中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

151 records (took 0.032 seconds)

    METHOD, SYSTEM AND COMPUTER READABLE MEDIUM TO DETERMINE A STRABISMUS ANGLE BETWEEN THE EYES OF AN INDIVIDUAL
    72.
    发明申请
    METHOD, SYSTEM AND COMPUTER READABLE MEDIUM TO DETERMINE A STRABISMUS ANGLE BETWEEN THE EYES OF AN INDIVIDUAL 审中-公开
    方法，系统和计算机可读介质确定个体眼睛之间的视觉角度

    公开(公告)号：WO2017123086A1

    公开(公告)日：2017-07-20

    申请号：PCT/NL2017/050011

    申请日：2017-01-11

    Applicant: STICHTING VU-VUMC ,  STICHTING VUMC

    Inventor： VAN DIJK, Bob Wilhelm

    IPC: A61B3/08

    CPC classification number: A61B3/085

    Abstract: The invention relates to a method, system and computer readable medium for determining a strabismus angle of the eyes of an individual by: positioning the individual with his or her eyes in front of an eye tracker device and in front of a screen at a viewing distance; displaying a small image element on the screen; measuring a position and line of sight of the eyes of the individual with the eye tracker device while the individual is focussing on the small image element; forwarding the measured position and line of sight of the eyes from the eye tracker device to a computer system; and, calculating the strabismus angle between the eyes by calculating the difference in line of sight of the left and right eyes of the individual.

    Abstract translation: 本发明涉及一种用于通过以下步骤确定个体眼睛的斜视角的方法，系统和计算机可读介质：将他的或她的眼睛定位在眼睛跟踪器装置的前方， 观看距离的屏幕前方; 在屏幕上显示小图像元素; 当个体聚焦在小图像元件上时用眼睛跟踪器装置测量个体眼睛的位置和视线; 将眼睛追踪装置的眼睛的测量位置和视线转发到计算机系统; 并通过计算个体左右眼视线的差异来计算眼睛之间的斜视角。

    WOUND HEALING FORMULATION
    73.
    发明申请
    WOUND HEALING FORMULATION 审中-公开
    创伤治疗配方

    公开(公告)号：WO2016126153A1

    公开(公告)日：2016-08-11

    申请号：PCT/NL2015/050901

    申请日：2015-12-22

    Applicant: STICHTING VU-VUMC ,  A-SKIN HOLDING B.V.

    Inventor： GIBBS, Susan ,  SCHEPER, Riekeld Johannes

    IPC: A61K35/33 ,  A61K35/36 ,  C12N5/071 ,  C12N5/077 ,  A61P17/02

    CPC classification number: A61K35/36 ,  A61K35/33 ,  C12N5/0629 ,  C12N5/0656 ,  C12N2502/094 ,  C12N2502/1323

    Abstract: The present disclosure relates to a method for producing a composition, wherein the method comprises the steps of co-culturing immortalized fibroblasts and immortalized keratinocytes, thereby producing secretion; separating the secretion from the fibroblasts and keratinocytes; and providing a pharmaceutically acceptable composition comprising the secretion. The present disclosure also relates to the composition obtainable by the method, wherein the composition preferably is a pharmaceutical composition for medical use, preferably for use in the treatment of a wound, preferably a chronic or acute wound.

    Abstract translation: 本公开涉及一种制备组合物的方法，其中所述方法包括共培养永生化成纤维细胞和永生化角化细胞的步骤，从而产生分泌; 从成纤维细胞和角质细胞分离分泌物; 并提供包含该分泌物的药学上可接受的组合物。 本公开还涉及通过该方法获得的组合物，其中所述组合物优选是用于医疗用途的药物组合物，优选用于治疗伤口，优选慢性或急性伤口。

    KIT FOR THE IMPLANTATION OF A DENTAL IMPLANT
    74.
    发明申请
    KIT FOR THE IMPLANTATION OF A DENTAL IMPLANT 审中-公开
    用于植入牙科植入物的工具包

    公开(公告)号：WO2016043578A1

    公开(公告)日：2016-03-24

    申请号：PCT/NL2014/050647

    申请日：2014-09-19

    Applicant: STICHTING VU-VUMC

    Inventor： KOOPS, Daniël

    IPC: A61C1/08 ,  A61C8/00

    CPC classification number: A61C8/0089 ,  A61C1/084 ,  A61C8/0087

    Abstract: The present invention provides a kit for use for the implantation of a dental implant, comprising an implant guide comprising a proximal end and a distal end, wherein the distal end is configured to be detachably attached to a dental implant, said implant guide comprising a cylindrical body, wherein the cylindrical body comprises a cylindrical outer surface and a circumferential groove in the outer surface, and a template configured to be arranged at a predetermined location with respect to a jaw, wherein the template comprises at least one implantation channel to guide the cylindrical body of the implant guide in a desired implantation direction during implantation of a dental implant in the jaw, and a stop surface at an end of the implantation channel. The kit comprises a stop element comprising a first part and a second part, wherein the first part and the second part are configured to be movable between a first state, in which the first part and the second part are spaced at a first distance, and a second state, in which the first part and the second part are spaced at a second distance, wherein the first distance is smaller than the second distance, and wherein the first and second parts are biased to the first state, wherein the second distance is the same or larger than a distance between diametrically opposite sides of the outer surface of the implant guide, such that, before implantation, the first part and the second part can be arranged, in the second state, on diametrically opposite sides of the outer surface, and that during movement in the implantation direction of the dental implant into the jaw, the stop surface of the implantation channel will push the stop element towards the groove until the groove will allow the first and second part to move towards the first state and the stop element will be caught by the groove, therewith blocking further movement of the implant guide in the implantation direction.

    Abstract translation: 本发明提供了一种用于植入牙科植入物的套件，包括植入物引导件，其包括近端和远端，其中所述远端构造成可拆卸地连接到牙科植入物，所述植入物引导件包括圆柱形 其中所述圆柱形主体包括外表面中的圆柱形外表面和周向凹槽，以及模板，其构造成相对于颚布置在预定位置，其中所述模板包括至少一个注入通道以引导所述圆柱形 在将牙科植入物植入颌骨期间以期望的植入方向的植入物引导体的主体以及植入通道的端部处的止动表面。 套件包括止动元件，其包括第一部分和第二部分，其中第一部分和第二部分构造成可在第一状态和第二部分之间移动，第一状态和第二部分间隔第一距离; 第二状态，其中第一部分和第二部分以第二距离间隔开，其中第一距离小于第二距离，并且其中第一和第二部分被偏置到第一状态，其中第二距离是 与植入物引导件的外表面的直径相对的两侧之间的距离相同或更大，使得在植入之前，第一部分和第二部分可以在第二状态下布置在外表面的径向相对侧上 ，并且在将牙科植入物的植入方向移动到颚中时，植入通道的止动表面将推动止动元件朝向凹槽，直到凹槽将允许冷杉 第一部分和第二部分朝向第一状态移动，并且止动元件将被凹槽捕获，从而阻止植入引导件在植入方向上的进一步移动。

    TRANSDUCER FOR USE IN A CAPACITIVE VIBRATION SENSOR
    78.
    发明申请
    TRANSDUCER FOR USE IN A CAPACITIVE VIBRATION SENSOR 审中-公开
    用于电容式振动传感器的传感器

    公开(公告)号：WO2015133903A1

    公开(公告)日：2015-09-11

    申请号：PCT/NL2015/050142

    申请日：2015-03-06

    Applicant: STICHTING VU-VUMC

    Inventor： SEDMIK, René Ignaz Peter

    IPC: G01P15/125 ,  G01H11/06 ,  G01P15/08

    CPC classification number: G01P15/125 ,  G01H11/06 ,  G01P2015/084 ,  G01P2015/0854 ,  G01P2015/0857

    Abstract: A transducer for use in a capacitive vibration sensor comprises a mass- spring system (3) and a first flat plate. The mass-spring system comprises a flat central proof mass (4), a surrounding support structure (5), and at least three interleaved spiral-shaped spring arms (6, 7, 8). The first flat plate is mounted at a first fixed position relative to the surrounding support structure, spaced from, and parallel to a first flat side (41) of the flat central proof mass. The flat central proof mass and the first flat plate are forming a first electric capacitance. Externally caused accelerations of the surrounding support structure cause parallel displacement of the flat central proof mass relative to the first flat plate, resulting in a changing first capacity of the first electric capacitance.

    Abstract translation: 用于电容式振动传感器的换能器包括质量弹簧系统（3）和第一平板。 质量弹簧系统包括平坦的中央证明物质（4），周围的支撑结构（5）和至少三个交错的螺旋形弹簧臂（6,7,8）。 第一平板相对于周围的支撑结构安装在第一固定位置处，与平坦中心证明块的第一平坦侧面（41）隔开并平行。 平坦的中央证明物质和第一平板形成第一电容。 外部引起周围支撑结构的加速度导致平面中心质量块相对于第一平板的平行位移，导致第一电容的第一容量变化。

    TREATMENT OF COGNITIVE IMPAIRMENT IN DEPRESSIVE DISORDERS
    79.
    发明申请
    TREATMENT OF COGNITIVE IMPAIRMENT IN DEPRESSIVE DISORDERS 审中-公开
    治疗严重疾病中的认知障碍

    公开(公告)号：WO2014171826A1

    公开(公告)日：2014-10-23

    申请号：PCT/NL2014/050242

    申请日：2014-04-17

    Applicant: STICHTING VU-VUMC

    Inventor： SMIT, August Benjamin ,  SPIJKER, Sabine

    IPC: A61K38/46

    CPC classification number: A61K38/46

    Abstract: The invention relates to treatments for depressive disorders based on reducing the extracellular matrix in the hippocampus. The invention also relates to methods of screening for new compounds to treat depressive disorders.

    Abstract translation: 本发明涉及基于减少海马体细胞外基质的抑郁症治疗。 本发明还涉及筛选新化合物以治疗抑郁障碍的方法。

    MEANS AND METHOD FOR INCREASING THE SENSITIVITY OF CANCERS FOR RADIOTHERAPY
    80.
    发明申请
    MEANS AND METHOD FOR INCREASING THE SENSITIVITY OF CANCERS FOR RADIOTHERAPY 审中-公开
    增加放射治疗癌症敏感性的手段和方法

    公开(公告)号：WO2014129895A1

    公开(公告)日：2014-08-28

    申请号：PCT/NL2014/050102

    申请日：2014-02-19

    Applicant: STICHTING VU-VUMC

    Inventor： VAN BEUSECHEM, Victor Willem ,  HODZIC, Jasmina

    IPC: C12Q1/68

    CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178

    Abstract: The invention relates to the use of a gene or a gene product as a target for identifying a pharmacologically active compound, preferably for sensitizing a cancer cell for ionizing radiation. The invention further relates to methods for determining whether a compound is capable of sensitizing a cancer cell for ionizing radiation and to methods for increasing the susceptibility of a cell to radiation. Additionally, the invention related to a compound for use in the treatment of an individual suffering from cancer, preferably wherein said treatment comprises irradiating said individual or part thereof with ionizing radiation. Furthermore, the invention relates to methods for determining the radiation sensitivity of a cancer in an individual. The preferred target of radiosensitization is GPR27.

    Abstract translation: 本发明涉及基因或基因产物作为鉴定药理学活性化合物的靶的用途，优选用于敏化用于电离辐射的癌细胞。 本发明还涉及用于确定化合物是否能够致敏癌细胞以进行电离辐射的方法以及用于增加细胞对辐射的敏感性的方法。 此外，本发明涉及用于治疗患有癌症的个体的化合物，优选其中所述治疗包括用电离辐射照射所述个体或其部分。 此外，本发明涉及用于确定个体中癌症的辐射敏感性的方法。 辐射敏化的首选目标是GPR27。

Patent Agency Ranking