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公开(公告)号：KR1020140069931A
公开(公告)日：2014-06-10
申请号：KR1020120137822
申请日：2012-11-30
Applicant: (주)아모레퍼시픽
IPC: C07C233/09 , C07C233/02
Abstract: The present invention provides a novel pseudo-ceramide compound represented by Chemical Formula 1, an isomer thereof, a pharmaceutically acceptable salt thereof, a pro-drug thereof, a hydrate thereof, and a solvate thereof. [Chemical Formula 1] (In Chemical Formula 1, R is a C9 to 17 saturated or unsaturated aliphatic chain, and R′ is an amino group or an alkoxy group having a C10 to 18 saturated aliphatic chain.) According to the present invention, the novel pseudo-ceramide compound has a skin protecting effect by having excellent stability, dissolubility, and skin moisturization, so that the novel pseudo-ceramide compound can be used as an active ingredient for protecting the skin from external stimuli without side effects, preventing the skin from damage, and recovering damaged skin. Accordingly, the novel pseudo-ceramide compound can be used as a skin-moisturizing composition for external application on skin, a cosmetic composition, or a pharmaceutical composition.
Abstract translation: 本发明提供由化学式1表示的新型假神经酰胺化合物，其异构体，药学上可接受的盐，其前体药物，其水合物及其溶剂合物。 [化学式1]（化学式1中，R为C 9〜17饱和或不饱和脂肪族链，R'为氨基或碳原子数为10〜18的饱和脂肪族链的烷氧基。）根据本发明， 新型伪神经酰胺化合物通过具有优异的稳定性，溶解性和皮肤保湿性而具有皮肤保护效果，因此新颖的假神经酰胺化合物可以用作保护皮肤免受外部刺激的活性成分而没有副作用，从而防止 皮肤受损，并恢复受损皮肤。 因此，新颖的假神经酰胺化合物可以用作皮肤外用的皮肤保湿组合物，化妆品组合物或药物组合物。
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公开(公告)号：KR101349185B1
公开(公告)日：2014-01-16
申请号：KR1020060121960
申请日：2006-12-05
Applicant: (주)아모레퍼시픽
IPC: A61K31/166 , A61K31/045 , A61P3/04
Abstract: 본 발명은 지방대사 이상질환의 치료 및 예방용 약학 조성물에 관한 것으로, 화학식 1의 화합물을 유효성분으로 포함하는 본 발명의 약학 조성물은 인간 간세포에서 생체내 에너지 대사에 중요한 역할을 하는 아이소싸이트레이트 탈수소효소 3α (IDH3α) 프로모터와 카르니틴 팔미토일 트랜스퍼레이즈 1A (CPT1A) 프로모터의 활성을 증가시켜, 혈당 및 중성지방의 감소 및 결과적으로 체중의 감소를 가져오므로, 비만, 고지혈증, 당뇨병 등의 지방대사 이상질환의 예방 및 치료에 유용하게 사용될 수 있다.
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公开(公告)号：KR1020130052243A
公开(公告)日：2013-05-22
申请号：KR1020110117591
申请日：2011-11-11
Applicant: (주)아모레퍼시픽
IPC: A61K31/192 , A61K31/185 , A61K31/047 , A61P17/00
Abstract: PURPOSE: A skin irritation relieving agent containing carnosic acid or a derivative thereof is provided to suppress release of IL-8(interleukin-8), MCP-1(monocyte chemotactic protein-1), and IL-6(interleukin-6), and to relieves skin irritation due to retinoid or surfactant. CONSTITUTION: A skin irritation relieving agent contains carnosic acid denoted by chemical formula 1, a derivative thereof, or pharmaceutically acceptable salt thereof as an active ingredient. The skin irritation relieving agent relieves inflammation, skin dryness, erythema, horny substance, itching, or burning sensation. The skin irritation is caused by retinoid or surfactant of an external use skin formulation. The retinoid is selected from the group consisting of retinol, retinal, and retinoic acid.
Abstract translation: 目的：提供含有肌痛酸或其衍生物的皮肤刺激缓解剂，以抑制IL-8（白细胞介素-8），MCP-1（单核细胞趋化蛋白-1）和IL-6（白细胞介素-6）的释放， 并减轻由类视黄醇或表面活性剂引起的皮肤刺激。 构成：皮肤刺激缓释剂含有以化学式1表示的棘皮酸，其衍生物或其药学上可接受的盐作为活性成分。 皮肤刺激缓解剂减轻炎症，皮肤干燥，红斑，角质，瘙痒或灼热感。 皮肤刺激是由外用皮肤制剂的类视色素或表面活性剂引起的。 类视黄醇选自视黄醇，视黄醛和视黄酸。
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公开(公告)号：KR1020130026626A
公开(公告)日：2013-03-14
申请号：KR1020110089286
申请日：2011-09-02
Applicant: (주)아모레퍼시픽
IPC: C07D407/12 , C07D407/14 , A61K8/49 , A61Q19/02
Abstract: PURPOSE: A method for preparing a kojic acid derivative is provided to obtain a high purity kojic acid derivative by reacting halogenated kojic acid, which is the product of substituting a halogen element for a hydroxyl group of a hydroxyl methyl group, with benzoate or cinnamate. CONSTITUTION: A method for preparing a kojic acid derivative of chemical formula 1 comprises a step of reacting halogenated kojic acid with benzoate or cinnamate under the presence of acid. In chemical formula 1, R_1 is -CH_2- or -CH_2CH_2-; and R_2 is -C(O)OCH_2- or -CH=CHC(O)OCH_2-.
Abstract translation: 目的：提供制备曲酸衍生物的方法，通过将卤代醇酸（羟基甲基的羟基取代卤素）与苯甲酸酯或肉桂酸酯反应得到高纯度曲酸衍生物。 构成：制备化学式1的曲酸衍生物的方法包括在酸存在下使卤代曲酸与苯甲酸酯或肉桂酸酯反应的步骤。 在化学式1中，R 1是-CH 2 - 或-CH 2 CH 2 - ; 和R 2是-C（O）OCH 2 - 或-CH = CHC（O）OCH 2 - 。
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公开(公告)号：KR1020130015954A
公开(公告)日：2013-02-14
申请号：KR1020110078309
申请日：2011-08-05
Applicant: (주)아모레퍼시픽
IPC: C07C235/46 , C07C235/48 , A61K8/42 , A61Q19/02
CPC classification number: A61K8/42 , A61Q19/00 , A61Q19/02 , C07C235/46 , C07C235/48 , C07C2603/74
Abstract: PURPOSE: A benzoic acid amide compound is provided to have excellent a skin-whitening effect without side effects by suppressing melanin generation and decreasing tyrosinase activity. CONSTITUTION: A benzoic acid amide compound, an isomer thereof, pharmaceutically-acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof is represented by chemical formula 1. In the chemical formula 1: each of R1, R3, and R4 is independently selected from hydrogen, hydroxy, C1-C5 alkoxy, C3-C6 cycloalkoxy, aryloxy, and C1-C15 haloalkoxy; R2 is selected from hydrogen, C1-C5 alkyl, C3-C6 cycloalkyl, aryl, and C1-C5 haloalkyl; and n is an integer from 1-5.
Abstract translation: 目的：提供苯甲酸酰胺化合物以通过抑制黑色素产生和降低酪氨酸酶活性而具有优异的美白效果而没有副作用。 构成：化学式1表示苯甲酸酰胺化合物，其异构体，药学上可接受的盐，其前药，其水合物或其溶剂合物。在化学式1中，R1，R3和 R 4独立地选自氢，羟基，C 1 -C 5烷氧基，C 3 -C 6环烷氧基，芳氧基和C 1 -C 15卤代烷氧基; R2选自氢，C1-C5烷基，C3-C6环烷基，芳基和C1-C5卤代烷基; n为1-5的整数。
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Patent Agency Ranking
公开(公告)号：KR1020120015823A
公开(公告)日：2012-02-22
申请号：KR1020100078280
申请日：2010-08-13
Applicant: (주)아모레퍼시픽
Inventor： 백흥수
CPC classification number: A61K31/05 , A61K31/01 , A61K36/60 , A61K2236/333
Abstract: PURPOSE: A composition for preventing and treating gray hair and vitiligo is provided to enhance MITF expression in melanocytes and to promote melanogenesis. CONSTITUTION: A composition for preventing or treating gray hair and vitiligo contains 0.001-50 wt% of propanoid derivative substituted with prenyl groups of chemical formula 1 as an active ingredient. The propanoid derivative substituted with prenyl groups is isolated from Broussonetia Kazinoki.
Abstract translation: 目的：提供用于预防和治疗灰白色头发和白癜风的组合物，以增强黑素细胞中的MITF表达并促进黑素生成。 构成：用于预防或治疗灰白色和白癜风的组合物含有以化学式1的异戊烯基作为有效成分取代的0.001-50重量％的类异构体衍生物。 被异戊烯基取代的脯氨酸衍生物从布鲁氏菌（Broussonetia Kazinoki）中分离出来。
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公开(公告)号：KR100899335B1
公开(公告)日：2009-05-26
申请号：KR1020070121550
申请日：2007-11-27
Applicant: (주)아모레퍼시픽
IPC: C07C233/07 , C07C233/53
Abstract: 본 발명은 하기 화학식 1로 표시되는 엘라스테아제 저해 효과를 보이는 아다만탄 유도체 화합물 및 그 제조방법에 관한 것이다:
[화학식 1]
상기 식 중에서,
X는 -NHCO- 또는 -CONH-이고,
R은 에틸, 프로필 또는 이소프로필기이다.
아다만탄 유도체 * 항노화 * 엘라스테아제 저해 * 탄력 개선-
公开(公告)号：KR100844277B1
公开(公告)日：2008-07-07
申请号：KR1020050035986
申请日：2005-04-29
Applicant: (주)아모레퍼시픽
IPC: C07C239/18
CPC classification number: C07C259/06 , A61K8/42 , A61Q19/08 , C07C259/10
Abstract: 본 발명은 하기 화학식 1로 표시되는 히드록삼산(Hydroxamic acid) 유도체 및 이의 제조방법에 관한 것이다:
[화학식 1]
[상기 식 중에서, R
1 및
R
2 는 C
1-10 의 알킬이고;
R
3 는 -(CH)
n - 이며, n = 0 또는 1이고;
R
4 는 수소 또는 메틸이다].
또한, 본 발명은 항산화, 콜라겐 생합성 증진 및 모공 축소 효과를 갖는 상기 화학식 1의 히드록삼산 유도체를 유효성분으로 함유하는 피부 외용제 조성물에관한 것이다.
히드록삼산 유도체*항산화*모공 축소*피부 외용제-
公开(公告)号：KR1020080051239A
公开(公告)日：2008-06-11
申请号：KR1020060121960
申请日：2006-12-05
Applicant: (주)아모레퍼시픽
IPC: A61K31/166 , A61K31/045 , A61P3/04
Abstract: A pharmaceutical composition comprising compounds capable of increasing expressions of isocitrate dehydrogenase 3alpha(IDH3alpha) and carnitine palmitoyl transferase 1A(CPT1A) by increasing activity of their promoters is provided to reduce synthesis of fatty acid and promote oxidation of fatty acid, so that the composition is useful for treating and preventing lipid metabolism-related diseases. A pharmaceutical composition for treating and preventing lipid metabolism-related diseases comprises compounds represented by the formula(1) in which R1 is adamantly group or phenyl group substituted by H, OH or C1-C5 alkyl, and R2 is CONH or NHCO, and further comprises pharmaceutically acceptable carriers, excipients or diluents selected from lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, crystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil.
Abstract translation: 提供了包含通过提高其启动子的活性而能够增加异柠檬酸脱氢酶3α（IDH3α）和肉碱棕榈酰转移酶1A（CPT1A）的表达的化合物的药物组合物，用于减少脂肪酸的合成并促进脂肪酸的氧化，使得组合物 用于治疗和预防脂质代谢相关疾病。 用于治疗和预防脂质代谢相关疾病的药物组合物包括由式（1）表示的化合物，其中R1是金刚烷基或被H，OH或C1-C5烷基取代的苯基，R2是CONH或NHCO， 包括药学上可接受的载体，赋形剂或稀释剂，其选自乳糖，葡萄糖，蔗糖，山梨糖醇，甘露糖醇，木糖醇，赤藓糖醇，麦芽糖醇，淀粉，阿拉伯胶，藻酸盐，明胶，磷酸钙，硅酸钙，纤维素，甲基纤维素，结晶纤维素，聚乙烯吡咯烷酮 ，水，羟基苯甲酸甲酯，羟基苯甲酸丙酯，滑石，硬脂酸镁和矿物油。
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公开(公告)号：KR100788161B1
公开(公告)日：2007-12-21
申请号：KR1020060001810
申请日：2006-01-06
Applicant: (주)아모레퍼시픽
CPC classification number: A61Q19/02 , A61K8/4926 , A61K8/4946
Abstract: 본 발명은 벤즈이미다졸 아민 유도체 및 아미노퀴놀린 유도체 중 어느 하나 이상을 함유하는 씨-킷트(c-kit) 단백질 저해용 조성물 또는 피부 미백용 조성물에 관한 것으로, 상기 벤즈이미다졸 아민 유도체는 1-(4-메톡시페닐)-N-(1-나프탈레닐메틸)-1H-벤즈이미다졸-5-아민이고, 상기 아미노퀴놀린 유도체는 2-아미노-3-(3,4-디메톡시페닐)-퀴놀린인 것을 특징으로 할 수 있다.
본 발명에 의한 상기 벤즈이미다졸 유도체 및 아미노퀴놀린 유도체는 멜라노사이트(melanocyte)의 세포 표면 단백질인 씨-킷트 단백질의 활성을 저해하는 작용이 있으며, 이에 의해 씨-킷트 단백질이 관여하는 멜라노사이트 내 세포의 신호 전달을 억제함으로써 멜라노사이트의 기능을 조절하고, 궁극적으로 멜라닌 생성을 억제하여 피부 미백 효능을 나타내므로, 이를 함유하는 씨-킷트 단백질 저해용 조성물 또는 피부 미백용 조성물은 화장료 조성물 또는 약학 조성물로서 유용하게 이용될 수 있다.
벤즈이미다졸 아민, 아미노퀴놀린, 씨-킷트, 미백, 멜라노사이트, 멜라민
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