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公开(公告)号：KR1019960003508B1
公开(公告)日：1996-03-14
申请号：KR1019930004103
申请日：1993-03-17
Applicant: 서울대학교의과대학의공학연구소 , 한국과학기술연구원
IPC: A61F2/24
Abstract: The sinkhole bileafle polymer heart valve having a blood compatibility and durability, is useful for an artificial heart valve for a blood pump, a total artificial heart valve for substitution and a heart valve of a ventricular assist device. A heart valve frame is prepared by impregnating isoplast having a width of 1 mm and a space of 3 mm into pellethane solution. The pellethane solution in dimethylacetamide is molded a thickness of 0.2 mm on the glass plate, and punched to a round shape to give a leaflet.
Abstract translation: 具有血液相容性和耐久性的沉孔胆汁聚合物心脏瓣膜可用于血液泵的人造心脏瓣膜，用于替代的总人造心脏瓣膜和心室辅助装置的心脏瓣膜。 通过将宽度为1mm，间距为3mm的异质体浸渍到透明液溶液中制备心脏瓣膜框架。 将二甲基乙酰胺中的硼烷溶液在玻璃板上成形为0.2mm的厚度，冲压成圆形，得到单张。
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公开(公告)号：KR20180047423A
公开(公告)日：2018-05-10
申请号：KR20160143469
申请日：2016-10-31
Applicant: 한국과학기술연구원
IPC: A61L27/26 , A61L27/10 , A61L27/36 , C08L101/16
CPC classification number: A61L27/58 , A61K9/0024 , A61L27/10 , A61L27/18 , A61L27/26 , A61L27/34 , A61L27/3633 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2400/18 , C12N5/0068 , C12N2533/90
Abstract: 염기성나노염기성나노세라믹입자, 동물조직또는세포유래생체활성제1 세포외기질물질및 생분해성고분자을포함하고, 기공내벽에제2 세포외기질물질이코팅된유무기복합-다공성생분해성고분자지지체가제공된다.
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公开(公告)号：KR1020170082386A
公开(公告)日：2017-07-14
申请号：KR1020160001706
申请日：2016-01-06
Applicant: 한국과학기술연구원
Abstract: 내피전구세포를선택적으로포획할수 있는나노실란화스텐트, 및이의제조방법을제공한다. 이에따르면, 항체를효율적으로고정하고, 고정된항체에의해내피전구세포를선택적으로포획하여신속한재내피화를촉진할수 있다.
Abstract translation: 一种能够选择性捕获内皮祖细胞的纳米硅化支架及其制备方法。 据此，抗体可以被有效地固定，并且内皮前体细胞可以被固定抗体选择性地捕获，从而促进再内皮化。
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公开(公告)号：KR1020130040748A
公开(公告)日：2013-04-24
申请号：KR1020120113833
申请日：2012-10-12
Applicant: 한국과학기술연구원
CPC classification number: C12N5/0062 , A61K35/28 , A61K35/32 , C12N2533/90
Abstract: PURPOSE: A method for preparing a self-assembled extracellular matrix and a use thereof are provided to obtain the self-assembled extracellular matrix with a nanofiber. CONSTITUTION: A method for preparing a self-assembled extracellular matrix comprises: a step of culturing cells on a two-dimensional surface to prepare an extracellular matrix; and a step of decellularizing the cells and preparing the extracellular matrix from the two-dimensional surface. The cell is an autologous cell or a stem cell.
Abstract translation: 目的：提供一种制备自组装细胞外基质的方法及其用途，以获得具有纳米纤维的自组装细胞外基质。 构成：制备自组装细胞外基质的方法包括：在二维表面上培养细胞以制备细胞外基质的步骤; 以及使细胞脱细胞化并从二维表面制备细胞外基质的步骤。 细胞是自体细胞或干细胞。
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Patent Agency Ranking
公开(公告)号：KR101161151B1
公开(公告)日：2012-07-02
申请号：KR1020090115872
申请日：2009-11-27
Applicant: 한국과학기술연구원
Abstract: 본 발명은 (a) 코팅 용액을 분사 노즐에 공급하는 공정, (b) 고전압을 인가하여 상기 코팅 용액을 하전시키는 공정, 및 (c) 하전된 코팅 용액을 분사 노즐을 이용하여 분사하여 스텐트 또는 생체 이식물의 표면을 코팅하는 공정을 포함하는, 스텐트 또는 생체 이식물의 표면 코팅 방법, 상기 방법에 이용되는 전기 분사 코팅 장치, 및 표면 코팅된 스텐트 또는 생체 이식물의 제조 방법에 관한 것이다. 본 발명에서는 코팅 두께를 나노미터부터 마이크로미터 수준까지 조절할 수 있고, 다층 구조의 코팅을 형성시킬 수 있으며, 약물 방출형 기능성 코팅을 할 수 있으므로, 다양한 물질의 표면을 코팅하여 부가 가치가 높은 스텐트 또는 생체 이식물을 제공할 수 있다.
스텐트, 생체 이식물, 전기 분사, 코팅, 고분자, 약물, 생리 활성 물질-
公开(公告)号：KR101111247B1
公开(公告)日：2012-06-12
申请号：KR1020090065466
申请日：2009-07-17
Applicant: 한국과학기술연구원
IPC: C07D231/04 , C07D231/02
CPC classification number: C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
Abstract: 본 발명은 신규 피라졸 화합물과 약제학적으로 허용 가능한 이의 염, 이 화합물의 제조방법, 그리고 이 화합물을 항암제로 사용하는 의약용도에 관한 것이다.
피라졸 화합물, 리셉터 타이로신 카이나제, Ros 단백질 저해제, 뇌암, 다형성 교아종, 항암제-
公开(公告)号：KR1020110051579A
公开(公告)日：2011-05-18
申请号：KR1020090108221
申请日：2009-11-10
Applicant: 한국과학기술연구원
CPC classification number: B05D7/14 , A61L27/00 , A61L27/28 , A61L27/34 , A61L31/10 , A61L2400/12 , A61L2400/18 , B05D1/18 , B05D3/142 , Y10T428/273 , Y10T428/31678 , C08L67/04
Abstract: PURPOSE: A method for manufacturing a surface-modified metal substrate is provided to simplify process and to reduce production cost. CONSTITUTION: A surface-modified metal substrate contains a metal substrate and polymer layer which is chemically conjugated to the surface through oxygen atoms. A method for manufacturing the surface-modified metal substrate comprises: a step of introducing a hydroxy group to the surface of the metal substrate; a step of polymerizing monomers on the surface to chemically bind polymers onto the surface through oxygen atoms. The metal is selected from stainless steel, covalt-chrome, titanium, nitinol, gold, silver, platinum, tantalum, magnesium, and metal alloy thereof.
Abstract translation: 目的：提供一种制造表面改性金属基材的方法，以简化工艺并降低生产成本。 构成：表面改性的金属基材含有金属基材和通过氧原子与表面化学偶合的聚合物层。 制造表面改性金属基材的方法包括：将羟基引入金属基材的表面的步骤; 在表面上聚合单体以通过氧原子将聚合物化学结合到表面上的步骤。 金属选自不锈钢，钴铬，钛，镍钛诺，金，银，铂，钽，镁及其金属合金。
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公开(公告)号：KR1020110023399A
公开(公告)日：2011-03-08
申请号：KR1020090081256
申请日：2009-08-31
Applicant: 한국과학기술연구원
CPC classification number: A61L24/106 , A61L24/0015 , A61L24/04 , A61L24/08 , A61L33/126
Abstract: PURPOSE: An intelligent fibrin bio-adhesive with superior hemostasis effect and mechanical properties is provided to obtain an anti-bacteria property by adding natural polymer and/or antibiotics. CONSTITUTION: Fibrin and natural polymer form crosslinkage, and interpenetrating network or semi-interpenetrating network is obtained. The natural polymer is one or more selected from a group including alginate, chitosan, chitin, cellulose, agarose, amylase, dextran, proteoglycan, glycosaminoglycan, collagen, gelatin, heparin, hyaluronic acid, pectin, carrageena, chondroitin sulfate, dextran sulfate, polylysine, pullulan, carboxylmethyl chitin, and the salt of the same. Antibiotics are additionally introduced into the interpenetrating network or the semi-interpenetrating network.
Abstract translation: 目的：提供具有优异止血效果和机械性能的智能纤维蛋白生物粘合剂，通过加入天然聚合物和/或抗生素获得抗细菌性能。 构成：纤维蛋白和天然聚合物形成交联，获得互穿网络或半互穿网络。 天然聚合物是选自藻酸盐，壳聚糖，壳多糖，纤维素，琼脂糖，淀粉酶，葡聚糖，蛋白聚糖，糖胺聚糖，胶原，明胶，肝素，透明质酸，果胶，角叉菜胶，硫酸软骨素，硫酸葡聚糖，聚赖氨酸 ，支链淀粉，羧甲基甲壳质及其盐。 抗生素还被引入到互穿网络或半互穿网络中。
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公开(公告)号：KR1020110007830A
公开(公告)日：2011-01-25
申请号：KR1020090065466
申请日：2009-07-17
Applicant: 한국과학기술연구원
IPC: C07D231/04 , C07D231/02
CPC classification number: C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
Abstract: PURPOSE: A novel pyrazole compound I provided to ensure excellent activity on ROS kinase enzyme and to suppress development of glioblastoma multiforma, CNS cancer, and brain cancer. CONSTITUTION: A pyrazole compound is denoted by chemical formula 1. A pharmaceutical composition for anti-cancer contains the pyrazole compound. An anticancer agent contains the pyrazole compound as an active ingredient. The anticancer agent is used for treating brain cancer, CNS caner, and glioblastoma multiforma. A method for preparing the pyrazole compound comprises: a step of reacting a hetero aromatic compound of chemical formula 3 with methyl 3-methoxy-5-methoxybenzoate compound of chemical formula 2 under the presence of lithium hexamethyldisilazide(LHMDS) to obtain a keto-enol tautomer compound; and a step of reacting the keto-enol tauotmer compound with hydrazine hydrate under anhydrous ethanol condition.
Abstract translation: 目的：提供一种新的吡唑化合物I，以确保对ROS激酶的优异活性，并抑制多形性胶质母细胞瘤，CNS癌和脑癌的发展。 构成：吡唑化合物由化学式1表示。用于抗癌的药物组合物含有吡唑化合物。 抗癌剂含有吡唑化合物作为活性成分。 抗癌剂用于治疗脑癌，CNS癌和多形性成胶质细胞瘤。 制备吡唑化合物的方法包括：使化学式3的杂芳族化合物与化学式2的3-甲氧基-5-甲氧基苯甲酸甲酯在六甲基二硅叠氮化锂（LHMDS）存在下反应，得到酮 - 烯醇 互变异构体 以及在无水乙醇条件下使酮 - 烯醇葡聚糖化合物与水合肼反应的步骤。
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