-
公开(公告)号：KR830000733A
公开(公告)日：1983-04-18
申请号：KR780001066
申请日：1978-04-13
Applicant: HOECHST AG
Inventor： DURCKBEIMER WALTER , SELIGER HUBERT , SCHRINNER ELMAR , EHLERS EBERHARD
IPC: C07D501/36
Abstract: Cephems I(R1=H, (un) substituted alkyl, acyl, arylsulfonyl, alkylsulfonyl, amino-protective group; R2=H, (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl, heterocycle; R3=H, esterforming group, cation; R4=H, alkoxy; A=H, (un) substituted alkoxy or alkenoxy, halo, alkyl; X=S, O, CH2, NH), useful as antimicrobial agents were prepd. I(R=R3=R4=H; R1=Me, Et; R2=H, Na; X=S) are esp. effective against Pseudomonas. E.g., dicyclohexylcarbodiimide-midiated coupling of 2-synmethoxyimino-2-(2tritylamino-4-thiazolyl) acetic acid with 7-aminoceph-3-em-4-carboxylic acid, followed by purifn. via the (H2NCH2)2 salt, gave I(R, R2-R4=H, R1=Me)
-
公开(公告)号：DK163244B
公开(公告)日：1992-02-10
申请号：DK162878
申请日：1978-04-14
Applicant: HOECHST AG
Inventor： DUERCKHEIMER WALTER , EHLERS EBERHARD , SELIGER HUBERT , SCHRINNER ELMAR
IPC: A61K20060101 , A61K31/545 , A61K31/546 , A61K31/675 , A61K31/695 , A61P31/04 , B23K1/18 , B23Q5/033 , C07D20060101 , C07D277/20 , C07D277/40 , C07D501/00 , C07D501/20 , C07D501/24 , C07D501/34 , C07D501/36 , C07D501/46 , C07D501/59 , C07D501/60 , C07D519/06
Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.
-
公开(公告)号：AU4595072A
公开(公告)日：1974-02-28
申请号：AU4595072
申请日：1972-08-24
Applicant: HOECHST AG
Inventor： RUSCHIG HEINRICH , SEIDL GUNTHER , SCHMITT KARL , ALPERMANN HANS GEORG , SELIGER HUBERT
IPC: C07D209/44 , A61K27/00 , C07D27/48
-
公开(公告)号：NZ228403A
公开(公告)日：1990-10-26
申请号：NZ22840389
申请日：1989-03-20
Applicant: HOECHST AG
Inventor： ADAM FRIEDHELM , DURCKHEIMER WALTER , FISCHER GERD , MENCKE BURGHARD , SELIGER HUBERT , ISERT DIETER , KLESEL NORBERT , SEIBERT GERHARD
IPC: A61K20060101 , A61K31/425 , A61K31/545 , A61K31/546 , A61P31/04 , B41M5/155 , B41M5/26 , C07D20060101 , C07D501/00 , C07D501/04 , C07D501/24 , C07D501/34
Abstract: Cephemcarboxylic acid esters of the general formula pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, process for the preparation of the cephem derivatives and of the pharmaceutical preparations, and use of the cephem derivatives for controlling bacterial infections.
-
公开(公告)号：CS8805458A2
公开(公告)日：1990-06-13
申请号：CS545888
申请日：1988-08-04
Applicant: HOECHST AG
Inventor： DURCKHEIMER WALTER DR , SELIGER HUBERT , DOST GUNTER DR , CHATTERJEE SUGATA , DESIKAN KALYANPURAM R , RUPP RICHARD H DR , GANGULI BIMAL N DR , FRANCO CHRISTOPHER M
CPC classification number: C07K7/06 , A23K20/195 , A61K38/00
-
Patent Agency Ranking
公开(公告)号：DK436488A
公开(公告)日：1989-02-06
申请号：DK436488
申请日：1988-08-04
Applicant: HOECHST AG
Inventor： DUERCKHEIMER WALTER , SELIGER HUBERT , DOST GUENTER , CHATTERJEE SUGATA , DESIKAN KALYANAPURAM RAJAGOPAL , RUPP RICHARD HELMUT , GANGULI BIMAL NARESH , FRANCO CHRISTOPHER MILTON MATH
Abstract: Streptogramin B metal complexes, especially the Cu, Zn and Mn complexes of etamycin, are valuable production promoters in livestock nutrition. They are obtained by reacting neoviridogriseins with metal salts in solution and subsequent neutralisation with bases.
-
公开(公告)号：HU184145B
公开(公告)日：1984-07-30
申请号：HUHO002063
申请日：1978-04-14
Applicant: HOECHST AG
Inventor： DUERCHEIMER WALTER , EHLERS EBERHARD , SELIGER HUBERT , SCHRINNER ELMAR
IPC: A61K20060101 , A61K31/545 , A61K31/546 , A61K31/675 , A61K31/695 , A61P31/04 , B23K1/18 , B23Q5/033 , C07D20060101 , C07D277/20 , C07D277/40 , C07D501/00 , C07D501/20 , C07D501/24 , C07D501/34 , C07D501/36 , C07D501/46 , C07D501/59 , C07D501/60 , C07D519/06
Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.
-
公开(公告)号：AU526890B2
公开(公告)日：1983-02-03
申请号：AU4278578
申请日：1978-12-21
Applicant: HOECHST AG
Inventor： BLUMBACH JURGEN , DURCKHEIMER WALTER , REDEN JURGEN , SELIGER HUBERT
IPC: C07D417/12 , C07D499/00 , C07D499/12 , C07D499/44 , C07D501/06 , C07D501/20 , C07D501/22 , C07D501/34 , C07D501/36
-
公开(公告)号：CS208748B2
公开(公告)日：1981-09-15
申请号：CS244378
申请日：1978-04-14
Applicant: HOECHST AG
Inventor： DUERCKHEIMER WALTER , EHLERS EBERHARD , SELIGER HUBERT , SCHRINNER ELMAR
IPC: A61K20060101 , A61K31/545 , A61K31/546 , A61K31/675 , A61K31/695 , A61P31/04 , B23K1/18 , B23Q5/033 , C07D20060101 , C07D277/20 , C07D277/40 , C07D501/00 , C07D501/20 , C07D501/24 , C07D501/34 , C07D501/36 , C07D501/46 , C07D501/59 , C07D501/60 , C07D519/06
Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.
-
公开(公告)号：NO781322A
公开(公告)日：1978-10-17
申请号：NO781322
申请日：1978-04-14
Applicant: HOECHST AG
Inventor： DUERCKHEIMER WALTER , EHLERS EBERHARD , SELIGER HUBERT , SCHRINNER ELMAR
IPC: A61K20060101 , A61K31/545 , A61K31/546 , A61K31/675 , A61K31/695 , A61P31/04 , B23K1/18 , B23Q5/033 , C07D20060101 , C07D277/20 , C07D277/40 , C07D501/00 , C07D501/20 , C07D501/24 , C07D501/34 , C07D501/36 , C07D501/46 , C07D501/59 , C07D501/60 , C07D519/06 , C07D
CPC classification number: C07D501/20 , Y02P20/55
-
-
-
-
-
-
-
-
-
Search Results
39
records
(took 0.028 seconds)
