公开(公告)号：AU699579B2

公开(公告)日：1998-12-10

申请号：AU4255996

申请日：1995-11-25

Applicant: BASF AG

Inventor： BOHM HANS JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61P7/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087

公开(公告)号：SK104697A3

公开(公告)日：1998-11-04

申请号：SK104697

申请日：1996-02-12

Applicant: BASF AG

Inventor： BOHM HANS-JOACHIM ,  HOFFKEN HANS W ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495

Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.

公开(公告)号：AT166065T

公开(公告)日：1998-05-15

申请号：AT92913125

申请日：1992-06-23

Applicant: BASF AG

Inventor： MACK HELMUT ,  PFEIFFER THOMAS ,  HOEFFKEN HANS WOLFGANG ,  BOEHM HANS-JOACHIM ,  HORNBERGER WILFRIED

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  C07K1/113 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/078

Abstract: PCT No. PCT/EP92/01411 Sec. 371 Date Dec. 28, 1993 Sec. 102(e) Date Dec. 28, 1993 PCT Filed Jun. 23, 1992 PCT Pub. No. WO93/01208 PCT Pub. Date Jan. 21, 1993.2-Substituted 3-(4-amidinophenyl)propionic acid derivatives of the formula in which A, Ar and B have the meanings stated in the description, and the preparation thereof are described. The compounds are suitable for controlling diseases.

公开(公告)号：HRP950338A2

公开(公告)日：1997-10-31

申请号：HRP950338

申请日：1995-06-14

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFER THOMAS ,  SEITZ WERNER ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07C279/00 ,  C07D205/04 ,  C07D207/06 ,  C07D207/16 ,  C07D207/48 ,  C07D211/60 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078

Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.

公开(公告)号：FI973360A

公开(公告)日：1997-08-15

申请号：FI973360

申请日：1997-08-15

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  C07K

Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.

公开(公告)号：BR9508057A

公开(公告)日：1997-08-12

申请号：BR9508057

申请日：1995-06-06

Applicant: BASF AG

Inventor： BOHN HANS-JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07C279/00 ,  C07D205/04 ,  C07D207/06 ,  C07D207/16 ,  C07D207/48 ,  C07D211/60 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078

Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.

公开(公告)号：FI973282A

公开(公告)日：1997-08-08

申请号：FI973282

申请日：1997-08-08

Applicant: BASF AG

Inventor： SEITZ WERNER ,  MACK HELMUT ,  ZIERKE THOMAS ,  BOEHM HANS-JOACHIM ,  HOEFFKEN HANS WOLFGANG ,  KOSER STEFAN ,  PFEIFFER THOMAS ,  HORNBERGER WILFRIED

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087 ,  C07K

Abstract: PCT No. PCT/EP96/00472 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 6, 1996 PCT Pub. No. WO96/24609 PCT Pub. Date Aug. 15, 1996Thrombin inhibitors of the formula where R1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described. The compounds I are suitable for controlling diseases.

公开(公告)号：NO972559A

公开(公告)日：1997-08-05

申请号：NO972559

申请日：1997-06-05

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087 ,  A61K38/55

CPC classification number: C07K5/0812 ,  A61K38/00 ,  C07K5/06026 ,  C07K5/06043 ,  C07K5/06078 ,  C07K5/06113

公开(公告)号：SI9520075A

公开(公告)日：1997-06-30

申请号：SI9520075

申请日：1995-06-06

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07C279/00 ,  C07D205/04 ,  C07D207/06 ,  C07D207/16 ,  C07D207/48 ,  C07D211/60 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078 ,  C07C279/18 ,  C07C279/16 ,  A61K31/395

Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.

公开(公告)号：SK67596A3

公开(公告)日：1996-12-04

申请号：SK67596

申请日：1994-11-25

Applicant: BASF AG

Inventor： SCHWEDEN JURGEN ,  ECKES PETER ,  HORNBERGER WILFRIED ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.