公开(公告)号：IN176220B

公开(公告)日：1996-03-16

申请号：IN761CA1993

申请日：1993-12-06

Applicant: HOECHST AG

Inventor： PAPENFUHS THEODOR ,  PLANKER SIEGFRIED

IPC: C07C87/60

公开(公告)号：DE59106559D1

公开(公告)日：1995-10-26

申请号：DE59106559

申请日：1991-10-16

Applicant: HOECHST AG

Inventor： SCHACH THOMAS ,  PAPENFUHS THEODOR ,  HACKENBRUCH JOACHIM

IPC: B01J23/44 ,  C07B37/04 ,  C07B61/00 ,  C07C1/26 ,  C07C15/14 ,  C07C15/24 ,  C07C17/26 ,  C07C25/18 ,  C07C25/22 ,  C07C41/30 ,  C07C43/20 ,  C07C43/205 ,  C07C315/04 ,  C07C317/14

公开(公告)号：DE59106553D1

公开(公告)日：1995-10-26

申请号：DE59106553

申请日：1991-06-08

Applicant: HOECHST AG

Inventor： PAPENFUHS THEODOR ,  KANSCHIK-CONRADSEN ANDREAS ,  PRESSLER WILFRIED

IPC: B01J31/02 ,  C07B61/00 ,  C07C201/12 ,  C07C201/14 ,  C07C205/12

Abstract: PCT No. PCT/EP92/01079 Sec. 371 Date Dec. 22, 1992 Sec. 102(e) Date Dec. 22, 1992 PCT Filed Jun. 8, 1991 PCT Pub. No. WO91/00270 PCT Pub. Date Jan. 9, 1992A process for the preparation of chlorofluoronitrobenzenes and difluoronitrobenzenes, which comprises heating dichloronitrobenzene to not more than 200 DEG C. in excess with an alkali metal fluoride having a total water content of about 0.2 to about 2.5% by weight in the presence of a quaternary ammonium and/or phosphonium salt, crown ether and/or polyethylene glycol dimethyl ether as catalyst in the absence of a solvent.

公开(公告)号：HUT66738A

公开(公告)日：1994-12-28

申请号：HU9400950

申请日：1994-04-01

Applicant: HOECHST AG

Inventor： FOLZ GEORG ,  PAPENFUHS THEODOR

IPC: C07C313/04 ,  C07C315/00 ,  C07C315/04 ,  C07C317/14 ,  C07C317/44 ,  C07C313/02 ,  C07C309/87

Abstract: Process for the preparation of 4-alkyl-3-chloroalkylsulphonylbenzenes of the formula (1) in which R and R are identical or different and denote (C1-C4)-alkyl, by chlorinating p-alkylbenzenesulphonyl chloride of the formula (2) in which R has the abovementioned meaning, with at least one mole of chlorine in the presence of a chlorine donor at temperatures of approximately 50 to approximately 100@C to give a compound of the general formula (3) in which R has the abovementioned meaning, and this compound is subsequently reduced using sodium hydrogen sulphite or sodium sulphite in an aqueous medium at temperatures of approximately 40 to approximately 90@C to give a compound of the general formula (4) in which R has the abovementioned meaning, and this compound is subjected to a condensation reaction with an alpha -halocarboxylic acid of the general formula (5) in which R is hydrogen or (C1-C3)-alkyl and X is bromine or chlorine, or one of its salts, to give a 4-alkyl-3-chlorobenzenesulphonylcarboxylic acid of the general formula (6) in which R and R have the abovementioned meaning, or one of its salts, and this compound is subsequently decarboxylated by heating. The invention furthermore relates to compounds of the formula (1) in which R is (C1-C4)-alkyl and R is (C2-C4)-alkyl or R is (C2-C4)-alkyl and R is (C1-C4)-alkyl, and to compounds of the formula (4) in which R is (C1-C4)-alkyl, and to compounds of the formula (6) in which R is hydrogen or (C1-C3)-alkyl and R is (C1-C4)-alkyl, and to the corresponding alkali metal salts.

公开(公告)号：IN174448B

公开(公告)日：1994-12-10

申请号：IN405CA1992

申请日：1992-06-05

Applicant: HOECHST AG

Inventor： PAPENFUHS THEODOR ,  KANCHIK-CONRADSEN ANDREAS

IPC: A01N29/00 ,  A01N29/08 ,  A01N35/00 ,  A01N35/04 ,  A61K31/03 ,  A61K31/11 ,  C07C47/54 ,  C07C47/55

公开(公告)号：CA2120419A1

公开(公告)日：1994-10-04

申请号：CA2120419

申请日：1994-03-31

Applicant: HOECHST AG

Inventor： FOLZ GEORG ,  PAPENFUHS THEODOR

IPC: C07C313/04 ,  C07C315/00 ,  C07C315/04 ,  C07C317/14 ,  C07C317/44

Abstract: of the disclosure 4-Alkyl-3-chlorobenzenesulfinic acids, 4-alkyl-3-chloro-benzenesulfonylcarboxylic acids, 4-alkyl-3-chloroalkyl-sulfonylbenzenes and preparation thereof Process for preparing 4-alkyl-3-chloroalkylsulfonyl-benzenes of the formula (1) (1) in which R1 and R2 are identical or different and are each (C1-C4)-alkyl, by chlorinating a p-alkylbenzene-sulfonyl chloride of the formula (2) (2) in which R1 is as defined above, with at least 1 mol of chlorine in the presence of a chlorine transferrer at temperatures from about 50 to about 100.degree.C to form a compound of the formula (3) (3) in which R1 is as defined above, subsequently reducing this compound in aqueous medium with sodium sulfite or bisulfite at temperatures from about 40 to about 90.degree.C to form a compound of the formula (4) (4) in which R1 is as defined above, condensing this compound with an .alpha.-halocarboxylic acid of the formula (5) (5) in which R is hydrogen or (C1-C3)-alkyl and X is bromine or chlorine, or a salt thereof, to form a 4-alkyl-3-chlorobenzensulfonylcarboxylic acid of the formula (6), in which R1 and R are as defined above, or a salt thereof (6) and subsequently decarboxylating it by heating. The invention also relates to compounds of the formula (1) in which R1 is (C1-C4)-alkyl and R2 is (C2-C4)-alkyl or R1 is (C2-C4)-alkyl and R2 is (C1-C4)-alkyl and also to compounds of the formula (4) is which R1 is (C1-C4)-alkyl and compounds of the formula (6) in which R is hydrogen or (C1-C3)-alkyl and R1 is (C1-C4)-alkyl and the corresponding alkali metal salts.

公开(公告)号：CA2113973A1

公开(公告)日：1994-07-24

申请号：CA2113973

申请日：1994-01-21

Applicant: HOECHST AG

Inventor： PFIRMANN RALF ,  PAPENFUHS THEODOR

IPC: C07C51/08 ,  C07C63/70 ,  C07C253/14 ,  C07C253/30 ,  C07C255/50 ,  C07C255/49

Abstract: 2,3-Difluoro-6-nitrobenzonitrile and 2 chloro-5,6-di-fluorobenzonitrile, process for their preparation and their use for the preparation of 2,3,6 trifluorobenzoic acid The present invention describes the novel intermediates 2,3-difluoro-6-nitrobenzonitrile and 2-chloro-5,6-di-fluorobenzonitrile, a process for their preparation and their advantageous use for the preparation of 2,3,6trifluorobenzoic acid, which in turn is a valuable intermediate for the preparation of insecticides and antibacterial agents. The intermediates according to the invention are prepared from 2,3,4-trifluoronitrobenzene by fluorine/cyanide exchange and subsequent denitrating chlorination. 2,3,6-Trifluorobenzoic acid can be prepared from the novel intermediates, in a manner known per se in the literature, by simple chlorine/fluorine exchange and subsequent hydrolysis in a process which overall is industrially advantageous and economically favorable.

公开(公告)号：HU9400950D0

公开(公告)日：1994-06-28

申请号：HU9400950

申请日：1994-04-01

Applicant: HOECHST AG

Inventor： FOLZ GEORG ,  PAPENFUHS THEODOR

IPC: C07C313/04 ,  C07C315/00 ,  C07C315/04 ,  C07C317/14 ,  C07C317/44

Abstract: Process for the preparation of 4-alkyl-3-chloroalkylsulphonylbenzenes of the formula (1) in which R and R are identical or different and denote (C1-C4)-alkyl, by chlorinating p-alkylbenzenesulphonyl chloride of the formula (2) in which R has the abovementioned meaning, with at least one mole of chlorine in the presence of a chlorine donor at temperatures of approximately 50 to approximately 100@C to give a compound of the general formula (3) in which R has the abovementioned meaning, and this compound is subsequently reduced using sodium hydrogen sulphite or sodium sulphite in an aqueous medium at temperatures of approximately 40 to approximately 90@C to give a compound of the general formula (4) in which R has the abovementioned meaning, and this compound is subjected to a condensation reaction with an alpha -halocarboxylic acid of the general formula (5) in which R is hydrogen or (C1-C3)-alkyl and X is bromine or chlorine, or one of its salts, to give a 4-alkyl-3-chlorobenzenesulphonylcarboxylic acid of the general formula (6) in which R and R have the abovementioned meaning, or one of its salts, and this compound is subsequently decarboxylated by heating. The invention furthermore relates to compounds of the formula (1) in which R is (C1-C4)-alkyl and R is (C2-C4)-alkyl or R is (C2-C4)-alkyl and R is (C1-C4)-alkyl, and to compounds of the formula (4) in which R is (C1-C4)-alkyl, and to compounds of the formula (6) in which R is hydrogen or (C1-C3)-alkyl and R is (C1-C4)-alkyl, and to the corresponding alkali metal salts.

公开(公告)号：CA2103303A1

公开(公告)日：1994-05-19

申请号：CA2103303

申请日：1993-11-17

Applicant: HOECHST AG

Inventor： SCHACH THOMAS ,  PAPENFUHS THEODOR

IPC: B01J23/44 ,  C07B39/00 ,  C07B61/00 ,  C07C17/00 ,  C07C17/23 ,  C07C25/13 ,  C07D213/61 ,  C07C17/24

Abstract: of the disclosure Process for preparing 1,3-difluorobenzene Process for preparing 1,3-difluorobenzene by means of the catalytic elimination of halogen from a 1,3-difluorohalo-benzene, by reacting a 1,3-difluorohalobenzene of the formula (1) (1) in which R1 to R4 are H, Cl or Br, and at least one of the radicals R1 to R4 is Cl or Br, in the presence of a palladium catalyst and of an amine, where appropriate in the presence of water or of an organic solvent which is inert towards the reactants and the reaction conditions, with hydrogen under pressure and at temperatures from about 70.degree. to about 140.degree.C.

公开(公告)号：AU648923B2

公开(公告)日：1994-05-05

申请号：AU2100892

申请日：1992-08-14

Applicant: HOECHST AG

Inventor： PAPENFUHS THEODOR ,  RAPP JOCHEN

IPC: B01J27/122 ,  C07B61/00 ,  C07C227/08 ,  C07C229/56 ,  C07C229/38

Abstract: The present invention relates to a process for the preparation of 2-amino-3-chlorobenzoic acid by dissolving 1 mol of 2,3-dichlorobenzoic acid in about 400 to about 2000 parts of water with at least the equimolar amount of an alkali metal hydroxide or with an aqueous solution of the equimolar amount of an alkali metal hydroxide, and subsequently reacting it with about 500 to about 2500 mol % of ammonia at temperatures of about 150 DEG to about 220 DEG C. in the presence of copper bronze, copper(I) salts and/or copper(II) salts.