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公开(公告)号：DE10035227A1
公开(公告)日：2002-01-31
申请号：DE10035227
申请日：2000-07-20
Applicant: SOLVAY PHARM GMBH
Inventor： HEBEBRAND JOHANNES , ANTEL JOCHEN , PREUSCHOFF ULF , DAVID SAMUEL , SANN HOLGER , WESKE MICHAEL
Abstract: Compounds for the treatment and/or prevention of obesity are selected on the basis of their capability to inhibit de novo lipogenesis in mammals. An independent claim is also included for the use of compounds which are capable of inhibiting de novo lipogenesis in mammals and which have no anticonvulsant activity for the production of a medicament for the treatment and/or prevention of obesity. - ACTIVITY : Anorectic. - MECHANISM OF ACTION : Lipogenesis inhibitor; Carboanhydrase inhibitor. No biological data given.
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公开(公告)号：UA96734C2
公开(公告)日：2011-12-12
申请号：UAA200712393
申请日：2006-04-11
Applicant: SOLVAY PHARM GMBH
Inventor： MOLONEY BRIAN , MARRISON LESTER , CYGLER DITER , MLINARIC MICHAEL , BOECKER CHRISTIANE , WESKE MICHAEL , WITTE KLAUS , FISCHER YVAN , BRUCKNER RAINHARD
IPC: C07D311/68 , A61K31/353 , A61K31/4025 , A61K31/497 , A61K31/5355 , A61P9/00 , C07D405/12 , C07D413/12
Abstract: Взаявкеописанысоединенияобщейформулы I, (I)вкоторой R, R, R, R, R, R, R, R, R, Rи n имеютзначения, указанныев описании, которыеимеютсердечно-сосудистуюактивность, атакжеспособполученияэтихсоединенийи промежуточныепродукты. Крометого, описаныфармацевтическиекомпозиции, которыесодержатсоединенияформулы I.
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公开(公告)号：UA92348C2
公开(公告)日：2010-10-25
申请号：UAA200714185
申请日：2006-05-24
Applicant: SOLVAY PHARM GMBH
Inventor： MESSINGER JOSEF , THOLE HEINRICH-HUBERT , HUSEN BETTINA , KOSKIMIES PASI , PIRKKALA LILA , WESKE MICHAEL
Abstract: Взаявкеописаныновыезамещенныепроизводныестероидов, которыеявляютсяселективнымиингибиторами 17β-гидроксистероиддегидрогеназытипаИ (17β-ГСД1) икоторыедополнительномогутбытьингибиторамистероидсульфатазы, атакжеихсоли, фармацевтическиепрепараты, которыесодержатэтисоединения, испособыполученияэтихсоединений. Крометого, взаявкеописаноприменениеуказанныхновыхзамещенныхпроизводныхстероидовдлялечения, особенноихприменениедлялеченияилипредупреждениязависимыхотстероидногогормоназаболеванийилинарушений, такихкакзависимыеотстероидногогормоназаболеванияилинарушения, длякоторыхнеобходимоингибированиефермента 17β-гидроксистероиддегидрогеназытипаИ и/илистероидсульфатазыи/илинеобходимоснижениеконцентрацииэндогенного 17β-эстрадиола.
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公开(公告)号：BRPI0611623A2
公开(公告)日：2010-09-21
申请号：BRPI0611623
申请日：2006-05-24
Applicant: SOLVAY PHARM GMBH
Inventor： THOLE HEINRICH-HUBERT , HUSEN BETTINA , KOSKIMIES PASI , PIRKKALA LILA , WESKE MICHAEL , MESSINGER JOSEF
Abstract: The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17ß-hydroxysteroid dehydrogenase type I (17ß-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17ß-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17ß-estradiol concentration.
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公开(公告)号：HRP20080602T3
公开(公告)日：2008-12-31
申请号：HRP20080602
申请日：2008-11-20
Applicant: SOLVAY PHARM GMBH
Inventor： SYKES DAVID , MOLONEY BRIAN , MARRISON LESTER , ZIEGLER DIETER , MLINARIC MICHAEL , BOECKER CHRISTIANE , BRUECKNER REINHARD , WESKE MICHAEL , WITTE KLAUS , FISCHER YVAN
IPC: C07D201/00 , A61K31/353 , C07D311/68 , C07D407/12
Abstract: The invention relates to compounds of general formula (I), wherein the meaning of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is given in a description, to a method for producing said compounds and to intermediate products thereof. Drugs containing the inventive compounds of formula (1) are also disclosed.
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Patent Agency Ranking
公开(公告)号：PT1678130E
公开(公告)日：2008-10-08
申请号：PT04817204
申请日：2004-10-14
Applicant: SOLVAY PHARM GMBH
Inventor： ZIEGLER DIETER , MOLONEY BRIAN , SYKES DAVID , MARRISON LESTER , MLINARIC MICHAEL , BOECKER CHRISTIANE , BRUECKNER REINHARD , WESKE MICHAEL , WITTE KLAUS , FISCHER YVAN
IPC: C07D201/00 , A61K31/353 , C07D311/68 , C07D407/12
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公开(公告)号：DE502004007916D1
公开(公告)日：2008-10-02
申请号：DE502004007916
申请日：2004-10-14
Applicant: SOLVAY PHARM GMBH
Inventor： SYKES DAVID , MOLONEY BRIAN , MARRISON LESTER , ZIEGLER DIETER , MLINARIC MICHAEL , BOECKER CHRISTIANE , BRUECKNER REINHARD , WESKE MICHAEL , WITTE KLAUS , FISCHER YVAN
IPC: C07D201/00 , A61K31/353 , C07D311/68 , C07D407/12
Abstract: The invention relates to compounds of general formula (I), wherein the meaning of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is given in a description, to a method for producing said compounds and to intermediate products thereof. Drugs containing the inventive compounds of formula (1) are also disclosed.
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公开(公告)号：NO20076616A
公开(公告)日：2008-02-01
申请号：NO20076616
申请日：2007-12-21
Applicant: SOLVAY PHARM GMBH
Inventor： MESSINGER JOSEF , WESKE MICHAEL , KOSKIMIES PASI , THOLE HEINRICH-HUBERT , HUSEN BETTINA , PIRKKALA LILA
IPC: C07J41/00
CPC classification number: C07J71/0052 , C07J41/0072 , C07J43/003 , C07J71/0068
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公开(公告)号：BRPI0415523A
公开(公告)日：2006-12-26
申请号：BRPI0415523
申请日：2004-10-14
Applicant: SOLVAY PHARM GMBH
Inventor： SYKES DAVID , MOLONEY BRIAN , MARRISON LESTER , ZIEGLER DIETER , MLINARIC MICHAEL , BOECKER CHRISTIANE , BRUECKNER REINHARD , WESKE MICHAEL , WITTE KLAUS , FISCHER YVAN
IPC: A61K31/353 , C07D311/68 , C07D407/12
Abstract: The invention relates to compounds of general formula (I), wherein the meaning of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is given in a description, to a method for producing said compounds and to intermediate products thereof. Drugs containing the inventive compounds of formula (1) are also disclosed.
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公开(公告)号：AU2006251154A1
公开(公告)日：2006-11-30
申请号：AU2006251154
申请日：2006-05-24
Applicant: SOLVAY PHARM GMBH
Inventor： MESSINGER JOSEF , KOSKIMIES PASI , THOLE HEINRICH-HUBERT , PIRKKALA LILA , HUSEN BETTINA , WESKE MICHAEL
Abstract: The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17ß-hydroxysteroid dehydrogenase type I (17ß-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17ß-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17ß-estradiol concentration.
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