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公开(公告)号：HU9802570A2
公开(公告)日：1999-04-28
申请号：HU9802570
申请日：1996-07-12
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANSSEN BERND , KLING ANDREAS , MUELLER STEFAN , RITTER KURT , ULRICH KARL , ZIERKE THOMAS
IPC: C07K1/02 , C07K1/12 , C07K5/06 , C07K5/078 , C07K5/08 , C07K5/083 , C07K5/10 , C07K5/103 , C07K7/06
Abstract: PCT No. PCT/EP96/03073 Sec. 371 Date Jan. 13, 1998 Sec. 102(e) Date Jan. 13, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/05162 PCT Pub. Date Feb. 13, 1997A process for preparing pentapeptides of the formula I where A and R1-R3 have the stated meanings, comprises assembling the pentapeptide stepwise starting from a prolinamide of the formula II where R1 and R2 have the abovementioned meanings, and eliminating the group -NR1R2 by hydrolysis where appropriate the peptide obtained in this way.
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公开(公告)号：AU8475898A
公开(公告)日：1999-02-10
申请号：AU8475898
申请日：1998-07-07
Applicant: BASF AG , BASF BIORESEARCH CORP
Inventor： JANSSEN BERND , BARLOZZARI TERESA , HAUPT ANDREAS , ZIERKE THOMAS , KLING ANDREAS
Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.
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公开(公告)号：HU9802329A2
公开(公告)日：1999-02-01
申请号：HU9802329
申请日：1996-08-29
Applicant: BASF AG
Inventor： AMBERG WILHELM , ELGER BERND , HERGENROEDER STEFAN , KLING ANDREAS , KLINGE DAGMAR , RASCHACK MANFRED , RIECHERS HARTMUT , SCHULT SABINE , UNGER LILIANE
IPC: A61K31/00 , A61K31/19 , A61K31/192 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/357 , C07D317/02 , A61K31/36 , A61K31/435 , A61K31/44 , A61K31/505 , A61P9/00 , A61P9/08 , C07C53/134 , C07C57/30 , C07C57/32 , C07C57/38 , C07C59/64 , C07C69/616 , C07C69/734 , C07C255/00 , C07D213/55 , C07D213/64 , C07D221/04 , C07D239/26 , C07D239/34 , C07D239/52 , C07D239/70 , C07D257/04 , C07D307/79 , C07D317/50 , C07D317/60 , C07D319/02 , C07D319/18 , A61K31/275 , A61K31/335 , A61K31/395
Abstract: PCT No. PCT/EP96/03793 Sec. 371 Date Feb. 24, 1998 Sec. 102(e) Date Feb. 24, 1998 PCT Filed Aug. 29, 1996 PCT Pub. No. WO97/09294 PCT Pub. Date Mar. 13, 1997Carboxylic acid derivatives of the formula I here R1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the meaning explained in the description.
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公开(公告)号：ZA9703098B
公开(公告)日：1998-10-12
申请号：ZA9703098
申请日：1997-04-11
Applicant: BASF AG
Inventor： RIECHERS HARTMUT , KLINGE DAGMAR , AMBERG WILHELM , KLING ANDREAS , HILLEN HEINZ , UNGER LILIANE , ELGER BERND
IPC: C07D251/30 , A61K31/00 , A61K31/505 , A61K31/517 , A61K31/529 , A61K31/53 , A61P7/00 , A61P9/00 , A61P9/02 , A61P9/12 , A61P13/00 , A61P13/08 , A61P13/12 , C07D239/34 , C07D239/46 , C07D239/52 , C07D239/60 , C07D239/70 , C07D251/48 , C07D403/12 , C07D491/044 , C07D , A61K
CPC classification number: C07D239/46
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公开(公告)号：NO984714D0
公开(公告)日：1998-10-09
申请号：NO984714
申请日：1998-10-09
Applicant: BASF AG
Inventor： RIECHERS HARTMUT , KLINGE DAGMAR , AMBERG WILHELM , KLING ANDREAS , HILLEN HEINZ , UNGER LILIANE , ELGER BERND
IPC: C07D251/30 , A61K31/00 , A61K31/505 , A61K31/517 , A61K31/529 , A61K31/53 , A61P7/00 , A61P9/00 , A61P9/02 , A61P9/12 , A61P13/00 , A61P13/08 , A61P13/12 , C07D239/34 , C07D239/46 , C07D239/52 , C07D239/60 , C07D239/70 , C07D251/48 , C07D403/12 , C07D491/044 , C07D
Abstract: The invention relates to carboxylic acid derivatives of the formulawhere the radicals have the meanings defined in the description, to the preparation of these compounds and to their use as drugs.
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Patent Agency Ranking
公开(公告)号：NO984714A
公开(公告)日：1998-10-09
申请号：NO984714
申请日：1998-10-09
Applicant: BASF AG
Inventor： RIECHERS HARTMUT , KLINGE DAGMAR , AMBERG WILHELM , KLING ANDREAS , HILLEN HEINZ , UNGER LILIANE , ELGER BERND
IPC: C07D251/30 , A61K31/00 , A61K31/505 , A61K31/517 , A61K31/529 , A61K31/53 , A61P7/00 , A61P9/00 , A61P9/02 , A61P9/12 , A61P13/00 , A61P13/08 , A61P13/12 , C07D239/34 , C07D239/46 , C07D239/52 , C07D239/60 , C07D239/70 , C07D251/48 , C07D403/12 , C07D491/044
CPC classification number: C07D239/46
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公开(公告)号：MX9803953A
公开(公告)日：1998-09-30
申请号：MX9803953
申请日：1998-05-19
Applicant: BASF AG
Inventor： AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT
IPC: A61K31/00 , A61K38/08 , A61P35/00 , A61K38/00 , A61P35/02 , C07K1/00 , C07K7/06 , C07K07/06 , C07K01/00
Abstract: Se describen péptidos novedosos de la formula R1R2N-CHX-CO-A-B-D-E-(G)s-k en donde R1, R2, A, B, D, E, G, K, X y s tienen los significados establecidos en la descripcion, así como la preparacion de los mismos. Los péptidos novedosos tienen un efecto antineoplásico.
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公开(公告)号：MX9801987A
公开(公告)日：1998-08-30
申请号：MX9801987
申请日：1998-03-13
Applicant: BASF AG
Inventor： KLINGE DAGMAR , AMBERG WILHELM , KLING ANDREAS , RIECHERS HARTMUT , UNGER LILIANE , RASCHACK MANFRED
IPC: A61K31/00 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/505 , A61K31/53 , A61P5/24 , A61P5/36 , A61P5/42 , A61P9/12 , C07D213/74 , C07D239/10 , C07D239/42 , C07D239/46 , C07D239/48 , C07D239/50 , C07D239/52 , C07D239/58 , C07D251/46 , C07D401/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , C07D491/052 , C07D491/056 , C07D239/32 , A61K31/50 , C07D239/70 , C07D487/02
Abstract: El invento se refiere a derivados de aminoácido de la formula I, en la que los radicales tienen el significado indicado en la descripcion, así como al uso de los mismos como medicamentos.
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公开(公告)号：PL325398A1
公开(公告)日：1998-07-20
申请号：PL32539896
申请日：1996-08-29
Applicant: BASF AG
Inventor： AMBERG WILHELM , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , UNGER LILIANE , RASCHACK MANFRED , HERGENROEDER STEFAN , ELGER BERND , SCHULT SABINE
IPC: A61K31/00 , A61K31/19 , A61K31/192 , A61K31/34 , A61K31/341 , C07D317/02 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/435 , A61K31/44 , A61K31/505 , A61P9/00 , A61P9/08 , C07C53/134 , C07C57/30 , C07C57/32 , C07C57/38 , C07C59/64 , C07C69/616 , C07C69/734 , C07C255/00 , C07D213/55 , C07D213/64 , C07D221/04 , C07D239/26 , C07D239/34 , C07D239/52 , C07D239/70 , C07D257/04 , C07D307/79 , C07D317/50 , C07D317/60 , C07D319/02 , C07D319/18
Abstract: PCT No. PCT/EP96/03793 Sec. 371 Date Feb. 24, 1998 Sec. 102(e) Date Feb. 24, 1998 PCT Filed Aug. 29, 1996 PCT Pub. No. WO97/09294 PCT Pub. Date Mar. 13, 1997Carboxylic acid derivatives of the formula I here R1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the meaning explained in the description.
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公开(公告)号：NO982711D0
公开(公告)日：1998-06-12
申请号：NO982711
申请日：1998-06-12
Applicant: BASF AG
Inventor： AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JUERGEN , ZIERKE THOMAS
Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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