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公开(公告)号:KR840000034B1
公开(公告)日:1984-01-28
申请号:KR790004332
申请日:1979-12-07
Applicant: HOECHST AG
Inventor: KLAUS-DIETER KAMPE , ERNOLD GRANZER
IPC: C07D403/04
Abstract: 4-Amino-2-ureido-pyrimidine-5-carboxylic acid anilide(I) and its acid-added salt are prepared through reaction between compd.(III) and compd.(IV) or its acid-added salt. In I, R5=H2; R6 = H2, C1 - C3 alkyl gp., C3 -C4 alkenyl gp., methoxy gp., benzyl gp. or phenyl gp.; R7 = H2, C1-C3 alkyl, C3 -C4 alkenyl, C5 - C6 cycloalkyl, phenyl, halogen atom, trifluoromethyl, C1 -C4 alkylthio, C1-C2 alkoxy carbonyl, cyano, acetamino, amino, nitro, carboxyl, C1-C4 alkoxy or comp. (II), where Z = O, S stom, -CO-, -CH2- or -CH2CH2- gp; R9 to R13 = H, halogen atoms, alkyl, alkoxy, alkenyl, alkoxycarbonyl, carboxyl gp., etc.; and n = 0 - 3.
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公开(公告)号:ZA897233B
公开(公告)日:1990-06-27
申请号:ZA897233
申请日:1989-09-22
Applicant: HOECHST AG
Inventor: KESSELER KURT , KURT KESSELER , BARTMANN WILHELM , WILHELM BARTMANN , WESS GUENTHER , GUENTHER WESS , GRANZER ERNOLD , ERNOLD GRANZER
IPC: A61K31/215 , A61K31/34 , A61K31/35 , A61K31/351 , A61K31/365 , A61K31/366 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/4418 , A61K31/443 , A61K31/496 , A61K31/50 , A61K31/505 , A61P3/06 , A61P9/10 , A61P43/00 , C07C33/48 , C07C45/30 , C07C47/222 , C07C47/24 , C07C51/367 , C07C59/42 , C07C59/46 , C07C59/48 , C07C59/56 , C07C59/76 , C07C67/31 , C07C69/606 , C07C69/732 , C07C69/734 , C07D207/08 , C07D207/32 , C07D207/333 , C07D207/337 , C07D213/48 , C07D213/55 , C07D213/62 , C07D213/63 , C07D231/12 , C07D233/64 , C07D237/08 , C07D239/26 , C07D261/08 , C07D275/02 , C07D309/30 , C07D405/06 , C07D , C07C , A61K
Abstract: 7-Substituted 3,5-dihydroxyhept-6-ynoic acids and the derivatives thereof of the formula I I as well as the corresponding lactones of the formula II II in which R and R DEG have the specified meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.
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公开(公告)号:ZA882851B
公开(公告)日:1988-12-28
申请号:ZA882851
申请日:1988-04-22
Applicant: HOECHST AG
Inventor: LANG HANS-JOCHEN , HANS-JOCHEN LANG , KEREKJARTO BELA , BELA KEREKJARTO , HROPOT MAX , MAX HROPOT , GRANZER ERNOLD , ERNOLD GRANZER
IPC: C07D207/26 , C07D207/273 , C07D207/27 , C07D , C07C , A61K
Abstract: Compounds of the formula I I with R1 equal to H or (cyclo)alk(en)yl, R2 equal to H or alkyl, R3 equal to alkyl, R4/R5 equal to H, alkyl or acyl, and Y equal to H, alkyl, CF3 or Hal, are described, as are processes for the preparation thereof. They are effective diuretics and antihypertensive agents with a lipid-lowering action.
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公开(公告)号:ZA9001189B
公开(公告)日:1990-10-31
申请号:ZA9001189
申请日:1990-02-16
Applicant: HOECHST AG
Inventor: LANG HANS-JOCHEN , HANS-JOCHEN LANG , GRANZER ERNOLD , ERNOLD GRANZER , KEREKJARTO BELA , BELA KEREKJARTO
IPC: A61K31/18 , A61P3/06 , C07C303/38 , C07C311/21 , C07C311/29 , C07C311/44 , C07C317/10 , C07C317/14 , C07C323/67 , C07C , A61K
CPC classification number: C07C323/67 , C07C311/21 , C07C311/29 , C07C317/14 , Y10S514/824 , Y10S514/869
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公开(公告)号:ZA899100B
公开(公告)日:1990-08-29
申请号:ZA899100
申请日:1989-11-29
Applicant: HOECHST AG
Inventor: LANG HANS-JOCHEN , HANS-JOCHEN LANG , GRANZER ERNOLD , ERNOLD GRANZER , HROPOT MAX , MAX HROPOT , KEREKJARTO BELA , BELA KEREKJARTO
IPC: A61K31/18 , A61K31/40 , A61K31/403 , A61K31/4035 , A61P3/06 , A61P9/10 , C07C311/21 , C07D209/48 , C07D , A61K , C07C
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公开(公告)号:ZA8904469B
公开(公告)日:1990-02-28
申请号:ZA8904469
申请日:1989-06-13
Applicant: HOECHST AG
Inventor: KREISER WOLFGANG HERMANN , WOLFGANG HERMANN KREISER , SCHAREIN PETER , PETER SCHAREIN , GRANZER ERNOLD , ERNOLD GRANZER
IPC: A61K31/575 , A61P3/06 , A61P9/10 , C07F9/655 , C07J9/00 , C07J17/00 , C07J31/00 , C07J53/00 , C07J
CPC classification number: C07F9/65515 , C07J9/00 , C07J9/005 , C07J17/00 , C07J31/006 , C07J53/00
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公开(公告)号:ZA887047B
公开(公告)日:1989-06-28
申请号:ZA887047
申请日:1988-09-21
Applicant: HOECHST AG
Inventor: SIEGEL HERBERT , HERBERT SIEGEL , GRANZER ERNOLD , ERNOLD GRANZER
IPC: A61K31/045 , A61K31/12 , A61K31/135 , A61K31/15 , C07C251/44 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/275 , A61K31/34 , A61K31/343 , A61K31/40 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P3/06 , A61P9/10 , C07C45/00 , C07C49/643 , C07C61/39 , C07C61/40 , C07C62/32 , C07C67/00 , C07C209/00 , C07C209/40 , C07C209/50 , C07C211/29 , C07C213/00 , C07C217/74 , C07C217/76 , C07C217/80 , C07C227/00 , C07C227/18 , C07C229/46 , C07C231/00 , C07C231/02 , C07C233/58 , C07C235/40 , C07C237/24 , C07C239/00 , C07D209/76 , C07D295/06 , C07D295/073 , C07D295/18 , C07D295/185 , C07D307/93 , C07C , A61K , C07D
Abstract: Pharmaceutical products containing a 7-diphenylmethylenebicycloheptane or 7-diphenylmethylenebicycloheptene derivative of the formula I I in which A, B, R1, R2, R3 and R4 have the stated meanings, or a physiologically tolerated acid addition salt of these compounds, and the use thereof as hypolipidemics are described. In addition, new 7-diphenylmethylenebicycloheptane and -heptene derivatives of the formula Ia Ia in which A, B, R1, R2, R3 and R4 have the stated meanings, and the physiologically tolerated acid addition salts thereof, as well as processes for the preparation thereof, are described.
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公开(公告)号:ZA9305266B
公开(公告)日:1994-02-10
申请号:ZA9305266
申请日:1993-07-21
Applicant: HOECHST AG
Inventor: AHLERS MICHAEL , GLOMBIK HEINER , GRABLEY SUSANNE , ERNOLD GRANZER , MUELLNER STEFAN , WALCH AXEL , GUAN-YU-XU
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公开(公告)号:ZA912535B
公开(公告)日:1991-12-24
申请号:ZA912535
申请日:1991-04-05
Applicant: HOECHST AG
Inventor: BECK GERHARD , GERHARD BECK , KEBELER KURT , KURT KEBELER , SCHACHT ULRICH , ULRICH SCHACHT , GRANZER ERNOLD , ERNOLD GRANZER
IPC: A61K31/35 , A61K31/352 , A61P3/06 , A61P9/10 , A61P31/00 , C07D211/20 , C07D311/30 , C07D , A61K
Abstract: Substituted 3-thia- and 3-oxa-alkylflavones of formula I I wherein R, R1, R2, R3, R4+L, X, m and n have the indicated meanings, a process for the preparation of these compounds and their use as medicaments and pharmaceutical preparations are described. In addition, new intermediates for the preparation of the compounds of formula I are described.
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公开(公告)号:ZA8909100B
公开(公告)日:1990-08-29
申请号:ZA8909100
申请日:1989-11-29
Applicant: HOECHST AG
Inventor: LANG HANS-JOCHEN , HANS-JOCHEN LANG , GRANZER ERNOLD , ERNOLD GRANZER , HROPOT MAX , MAX HROPOT , KEREKJARTO BELA , BELA KEREKJARTO
IPC: A61K31/18 , A61K31/40 , A61K31/403 , A61K31/4035 , A61P3/06 , A61P9/10 , C07C311/21 , C07D209/48 , C07D , A61K , C07C
CPC classification number: C07D209/48
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