公开(公告)号：NO784366L

公开(公告)日：1979-06-26

申请号：NO784366

申请日：1978-12-22

Applicant: HOECHST AG

Inventor： BLUMBACH JUERGEN ,  DUERCKHEIMER WALTER ,  SCHRINNER ELMAR

IPC: C07D501/06 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D277/46 ,  C07D501/34 ,  C07D

Abstract: Cephalosporin derivatives of the formula I processes for their manufacture and their use for combating bacterial infections.

公开(公告)号：FI781131A

公开(公告)日：1978-10-16

申请号：FI781131

申请日：1978-04-13

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  EHLERS EBERHARD ,  SELIGER HUBERT ,  SCHRINNER ELMAR

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61K31/675 ,  A61K31/695 ,  A61P31/04 ,  B23K1/18 ,  B23Q5/033 ,  C07D20060101 ,  C07D277/20 ,  C07D277/40 ,  C07D501/00 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D501/60 ,  C07D519/06 ,  C07D

Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.

公开(公告)号：NO781130L

公开(公告)日：1978-10-03

申请号：NO781130

申请日：1978-03-31

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  BORMANN DIETER ,  EHLERS EBERHARD ,  SCHRINNER ELMAR ,  HEYMES RENE

IPC: A61K31/397 ,  A61K31/435 ,  A61K31/505 ,  A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B25J15/08 ,  C07D205/08 ,  C07D277/20 ,  C07D277/40 ,  C07D277/42 ,  C07D277/50 ,  C07D463/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D501/20 ,  C07D501/24 ,  C07D501/36 ,  C07D505/00 ,  C07D519/06 ,  C07F9/6561 ,  C07D

Abstract: Cephem derivatives of the general formula in which the R2O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.

公开(公告)号：NO781130A

公开(公告)日：1978-10-03

申请号：NO781130

申请日：1978-03-31

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  BORMANN DIETER ,  EHLERS EBERHARD ,  SCHRINNER ELMAR ,  HEYMES RENE

IPC: A61K31/397 ,  A61K31/435 ,  A61K31/505 ,  A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B25J15/08 ,  C07D205/08 ,  C07D277/20 ,  C07D277/40 ,  C07D277/42 ,  C07D277/50 ,  C07D463/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D501/20 ,  C07D501/24 ,  C07D501/36 ,  C07D505/00 ,  C07D519/06 ,  C07F9/6561 ,  C07D

CPC classification number: C07D277/20 ,  A61K31/435 ,  A61K31/505 ,  A61K31/535 ,  A61K31/545 ,  C07D277/40 ,  C07D277/42 ,  C07D277/50 ,  C07D277/587 ,  C07D463/22 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D505/00

公开(公告)号：FI780757A

公开(公告)日：1978-09-13

申请号：FI780757

申请日：1978-03-09

Applicant: HOECHST AG

Inventor： BORMANN DIETER ,  KNABE BERND ,  SCHRINNER ELMAR ,  WORM MANFRED

IPC: A61K31/44 ,  A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D277/38 ,  C07D277/40 ,  C07D463/00 ,  C07D501/20 ,  C07D505/00 ,  C07D

Abstract: Cephem derivatives of the formula in which R1 denotes hydrogen or low-molecular alkoxy, R2 denotes hydrogen, optionally substituted alkyl, phthalide or a cation, X denotes sulfur, oxygen or CH2 and A denotes hydrogen, alkoxy, halogen or a group -CH2Y, in which Y represents hydrogen, acyloxy, alkoxy, optionally substituted carbamoyloxy or a group -SR3, in which R3 can represent acyl, alkyl or an optionally substituted 5-membered or 6-membered heterocyclic structure are disclosed as valuable antibiotics which are well suited for combating Gram-positive and in particular Gram-negative infections and also have an unexpectedly good action against penicillinase-forming staphylococci.

公开(公告)号：AU7581274A

公开(公告)日：1976-05-27

申请号：AU7581274

申请日：1974-11-27

Applicant: HOECHST AG

Inventor： BORMANN DIETER ,  KNABE BERND ,  SCHRINNER ELMAR ,  WORM MANFRED

IPC: A61K20060101 ,  A61K31/43 ,  A61K31/545 ,  C01D20060101 ,  C07D20060101 ,  C07D501/04 ,  C07D501/06 ,  C07D501/20 ,  C07D501/24 ,  C07D501/36 ,  C07D501/40 ,  C07D501/42 ,  C07D501/46 ,  C07D501/48 ,  C07D501/56 ,  C07D501/60 ,  C07D519/00 ,  C07D521/00 ,  C07D99/24 ,  A61K21/00

公开(公告)号：AU5516273A

公开(公告)日：1974-11-14

申请号：AU5516273

申请日：1973-05-03

Applicant: HOECHST AG

Inventor： SCHORR MANFRED ,  SCHRINNER ELMAR ,  WORM MANFRED

IPC: C07D233/22 ,  C07D233/26 ,  C07D239/06 ,  C07D333/38 ,  C07D501/20 ,  C07D501/22 ,  A61K27/00 ,  C07D99/24

公开(公告)号：CA871148A

公开(公告)日：1971-05-18

申请号：CA871148D

Applicant: HOECHST AG

Inventor： SCHORR MANFRED ,  SCHRINNER ELMAR ,  KLEEMANN AXEL ,  RIED WALTER ,  TEICHMANN KARL H ,  BAUMBACH ERNST-AUGUST

公开(公告)号：HRP940689B1

公开(公告)日：1997-10-31

申请号：HRP940689

申请日：1994-10-19

Applicant: HOECHST AG

Inventor： EHLERS EBERHARD ,  BORMANN DIETER ,  DUERCKHEMER WALTER ,  SCHRINNER ELMAR

IPC: A61K31/545 ,  C07D501/20

公开(公告)号：AU643291B2

公开(公告)日：1993-11-11

申请号：AU7848291

申请日：1991-06-19

Applicant: HOECHST AG

Inventor： KLESEL NORBERT ,  LIMBERT MICHAEL ,  SCHRINNER ELMAR

IPC: A61K31/52 ,  A61K31/522 ,  A61K31/545 ,  A61K31/546 ,  A61P7/00 ,  A61P9/00 ,  A61P31/00 ,  A61P31/04

Abstract: Pharmaceutical combination products containing at least one cephalosporin derivative and at least one xanthine derivative are suitable for the prophylaxis and treatment of bacterial infectious diseases and for the prophylaxis and treatment of septic shock.