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公开(公告)号：NO167798B
公开(公告)日：1991-09-02
申请号：NO883285
申请日：1988-07-22
Applicant: HOECHST AG
Inventor： WESS GUENTHER , BARTMANN WILHELM , BECK GERHARD , ANAGNOSTOPOULOS HIRISTO
IPC: A61K31/085 , A61K31/10 , A61K31/12 , A61K31/38 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/34 , A61K31/381 , A61K31/395 , A61K31/41 , A61K31/44 , A61K31/535 , A61K31/5375 , A61P1/04 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C43/00 , C07C43/178 , C07C43/20 , C07C43/235 , C07C43/263 , C07C45/00 , C07C47/52 , C07C49/84 , C07C51/00 , C07C59/125 , C07C65/21 , C07C67/00 , C07C69/007 , C07C69/025 , C07C69/675 , C07C69/92 , C07C201/00 , C07C235/06 , C07C235/16 , C07C239/00 , C07C239/14 , C07C313/00 , C07C317/00 , C07C317/04 , C07C317/18 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/46 , C07C323/00 , C07C323/16 , C07C323/19 , C07C323/22 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/65 , C07D213/30 , C07D257/04 , C07D295/18 , C07D317/36 , C07D317/38 , C07D333/16 , C07D317/34
Abstract: Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases (I) in which R1, R2, R3, R4, R5 and X have the indicated meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals, and pharmaceutical products based on these compounds, are described.
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公开(公告)号：AU609149B2
公开(公告)日：1991-04-26
申请号：AU1888288
申请日：1988-07-08
Applicant: HOECHST AG
Inventor： KESSELER KURT , BECK GERHARD , BARTMANN WILHELM , GRANZER ERNOLD
IPC: A61K31/44 , A61K31/365 , A61K31/4418 , A61K31/443 , A61K31/505 , A61P3/06 , A61P9/10 , C07D213/55 , C07D239/26 , C07D405/06 , C07D405/14 , C07F7/18 , A61K31/495
Abstract: 3-Desmethylmevalonic acid derivatives of the formula I ( delta -lactone) or II (corresponding dihydroxycarboxylic acid derivative) … … in which A-B, Z, R , R , R and R have the meanings given, are used as medicaments.
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公开(公告)号：NZ225344A
公开(公告)日：1990-08-28
申请号：NZ22534488
申请日：1988-07-08
Applicant: HOECHST AG
Inventor： KESSELER KURT , BECK GERHARD , BARTMANN WILHELM , GRANZER ERNOLD
IPC: A61K31/44 , A61K31/365 , A61K31/4418 , A61K31/443 , A61K31/505 , A61P3/06 , A61P9/10 , C07D213/55 , C07D239/26 , C07D405/06 , C07D405/14 , C07F7/18
Abstract: 3-Desmethylmevalonic acid derivatives of the formula I ( delta -lactone) or II (corresponding dihydroxycarboxylic acid derivative) … … in which A-B, Z, R , R , R and R have the meanings given, are used as medicaments.
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公开(公告)号：ZA8905959B
公开(公告)日：1990-04-25
申请号：ZA8905959
申请日：1989-08-04
Applicant: HOECHST AG
Inventor： BECK GERHARD , GERHARD BECK , BARTMANN WILHELM , WILHELM BARTMANN , WESS GUNTER , GUNTER WESS , GRANZER ERNOLD , ERNOLD GRANZER
IPC: A61K31/19 , A61K31/215 , A61K31/365 , A61K31/366 , A61K31/40 , A61K31/44 , A61K31/4406 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/50 , A61K31/505 , A61P3/06 , A61P9/10 , A61P43/00 , C07C27/00 , C07C29/147 , C07C33/48 , C07C45/56 , C07C47/55 , C07C59/56 , C07C67/00 , C07C67/31 , C07C67/343 , C07C69/65 , C07C69/732 , C07C69/738 , C07D207/32 , C07D207/333 , C07D207/337 , C07D213/30 , C07D213/48 , C07D213/55 , C07D213/79 , C07D237/08 , C07D239/26 , C07D307/54 , C07D309/30 , C07D333/24 , C07D405/06 , C07D407/06 , C07D409/06 , C07D , A61K , C07C
CPC classification number: C07D207/333 , C07C33/486 , C07C45/56 , C07C47/55 , C07D207/337 , C07D213/30 , C07D213/48 , C07D213/55 , C07D237/08 , C07D239/26 , C07D307/54 , C07D309/30 , C07D333/24 , C07D405/06 , C07D407/06 , C07D409/06
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公开(公告)号：HU199768B
公开(公告)日：1990-03-28
申请号：HU359688
申请日：1988-07-09
Applicant: HOECHST AG
Inventor： WESS GUENTHER , BARTMANN WILHELM , BECK GERHARD , GRANZER ERNOLD
IPC: C12N9/99 , A61K31/19 , A61K31/22 , A61K31/34 , A61K31/341 , A61K31/365 , A61K31/366 , A61K31/38 , A61K31/381 , A61P3/06 , A61P9/10 , A61P43/00 , C07C27/00 , C07C31/125 , C07C31/13 , C07C31/135 , C07C31/137 , C07C33/025 , C07C33/12 , C07C33/14 , C07C33/28 , C07C33/38 , C07C33/46 , C07C33/48 , C07C41/00 , C07C43/13 , C07C43/178 , C07C47/00 , C07C47/21 , C07C51/00 , C07C51/09 , C07C59/42 , C07C59/48 , C07C59/54 , C07C59/56 , C07C59/58 , C07C59/64 , C07C67/00 , C07C69/65 , C07C69/66 , C07C69/675 , C07C69/732 , C07C69/738 , C07C253/00 , C07D307/34 , C07D307/54 , C07D309/30 , C07D333/02 , C07D333/38 , C07D405/06 , C07D407/02 , C07D407/06 , C07D409/02 , C07D409/06 , C07C59/11 , A61K31/185
Abstract: 3,5-dihydroxycarboxylic acids of formula (I) and their lactones of formula (II) are new: A-B = CH-CH or C=C; X-Y = CH2CH2 or CH=CH; R1 and R2 are each up to 20C, opt. unsatd., alkyl (opt. substd. by 1-6C alkoxy or OCOR5); 3-7C cycloalkyl; phenyl, thiophene, furan or naphthalene residue (these all opt. substd. by 1-3 of halo, 1-6C alkyl or alkoxy, 3-7C cycloalkyl or OCOR5) or pyridyl, opt. substd. by 1-3, 1-4C alkyl; R5 = 1-8C alkyl; R3 = up to 8C alkyl (opt. unsatd.); benzyl, phenyl, thiophene, furan or naphthalene residue (all opt. substd. as above), or 3-7C cycloalkyl; R4 = H, 1-8C alkyl, metal cation, ammonium ion, phenyl, benzyl or 2,3-dihydroxypropyl. Also new are the intermediates of formula (III), (IV), (VI), (VII), (VIII), (IX) or (XII): Q-X-Y-CHO (III); Q-X-Y-CHOH-CH2-CO-CH2-COOR4 (IV); Q-Z; Z = -X-Y-CN (cpds. (VI)); -CHO (cpds. (VII)); -CH2OH (cpds. (VIII)); or COOR7 (cpds. (IX)); R4 = 1-8C alkyl; R7 = protecting gp.; Q = a gp. of formula (i).
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Patent Agency Ranking
公开(公告)号：ZA893509B
公开(公告)日：1989-12-27
申请号：ZA893509
申请日：1989-05-11
Applicant: HOECHST AG
Inventor： JENDRALLA HEINER , HEINER JENDRALLA , WESS GUENTHER , GUENTHER WESS , BARTMANN WILHELM , WILHELM BARTMANN , BECK GERHARD , GERHARD BECK
IPC: C07C59/68 , C07C323/09 , C07D309/30 , C07D , A61K , C07C
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公开(公告)号：NO891937A
公开(公告)日：1989-11-14
申请号：NO891937
申请日：1989-05-12
Applicant: HOECHST AG
Inventor： JENDRALLA HEINER , WESS GUENTHER , BARTMANN WILHELM , BECK GERHARD
IPC: A61K31/365 , A61K31/19 , A61K31/366 , A61P3/06 , C07C39/367 , C07C59/64 , C07C59/68 , C07C323/09 , C07D309/30 , C07D309/00 , C07C59/00
CPC classification number: C07C59/68 , C07C323/09 , C07D309/30
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公开(公告)号：NO891937D0
公开(公告)日：1989-05-12
申请号：NO891937
申请日：1989-05-12
Applicant: HOECHST AG
Inventor： JENDRALLA HEINER , WESS GUENTHER , BARTMANN WILHELM , BECK GERHARD
IPC: A61K31/365 , A61K31/185 , A61K31/19 , A61K31/35 , A61K31/366 , A61P3/06 , C07C39/367 , C07C59/64 , C07C59/68 , C07C323/01 , C07C323/09 , C07D309/30 , C07D309/00 , C07C59/00
Abstract: Compounds of the general formula I and the corresponding open-chain dihydroxy carboxylic acids of the formula II in which X, Y and Z have the stated meanings, and their pharmacologically tolerated salts with bases and their pharmacologically tolerated esters, process for preparing this compound, its use as pharmaceutical and pharmaceutical products are described. Also described are phenols and thiophenols of the formula III in which X, Y and Z have the stated meanings.
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公开(公告)号：DK152675C
公开(公告)日：1988-10-31
申请号：DK248176
申请日：1976-06-04
Applicant: HOECHST AG
Inventor： BARTMANN WILHELM , REUSCHLING DIETER-BERND , SEEGER KARL , TEUFEL HERMANN , BECK GERHARD
IPC: C07D333/16 , A61K31/557 , A61K31/5575 , A61P1/04 , A61P7/02 , A61P7/10 , A61P9/12 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07D333/00 , C07D333/32 , C07D333/64 , C07D333/78 , C07D409/12 , C07D409/14 , C07F9/54
Abstract: The present invention relates to thienyl-prostaglandin derivatives and to a process for their manufacture. The compounds according to the invention have valuable pharmaceutical properties.
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公开(公告)号：NO870078L
公开(公告)日：1987-07-10
申请号：NO870078
申请日：1987-01-08
Applicant: HOECHST AG
Inventor： RUEGER WOLFGANG , URBACH HANSJOERG , BARTMANN WILHELM , KAISER JOACHIM
IPC: A61K31/395 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/451 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/55 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/08 , A61P9/10 , C07D211/18 , C07D211/22 , C07D211/48 , C07D211/58 , C07D211/70 , C07D215/20 , C07D215/22 , C07D215/227 , C07D215/26 , C07D217/02 , C07D217/04 , C07D217/06 , C07D223/04 , C07D223/12 , C07D225/02 , C07D241/04 , C07D243/08 , C07D295/073 , C07D295/08 , C07D295/088 , C07D295/092 , C07D295/096 , C07D401/12 , C07D401/00 , C07D403/00 , C07D241/00
Abstract: Compounds I … … where R is equal to cycloalkyl, alkenyl, cycloalkenyl, phenyl, … … where B, C, D and E are equal to methine or nitrogen and… B', C', D' and E' are equal to methylene, carbonyl or imino;… R is equal to phenyl or phenylalkyl;… A is equal to various amine radicals;… m is equal to 2, 3 or 4; and… n is equal to 1, 2, 3 or 4;… salts of these compounds I are also described. Compounds I and the salts are calcium antagonists.
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