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公开(公告)号：KR1020150062443A
公开(公告)日：2015-06-08
申请号：KR1020130147098
申请日：2013-11-29
Applicant: (주)아모레퍼시픽
IPC: C07C235/24 , A61K31/166 , A61P17/18
Abstract: 본발명은일측면에서아이오논유도체화합물, 이의이성질체, 이의약학적으로허용가능한염, 이의프로드럭, 이의수화물또는이의용매화물에관한것이다. 본발명은다른일측면에서아이오논유도체화합물, 이의이성질체, 이의약학적으로허용가능한염, 이의프로드럭, 이의수화물또는이의용매화물을포함하는피부노화방지용조성물에관한것이다.
Abstract translation: 本发明的一个方面涉及紫罗兰酮衍生物化合物，其异构体，其异构体，其药学上可接受的盐，其前体药物，其水合物或其溶剂合物。 本发明的另一方面涉及一种用于防止皮肤老化的组合物，其中紫罗兰酮衍生物化合物，其异构体，其药学上可接受的盐，其前药，其水合物或 包括其中的溶剂合物。
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公开(公告)号：KR1020140117842A
公开(公告)日：2014-10-08
申请号：KR1020130032634
申请日：2013-03-27
Applicant: (주)아모레퍼시픽
IPC: C07C233/05 , A61K31/165 , A61P17/16
Abstract: The present invention relates to a novel phenylacetic acid amide derivative compound, isomers thereof, pharmaceutically acceptable salt thereof, prodrug thereof, a hydrate or a solvate thereof, and a composition for skin whitening comprising the same. The novel compound or the like has excellent skin whitening effect.
Abstract translation: 本发明涉及一种新的苯乙酸酰胺衍生物化合物，其异构体，其药学上可接受的盐，其前体药物，其水合物或溶剂合物，以及包含其的皮肤美白组合物。 新颖的化合物等具有优异的皮肤美白效果。
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公开(公告)号：KR1020140069931A
公开(公告)日：2014-06-10
申请号：KR1020120137822
申请日：2012-11-30
Applicant: (주)아모레퍼시픽
IPC: C07C233/09 , C07C233/02
Abstract: The present invention provides a novel pseudo-ceramide compound represented by Chemical Formula 1, an isomer thereof, a pharmaceutically acceptable salt thereof, a pro-drug thereof, a hydrate thereof, and a solvate thereof. [Chemical Formula 1] (In Chemical Formula 1, R is a C9 to 17 saturated or unsaturated aliphatic chain, and R′ is an amino group or an alkoxy group having a C10 to 18 saturated aliphatic chain.) According to the present invention, the novel pseudo-ceramide compound has a skin protecting effect by having excellent stability, dissolubility, and skin moisturization, so that the novel pseudo-ceramide compound can be used as an active ingredient for protecting the skin from external stimuli without side effects, preventing the skin from damage, and recovering damaged skin. Accordingly, the novel pseudo-ceramide compound can be used as a skin-moisturizing composition for external application on skin, a cosmetic composition, or a pharmaceutical composition.
Abstract translation: 本发明提供由化学式1表示的新型假神经酰胺化合物，其异构体，药学上可接受的盐，其前体药物，其水合物及其溶剂合物。 [化学式1]（化学式1中，R为C 9〜17饱和或不饱和脂肪族链，R'为氨基或碳原子数为10〜18的饱和脂肪族链的烷氧基。）根据本发明， 新型伪神经酰胺化合物通过具有优异的稳定性，溶解性和皮肤保湿性而具有皮肤保护效果，因此新颖的假神经酰胺化合物可以用作保护皮肤免受外部刺激的活性成分而没有副作用，从而防止 皮肤受损，并恢复受损皮肤。 因此，新颖的假神经酰胺化合物可以用作皮肤外用的皮肤保湿组合物，化妆品组合物或药物组合物。
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公开(公告)号：KR101349185B1
公开(公告)日：2014-01-16
申请号：KR1020060121960
申请日：2006-12-05
Applicant: (주)아모레퍼시픽
IPC: A61K31/166 , A61K31/045 , A61P3/04
Abstract: 본 발명은 지방대사 이상질환의 치료 및 예방용 약학 조성물에 관한 것으로, 화학식 1의 화합물을 유효성분으로 포함하는 본 발명의 약학 조성물은 인간 간세포에서 생체내 에너지 대사에 중요한 역할을 하는 아이소싸이트레이트 탈수소효소 3α (IDH3α) 프로모터와 카르니틴 팔미토일 트랜스퍼레이즈 1A (CPT1A) 프로모터의 활성을 증가시켜, 혈당 및 중성지방의 감소 및 결과적으로 체중의 감소를 가져오므로, 비만, 고지혈증, 당뇨병 등의 지방대사 이상질환의 예방 및 치료에 유용하게 사용될 수 있다.
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公开(公告)号：KR1020130052243A
公开(公告)日：2013-05-22
申请号：KR1020110117591
申请日：2011-11-11
Applicant: (주)아모레퍼시픽
IPC: A61K31/192 , A61K31/185 , A61K31/047 , A61P17/00
Abstract: PURPOSE: A skin irritation relieving agent containing carnosic acid or a derivative thereof is provided to suppress release of IL-8(interleukin-8), MCP-1(monocyte chemotactic protein-1), and IL-6(interleukin-6), and to relieves skin irritation due to retinoid or surfactant. CONSTITUTION: A skin irritation relieving agent contains carnosic acid denoted by chemical formula 1, a derivative thereof, or pharmaceutically acceptable salt thereof as an active ingredient. The skin irritation relieving agent relieves inflammation, skin dryness, erythema, horny substance, itching, or burning sensation. The skin irritation is caused by retinoid or surfactant of an external use skin formulation. The retinoid is selected from the group consisting of retinol, retinal, and retinoic acid.
Abstract translation: 目的：提供含有肌痛酸或其衍生物的皮肤刺激缓解剂，以抑制IL-8（白细胞介素-8），MCP-1（单核细胞趋化蛋白-1）和IL-6（白细胞介素-6）的释放， 并减轻由类视黄醇或表面活性剂引起的皮肤刺激。 构成：皮肤刺激缓释剂含有以化学式1表示的棘皮酸，其衍生物或其药学上可接受的盐作为活性成分。 皮肤刺激缓解剂减轻炎症，皮肤干燥，红斑，角质，瘙痒或灼热感。 皮肤刺激是由外用皮肤制剂的类视色素或表面活性剂引起的。 类视黄醇选自视黄醇，视黄醛和视黄酸。
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Patent Agency Ranking
公开(公告)号：KR1020130026626A
公开(公告)日：2013-03-14
申请号：KR1020110089286
申请日：2011-09-02
Applicant: (주)아모레퍼시픽
IPC: C07D407/12 , C07D407/14 , A61K8/49 , A61Q19/02
Abstract: PURPOSE: A method for preparing a kojic acid derivative is provided to obtain a high purity kojic acid derivative by reacting halogenated kojic acid, which is the product of substituting a halogen element for a hydroxyl group of a hydroxyl methyl group, with benzoate or cinnamate. CONSTITUTION: A method for preparing a kojic acid derivative of chemical formula 1 comprises a step of reacting halogenated kojic acid with benzoate or cinnamate under the presence of acid. In chemical formula 1, R_1 is -CH_2- or -CH_2CH_2-; and R_2 is -C(O)OCH_2- or -CH=CHC(O)OCH_2-.
Abstract translation: 目的：提供制备曲酸衍生物的方法，通过将卤代醇酸（羟基甲基的羟基取代卤素）与苯甲酸酯或肉桂酸酯反应得到高纯度曲酸衍生物。 构成：制备化学式1的曲酸衍生物的方法包括在酸存在下使卤代曲酸与苯甲酸酯或肉桂酸酯反应的步骤。 在化学式1中，R 1是-CH 2 - 或-CH 2 CH 2 - ; 和R 2是-C（O）OCH 2 - 或-CH = CHC（O）OCH 2 - 。
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公开(公告)号：KR1020130015954A
公开(公告)日：2013-02-14
申请号：KR1020110078309
申请日：2011-08-05
Applicant: (주)아모레퍼시픽
IPC: C07C235/46 , C07C235/48 , A61K8/42 , A61Q19/02
CPC classification number: A61K8/42 , A61Q19/00 , A61Q19/02 , C07C235/46 , C07C235/48 , C07C2603/74
Abstract: PURPOSE: A benzoic acid amide compound is provided to have excellent a skin-whitening effect without side effects by suppressing melanin generation and decreasing tyrosinase activity. CONSTITUTION: A benzoic acid amide compound, an isomer thereof, pharmaceutically-acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof is represented by chemical formula 1. In the chemical formula 1: each of R1, R3, and R4 is independently selected from hydrogen, hydroxy, C1-C5 alkoxy, C3-C6 cycloalkoxy, aryloxy, and C1-C15 haloalkoxy; R2 is selected from hydrogen, C1-C5 alkyl, C3-C6 cycloalkyl, aryl, and C1-C5 haloalkyl; and n is an integer from 1-5.
Abstract translation: 目的：提供苯甲酸酰胺化合物以通过抑制黑色素产生和降低酪氨酸酶活性而具有优异的美白效果而没有副作用。 构成：化学式1表示苯甲酸酰胺化合物，其异构体，药学上可接受的盐，其前药，其水合物或其溶剂合物。在化学式1中，R1，R3和 R 4独立地选自氢，羟基，C 1 -C 5烷氧基，C 3 -C 6环烷氧基，芳氧基和C 1 -C 15卤代烷氧基; R2选自氢，C1-C5烷基，C3-C6环烷基，芳基和C1-C5卤代烷基; n为1-5的整数。
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公开(公告)号：KR1020120015823A
公开(公告)日：2012-02-22
申请号：KR1020100078280
申请日：2010-08-13
Applicant: (주)아모레퍼시픽
Inventor： 백흥수
CPC classification number: A61K31/05 , A61K31/01 , A61K36/60 , A61K2236/333
Abstract: PURPOSE: A composition for preventing and treating gray hair and vitiligo is provided to enhance MITF expression in melanocytes and to promote melanogenesis. CONSTITUTION: A composition for preventing or treating gray hair and vitiligo contains 0.001-50 wt% of propanoid derivative substituted with prenyl groups of chemical formula 1 as an active ingredient. The propanoid derivative substituted with prenyl groups is isolated from Broussonetia Kazinoki.
Abstract translation: 目的：提供用于预防和治疗灰白色头发和白癜风的组合物，以增强黑素细胞中的MITF表达并促进黑素生成。 构成：用于预防或治疗灰白色和白癜风的组合物含有以化学式1的异戊烯基作为有效成分取代的0.001-50重量％的类异构体衍生物。 被异戊烯基取代的脯氨酸衍生物从布鲁氏菌（Broussonetia Kazinoki）中分离出来。
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公开(公告)号：KR100899335B1
公开(公告)日：2009-05-26
申请号：KR1020070121550
申请日：2007-11-27
Applicant: (주)아모레퍼시픽
IPC: C07C233/07 , C07C233/53
Abstract: 본 발명은 하기 화학식 1로 표시되는 엘라스테아제 저해 효과를 보이는 아다만탄 유도체 화합물 및 그 제조방법에 관한 것이다:
[화학식 1]
상기 식 중에서,
X는 -NHCO- 또는 -CONH-이고,
R은 에틸, 프로필 또는 이소프로필기이다.
아다만탄 유도체 * 항노화 * 엘라스테아제 저해 * 탄력 개선-
公开(公告)号：KR100844277B1
公开(公告)日：2008-07-07
申请号：KR1020050035986
申请日：2005-04-29
Applicant: (주)아모레퍼시픽
IPC: C07C239/18
CPC classification number: C07C259/06 , A61K8/42 , A61Q19/08 , C07C259/10
Abstract: 본 발명은 하기 화학식 1로 표시되는 히드록삼산(Hydroxamic acid) 유도체 및 이의 제조방법에 관한 것이다:
[화학식 1]
[상기 식 중에서, R
1 및
R
2 는 C
1-10 의 알킬이고;
R
3 는 -(CH)
n - 이며, n = 0 또는 1이고;
R
4 는 수소 또는 메틸이다].
또한, 본 발명은 항산화, 콜라겐 생합성 증진 및 모공 축소 효과를 갖는 상기 화학식 1의 히드록삼산 유도체를 유효성분으로 함유하는 피부 외용제 조성물에관한 것이다.
히드록삼산 유도체*항산화*모공 축소*피부 외용제
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