公开(公告)号：ZA9809664B

公开(公告)日：2000-04-25

申请号：ZA9809664

申请日：1998-10-23

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD ,  BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS JUERGEN ,  WICKE KARSTEN

IPC: A61K31/519 ,  A61P1/00 ,  A61P1/14 ,  A61P3/04 ,  A61P5/00 ,  A61P9/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/04 ,  C07D ,  A61K

CPC classification number: C07D471/04

公开(公告)号：DE59507539D1

公开(公告)日：2000-02-03

申请号：DE59507539

申请日：1995-10-02

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  VIERLING MICHAEL ,  BEHL BERTHOLD ,  HOFMANN HANS

IPC: A61K31/495 ,  A61P25/00 ,  A61P43/00 ,  C07D403/04

Abstract: PCT No. PCT/EP95/03902 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Oct. 2, 1995 PCT Pub. No. WO90/11922 PCT Pub. Date Apr. 25, 1996Pyrrolyltetrahydrobenzoquinoxalinediones of the formula I I and their tautomeric and isomeric forms, and their physiologically tolerated salts, in which the variables have the meanings stated in the description, and the preparation thereof are described. The novel compounds are antagonists of the glutamate receptor subtypes and are thus suitable for controlling various diseases.

公开(公告)号：DE19817461A1

公开(公告)日：1999-10-21

申请号：DE19817461

申请日：1998-04-20

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  MOELLER ACHIM ,  TREIBER HANS-JOERG ,  KNOPP MONIKA

IPC: C07D295/08 ,  A61K31/18 ,  A61K31/27 ,  A61K31/4409 ,  A61K31/4418 ,  A61P9/00 ,  A61P13/12 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/02 ,  A61P43/00 ,  C07C233/78 ,  C07C235/42 ,  C07C237/34 ,  C07C311/21 ,  C07D213/56 ,  C07D295/096 ,  C07C311/18 ,  C07D213/24 ,  C12N9/99 ,  A61K31/165 ,  A61K31/395 ,  C07D227/02 ,  C07D247/00

Abstract: Benzamide derivatives (I) are new. Benzamide derivatives of formula (I) and their tautomers, isomers and salts are new: R = 1-6C alkyl optionally monosubstituted by Ar, cyclohexyl, indolyl or SMe; Ar = phenyl optionally substituted by 1-2 R groups; R = H, 1-4C alkyl, 1-4C alkoxy, OH, halogen, CN, COOH, 2-5C alkoxycarbonyl or 2-5C alkanoylamino; R = N(R )COR or N(R )SO2R ; R = halogen, 1-6C alkyl, 2-5C alkanoylamino, 1-4C alkylsulfonylamino, NO2, 1-4C alkoxy, CN, COOH, CONH2, 2-5C alkoxycarbonyl, 1-4C alkylsulfonyl, phenylsulfonyl, 1-4C alkylsulfamoyl, SO2NH2 or NH2; A = aryl or heteroaryl, e.g. naphthyl, quinolyl, quinoxalinyl, benzimidazolyl, benzothienyl, quinazolinyl, phenyl, thienyl, imidazolyl, pyridyl, pyrimidinyl or pyridazinyl, all optionally substituted by R and 0-2 R groups; B = a bond; (CH2)m, (CH2)mQ(CH2)o, CH=CH, ethynylene, COCH=CH or NHCOCH=CH; Q = O, S, SO, SO2, CO, NHCO, CONH, NHSO2 or SO2NH; or A-B = a group of formula (i)-(iv): R = H or 1-4C alkyl; R = H, phenyl, naphthyl, or 1-6C alkyl optionally substituted by Ar; R = H, 1-4C alkyl, 1-4C alkoxy, OH, halogen, CF3, NO2, NH2, CN, COOH, 2-5C alkoxycarbonyl, 2-5C alkanoylamino, phenyl, benzamido, 1-4C alkylsulfonylamino, phenylsulfonylamino, 1-4C alkylsulfonyl, pyridyl or phenylsulfonyl; R = H or (CH2)pR ; R = pyrrolidinyl, morpholinyl, piperidyl, homopiperazinyl, NR R or 4-R -1-piperazinyl; R = 1-6C alkyl optionally substituted by Ar'; Ar' = phenyl optionally substituted by 1-2 R groups; R = H, 1-4C alkyl, 1-4C alkoxy, OH, halogen, CF3, NO2, NH2, CN, COOH, 2-5C alkoxycarbonyl, 2-5C alkanoylamino, 1-4C alkylsulfonylamino or 1-4C alkylsulfonyl; R = H or 1-6C alkyl; n = 0-2; m, q (sic; o and p are not defined) = 0-4.

公开(公告)号：PL332720A1

公开(公告)日：1999-10-11

申请号：PL33272097

申请日：1997-09-23

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  MOELLER ACHIM ,  DELZER JUERGEN

IPC: A61K31/445 ,  A61K31/4523 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/5355 ,  A61P9/10 ,  A61P25/14 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D211/62 ,  C07D213/40 ,  C07D295/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/06 ,  C07D413/12 ,  C07D413/14

Abstract: Piperidineketocarboxylic acid derivatives of the general formula Iand their tautomeric and isomeric forms, and physiologically tolerable salts thereof, where the variables have the meanings given in the description, preparation of these compounds and their use as drugs.

公开(公告)号：SK23099A3

公开(公告)日：1999-08-06

申请号：SK23099

申请日：1997-08-22

Applicant: BASF AG

Inventor： STEINER GERD ,  LUBISCH WILFRIED ,  BACH ALFRED ,  EMLING FRANZ ,  WICKE KARSTEN ,  TESCHENDORF HANS-JURGEN ,  BEHL BERTHOLD ,  KERRRIGAN FRANK ,  CHEETHAM SHARON

IPC: A61K31/435 ,  A61K31/519 ,  A61P25/24 ,  A61P43/00 ,  C07D211/00 ,  C07D239/00 ,  C07D333/00 ,  C07D495/14

Abstract: The invention concerns 3-substituted 3,4,5,6,7,8-hexahydro- pyrid3':4,5]thieno-[2,3-d]pyrimidine derivatives of formula (I), their physiologically acceptable salts and use in the therapy.

公开(公告)号：CZ9901268A3

公开(公告)日：1999-07-14

申请号：CZ126899

申请日：1997-09-23

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  MOLLER ACHIM ,  DELZER JURGEN

IPC: A61K31/445 ,  A61K31/4523 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/5355 ,  A61P9/10 ,  A61P25/14 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D211/62 ,  C07D213/40 ,  C07D295/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/06 ,  C07D413/12 ,  C07D413/14

CPC classification number: C07D401/06 ,  C07D211/62 ,  C07D401/12

公开(公告)号：CZ126899A3

公开(公告)日：1999-07-14

申请号：CZ126899

申请日：1997-09-23

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  MOLLER ACHIM ,  DELZER JURGEN

IPC: A61K31/445 ,  A61K31/4523 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/5355 ,  A61P9/10 ,  A61P25/14 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D211/62 ,  C07D213/40 ,  C07D295/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/06 ,  C07D413/12 ,  C07D413/14

Abstract: Piperidineketocarboxylic acid derivatives of the general formula Iand their tautomeric and isomeric forms, and physiologically tolerable salts thereof, where the variables have the meanings given in the description, preparation of these compounds and their use as drugs.

公开(公告)号：NO992821A

公开(公告)日：1999-06-11

申请号：NO992821

申请日：1999-06-10

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  M LLER ACHIM ,  TREIBER HANS-J RG

IPC: C07D295/12 ,  A61K31/16 ,  A61K31/166 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4164 ,  A61K31/4402 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/4468 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/496 ,  A61K31/498 ,  A61K31/5355 ,  A61K31/5375 ,  A61K31/5377 ,  A61P9/10 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07C233/87 ,  C07C237/22 ,  C07C237/36 ,  C07C237/42 ,  C07C311/19 ,  C07C311/21 ,  C07D211/58 ,  C07D213/56 ,  C07D215/12 ,  C07D215/36 ,  C07D215/48 ,  C07D233/54 ,  C07D233/61 ,  C07D241/42 ,  C07D241/44 ,  C07D295/02 ,  C07D295/13 ,  C07D333/38 ,  C07D333/56 ,  C07D333/60 ,  C07D401/12 ,  C07D521/00 ,  C07K5/02

CPC classification number: C07D295/13 ,  C07C237/36 ,  C07C311/19 ,  C07C311/21 ,  C07D211/58 ,  C07D213/56 ,  C07D215/12 ,  C07D215/36 ,  C07D215/48 ,  C07D231/12 ,  C07D233/56 ,  C07D241/42 ,  C07D241/44 ,  C07D249/08 ,  C07D333/38 ,  C07D333/60 ,  C07K5/0205

公开(公告)号：NO992821D0

公开(公告)日：1999-06-10

申请号：NO992821

申请日：1999-06-10

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  MUELLER ACHIM ,  TREIBER HANS-J RG

IPC: C07D295/12 ,  A61K31/16 ,  A61K31/166 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4164 ,  A61K31/4402 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/4468 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/496 ,  A61K31/498 ,  A61K31/5355 ,  A61K31/5375 ,  A61K31/5377 ,  A61P9/10 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07C233/87 ,  C07C237/22 ,  C07C237/36 ,  C07C237/42 ,  C07C311/19 ,  C07C311/21 ,  C07D211/58 ,  C07D213/56 ,  C07D215/12 ,  C07D215/36 ,  C07D215/48 ,  C07D233/54 ,  C07D233/61 ,  C07D241/42 ,  C07D241/44 ,  C07D295/02 ,  C07D295/13 ,  C07D333/38 ,  C07D333/56 ,  C07D333/60 ,  C07D401/12 ,  C07D521/00 ,  C07K5/02

Abstract: PCT No. PCT/EP97/06655 Sec. 371 Date Jun. 8, 1999 Sec. 102(e) Date Jun. 8, 1999 PCT Filed Nov. 28, 1997 PCT Pub. No. WO98/25883 PCT Pub. Date Jun. 18, 1998The patent describes ketobenzamides of the formula where R1, R2, R3, R4, X and n have the meanings given in the description, and their preparation. The novel compounds are useful for controlling disorders.

公开(公告)号：NO992770L

公开(公告)日：1999-06-08

申请号：NO992770

申请日：1999-06-08

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  M LLER ACHIM ,  TREIBER HANS-J RG

IPC: A61K31/403 ,  A61K31/4035 ,  A61K31/405 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61P9/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/28 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D209/48 ,  C07D209/66 ,  C07D239/70 ,  C07D239/96 ,  C07D401/12 ,  C07D471/04 ,  C07D475/02 ,  A61K31/40

Abstract: Heterocyclically substituted benzamides of the formula Iare described, where R1, R2, R3, R4, R5, X, m and n have the meanings given in the description. The novel compounds are useful for controlling diseases.