公开(公告)号：CA2587276A1

公开(公告)日：2006-05-18

申请号：CA2587276

申请日：2005-11-03

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： PAPADOPOULOS PAVLOS ,  DOTY MARK ,  KIPP JAMES E ,  ROESSLER BERTHOLD

IPC: A61K31/404 ,  A61K9/00 ,  A61P35/00

Abstract: The present invention is directed to novel pharmaceutical compositions comprising nano- and micro-particulate formulations of poorly water soluble tubulin inhibitors of the indole chemical class, preferably N-substituted indol-3-glyoxyamides, and more preferably N-(Pyridin-4-yl)-[1-(4-chlorobenzyl)-indol-3-yl]glyoxylic acid amide (D-24851), also known as “Indibulin,” and methods of making and using such compositions for the treatment of anti-tumor agent resistant cancers and other diseases.

公开(公告)号：AT319432T

公开(公告)日：2006-03-15

申请号：AT01998077

申请日：2001-12-20

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN ,  WERLING JANE ,  SRIRAM RAJARAM

IPC: C07D407/14 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/24 ,  A61K47/28 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61P31/10 ,  A61K9/20 ,  A61K9/51 ,  A61K31/192 ,  A61K31/55 ,  A61K31/573

公开(公告)号：NO20055616L

公开(公告)日：2006-01-25

申请号：NO20055616

申请日：2005-11-28

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  SUN CHONG-SON ,  PAPADOPOULOS PAVLOS ,  RABINOW BARRETT E ,  WHITE RANDY

IPC: A61K9/14 ,  A61K9/50 ,  A61K9/51 ,  A61K31/496

Abstract: The present invention relates to compositions of submicron- to micron-size particles of antimicrobial agents. More particularly the invention relates to a composition of an antimicrobial agent that renders the agent potent against organisms normally considered to be resistant to the agent. The composition comprises an aqueous suspension of submicron-tomicron-size particles containing the agent coated with at least one surfactant selected from the group consisting of: ionic surfactants, non-ionic surfactants, biologically derived surfactants, and amino acids and their derivatives. The particles have a volume-weighted mean particle size of less than 5 µm as measured by laser diffractonetry.

公开(公告)号：NO20055616A

公开(公告)日：2006-01-25

申请号：NO20055616

申请日：2005-11-28

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  SUN CHONG-SON ,  PAPADOPOULOS PAVLOS ,  RABINOW BARRETT E ,  WHITE RANDY

IPC: A61K9/14 ,  A61K9/50 ,  A61K9/51 ,  A61K31/496

CPC classification number: A61K9/5123 ,  A61K9/5015 ,  A61K9/5138 ,  A61K9/5146 ,  A61K9/5192 ,  A61K31/496

公开(公告)号：CA2565972A1

公开(公告)日：2005-12-29

申请号：CA2565972

申请日：2005-06-08

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： KIPP JAMES E ,  RABINOW BARRETT E

IPC: C12N5/06 ,  A61K9/14 ,  A61K35/12 ,  A61K45/00 ,  A61K47/48 ,  A61K49/00

Abstract: The present invention is concerned with a method of preparing and delivering small particles of a pharmaceutically active material to a mammalian subject for treating diseases or disorders. A preferred embodiment entails: (i) the collection of tissue cells from an animal donor, (ii) selective or non-selective growth of these cells in a cell culture medium to which is added solid particles of a therapeutically active compound, mostly free of a drug carrier (about 10% or less, by weight), and having an average particle size of less than about 100 microns, (iii) contacting the cells in the cell culture medium with the solid particles of therapeutically active compound causing the particles to be taken up by the cells into either the intracellular compartment of the cultured cells, attachment of the active compound as particles to the periphery of such cells, or a combination of intracellular uptake and attachment to the cell surface, (iv) optionally, isolation and/or resuspension of the cells prepared in steps i through iii, (v) administering the cells to the mammalian subject. The pharmaceutically active material can be administered intravenously, intramuscularly, subcutaneously, intradermally, intra-articularly, intrathecally, epidurally, intracerebrally, via buccal route, rectally, topically, transdermally, orally, intranasally, via pulmonary route, intraperitoneally, or combinations thereof. After administration, the loaded cells transport the pharmaceutical composition as particles.

公开(公告)号：ZA200502740B

公开(公告)日：2005-10-13

申请号：ZA200502740

申请日：2005-04-05

Applicant: BAXTER INT

Inventor： WONG JOSEPH CHUNG TAK ,  KIPP JAMES E ,  DOTTY MARK J ,  REBBECK CHRISTINE L ,  PAPADOPOULOS PAVLOS

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A61K31/495 ,  A61K31/496 ,  A61K

Abstract: The present invention relates to compositions of submicron-to micron-size particles of antifungal agents. More particularly the invention relates to aqueous suspensions of antifungal agents for pharmaceutical use.

公开(公告)号：PL364558A1

公开(公告)日：2004-12-13

申请号：PL36455802

申请日：2002-03-28

Applicant: BAXTER INT

Inventor： DOTY MARK J ,  REBBECK CHRISTINE L ,  KIPP JAMES E ,  RAGHAVAN NEERVALUR V

IPC: C07D307/80 ,  A61K9/00 ,  A61K9/08 ,  A61K31/343 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  A61P9/06

公开(公告)号：AU2004224307A1

公开(公告)日：2004-10-07

申请号：AU2004224307

申请日：2004-03-24

Applicant: BAXTER INT

Inventor： WISLER MONTE ,  KIPP JAMES E ,  GARCIA RHONDA ,  WONG JOSEPH CHUNG TAK

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/00

Abstract: Methods and apparatuses for comminuting and stabilizing small particles are provided. In one embodiment, an apparatus moves an organic compound dissolved in a solvent to form a suspension of particles in a first fluid stream and moves the suspension in a second fluid stream, wherein the second fluid stream is oriented and positioned with respect to the first stream to cause shearing between the streams and mixing of at least some of the particles in the first and second streams.

公开(公告)号：AU2003302162A1

公开(公告)日：2004-07-09

申请号：AU2003302162

申请日：2003-08-04

Applicant: BAXTER INT

Inventor： WERLING JANE ,  KIPP JAMES E ,  SRIRAM RAJARAM ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  WONG JOSEPH CHUNG TAK

IPC: A61K9/00 ,  A61K31/495

公开(公告)号：AU764225B2

公开(公告)日：2003-08-14

申请号：AU2351600

申请日：1999-12-02

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WEHRMANN GLENN JR ,  HAMMOND RICHARD B ,  REBBECK CHRISTINE L

IPC: G01N27/30 ,  G01N27/416

Abstract: The present invention provides a reference electrode solution containing ammonium salts and phosphonium salts for the potentiometric measurement of pH and method of using the same. The use of the ammonium salts and the phosphonium salts to replace potassium chloride or sodium chloride as reference electrolytes in a standard reference electrode minimizes the formation of precipitates in sample solutions containing cation-sensitive compounds. Disruption of ion flow through the reference electrode is eliminated, and accurate pH measurements may be obtained in solutions that contain compounds having a strong affinity for hard cations.