公开(公告)号：SE421694B

公开(公告)日：1982-01-25

申请号：SE7602069

申请日：1976-02-20

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  PFOERTNER K ,  SCHNEIDER F ,  SCHMID H

IPC: C07D213/50 ,  C07D401/04

Abstract: Compounds represented by the formula +q,10 WHEREIN R1 is a pyridyl, R2 is hydrogen or lower alkyl, R3 is hydrogen, lower alkyl or benzyl and R4 is phenyl or phenyl substituted at one or more carbon atoms with one or more of halogen, lower alkyl, lower alkoxy, nitro or amino AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, HAVING ANALGESIC ACTIVITY ARE DISCLOSED.

公开(公告)号：LU80422A1

公开(公告)日：1980-05-07

申请号：LU80422

申请日：1978-10-26

Applicant: HOFFMANN LA ROCHE

Inventor： STOHLER H ,  BERNAUER K ,  LINK H

IPC: A61K31/24 ,  C07D233/72 ,  C07D233/88 ,  A61K ,  C07C ,  C07D

公开(公告)号：MC1220A1

公开(公告)日：1979-07-20

申请号：MC1334

申请日：1978-10-13

Applicant: HOFFMANN LA ROCHE

Inventor： LINK H ,  BERNAUER K ,  STOHLER H

IPC: A61K31/415 ,  A61K31/4166 ,  A61P5/00 ,  A61P33/10 ,  C07D233/66 ,  C07D233/72 ,  C07D233/74 ,  C07D233/88 ,  C07B ,  C07D

Abstract: Imidazolidine derivatives of the formula I wherein X is oxygen or imino and R is one of the groups their preparation, use as antiandrogenically or schistosomicidally active agents, and corresponding pharmaceutical preparations, are described.

公开(公告)号：SE7811193L

公开(公告)日：1979-04-29

申请号：SE7811193

申请日：1978-10-27

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  LINK H ,  STOHLER H

IPC: A61K31/215 ,  A61K31/22 ,  A61K31/24 ,  A61P5/00 ,  A61P33/00 ,  C07C67/00 ,  C07C239/00 ,  C07C275/42 ,  C07D233/66 ,  C07D233/72 ,  C07D233/88 ,  A61K9/00

Abstract: Imidazolidine derivatives, as well as processes for their preparation, which have antiandrogenic and schistosomicidal activity.

公开(公告)号：DK481778A

公开(公告)日：1979-04-29

申请号：DK481778

申请日：1978-10-27

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  LINK H ,  STOHLER H

IPC: A61K31/215 ,  A61K31/22 ,  A61K31/24 ,  A61P5/00 ,  A61P33/00 ,  C07C67/00 ,  C07C239/00 ,  C07C275/42 ,  C07D233/66 ,  C07D233/72 ,  C07D233/88 ,  A61K

Abstract: Imidazolidine derivatives, as well as processes for their preparation, which have antiandrogenic and schistosomicidal activity.

公开(公告)号：DK481678A

公开(公告)日：1979-04-29

申请号：DK481678

申请日：1978-10-27

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  LINK H ,  STOHLER H

IPC: A61K31/415 ,  A61K31/4166 ,  A61P5/00 ,  A61P33/10 ,  C07D233/66 ,  C07D233/72 ,  C07D233/74 ,  C07D233/88 ,  C07D

Abstract: Imidazolidine derivatives of the formula I wherein X is oxygen or imino and R is one of the groups their preparation, use as antiandrogenically or schistosomicidally active agents, and corresponding pharmaceutical preparations, are described.

公开(公告)号：NO760561L

公开(公告)日：1976-08-24

申请号：NO760561

申请日：1976-02-20

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  PFOERTNER K ,  SCHNEIDER F ,  SCHMID H

IPC: C07D213/50 ,  C07D401/04 ,  C07D

Abstract: Compounds represented by the formula +q,10 WHEREIN R1 is a pyridyl, R2 is hydrogen or lower alkyl, R3 is hydrogen, lower alkyl or benzyl and R4 is phenyl or phenyl substituted at one or more carbon atoms with one or more of halogen, lower alkyl, lower alkoxy, nitro or amino AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, HAVING ANALGESIC ACTIVITY ARE DISCLOSED.

公开(公告)号：SU439964A3

公开(公告)日：1974-08-15

申请号：SU1684056

申请日：1971-07-16

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  BORGULYA J ,  BOEHNI E

IPC: C07C211/00 ,  C07C35/29 ,  C07C49/433 ,  C07C49/657 ,  C07C225/30 ,  C07C87/64 ,  C07C49/66

公开(公告)号：ZA714356B

公开(公告)日：1972-03-29

申请号：ZA714356

申请日：1971-07-02

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  JALFRE J ,  MOSIMANN W

IPC: C07C211/38 ,  C07C35/52 ,  C07C49/433 ,  C07C49/657 ,  C07C

公开(公告)号：ZA7104356B

公开(公告)日：1972-03-29

申请号：ZA7104356

申请日：1971-07-02

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  JALFRE J ,  MOSIMANN W

IPC: C07C211/38 ,  C07C35/52 ,  C07C49/433 ,  C07C49/657 ,  C07C

CPC classification number: C07C35/52 ,  C07C209/40 ,  C07C211/34