公开(公告)号：AU2005224129A1

公开(公告)日：2005-09-29

申请号：AU2005224129

申请日：2005-02-18

Applicant: SERVIER LAB

Inventor： CHOLLET ANNE-MARIE ,  DHAINAUT ALAIN ,  BERT LIONEL ,  LOCKHART BRIAN ,  CASARA PATRICK ,  LESTAGE PIERRE

IPC: C07D209/52 ,  C07D403/12

Abstract: Azabicyclic derivatives (I) are new. Azabicyclic derivatives of formula (I) and their enantiomers, diastereoisomers or acid or base addition salts are new. ALK : alkylene, 2-6C alkenylene (contains 1-3 double bonds) or 2-6C alkynylene (contains 1-3 triple bonds); Y, Y 1> : H, halo, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, SH, OH, perhaloalkyl, nitro, amino (optionally substituted by one or two alkyl), acyl of formula C(O)R1a, aminocarbonyl (optionally N-substituted by one or two alkyl), acylamino (optionally N-substituted by alkyl), alkoxycarbonyl, COOH, sulfo or CN; R1a : H or alkyl; X : O, S or NR; R : H or alkyl; W 1> : CN (only when X = O or NR), N(R 1>)Z 1>R 2>or Z 1>NR 1>R 2>; Z 1> : C(O), C(S), C(NR 4>), C(O)N(R 3>), C(S)N(R 3>), C(NR 4>)N(R 3>), C(O)O, C(S)O or S(O) r; r : 1 or 2; Z 2> : C(O), C(S), C(NR 4>), S(O) ror bond; R 1>-R 4> : alkyl, 3-6C alkenyl (contains 1-3 double bonds), 3-6C alkynyl (contains 1-3 triple bonds), cycloalkyl, heterocycloalkyl, aryl or heteroaryl (all optionally substituted), alkoxy or H; or R 1>+R 2>or R 2>+R 3> : heterocyclyl or heteroaryl (both optionally substituted); m, n : 0-2, where the sum of m+n is 2 or 3; and p, q : 0-2. alkyl = 1-6C unless specified; perhaloalkyl = 1-3C with 1-7 halogen; aryl = phenyl, naphthyl, indanyl, indenyl, dihydronaphthyl or tetrahydronaphthyl; cycloalkyl = 3-11 membered mono- or bi-cyclic ring system, optionally with 1 or 2 unsaturations; heterocyclyl = 4-11 membered mono- or bicyclic ring system optionally with 1 or 2 unsaturations and/or 1-4 heteroatoms from N, O and/or S; heteroaryl = 5-11 membered mono- or bicyclic ring system with 1-4 heteroatoms from N, O and/or S; for cycloalkyl, aryl, heteroaryl or heterocyclyl, 'optionally substituted' comprises 1-3 substituents from alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, halogen, OH, SH, perhaloalkyl, nitro, amino or aminocarbonyl (optionally substituted by 1 or 2 alkyl), C(O)R1a, NHC(O)R1a (optionally N-substituted by alkyl), alkoxycarbonyl, COOH, sulfo or CN; or aryl, heteroaryl, cycloalkyl, heterocyclyl or benzyl with one or two optional oxo substituents where possible; for alkyl, alkenyl or alkynyl, 'optionally substituted ' comprises one or two of alkylthio, alkylsulfinyl, alkylsulfonyl, alkoxy, halogen, OH, SH, nitro, amino, C(O)R1a, aminocarbonyl, NHC(O)R1a, alkoxycarbonyl, COOH, sulfo, CN or aryl, heteroaryl, cycloalkyl, heterocylyl or aryloxy (all optionally substituted). An independent claim is included for the preparation of (I). [Image] ACTIVITY : Nootropic; Neuroprotective; Anticonvulsant; Tranquilizer; Anorectic; Analgesic. MECHANISM OF ACTION : Histamine (H3) activator. The ability of (I) to activate histamine was tested in mice. The results showed that 4-(3-hexahydrocyclopenta[c]-pyrrol-2(1H)-ylpropoxy)benzonitrile oxalate exhibited the percentage increase of N-methylhistamine in brain of 92%.

公开(公告)号：MXPA02006699A

公开(公告)日：2005-08-16

申请号：MXPA02006699

申请日：2002-07-05

Applicant: SERVIER LAB

Inventor： LOCKHART BRIAN

IPC: A61K31/4985 ,  A61K31/5025 ,  A61P3/04 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/28 ,  A61P43/00 ,  C07D221/00 ,  C07D241/00 ,  C07D471/04 ,  A61K31/505

Abstract: La presente invencion describe compuestos de formula (I): (ver formula) en donde: Ra representa una cadena de alquileno de 1 a 6 atomos de carbono lineal o ramificado, X representa un grupo seleccionado de W1, -c(W1) -W2-, -w2-c(W1)-, -W2-C(W1)W2-, -W2-Ra- y -CH(OR1)-, en donde W1, W2 y R1 son como se definieron en la descripcion, cuando Y representa un grupo arilo o heteroarilo, o X representa un grupo seleccionado de un enlace simple, -C (W1)-, -W2-C (W1)-, -W2-Ra-, y -CH(OR1)-, en donde W1, W2, Ra y R1 son como se definio en lo anterior, cuando Y representa un grupo biciclico fusionado, de formula: (ver formula) en donde: A representa un heterociclo que contiene nitrogeno, que contiene desde 4 a 7 miembros en el anillo, que esta insaturado o parcialmente saturado, y opcionalmente contiene un segundo heteroatomo, B representa un anillo de fenilo opcionalmente substituido por uno o mas grupos definidos en la descripcion, sus isomeros, y sales de adicion de los mismos con un acido o base farmaceuticamente aceptable. Medicamentos.

公开(公告)号：NZ520120A

公开(公告)日：2004-03-26

申请号：NZ52012002

申请日：2002-07-11

Applicant: SERVIER LAB

Inventor： GOLDSTEIN SOLO ,  POISSONNET GUILLAUME ,  PARMENTIER JEAN-GILLES ,  LESTAGE PIERRE ,  LOCKHART BRIAN

IPC: A61K31/4985 ,  A61K31/5025 ,  A61P3/04 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/28 ,  A61P43/00 ,  C07D221/00 ,  C07D241/00 ,  C07D471/04 ,  A61K31/495

Abstract: Disclosed are compounds of formula (I), for which the substituents are defined herein. The compounds are used in the manufacture of medicaments for the treatment of diseases mediated by an antagonist of type H3 central histamine receptors.

公开(公告)号：FR2827288B1

公开(公告)日：2003-10-31

申请号：FR0109260

申请日：2001-07-12

Applicant: SERVIER LAB

Inventor： GOLDSTEIN SOLO ,  POISSONNET GUILLAUME ,  PARMENTIER JEAN GILLES ,  LESTAGE PIERRE ,  LOCKHART BRIAN

IPC: A61K31/4985 ,  A61K31/5025 ,  A61P3/04 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/28 ,  A61P43/00 ,  C07D221/00 ,  C07D241/00 ,  C07D471/04

Abstract: Octahydro-2H-pyrido(1,2-a) pyrazine derivatives (I), their enantiomers, diastereoisomers, and salts with acids and bases are new. Octahydro-2H-pyrido(1,2-a) pyrazine derivatives of formula (I), their enantiomers, diastereoisomers, and salts with acids and bases are new. Ra = 1-6C alkylene chain; Y = aryl, heteroaryl, or a fused bicyclic ring of formula (a); W1 and W2 = O, S, or NR2; R2 = H, 1-6C alkyl or acyl, aryl, or arylalkyl; R1 = H or 1-6C alkyl; A = a 4-7 membered N heterocycle which is unsaturated or partially saturated (optionally containing a second hetero atom (O, N or S) and optionally substituted by oxo, or 1-6C alkyl); and B = phenyl (optionally substituted by one or more groups selected from halogens, nitro, CN, OH, 1-6C (alkoxy, alkyl, trihaloalkyl, acyl, acyloxy, alkoxycarbonyl or alkylsulfanyl), sulfanyl or amino (optionally substituted by one or two 1-6C alkyl, aryl and 1-6C arylalkyl groups). Provided that: (1) when Y is aryl or heteroaryl, then X is W1, -C(W1)-W2-, -W2-C(W1)-, -W2-C(W1)W2-, -W2-Ra, or -CH(OR1); (2) when Y is a fused bicyclic ring, then X is a simple bond, -C(W1)-, -W2-C(W1)-, -W2-Ra, or -CH(OR1); and (3) compounds 2-octahydro-2H-pyrido(1,2-a)pyrazin-2-yl-1-phenyl ethanol;3-octahydro-2H-pyrido(1,2-a)pyrazin-2-yl propyl-3,4,5-trimethoxy benzoate; and 2-octahydro-2H-pyrido(1,2-a)pyrazin-2-yl ethyl-3,4,5-trimethoxy benzoate are excluded.

公开(公告)号：SI0995743T1

公开(公告)日：2003-08-31

申请号：SI9930251

申请日：1999-10-22

Applicant: SERVIER LAB

Inventor： CASARA PATRICK ,  DOREY GILBERT ,  LESTAGE PIERRE ,  LOCKHART BRIAN

IPC: C07D215/06 ,  A61K31/47 ,  A61K31/497 ,  A61K31/517 ,  A61P9/10 ,  A61P25/00 ,  A61P25/08 ,  A61P25/16 ,  A61P25/28 ,  A61P27/12 ,  A61P43/00 ,  C07D215/20 ,  C07D221/20 ,  C07D401/06 ,  C07D471/10

Abstract: Dihydro- and tetrahydro-quinoline derivatives (I) are new. Dihydro- and tetrahydro-quinoline derivatives of formula (I) and their acid or base addition salts are new. R1 = H or a group of formula (i); A = H or -B'NZ1Z2; B' = 1-6C alkylene; Z1, Z2 = H, alkyl, 3-8C cycloalkyl or optionally substituted aryl; or NZ1Z2 = heterocycloalkyl or heteroaryl (optionally substituted); R2, R3 = alkyl, 3-8C cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl or aminoalkyl (optionally substituted on N with 1 or 2 alkyl, cycloalkyl, aryl or arylalkyl); or R2 + R3 = form with C of quinoline, 3-8C cycloalkyl or heterocycloalkyl (optionally substituted with alkyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl); R40 = alkyl, 2-6C alkenyl, 2-6C alkynyl (all optionally substituted), H, Q or -V'-Q; V' = 1-6C alkylene, 2-6C alkenylene or 2-6C alkynylene; Q = 3-8C cycloalkyl, aryl, heterocycloalkyl, heteroaryl (all optionally substituted); R5, R41 = H; or R5 + R41 = bond; R6-R9 = H, halo, alkyl, 3-8C cycloalkyl or -OW'; W' = aryl, heteroaryl, arylalkyl, heteroarylalkyl (all optionally substituted), H, alkyl, acyl, 3-8C cycloalkyl or heterocycloalkyl; alkyl = 1-6C; aryl = phenyl, naphthyl or biphenyl; heterocycloalkyl = partially unsaturated 4- to 11-membered mono- or bi-cyclic ring containing 1-6 N, S or O; heteroaryl = aromatic or partially aromatic 4- to 11-membered mono- or bi-cyclic ring containing 1-6 N, S or O; substituted aryl, arylalkyl = aryl or arylalkyl substituted with at least one halo, alkyl, 1-6C alkoxy, 1-6C perhaloalkyl, amino (optionally substituted by 1 or 2 alkyl), CN, carboxy, 1-6C alkoxycarbonyl, aminocarbonyl (optionally substituted with 1 or 2 alkyl on N), nitro or OH; substituted alkyl, alkenyl, alkynyl and cycloalkyl = alkyl, alkenyl, alkynyl and cycloalkyl substituted with at least one OH, 1-6C alkoxy, 1-6C alkylthio, amino (optionally substituted with 1 or 2 alkyl), carboxy, nitro, CN, 1-6C alkoxycarbonyl or aminocarbonyl (optionally substituted with 1 or 2 alkyl on N); substituted heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, heteroarylalkyl = heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, heteroarylalkyl substituted with at least one halo, alkyl, 1-6C alkoxy, 1-6C perhaloalkyl, amino (optionally substituted with 1 or 2 alkyl), CN, carboxy, 1-6C alkoxycarbonyl, aminocarbonyl (optionally substituted with 1 or 2 alkyl on N), nitro, OH or oxo; and provided that R6-R9 are not all H and at least one of R6-R9 is -OW', that R2 and R3 are alkyl when R6-R9 are H, alkyl, alkoxy, R41 and R5 form a bond, R40 is other than H or alkyl; when (I) has one OH and R40 is other than H; when (I) has one methoxy and R40 is other than hydroxyalkyl; and (I) is other than 7-methoxy-2,2-diphenyl-1,2-dihydroquinoline. An Independent claim is also included for the preparation of (I).

公开(公告)号：BR0202681A

公开(公告)日：2003-05-06

申请号：BR0202681

申请日：2002-07-11

Applicant: SERVIER LAB

Inventor： GOLDSTEIN SOLO ,  POISSONET GUILLAUME ,  PARMENTIER JEAN-GILLES ,  LESTAGE PIERRE ,  LOCKHART BRIAN

IPC: A61K31/4985 ,  A61K31/5025 ,  A61P3/04 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/28 ,  A61P43/00 ,  C07D221/00 ,  C07D241/00 ,  C07D471/04 ,  A61K31/495

Abstract: Octahydro-2H-pyrido(1,2-a) pyrazine derivatives (I), their enantiomers, diastereoisomers, and salts with acids and bases are new. Octahydro-2H-pyrido(1,2-a) pyrazine derivatives of formula (I), their enantiomers, diastereoisomers, and salts with acids and bases are new. Ra = 1-6C alkylene chain; Y = aryl, heteroaryl, or a fused bicyclic ring of formula (a); W1 and W2 = O, S, or NR2; R2 = H, 1-6C alkyl or acyl, aryl, or arylalkyl; R1 = H or 1-6C alkyl; A = a 4-7 membered N heterocycle which is unsaturated or partially saturated (optionally containing a second hetero atom (O, N or S) and optionally substituted by oxo, or 1-6C alkyl); and B = phenyl (optionally substituted by one or more groups selected from halogens, nitro, CN, OH, 1-6C (alkoxy, alkyl, trihaloalkyl, acyl, acyloxy, alkoxycarbonyl or alkylsulfanyl), sulfanyl or amino (optionally substituted by one or two 1-6C alkyl, aryl and 1-6C arylalkyl groups). Provided that: (1) when Y is aryl or heteroaryl, then X is W1, -C(W1)-W2-, -W2-C(W1)-, -W2-C(W1)W2-, -W2-Ra, or -CH(OR1); (2) when Y is a fused bicyclic ring, then X is a simple bond, -C(W1)-, -W2-C(W1)-, -W2-Ra, or -CH(OR1); and (3) compounds 2-octahydro-2H-pyrido(1,2-a)pyrazin-2-yl-1-phenyl ethanol;3-octahydro-2H-pyrido(1,2-a)pyrazin-2-yl propyl-3,4,5-trimethoxy benzoate; and 2-octahydro-2H-pyrido(1,2-a)pyrazin-2-yl ethyl-3,4,5-trimethoxy benzoate are excluded.

公开(公告)号：AU753044B2

公开(公告)日：2002-10-03

申请号：AU5600999

申请日：1999-10-22

Applicant: SERVIER LAB

Inventor： CASARA PATRICK ,  DOREY GILBERT ,  LESTAGE PIERRE ,  LOCKHART BRIAN

IPC: C07D215/06 ,  A61K31/47 ,  A61K31/497 ,  A61K31/517 ,  A61P9/10 ,  A61P25/00 ,  A61P25/08 ,  A61P25/16 ,  A61P25/28 ,  A61P27/12 ,  A61P43/00 ,  C07D215/20 ,  C07D221/20 ,  C07D401/06 ,  C07D471/10

Abstract: Dihydro- and tetrahydro-quinoline derivatives (I) are new. Dihydro- and tetrahydro-quinoline derivatives of formula (I) and their acid or base addition salts are new. R1 = H or a group of formula (i); A = H or -B'NZ1Z2; B' = 1-6C alkylene; Z1, Z2 = H, alkyl, 3-8C cycloalkyl or optionally substituted aryl; or NZ1Z2 = heterocycloalkyl or heteroaryl (optionally substituted); R2, R3 = alkyl, 3-8C cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl or aminoalkyl (optionally substituted on N with 1 or 2 alkyl, cycloalkyl, aryl or arylalkyl); or R2 + R3 = form with C of quinoline, 3-8C cycloalkyl or heterocycloalkyl (optionally substituted with alkyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl); R40 = alkyl, 2-6C alkenyl, 2-6C alkynyl (all optionally substituted), H, Q or -V'-Q; V' = 1-6C alkylene, 2-6C alkenylene or 2-6C alkynylene; Q = 3-8C cycloalkyl, aryl, heterocycloalkyl, heteroaryl (all optionally substituted); R5, R41 = H; or R5 + R41 = bond; R6-R9 = H, halo, alkyl, 3-8C cycloalkyl or -OW'; W' = aryl, heteroaryl, arylalkyl, heteroarylalkyl (all optionally substituted), H, alkyl, acyl, 3-8C cycloalkyl or heterocycloalkyl; alkyl = 1-6C; aryl = phenyl, naphthyl or biphenyl; heterocycloalkyl = partially unsaturated 4- to 11-membered mono- or bi-cyclic ring containing 1-6 N, S or O; heteroaryl = aromatic or partially aromatic 4- to 11-membered mono- or bi-cyclic ring containing 1-6 N, S or O; substituted aryl, arylalkyl = aryl or arylalkyl substituted with at least one halo, alkyl, 1-6C alkoxy, 1-6C perhaloalkyl, amino (optionally substituted by 1 or 2 alkyl), CN, carboxy, 1-6C alkoxycarbonyl, aminocarbonyl (optionally substituted with 1 or 2 alkyl on N), nitro or OH; substituted alkyl, alkenyl, alkynyl and cycloalkyl = alkyl, alkenyl, alkynyl and cycloalkyl substituted with at least one OH, 1-6C alkoxy, 1-6C alkylthio, amino (optionally substituted with 1 or 2 alkyl), carboxy, nitro, CN, 1-6C alkoxycarbonyl or aminocarbonyl (optionally substituted with 1 or 2 alkyl on N); substituted heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, heteroarylalkyl = heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, heteroarylalkyl substituted with at least one halo, alkyl, 1-6C alkoxy, 1-6C perhaloalkyl, amino (optionally substituted with 1 or 2 alkyl), CN, carboxy, 1-6C alkoxycarbonyl, aminocarbonyl (optionally substituted with 1 or 2 alkyl on N), nitro, OH or oxo; and provided that R6-R9 are not all H and at least one of R6-R9 is -OW', that R2 and R3 are alkyl when R6-R9 are H, alkyl, alkoxy, R41 and R5 form a bond, R40 is other than H or alkyl; when (I) has one OH and R40 is other than H; when (I) has one methoxy and R40 is other than hydroxyalkyl; and (I) is other than 7-methoxy-2,2-diphenyl-1,2-dihydroquinoline. An Independent claim is also included for the preparation of (I).

公开(公告)号：AT223904T

公开(公告)日：2002-09-15

申请号：AT99401565

申请日：1999-06-24

Applicant: SERVIER LAB

Inventor： GOLDSTEIN SOLO ,  DHAINAUT ALAIN ,  TIZOT ANDRE ,  LOCKHART BRIAN ,  LESTAGE PIERRE

IPC: A61K31/00 ,  A61K31/415 ,  A61K31/4164 ,  A61P25/00 ,  A61P25/28 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D233/66 ,  C07D233/90 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04

公开(公告)号：SI1010698T1

公开(公告)日：2002-06-30

申请号：SI9930035

申请日：1999-12-14

Applicant: SERVIER LAB

Inventor： GOLSTEIN SOLO ,  GUILLONNEAU CLAUDE ,  CHARTON YVES ,  LESTAGE PIERRE ,  LOCKHART BRIAN

IPC: A61K31/385 ,  A61K31/5377 ,  A61P25/00 ,  A61P25/28 ,  A61P39/06 ,  A61P43/00 ,  C07D339/04 ,  C07D413/12

Abstract: 1,2-dithiolane derivatives (I) are new. 1,2-dithiolane derivatives of formula (I) and their acid or base addition salts are new. Ra = 1-8C alkylene; Rb = bond or 1-6C alkylene; Z = -O-C(S)-N(R1)- or -C(S)-N(R1)- (N being attached to Rb); R1 = H, 1-6C alkyl, aryl or 1-6C aralkyl; T = a group of formula (i); R2, R3 = H, 1-6C alkyl, cycloalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, 1-6C aralkyl, heteroaryl, heterarylalkyl, 1-6C aminoalkyl (amino being optionally substituted with 1 or 2 1-6C alkyl, aryl or 1-6C aralkyl). Independent claims are also included for: (1) the preparation of (I); and (2) pharmaceutical compositions comprising at least one (I).

公开(公告)号：NO20013206L

公开(公告)日：2001-12-28

申请号：NO20013206

申请日：2001-06-26

Applicant: SERVIER LAB

Inventor： GOLDSTEIN SOLO ,  GUILLONNEAU CLAUDE ,  CHARTON YVES ,  LOCKHART BRIAN ,  LESTAGE PIERRE

IPC: C07D295/08 ,  A61K31/10 ,  A61K31/13 ,  A61K31/133 ,  A61K31/15 ,  A61K31/16 ,  A61K31/215 ,  A61K31/22 ,  A61K31/221 ,  A61K31/223 ,  A61K31/27 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/445 ,  A61K31/455 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/28 ,  A61P25/34 ,  A61P29/00 ,  A61P29/02 ,  A61P43/00 ,  C07C62/02 ,  C07C209/00 ,  C07C211/37 ,  C07C213/00 ,  C07C213/02 ,  C07C213/06 ,  C07C215/20 ,  C07C215/42 ,  C07C217/44 ,  C07C217/52 ,  C07C219/18 ,  C07C219/20 ,  C07C219/24 ,  C07C269/00 ,  C07C269/02 ,  C07C271/12 ,  C07C271/22 ,  C07C271/24 ,  C07C271/34 ,  C07C319/14 ,  C07C321/28 ,  C07C323/26 ,  C07C323/33 ,  C07D213/30 ,  C07D213/38 ,  C07D213/53 ,  C07D213/65 ,  C07D213/70 ,  C07D213/80 ,  C07D213/803 ,  C07D295/096 ,  C07D417/12 ,  C07C211/34

Abstract: A compound selected from those of formula (I): wherein: p represents an integer of from 0 to 6 inclusive, n represents an integer of from 0 to 6 inclusive, R 1 , and R 2 represent a group selected from hydrogen, alkyl, aryl and arylalkyl, or R 1 +R 2 form together with nitrogen carrying them saturated, monocyclic, or bicyclic system, X represents a group selected from oxygen, sulphur, a group -CH-CH-, methylene, a group of formula -HC-N-O- and a group of formula -O-CH 2 -CH-CH-, in which groups oxygen is linked to Y of the compounds of formula (I), Y represents a group selected from aryl, heteroaryl, arylalkyl, heteroarylalkyl, -C(O)-A, and -C(S)-A, A represents a group selected from alkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, and NR 3 R 4 wherein R 3 , and R 4 represent a group selected from hydrogen, alkyl, aryl, and arylalkyl, or R 3 +R 4 form together with nitrogen carrying them monocyclic, or bicyclic (C 3 -C 10 ) system, its isomers and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful as specific nicotinic ligand of alpha 4 beta 2 receptors.