公开(公告)号：PT1418174E

公开(公告)日：2009-06-08

申请号：PT03029709

申请日：1999-07-19

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  PATEL KETAN ,  SPIWEK HARRY O ,  CHEMBURKAR SANJAY R ,  SALEKI-GERHARDT AZITA

IPC: C07D277/24 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

公开(公告)号：AT425974T

公开(公告)日：2009-04-15

申请号：AT03029709

申请日：1999-07-19

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  CHEMBURKAR SANJAY R ,  PATEL KETAN ,  SPIWEK HARRY O

IPC: C07D277/24 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: This Application concerns the use of Form II crystalline ritonavir as a pharmaceutical agent, as well as methods of preparing pharmaceutical compositions, which methods employ Form II crystalline ritonavir. The Application further concerns methods for obtaining Form I crystalline ritonavir, which methods employ Form II crystalline ritonavir.

公开(公告)号：ES2284684T3

公开(公告)日：2007-11-16

申请号：ES01966367

申请日：2001-08-29

Applicant: ABBOTT LAB

Inventor： CHEMBURKAR SANJAY R ,  PATEL KETAN M ,  SPIWEK HARRY O

IPC: C07D239/10 ,  C07B53/00 ,  C07D403/06 ,  C07D521/00

Abstract: 1. Un procedimiento para la preparación de un compuesto de la fórmula: donde R3 es alquilo inferior, hidroxialquilo o cicloalquilalquilo y P1 y P2 son independientemente seleccionados entre hidrógeno y un grupo N-protector, consistente en hacer reaccionar un compuesto de la fórmula: donde P1 y P2 son como se ha definido antes, en un solvente inerte con un compuesto de la fórmula: donde R3 es como se ha definido antes y R4 es un heterociclo que contiene nitrógeno, unido a través de un átomo de nitrógeno del anillo al grupo carbonilo, donde el heterociclo es seleccionado entre el grupo consistente en imidazolilo, pirrolilo, pirazolilo, 1, 2, 3-triazolilo, 1, 2, 4-triazolilo, tetrazolilo, indolilo, bencimidazolilo y benzotriazolilo.

公开(公告)号：PT1313712E

公开(公告)日：2007-07-25

申请号：PT01966367

申请日：2001-08-29

Applicant: ABBOTT LAB

Inventor： SPIWEK HARRY O ,  CHEMBURKAR SANJAY R ,  PATEL KETAN M

IPC: C07D239/10 ,  C07B53/00 ,  C07D403/06 ,  C07D521/00

公开(公告)号：AU2007202956A1

公开(公告)日：2007-07-19

申请号：AU2007202956

申请日：2007-06-27

Applicant: ABBOTT LAB

Inventor： SALEKI-GERHARDT AZITA ,  ALLEN KIMBERLY A ,  NARAYANAN BIKSHANDARKOIL A ,  SPIWEK HARRY O ,  BAUER JOHN F ,  CHEMBURKAR SANJAY R ,  PATEL KETAN ,  BAUER PHILIP E

IPC: C07D417/00

公开(公告)号：MY121765A

公开(公告)日：2006-02-28

申请号：MYPI9903007

申请日：1999-07-16

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOR A ,  CHEMBURKAR SANJAY R ,  PATEL KETAN M ,  SPIWEK HARRY O ,  BAUER PHILIP E ,  ALLEN KIMBERLY A

IPC: C07D277/24 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: THERE IS DISCLOSED A CRYSTALLINE POLYMORPH AND A GREATER THAN 90% PURE CRYSTALLINE POLYMORPH OF (2S, 3S, 5S)-5-(N-(N-((-METHYL-N-((2-ISOPROPYL-4-THIAZOLYL)ME-THYL)AMINO)CARBONYL)-L-VALINYL)AMINO)-2-(N-((5-THIAZOLYL)METHOXYCARBONYL)AMINO)-1, 6-DIPHENYL-3-HYDROXYHEXANE. IT HAS CHARACTERISTIC PEAKS IN THE POWDER X-RAY DIFFRACTION PATTERN AT VALUES OF TWO THETA OF 8.67°± 0.1, 9.88°±0.1°, 16.11° ± 0.1°, 16.70° ± 0.1°, 17.36° ± 0.1°, 17.78° ± 0.1°, 18.40° ± 0.1°, 18.93° ± 0.1° 20.07° ± 0.1°, 20.65° ± 0.1°, 21.71° ± 0.1° AND 25.38° ± 0.1°. A PROCESS FOR THE PREPARATION OF THE GREATER THAN 90% PURE CRYSTALLINE POLYMORPH IS ALSO DISCLOSED.

公开(公告)号：CA2502320A1

公开(公告)日：2004-05-06

申请号：CA2502320

申请日：2003-10-22

Applicant: ABBOTT LAB

Inventor： CHANG SOU-JEN ,  BENNANI YOUSSEF L ,  CHEMBURKAR SANJAY R ,  DART MICHAEL J ,  GRIEME TIMOTHY A ,  FERNANADO DILINIE P

IPC: A61K31/33 ,  A61K31/397 ,  A61K31/401 ,  A61K31/495 ,  A61K31/537 ,  A61K31/54 ,  A61K31/55 ,  A61P25/08 ,  C07C61/13 ,  C07C61/135 ,  C07C61/29 ,  C07C69/753 ,  C07C233/58 ,  C07C237/22 ,  A61K31/19 ,  C07C237/24

Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.

公开(公告)号：DK1097148T3

公开(公告)日：2004-04-26

申请号：DK99934143

申请日：1999-07-19

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOIL A ,  CHEMBURKAR SANJAY R ,  PATEL KETAN ,  SPIWEK HARRY O ,  BAUER PHILIP E ,  ALLEN KIMBERLY A

IPC: A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12 ,  A61K31/425

Abstract: This Application concerns the use of Form II crystalline ritonavir as a pharmaceutical agent, as well as methods of preparing pharmaceutical compositions, which methods employ Form II crystalline ritonavir. The Application further concerns methods for obtaining Form I crystalline ritonavir, which methods employ Form II crystalline ritonavir.

公开(公告)号：AT261947T

公开(公告)日：2004-04-15

申请号：AT99934143

申请日：1999-07-19

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOIL A ,  CHEMBURKAR SANJAY R ,  PATEL KETAN ,  SPIWEK HARRY O ,  BAUER PHILIP E ,  ALLEN KIMBERLY A

IPC: A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12 ,  A61K31/425

Abstract: This Application concerns the use of Form II crystalline ritonavir as a pharmaceutical agent, as well as methods of preparing pharmaceutical compositions, which methods employ Form II crystalline ritonavir. The Application further concerns methods for obtaining Form I crystalline ritonavir, which methods employ Form II crystalline ritonavir.

公开(公告)号：MXPA03001751A

公开(公告)日：2003-09-10

申请号：MXPA03001751

申请日：2001-08-29

Applicant: ABBOTT LAB

Inventor： CHEMBURKAR SANJAY R

IPC: C07B53/00 ,  C07D239/10 ,  C07D403/06 ,  C07D521/00