公开(公告)号：ES2207226T3

公开(公告)日：2004-05-16

申请号：ES99924920

申请日：1999-05-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG

IPC: B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08

Abstract: A process for the preparation of racemic amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III and the amine of the formula R3NH2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.

公开(公告)号：ES2205824T3

公开(公告)日：2004-05-01

申请号：ES99923569

申请日：1999-05-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG

IPC: B01J23/88 ,  B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/00 ,  C07C209/68 ,  C07C209/86 ,  C07C209/88 ,  C07C211/03 ,  C07C213/08 ,  C07C217/08

公开(公告)号：DE59906807D1

公开(公告)日：2003-10-02

申请号：DE59906807

申请日：1999-05-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08

Abstract: A process for the preparation of racemic amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III and the amine of the formula R3NH2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.

公开(公告)号：AT248140T

公开(公告)日：2003-09-15

申请号：AT99924920

申请日：1999-05-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08

Abstract: A process for the preparation of racemic amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III and the amine of the formula R3NH2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.

公开(公告)号：DE59906464D1

公开(公告)日：2003-09-04

申请号：DE59906464

申请日：1999-05-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/88 ,  B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/00 ,  C07C209/68 ,  C07C209/86 ,  C07C209/88 ,  C07C211/03 ,  C07C213/08 ,  C07C217/08

公开(公告)号：NO313519B1

公开(公告)日：2002-10-14

申请号：NO992976

申请日：1999-06-17

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: C07D253/06 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61K31/53 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/08 ,  C07D237/14 ,  C07D237/16 ,  C07D241/18 ,  C07D253/07 ,  C07D253/075 ,  C07D253/10 ,  C07D403/12 ,  C07D491/04

Abstract: The present invention relates to carboxylic acid derivatives of the formula Iwhere the substituents have the meanings explained in the description, and to preparation and use as endothelin receptor antagonists.

公开(公告)号：ZA200107485B

公开(公告)日：2002-09-11

申请号：ZA200107485

申请日：2001-09-11

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08 ,  C07C ,  C07B

Abstract: A process for the preparation of racemic amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III and the amine of the formula R3NH2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.

公开(公告)号：CZ20012186A3

公开(公告)日：2002-07-17

申请号：CZ20012186

申请日：1999-12-09

Applicant: BASF AG

Inventor： AMBERG WILJHEM ,  JANSEN ROLF ,  KETTSCHAU GEORG ,  RIECHERS HARTMUT ,  BAUMANN ERNST ,  HERGENRODER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: C07D251/24 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P15/10 ,  A61P35/00 ,  A61P43/00 ,  C07C229/34 ,  C07C233/87 ,  C07C235/52 ,  C07D239/34 ,  C07D251/22 ,  C07D401/12 ,  C07D491/048 ,  C07D403/12 ,  A61P9/00 ,  A61P13/00

Abstract: The invention relates to carboxylic acid derivatives of formula (I), in which the substituents have the following meanings: R is tetrazol or a group (a); W and Z, can be identical or different and are nitrogen or methine, provided that if W and Z are methine, then Q is nitrogen; X is nitrogen or CR ; Y is nitrogen or CR ; Q is nitrogen or CR , provided that if Q is nitrogen then X is CR and Y is CR ; R and R are identical or different and are possibly substituted phenyl or naphthyl or phenyl or naphthyl which are linked in an ortho position via a direct bond, a methlyene, ethylene or ethenylene group, an oxygen or sulfur atom or a SO2-, NH- or N-alkyl group or possibly substituted C5-C6-cycloalkyl; R is a rest (b) or (c); and R is hydrogen, C1-C4-alkyl. The invention further relates to their preparation and their use as endothelin receptor antagonists. The invention also relates to compounds of formula (II) and a structural fragment of formula (d) in which the rests R , R , R , R and R have the meanings given in claim no. 1 and to their use as structural elements in an endothelin receptor antagonist.

公开(公告)号：HRP950115B1

公开(公告)日：2001-12-31

申请号：HRP950115

申请日：1995-03-09

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  KROEGER BURGHARD ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: C07D251/26 ,  A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I

公开(公告)号：GR3036606T3

公开(公告)日：2001-12-31

申请号：GR20010401467

申请日：2001-09-12

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  KROEGER BURKHARD ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: C07D251/26 ,  A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I