公开(公告)号：NO315840B1

公开(公告)日：2003-11-03

申请号：NO972764

申请日：1997-06-16

Applicant: SERVIER LAB

Inventor： TSOUDEROS YANNIS ,  DELOFFRE PASCALE ,  WIERZBICKI MICHEL

IPC: C07D333/38 ,  A61K31/19 ,  A61K31/38 ,  A61K31/381 ,  A61K33/00 ,  A61K33/24 ,  A61P19/02 ,  A61P43/00

Abstract: Use of strontium salts (I) in compositions for the prevention and treatment of arthrosis is new.

公开(公告)号：AT250578T

公开(公告)日：2003-10-15

申请号：AT02290668

申请日：2002-03-18

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN-ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D491/056 ,  A61K31/40 ,  A61K31/403 ,  A61K31/407 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D209/80 ,  C07D209/94

Abstract: Compound of formula (I):wherein:R represents hydrogen or a group selected from alkenyl and optionally substituted alkyl,each of R1 to R8, which may be identical or different, represents hydrogen or a group selected from alkyl, alkenyl, hydroxy, alkoxy, alkenyloxy, arylalkyl, arylalkoxy, carboxy, acyloxy and arylcarbonyloxy,or one of R1 to R8 forms with an adjacent one R1 to R8 an alkylenedioxy group,its optical isomers when they exist, and addition salts thereof with a pharmaceutically acceptable acid or base,with the proviso that:when R does not represent hydrogen, then at least one of R1 to R8 represents hydroxy or acyloxy,and the compounds of formula (I) are other than indeno[1,2-b]indol-10(5H)-one and medicinal products containing the same which are useful for treatment of disorders of the melatoninergic system.

公开(公告)号：HK1052172A1

公开(公告)日：2003-09-05

申请号：HK03102396

申请日：2003-04-03

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  ROUSSEAU ANNE ,  ATASSI GHANEM ,  HICKMAN JOHN ,  PIERRE ALAIN ,  LEONCE STEPHANE ,  GUILBAUD NICOLAS ,  KRAUS-BERTHIER LAURENCE

IPC: C07D209/80 ,  A61K31/403 ,  A61K31/433 ,  A61K31/4439 ,  A61P35/00 ,  C07D209/94 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D491/04 ,  C07D491/056 ,  C07D ,  A61K ,  A61P

Abstract: Indenoindolone derivatives (I), their isomers and salts with acids and bases are new. Indenoindolone derivatives (I), their isomers and salts with acids and bases are new; R = H, alkyl (optionally substituted by carboxy, alkoxycarbonyl, or NR10R11), or alkenyl; R1-R8 = H, alkyl (optionally substituted by aryl, carboxy or alkoxycarbonyl), OH, acyloxy, NR12R13, carboxy, alkoxy (optionally substituted by aryl or NR14R15), alkenyloxy, or to adjacent groups R1-R8 = 1 or 2C alkylenedioxy; R9 = H, aryl, heteroaryl or alkyl (optionally containing one or more unsaturations and optionally substituted by one or more aryl, heteroaryl, 3-8C cycloalkyl, CN, or NR17R18 groups); X = O or NR16; R10, R11, R14, R15, R17, R18 = alkyl; NR10+R11, NR14+R15, NR17+R18 = nitrogen heterocycle; R12, R13 = H, alkyl, or NR14R15; R16 = H, alkyl, aryl, or aryl alkyl. Where alkyl, alkoxy, acyloxy, alkenyl and alkenyloxy groups have up to 6 C atoms, aryl is defined as phenyl, biphenyl, or naphthyl (optionally substituted by one or more halogen, alkyl, alkenyl, alkoxy, phenoxy, nitro, CN, amino, mono- and di-alkylamino or 1-2C alkylenedioxy groups) and heteroaryl groups may be mono- or bicyclic of 5-12 members with 1-3 heteroatoms (O, N, S) and optionally substituted by halogen, alkyl, OH, alkoxy, polyhaloalkyl, amino, mono- and di-alkylamino groups, and nitrogen heterocycles are monocyclic having 5-7 members including 1-3 heteroatoms, one of which is N and the others may be O, N, or S. An Independent claim is also included for the preparation of (I).

公开(公告)号：DK0813869T3

公开(公告)日：2003-06-02

申请号：DK97401362

申请日：1997-06-16

Applicant: SERVIER LAB

Inventor： TSOUDEROS YANNIS ,  DELOFFRE PASCALE ,  WIERZBICKI MICHEL

IPC: C07D333/38 ,  A61K31/19 ,  A61K31/38 ,  A61K31/381 ,  A61K33/00 ,  A61K33/24 ,  A61P19/02 ,  A61P43/00

Abstract: Use of strontium salts (I) in compositions for the prevention and treatment of arthrosis is new.

公开(公告)号：NZ519610A

公开(公告)日：2003-05-30

申请号：NZ51961002

申请日：2002-06-17

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  FOURQUEZ JEAN-MARIE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE ,  NOSJEAN OLIVIER ,  BOULANGER MICHELLE

IPC: A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  C07D295/18 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185 ,  C07D295/13 ,  C07C233/10

Abstract: Described are compounds of formula (I), processes for their preparation and pharmaceutical compositions comprising compounds of formula (I) for use in treating diabetes, wherein; A represents a saturated carbon ring having from 4 to 8 ring members, optionally substituted by one or more linear or branched (C1-C6)alkyl groups, R1 and R4, which may be identical or different, each represent a hydrogen atom or a linear or branched (C1-C6)acyl group, R2 and R3, which may be identical or different, each represent a hydrogen atom or a linear or branched (C1-C6)alkyl group, R5 and R6, which may be identical or different, each represent a hydrogen atom or a linear or branched (C1-C6)alkyl group, or R5 and R6 together with the nitrogen atom carrying thrm, form a nitrogen containing heterocycle optionally substituted by one or more identical or different groups selected from cyano, CO2R7, nitro, CONR8aR8b (wherein R8a and R8b, which may be identical or different, each represent a hydrogen atom or a linear or branched (C1-C6)alkyl group or R8a and R8b together form a nitrogen-containing heterocycle), S(O)nR9 (wherein n represents 1, 2 or 3, and R9 represents a hydrogen atom, a linear or branched (C1-C6)alkyl group or an aryl group) and PO3R10aR10b (wherein R10a and R10b, which may be identical or different, each represents a hydrogen atom or a linear or branched (C1-C6)alkyl group).

公开(公告)号：HK1049159A1

公开(公告)日：2003-05-02

申请号：HK03101148

申请日：2003-02-18

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN-ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D491/056 ,  A61K31/40 ,  A61K31/403 ,  A61K31/407 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D209/80 ,  C07D209/94 ,  C07D ,  A61K ,  A61P

Abstract: Compound of formula (I):wherein:R represents hydrogen or a group selected from alkenyl and optionally substituted alkyl,each of R1 to R8, which may be identical or different, represents hydrogen or a group selected from alkyl, alkenyl, hydroxy, alkoxy, alkenyloxy, arylalkyl, arylalkoxy, carboxy, acyloxy and arylcarbonyloxy,or one of R1 to R8 forms with an adjacent one R1 to R8 an alkylenedioxy group,its optical isomers when they exist, and addition salts thereof with a pharmaceutically acceptable acid or base,with the proviso that:when R does not represent hydrogen, then at least one of R1 to R8 represents hydroxy or acyloxy,and the compounds of formula (I) are other than indeno[1,2-b]indol-10(5H)-one and medicinal products containing the same which are useful for treatment of disorders of the melatoninergic system.

公开(公告)号：CZ20022083A3

公开(公告)日：2003-04-16

申请号：CZ20022083

申请日：2002-06-13

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  ROUSSEAU ANNE ,  ATASSI GHANEM ,  HICKMAN JOHN

IPC: C07D209/80 ,  A61K31/403 ,  A61K31/433 ,  A61K31/4439 ,  A61P35/00 ,  C07D209/94 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D491/04 ,  C07D491/056 ,  A61K31/404 ,  A61K31/44 ,  A61K31/445

Abstract: Indenoindolone derivatives (I), their isomers and salts with acids and bases are new. Indenoindolone derivatives (I), their isomers and salts with acids and bases are new; R = H, alkyl (optionally substituted by carboxy, alkoxycarbonyl, or NR10R11), or alkenyl; R1-R8 = H, alkyl (optionally substituted by aryl, carboxy or alkoxycarbonyl), OH, acyloxy, NR12R13, carboxy, alkoxy (optionally substituted by aryl or NR14R15), alkenyloxy, or to adjacent groups R1-R8 = 1 or 2C alkylenedioxy; R9 = H, aryl, heteroaryl or alkyl (optionally containing one or more unsaturations and optionally substituted by one or more aryl, heteroaryl, 3-8C cycloalkyl, CN, or NR17R18 groups); X = O or NR16; R10, R11, R14, R15, R17, R18 = alkyl; NR10+R11, NR14+R15, NR17+R18 = nitrogen heterocycle; R12, R13 = H, alkyl, or NR14R15; R16 = H, alkyl, aryl, or aryl alkyl. Where alkyl, alkoxy, acyloxy, alkenyl and alkenyloxy groups have up to 6 C atoms, aryl is defined as phenyl, biphenyl, or naphthyl (optionally substituted by one or more halogen, alkyl, alkenyl, alkoxy, phenoxy, nitro, CN, amino, mono- and di-alkylamino or 1-2C alkylenedioxy groups) and heteroaryl groups may be mono- or bicyclic of 5-12 members with 1-3 heteroatoms (O, N, S) and optionally substituted by halogen, alkyl, OH, alkoxy, polyhaloalkyl, amino, mono- and di-alkylamino groups, and nitrogen heterocycles are monocyclic having 5-7 members including 1-3 heteroatoms, one of which is N and the others may be O, N, or S. An Independent claim is also included for the preparation of (I).

公开(公告)号：CZ20022119A3

公开(公告)日：2003-02-12

申请号：CZ20022119

申请日：2002-06-17

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  FOURQUEZ JEAN-MARIE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE ,  NOSJEAN OLIVIER ,  BOULANGER MICHELLE

IPC: C07D295/18 ,  A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185

Abstract: A compound of formula (I):wherein:represents an optionally substituted saturated carbon ring having from 4 to 8 ring members,R1 and R4, which may be identical or different, each represents hydrogen or acyl,R2 and R3, which may be identical or different, each represents hydrogen or alkyl,R5 and R6, which may be identical or different, each represents hydrogen or alkyl, or R5 and R6 together, with the nitrogen atom carrying them, form an optionally substituted nitrogen-containing heterocycle,stereoisomers thereof, and also addition salts thereof with a pharmaceutically acceptable acid.Medicinal products containing the same which are useful for treatment of glucose intolerance or of disorders associated with hyperglycaemia.

公开(公告)号：FR2826003A1

公开(公告)日：2002-12-20

申请号：FR0107934

申请日：2001-06-18

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  FOURQUEZ JEAN MARIE ,  LEVENS NIGEL ,  HUSSON ROBERT BERNADETTE ,  NOSJEAN OLIVIER ,  BOULANGER MICHELLE

IPC: C07D295/18 ,  A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185 ,  C07D207/12

Abstract: Cyclic alpha- amino gamma-hydroxy amides (I), their stereoisomers, and acid addition salts are new. Cyclic alpha- amino gamma-hydroxy amides (I), their stereoisomers, and acid addition salts are new. ring A = 4-8 membered saturated C ring that may be substituted by one or more 1-6C alkyl groups; R1 and R4 = H or 1-6C acyl; R2 and R3 = H or 1-6C alkyl; R5 and R6 = H, 1-6C alkyl, or together with the N atom form a saturated mono- or bicyclic nitrogen heterocycle having 1-3 heteroatoms (additional heteroatoms being O, N, or S) optionally substituted by one or more groups CN, COOR7, COR7, NO2, CONR8aR8b, S(O)nR9, or PO3R10aR10b; R7 = H or 1-6C alkyl; R8a and R8b = H, 1-6C alkyl or together form a N heterocycle as defined; R9 = H, 1-6C alkyl, or phenyl, biphenyl, naphthyl, or tetrahydronaphthyl all these aryl groups being optionally substituted by halogen, 1-6C alkyl or alkoxy, OH, 1-6C polyhalolalkyl, NO2, or 1 or 2 C alkylene dioxy; R10a and R10b = H or 1-6C alkyl; n = 1, 2, or 3.

公开(公告)号：CA2389766A1

公开(公告)日：2002-12-13

申请号：CA2389766

申请日：2002-06-13

Applicant: SERVIER LAB

Inventor： ROUSSEAU ANNE ,  HICKMAN JOHN ,  ATASSI GHANEM ,  LEONCE STEPHANE ,  GUILBAUD NICOLAS ,  WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  PIERRE ALAIN ,  KRAUS-BERTHIER LAURENCE

IPC: C07D209/80 ,  A61K31/403 ,  A61K31/433 ,  A61K31/4439 ,  A61P35/00 ,  C07D209/94 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D491/04 ,  C07D491/056 ,  C07D209/56

Abstract: L'invention concerne de nouveaux composés répondant à la formule (I) (see Formula I) dans laquelle R représente un atome d'hydrogène ou un groupement alkyle éventuellement substitué ou alkényle; R1 à R8, identiques ou différents, représentent chacu n un atome d'hydrogène ou un groupement alkyle éventuellement substitué, hydroxy, acyloxy, amino éventuellement subsitué, carboxy, alkoxy éventuellement subsitué ou alkényloxy, ou bien l'un des groupements R1 à R8 forme avec un autre groupement R1 à R8 contigu un groupement alkylènedioxy; X représente un atome d'oxygène ou un groupement NR16 dans lequel R16 représente un atome d'hydrogène ou un groupement alkyle, ary le ou arylalkyle; et R9 représente un atome d'hydrogène, un groupement aryle ou hétéroaryle ou un groupement alkyle saturé ou insaturé, éventuellement substitué. L'inventi on vise également les isomères des composés de formule (I), ainsi que leurs sels d'addition à un acide ou à une base pharmaceutiquement acceptable. Les composés selon l'invention sont utiles comme médicaments pour le traitement de cancers.