,5-dihydro-3(2H)-pyridazinones of the formula (I) where R is hydrogen, R1 is hydrogen or C1-C3-alkyl, or R and R1 together are methylene, R2 and R3 are identical or different and are each hydrogen or C1-C6-alkyl, and A is hydroxyl, C1-C6-alkoxy, C2-C7-acyloxy, a C2-C7-carbamic acid ester group, C1-C6-alkylsulfonyloxy, C1-C6-alkylmercapto, carboxyl, C2-C7-alkoxycarbonyl or nitrile, and their preparation are described. The substances are suitable for treating disorders.

公开(公告)号：DE2935359A1

公开(公告)日：1981-03-26

申请号：DE2935359

申请日：1979-09-01

Applicant: BASF AG

Inventor： STEINER GERD DIPL CHEM DR ,  GRIES JOSEF DR MED ,  LENKE DIETER PROF DR

IPC: C07D403/04 ,  A61K31/50 ,  A61P9/12 ,  C07D521/00 ,  A61K31/415

公开(公告)号：DE2854475A1

公开(公告)日：1980-07-03

申请号：DE2854475

申请日：1978-12-16

Applicant: BASF AG

Inventor： THYES MARCO DIPL CHEM DR ,  GRIES JOSEF DR MED ,  LEHMANN HANS DIETER DR MED ,  LENKE DIETER PROF DR ,  KUNZE JOHANNES DR MED

IPC: A61K31/50 ,  A61K31/395 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07C62/38 ,  C07C205/56 ,  C07D231/54 ,  C07D237/26 ,  A61K31/52

Abstract: 2-Aryl-3,4-diaza-bicyclo-[4.1.0]hept-2-en-5-ones, substituted in the phenyl ring, of the general formula their preparation, and therapeutic agents, containing these compounds, which may be used for the treatment of hypertension or of thrombo-embolic disorders.

公开(公告)号：DE2854191A1

公开(公告)日：1980-07-03

申请号：DE2854191

申请日：1978-12-15

Applicant: BASF AG

Inventor： THYES MARCO DIPL CHEM DR ,  GRIES JOSEF DR MED ,  LEHMANN HANS DIETER DR MED ,  LENKE DIETER PROF DR ,  KUNZE JOHANNES DR MED

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

公开(公告)号：DE3727736A1

公开(公告)日：1989-03-02

申请号：DE3727736

申请日：1987-08-20

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  RASCHACK MANFRED DR ,  GRIES JOSEF DR MED

IPC: A61K31/34 ,  A61K31/343 ,  A61K31/40 ,  A61K31/44 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  C07D307/86 ,  C07D405/06 ,  C07D405/12

Abstract: Benzofuran derivatives of the formula I I where R1 to R5 and X have the meanings stated in the description, and therapeutic agents containing these derivatives.

公开(公告)号：DE3535170A1

公开(公告)日：1987-04-16

申请号：DE3535170

申请日：1985-10-02

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ DR ,  THYES MARCO DR ,  KOENIG HORST PROF DR ,  LEHMANN HANS DIETER PROF DR ,  TRAUT MARTIN DR ,  GRIES JOSEF DR MED ,  ROSSY PHILLIP A DR

IPC: C07D401/04 ,  A61K31/50 ,  A61K31/55 ,  A61P3/02 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  C07D209/34 ,  C07D215/22 ,  C07D223/16 ,  C07D237/00 ,  C07D403/04 ,  C12N9/99 ,  C07D215/12

Abstract: 2-aryl-3,4-diazabicyclo[4.n.0]-alk-2-en-5-ones of the formula I where m, n, R, R1, R2 and R3 have the stated meanings, are used for the treatment of cardiac insufficiency.

公开(公告)号：DE3243369A1

公开(公告)日：1984-05-24

申请号：DE3243369

申请日：1982-11-24

Applicant: BASF AG

Inventor： KUBINYI HUGO DR ,  TRAUT MARTIN DR ,  GRIES JOSEF DR MED

IPC: A61K31/455 ,  A61K31/185 ,  A61K38/00 ,  A61P9/12 ,  A61P25/04 ,  C07C67/00 ,  C07C325/00 ,  C07C327/20 ,  C07C327/32 ,  C07D205/04 ,  C07D207/16 ,  C07D209/20 ,  C07D209/26 ,  C07D211/60 ,  C07D217/26 ,  C07D277/06 ,  C07D333/24 ,  C07K5/062 ,  C07K5/065 ,  C07K5/078 ,  C07C153/09

公开(公告)号：DE3101502A1

公开(公告)日：1982-08-26

申请号：DE3101502

申请日：1981-01-19

Applicant: BASF AG

Inventor： THIEME PETER C DR ,  STEINER GERD DR ,  ROHR WOLFGANG DR ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR MED ,  WEIFENBACH HARALD DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST DR

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/496 ,  A61P9/02 ,  A61P11/00 ,  A61P25/20 ,  C07D231/12 ,  C07D233/60 ,  C07D233/61 ,  C07D271/10 ,  C07D295/06 ,  C07D295/067 ,  C07D295/096 ,  C07D521/00 ,  C07D403/12 ,  C07D413/12

Abstract: Novel phenylpiperazinylpropane and -butane derivatives of hetarylphenols and hetarylanilines of the formula where R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R2, X is oxygen or an NH group, and the heterocyclic structure Het. is 1,3,4-oxadiazolyl, triazolyl, imidazolyl or pyrazolyl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly sedative, neuroleptic and hypotensive properties.