公开(公告)号：FI852252L

公开(公告)日：1985-06-05

申请号：FI852252

申请日：1985-06-05

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  BORMANN DIETER ,  EHLERS EBERHARD ,  SCHRINNER ELMAR ,  HEYMES RENE

IPC: C07D20060101 ,  C07D

公开(公告)号：FI852252A0

公开(公告)日：1985-06-05

申请号：FI852252

申请日：1985-06-05

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  BORMANN DIETER ,  EHLERS EBERHARD ,  SCHRINNER ELMAR ,  HEYMES RENE

IPC: C07D20060101 ,  C07D

公开(公告)号：FI66007C

公开(公告)日：1984-08-10

申请号：FI783960

申请日：1978-12-21

Applicant: HOECHST AG

Inventor： BLUMBACH JUERGEN ,  DUERCKHEIMER WALTER ,  SCHRINNER ELMAR

IPC: C07D501/06 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D277/46 ,  C07D501/34

Abstract: Cephalosporin derivatives of the formula I processes for their manufacture and their use for combating bacterial infections.

公开(公告)号：HU184140B

公开(公告)日：1984-07-30

申请号：HUHO002127

申请日：1978-12-22

Applicant: HOECHST AG

Inventor： BLUMBACH JUERGEN ,  DUERCKHEIMER WALTER ,  SCHRINNER ELMAR

IPC: C07D501/06 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D277/46 ,  C07D501/34 ,  C07D501/46

Abstract: Cephalosporin derivatives of the formula I processes for their manufacture and their use for combating bacterial infections.

公开(公告)号：FI66007B

公开(公告)日：1984-04-30

申请号：FI783960

申请日：1978-12-21

Applicant: HOECHST AG

Inventor： BLUMBACH JUERGEN ,  DUERCKHEIMER WALTER ,  SCHRINNER ELMAR

IPC: C07D501/06 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D277/46 ,  C07D501/34

Abstract: Cephalosporin derivatives of the formula I processes for their manufacture and their use for combating bacterial infections.

公开(公告)号：CA1161836A

公开(公告)日：1984-02-07

申请号：CA301193

申请日：1978-04-14

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  EHLERS EBERHARD ,  SELIGER HUBERT ,  SCHRINNER ELMAR

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61K31/675 ,  A61K31/695 ,  A61P31/04 ,  B23K1/18 ,  B23Q5/033 ,  C07D20060101 ,  C07D277/20 ,  C07D277/40 ,  C07D501/00 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D501/60 ,  C07D519/06

Abstract: HOE 77/F 079 CEPHEM DERIVATIVES AND PROCESSES FOR THEIR MANUFACTURE of the disclosure: Cephem derivatives of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an aminoprotective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkerlyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of nucleophilic compound, and in which the R2O group is in the syn-position are valuable chemotherapeutic agents which possess a very powerful antimicrobial action against Gram-postive and Gramnegative bacteria, have an unexpectedly god action against penicillinaseforming Staphilococci.

公开(公告)号：AU534258B2

公开(公告)日：1984-01-12

申请号：AU4284878

申请日：1978-12-22

Applicant: HOECHST AG

Inventor： BLUMBACH JURGEN ,  DURCHHEIMER WALTER ,  SCHRINNER ELMAR

IPC: C07D501/06 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D277/46 ,  C07D501/34 ,  A61K31/695 ,  C07D501/04

Abstract: Cephalosporin derivatives of the formula I processes for their manufacture and their use for combating bacterial infections.

公开(公告)号：CS208747B2

公开(公告)日：1981-09-15

申请号：CS214478

申请日：1978-04-03

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  BORMANN DIETER ,  EHLERS EBERHARD ,  SCHRINNER ELMAR ,  HEYMES RENE

IPC: A61K31/397 ,  A61K31/435 ,  A61K31/505 ,  A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B25J15/08 ,  C07D205/08 ,  C07D277/20 ,  C07D277/40 ,  C07D277/42 ,  C07D277/50 ,  C07D463/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D501/20 ,  C07D501/24 ,  C07D501/36 ,  C07D505/00 ,  C07D519/06 ,  C07F9/6561 ,  C07D501/60

Abstract: Cephem derivatives of the general formula in which the R2O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.

公开(公告)号：DD138423A5

公开(公告)日：1979-10-31

申请号：DD20475278

申请日：1978-04-12

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  EHLERS EBERHARD ,  SELIGER HUBERT ,  SCHRINNER ELMAR

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61K31/675 ,  A61K31/695 ,  A61P31/04 ,  B23K1/18 ,  B23Q5/033 ,  C07D20060101 ,  C07D277/20 ,  C07D277/40 ,  C07D501/00 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D501/60 ,  C07D519/06

Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.

公开(公告)号：AU4284878A

公开(公告)日：1979-06-28

申请号：AU4284878

申请日：1978-12-22

Applicant: HOECHST AG

Inventor： BLUMBACH JURGEN ,  DURCHHEIMER WALTER ,  SCHRINNER ELMAR

IPC: C07D501/06 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D277/46 ,  C07D501/34 ,  C07D501/04 ,  A61K31/695

Abstract: Cephalosporin derivatives of the formula I processes for their manufacture and their use for combating bacterial infections.