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公开(公告)号：GR3030371T3
公开(公告)日：1999-09-30
申请号：GR990401463
申请日：1999-05-28
Applicant: BASF AG
Inventor： HELLENDAHL BEATE , LANSKY ANNEGRET , MUNSCHAUER RAINER , BIALOJAN SIEGFRIED , UNGER LILIANE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN , DRESCHER KARLA
IPC: C07D249/08 , A61K31/41 , A61K31/435 , A61K31/4427 , A61K31/445 , A61K31/505 , A61K31/53 , A61P1/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D249/12 , C07D249/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
Abstract: PCT No. PCT/EP95/02781 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02520 PCT Pub. Date Feb. 1, 1996The present invention relates to triazole compounds of the following formula: where R1, R2, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
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公开(公告)号：AU2624799A
公开(公告)日：1999-09-20
申请号：AU2624799
申请日：1999-02-25
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , KLINGE DAGMAR , RIECHERS HARTMUT , HERGENRODER STEFAN , RASCHACK MANFRED , UNGER LILIANE
IPC: C07D251/22 , A61K31/192 , A61K31/216 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/53 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , A61P13/12 , A61P35/00 , A61P43/00 , C07C59/66 , C07C59/68 , C07C69/734 , C07D213/63 , C07D239/34 , C07D239/52 , C07D239/60 , C07D405/12 , C07D491/048 , C07D403/12 , C07D213/64
Abstract: The invention relates to carboxylic acid derivatives of formula (I), wherein R -R , Q, W, X, Y and Z have the meanings given in the description. The novel compounds are suitable for combating diseases.
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公开(公告)号：BG102362A
公开(公告)日：1999-08-31
申请号：BG10236298
申请日：1998-04-01
Applicant: BASF AG
Inventor： KLINGE DAGMAR , AMBERG WILHELM , KLING ANDREAS , RIECHERS HARTMUT , UNGER LILIANE , RASCHACK MANFRED
IPC: A61K31/00 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/505 , A61K31/53 , A61P5/24 , A61P5/36 , A61P5/42 , A61P9/12 , C07D213/74 , C07D239/10 , C07D239/42 , C07D239/46 , C07D239/48 , C07D239/50 , C07D239/52 , C07D239/58 , C07D251/46 , C07D401/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , C07D491/052 , C07D491/056 , C07D239/70 , C07D487/02 , C07D251/42
Abstract: The invention relates to derivatives of aminoacids with theformulawhere the radicals have the meanings listed in the description, aswell as to their use as medicamentous forms.4 claims
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公开(公告)号：HU9901590A2
公开(公告)日：1999-08-30
申请号：HU9901590
申请日：1997-01-10
Applicant: BASF AG
Inventor： BLANK STEFAN , STARCK DOROTHEA , TESCHENDORF HANS-JUERGEN , TREIBER HANS-JOERG , UNGER LILIANE , WICKE KARSTEN
IPC: C07D243/08 , A61K31/00 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/505 , A61K31/506 , A61K31/55 , A61K31/551 , A61K31/5513 , A61P25/18 , A61P43/00 , C07D213/73 , C07D223/04 , C07D245/02 , C07D401/04 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
Abstract: Aza- and diazacyclohexane and -cyclooctane compounds of the following formula:where Ar1, A, B and Ar2 have the meanings stated in the description have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
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公开(公告)号：DK0592453T3
公开(公告)日：1999-08-23
申请号：DK92908760
申请日：1992-05-11
Applicant: BASF AG
Inventor： TESCHENDORF HANS-JUERGEN , RENDENBACH-MUELLER BEATRICE , UNGER LILIANE
IPC: A61K31/395 , A61K31/433 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/41 , A61K31/495 , A61K31/496 , A61K31/506 , A61P9/12 , A61P25/00 , A61P25/16 , A61P25/18 , A61P43/00 , C07D285/12 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14
Abstract: PCT No. PCT/EP92/01028 Sec. 371 Date Dec. 13, 1993 Sec. 102(e) Date Dec. 13, 1993 PCT Filed May 11, 1992 PCT Pub. No. WO92/22541 PCT Pub. Date Dec. 23, 1992.Aminoalkyl-substituted 2-amino-1,3,4-thiadiazoles of the formula I where n and A have the meanings stated in the description, and the preparation thereof are described. The compounds are suitable for controlling diseases.
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Patent Agency Ranking
公开(公告)号：DE19806438A1
公开(公告)日：1999-08-19
申请号：DE19806438
申请日：1998-02-17
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , HERGENROEDER STEFAN , RASCHACK MANFRED , UNGER LILIANE
IPC: A61K31/505 , A61K31/506 , A61P5/14 , A61P9/02 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/12 , A61P35/00 , A61P43/00 , C07D239/34 , C07D239/46 , C07D239/52 , C07D239/60 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
Abstract: Pyrimidinyloxy-propionic acid derivatives (I) are new. Also new are combinations of (I) with inhibitors of the renin-angiotensin system, beta -blockers, diuretics, calcium antagonists and VEGF blockers. (Pyrimidin-2-yloxy)-propionic acid derivatives of formula (I) and their salts are new: R = tetrazolyl or C(O)R; R = OR , N-bonded heteroaryl optionally substituted with halo, alkyl or alkoxy, -O-(CH2)p-S(O)k-R or -NH-SO2-R ; R = H, an alkali or alkaline earth cation, NH4 , an organic ammonium ion, cycloalkyl, alkyl, optionally substituted benzyl, optionally halogenated alkenyl or alkynyl or optionally substituted phenyl; R = alkyl, cycloalkyl, alkenyl, alkynyl or optionally substituted phenyl; k = 0-2; p = 1-4; R = optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl or phenyl; R = H, OH, NH2, NH(alkyl), N(alkyl)2, halo, alkyl, alkenyl, alkynyl, hydroxyalkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio or morpholinyl; X = halo, haloalkyl or OH; R = H, OH, NH2, NH(alkyl), N(alkyl)2, halo, alkyl, alkenyl, alkynyl, hydroxyalkyl, haloalkyl, alkoxy, haloalkoxy, -NH-O-alkyl or alkylthio; R , R = optionally substituted phenyl or naphthyl; phenyl or naphthyl ortho-linked with one another via a bond, methylene, ethylene, ethenylene, O, S, SO2, NH or N(alkyl); optionally substituted heteroaryl; or cycloalkyl; Z' = S, O, or a single bond; and R = H (when Z = S or O), optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, naphthyl or heteroaryl. The full definitions are given in the DEFINITIONS (Full Definitions) Field. An Independent claim is also included for combinations of (I) with inhibitors of the renin-angiotensin system, beta -blockers, diuretics, calcium antagonists and VEGF blockers.
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公开(公告)号：FI103667B1
公开(公告)日：1999-08-13
申请号：FI935399
申请日：1993-12-02
Applicant: BASF AG
Inventor： STEINER GERD , UNGER LILIANE , BEHL BERTHOLD , TESCHENDORF HANS-JUERGEN
IPC: A61K31/40 , C07D20060101 , C07D209/52
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公开(公告)号：ES2131842T3
公开(公告)日：1999-08-01
申请号：ES95926895
申请日：1995-07-14
Applicant: BASF AG
Inventor： HELLENDAHL BEATE , LANSKY ANNEGRET , MUNSCHAUER RAINER , BIALOJAN SIEGFRIED , UNGER LILIANE , TESCHENDORF HANS-JURGEN
IPC: C07D249/08 , A61K31/41 , A61K31/435 , A61K31/4427 , A61K31/445 , A61K31/505 , A61K31/53 , A61P1/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D249/12 , C07D249/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
Abstract: PCT No. PCT/EP95/02781 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02520 PCT Pub. Date Feb. 1, 1996The present invention relates to triazole compounds of the following formula: where R1, R2, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
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公开(公告)号：DK0589903T3
公开(公告)日：1999-06-07
申请号：DK92909823
申请日：1992-05-08
Applicant: BASF AG
Inventor： RENDENBACH-MUELLER BEATRICE , UNGER LILIANE , TESCHENDORF HANS-JUERGEN
IPC: A61K31/435 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/496 , A61P9/12 , A61P25/16 , A61P25/18 , C07D277/20 , C07D277/40 , C07D277/54 , C07D417/12 , C07D417/14
Abstract: PCT No. PCT/EP92/01004 Sec. 371 Date Dec. 13, 1993 Sec. 102(e) Date Dec. 13, 1993 PCT Filed May 8, 1992 PCT Pub. No. WO92/22540 PCT Pub. Date Dec. 23, 1992.Aminoalkyl-substituted 5-mercaptothiazoles of the formula where R1, n and A have the meanings stated in the description, and the preparation thereof are described. The compounds are suitable for controlling diseases.
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公开(公告)号：AU1487899A
公开(公告)日：1999-06-07
申请号：AU1487899
申请日：1998-11-04
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , HILLEN HEINZ , HERGENRODER STEFAN , RASCHACK MANFRED , UNGER LILIANE
IPC: C07D249/12 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/433 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , A61P13/12 , A61P35/00 , A61P43/00 , C07D231/20 , C07D233/70 , C07D261/12 , C07D263/38 , C07D271/06 , C07D271/10 , C07D273/01 , C07D275/02 , C07D275/03 , C07D277/20 , C07D277/32 , C07D277/34 , C07D277/60 , C07D277/68 , C07D285/00 , C07D285/08 , C07D285/12 , C07D291/04 , C07D413/12 , C07D417/12
Abstract: The present invention relates to carboxylic acid derivatives of the formula Ithe substituents having the meanings explained in the description, preparation and use as endothelin receptor antagonists.
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