公开(公告)号：CA2755969A1

公开(公告)日：2010-09-23

申请号：CA2755969

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： YANG XIAOQING ,  HADIDA RUAH SARA S ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233 ,  A61K31/47 ,  A61P3/00

Abstract: This invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R is COOH or CH2OH.

公开(公告)号：AU2007244824A1

公开(公告)日：2007-11-08

申请号：AU2007244824

申请日：2007-04-25

Applicant: VERTEX PHARMA

Inventor： CARON PAUL R ,  BOTFIELD MARTYN C ,  HARE BRIAN J ,  KELLIHER KEVIN M ,  HARDING MATTHEW W ,  CORNELL CATHARINE N ,  RAMACHANDRAN RAVI K ,  BANDARU RAJ

IPC: C12Q1/68 ,  A61K49/00 ,  C07H21/04 ,  C12M1/34 ,  C12Q1/70

公开(公告)号：PL376149A1

公开(公告)日：2005-12-27

申请号：PL37614903

申请日：2003-10-02

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID J ,  BOTFIELD MARTYN C ,  ECKARD OTTOW

IPC: A61P25/28 ,  C07D207/16 ,  C07D211/60 ,  A61K31/496

Abstract: The present invention relates to piperazine and piperidine derivatives, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.

公开(公告)号：NO20052153L

公开(公告)日：2005-05-31

申请号：NO20052153

申请日：2005-05-02

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID JEFFREY ,  BOTFIELD MARTYN C ,  ECKARD OTTOW

IPC: A61P25/28 ,  C07D207/16 ,  C07D211/60 ,  A61K31/496

Abstract: The present invention relates to piperazine and piperidine derivatives, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.

公开(公告)号：NO20052153A

公开(公告)日：2005-05-31

申请号：NO20052153

申请日：2005-05-02

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID JEFFREY ,  BOTFIELD MARTYN C ,  ECKARD OTTOW

IPC: A61P25/28 ,  C07D207/16 ,  C07D211/60 ,  A61K31/496

CPC classification number: C07D207/16 ,  C07D211/60

公开(公告)号：AU2003299145A1

公开(公告)日：2004-04-23

申请号：AU2003299145

申请日：2003-10-02

Applicant: VERTEX PHARMA

Inventor： ECKARD OTTOW ,  LAUFFER DAVID J ,  BOTFIELD MARTYN C

IPC: A61P25/28 ,  C07D207/16 ,  C07D211/60 ,  A61K31/496

Abstract: The present invention relates to piperazine and piperidine derivatives, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.