公开(公告)号：KR830000733A

公开(公告)日：1983-04-18

申请号：KR780001066

申请日：1978-04-13

Applicant: HOECHST AG

Inventor： DURCKBEIMER WALTER ,  SELIGER HUBERT ,  SCHRINNER ELMAR ,  EHLERS EBERHARD

IPC: C07D501/36

Abstract: Cephems I(R1=H, (un) substituted alkyl, acyl, arylsulfonyl, alkylsulfonyl, amino-protective group; R2=H, (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl, heterocycle; R3=H, esterforming group, cation; R4=H, alkoxy; A=H, (un) substituted alkoxy or alkenoxy, halo, alkyl; X=S, O, CH2, NH), useful as antimicrobial agents were prepd. I(R=R3=R4=H; R1=Me, Et; R2=H, Na; X=S) are esp. effective against Pseudomonas. E.g., dicyclohexylcarbodiimide-midiated coupling of 2-synmethoxyimino-2-(2tritylamino-4-thiazolyl) acetic acid with 7-aminoceph-3-em-4-carboxylic acid, followed by purifn. via the (H2NCH2)2 salt, gave I(R, R2-R4=H, R1=Me)

公开(公告)号：DK165060B

公开(公告)日：1992-10-05

申请号：DK143378

申请日：1978-03-31

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  BORMANN DIETER ,  EHLERS EBERHARD ,  SCHRINNER ELMAR ,  HEYMES RENE

IPC: A61K31/397 ,  A61K31/435 ,  A61K31/505 ,  A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B25J15/08 ,  C07D205/08 ,  C07D277/20 ,  C07D277/40 ,  C07D277/42 ,  C07D277/50 ,  C07D463/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D501/20 ,  C07D501/24 ,  C07D501/36 ,  C07D505/00 ,  C07D519/06 ,  C07F9/6561

Abstract: Cephem derivatives of the general formula in which the R2O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.

公开(公告)号：NO894362A

公开(公告)日：1990-05-04

申请号：NO894362

申请日：1989-11-02

Applicant: HOECHST AG

Inventor： VERTESY LASZLO ,  SAUBER KLAUS ,  EHLERS EBERHARD

IPC: C07K14/62 ,  C12P21/06 ,  C07K13/00 ,  C07K7/10 ,  C07K7/40

CPC classification number: C07K14/62 ,  C12P21/06

公开(公告)号：CA1259606A

公开(公告)日：1989-09-19

申请号：CA300245

申请日：1978-03-31

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  BORMANN DIETER ,  EHLERS EBERHARD ,  SCHRINNER ELMAR ,  HEYMES RENE

IPC: A61K31/397 ,  A61K31/435 ,  A61K31/505 ,  A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B25J15/08 ,  C07D205/08 ,  C07D277/20 ,  C07D277/40 ,  C07D277/42 ,  C07D277/50 ,  C07D463/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D501/20 ,  C07D501/24 ,  C07D501/36 ,  C07D505/00 ,  C07D519/06 ,  C07F9/6561 ,  C07D501/46

Abstract: CEPHEM DERIVATIVES AND PROCESSES FOR THEIR MANUFACTURE of the disclosure: Cephem derivatives of the general formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl, or alkylsulfonyl group or an amino-protec-tive group, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes sulfur, oxygen or -CH2- and -NH- and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in th syn-position.

公开(公告)号：AU1567583A

公开(公告)日：1983-10-06

申请号：AU1567583

申请日：1983-06-09

Applicant: HOECHST AG

Inventor： DURCKHEIMER WALTER ,  BORMANN DIETER ,  EHLERS EBERHARD ,  SCHRINNER ELMER ,  HEYMES RENE

IPC: C07D463/00 ,  C07D501/20 ,  C07D501/36 ,  C07D501/57 ,  C07D505/00 ,  C07D519/00 ,  C07F9/32

公开(公告)号：AU526333B2

公开(公告)日：1983-01-06

申请号：AU3507178

申请日：1978-04-13

Applicant: HOECHST AG

Inventor： DURCKHEIMER WALTER ,  EHLERS EBERHARD ,  SELIGER HUBERT ,  SCHRINNER ELMAR

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61K31/675 ,  A61K31/695 ,  A61P31/04 ,  B23K1/18 ,  B23Q5/033 ,  C07D20060101 ,  C07D277/20 ,  C07D277/40 ,  C07D501/00 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D501/60 ,  C07D519/06

Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.

公开(公告)号：IN174079B

公开(公告)日：1994-09-10

申请号：IN65MA1992

申请日：1992-01-31

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  EHLERS EBERHARD ,  HEDTMANN UDO

IPC: C07C59/00

公开(公告)号：DK163244B

公开(公告)日：1992-02-10

申请号：DK162878

申请日：1978-04-14

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  EHLERS EBERHARD ,  SELIGER HUBERT ,  SCHRINNER ELMAR

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61K31/675 ,  A61K31/695 ,  A61P31/04 ,  B23K1/18 ,  B23Q5/033 ,  C07D20060101 ,  C07D277/20 ,  C07D277/40 ,  C07D501/00 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D501/60 ,  C07D519/06

Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.

公开(公告)号：ZA8908376B

公开(公告)日：1990-08-29

申请号：ZA8908376

申请日：1989-11-03

Applicant: HOECHST AG

Inventor： VERTESY LASZLO ,  LASZLO VERTESY ,  SAUBER KLAUS ,  KLAUS SAUBER ,  EHLERS EBERHARD ,  EBERHARD EHLERS

IPC: C07K14/62 ,  C12P21/06 ,  C07K

CPC classification number: C07K14/62 ,  C12P21/06

公开(公告)号：NO894362L

公开(公告)日：1990-05-04

申请号：NO894362

申请日：1989-11-02

Applicant: HOECHST AG

Inventor： VERTESY LASZLO ,  SAUBER KLAUS ,  EHLERS EBERHARD

IPC: C07K1/12 ,  C07K14/62 ,  C12P21/02 ,  C12P21/06 ,  C07K13/00 ,  C07K7/10 ,  C07K7/40

Abstract: Polypeptides or proteins such as, for example, insulins or de-B -insulins - especially human insulin or de-B -human insulin - are prepared by enzymatic cleavage, using a trypsin-like endopeptidase, of specific fusion proteins which can be obtained by genetic manipulation and which contain the residue of a peptide-like alpha -amylase inhibitor in the molecule. The use of the specific fusion proteins results in a reaction product which can be worked up advantageously; the working-up can take place, where appropriate, by crystallisation.