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71.发明公开
公开(公告)号：EP0168657A1
公开(公告)日：1986-01-22
申请号：EP85107526.7
申请日：1985-06-18
Applicant: FINBIOMEDICA S.r.l.
Inventor： Vicario, Guido , Vicario, Cesare
CPC classification number: G01N21/253 , B01J2219/00468 , G01N35/026 , G01N2201/122 , Y10S435/807 , Y10S435/809
Abstract: A detecting device is fitted so as to span a row of adjoining receptacles (5) which are set in a reciprocating continuous motion, so that each receptacle passes within the scanning field of the detecting device (18). The latter sends the signals sequentially to a processor (31) for elaboration into point curves showing the courses of each reaction through time. The row of receptacles (5) may be set in a reciprocating motion by a rack, a stepping motor, a cam-type control or a coupling device, etc.
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公开(公告)号：WO2017058777A1
公开(公告)日：2017-04-06
申请号：PCT/US2016/053936
申请日：2016-09-27
Applicant: SENSIQ TECHNOLOGIES, INC.
Inventor： MARTIN, Aaron, David
CPC classification number: G01N21/553 , G01N21/05 , G01N35/1095 , G01N2015/0092 , G01N2201/122 , G01N2201/129
Abstract: Disclosed is a method for preparing dispersion gradients and an SPR injection method for determining full kinetics and affinity analysis in the presence of a competitor molecule. The SPR injection provides a dispersion gradient of two or more samples to a SPR flow cell and detector.
Abstract translation: 公开了一种制备分散梯度的方法和用于在竞争分子存在下确定完全动力学和亲和力分析的SPR注射方法。 SPR注射提供两个或多个样品到SPR流动池和检测器的色散梯度。
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公开(公告)号：WO2004109295A1
公开(公告)日：2004-12-16
申请号：PCT/SE2004/000867
申请日：2004-06-04
Applicant: Biacore AB , ANDERSSON, Karl , WASS, Christina
Inventor： ANDERSSON, Karl , WASS, Christina
IPC: G01N35/08
CPC classification number: G01N21/05 , G01N21/553 , G01N35/08 , G01N2021/0162 , G01N2021/1723 , G01N2035/0097 , G01N2201/122
Abstract: The invention relates to a method of characterizing interaction between two species in a liquid environment, wherein a liquid comprising said at least one species is passed as a flow through a measurement system, and wherein the interaction takes place within said measurement system. The method comprises generating a concentration gradient of at least a first one of said species or of at least one other species having an influence on the interaction or on interacted components. The flow of liquid is passed through a sensor device, and a result of interaction between said at least two species is detected. The flow of liquid is intersected at least once with a further liquid before the flow is passed through said sensor, so as to create at least two separated liquid segments having different concentrations of at least one of said species forming the concentration gradient.
Abstract translation: 本发明涉及一种表征液体环境中两种物质之间的相互作用的方法，其中包含所述至少一种物质的液体作为流动通过测量系统，并且其中所述相互作用发生在所述测量系统内。 所述方法包括产生至少第一种所述物种或至少一种对相互作用或相互作用的组分具有影响的其它物质的浓度梯度。 液体的流动通过传感器装置，并且检测所述至少两种之间的相互作用的结果。 在流过所述传感器之前，液体的流动与另外的液体相交至少一次，以便产生具有不同浓度的至少一种形成浓度梯度的物质的至少两个分离的液体段。
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公开(公告)号：WO1992018849A1
公开(公告)日：1992-10-29
申请号：PCT/US1992003181
申请日：1992-04-16
Applicant: BAKER HUGHES INCORPORATED
IPC: G01N21/55
CPC classification number: G01N21/8483 , G01N21/783 , G01N2201/084 , G01N2201/122 , G01N2201/127
Abstract: A concentration measuring apparatus is provided having a reflective sensing media in a self-contained cassette (202), fiber optic line (302, 304) partially associated with a lamp (306) and a photocell (310). A signal is generated by the photocell (310) representative of the charge of reflectivity of the light from the reflective sensing media (600). The signal from the photocell (310) is accepted by a signal processor containing an amplifier (404), an analog to digital converter (430) and computer (480). An interface is associated with the signal processor and comprises a display (520) a 4-to-20 milliamp cord (530) and remote, explosion-proof switches (510) for operator interaction with the concentration measuring apparatus.
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75.发明申请
公开(公告)号：WO1992008123A1
公开(公告)日：1992-05-14
申请号：PCT/US1991008118
申请日：1991-10-30
Applicant: BAXTER DIAGNOSTICS INC.
Inventor： BAXTER DIAGNOSTICS INC. , MORRIS, Roger, James , BASCOMB, Shoshana , OLSON, Carolyn, Shelchuk
IPC: G01N21/78
CPC classification number: G01N21/17 , G01N21/534 , G01N21/78 , G01N2201/122 , Y10S436/80
Abstract: The present invention relates to a process to determine the concentration of any substance in a colorimetric, turbidimetric or nephelometric reaction using a fluorometric detector to measure fluorescence intensity. In particular, a change in color can be monitored by observing the measurement of fluorescence intensity of a fluorophore in an inert matrix. The absorption spectrum of the chromophore may overlap the excitation and/or emission spectrum of the fluorophore, thereby allowing the change in fluoroscence to be related to the intensity of color in the reaction and thus related to the quantity of the substance of interest.
Abstract translation: 本发明涉及使用荧光检测器测定荧光强度的比色法，比浊法或比浊法反应中任何物质的浓度的方法。 特别地，可以通过观察惰性基质中荧光团的荧光强度的测量来监测颜色变化。 发色团的吸收光谱可能与荧光团的激发和/或发射光谱重叠，从而允许荧光的变化与反应中的颜色强度相关，并且因此与感兴趣的物质的量有关。
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Patent Agency Ranking76.发明申请METHOD AND DEVICE FOR DETERMINING THE pH AND THE CELL CONCENTRATION IN A CELL CULTURE MEDIUM 审中-公开用于测定细胞培养液中pH和细胞浓度的方法和装置
公开(公告)号：WO1990003567A1
公开(公告)日：1990-04-05
申请号：PCT/FR1989000492
申请日：1989-09-27
Applicant: BERTIN & CIE , GEAHEL, Isabelle , DORDET, Yves , HACHE, Jean
Inventor： BERTIN & CIE
IPC: G01N21/80
CPC classification number: G01N21/532 , C12M41/26 , C12M41/36 , G01J3/2803 , G01N21/80 , G01N2021/0314 , G01N2201/084 , G01N2201/122 , G01N2201/12753
Abstract: A polychromatic light source (10) allows to illuminate a layer (14) of cell culture or fermentation, and an optical fiber (22) associated with a lens (18) and with a mirror (20) allows to collect the light transmitted and diffused by the medium. Means (24) for spectral analyses, associated with calculation means (26), allow to determine the pH and the cell concentration of the culture medium (14) which contains a colored indicator of which the tint varies as a function of the pH.
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公开(公告)号：WO1987003962A1
公开(公告)日：1987-07-02
申请号：PCT/US1986002778
申请日：1986-12-22
Applicant: BECKMAN INSTRUMENTS, INC.
IPC: G01N21/82
CPC classification number: G01N33/557 , G01N21/47 , G01N21/82 , G01N2201/122 , Y10S436/805 , Y10S436/909
Abstract: The peak verify time for kinetic nephelometric measurements of reactions between antigens and antibodies is adjusted as a function of the magnitude of the peak rate in order to reduce the time required for peak verification. The scatter signal is zeroed following the end of the peak verification period and the reaction is tested for antigen excess. Reactions during the antigen excess check having rates that exceed a threshold value are accepted as being valid, and no additional measurements are made for such samples. Reactions during the antigen excess check having rates that are less than the threshold value are rejected as being in antigen excess. Samples found to be in antigen excess are diluted and then reanalyzed.
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公开(公告)号：EP3356795A1
公开(公告)日：2018-08-08
申请号：EP16852403.1
申请日：2016-09-27
Applicant: Pall Corporation
Inventor： MARTIN, Aaron, David
CPC classification number: G01N21/554 , G01N15/1404 , G01N21/05 , G01N21/4133 , G01N21/553 , G01N35/1095 , G01N2015/0092 , G01N2201/122 , G01N2201/129
Abstract: Disclosed is a method for preparing dispersion gradients and an SPR injection method for determining full kinetics and affinity analysis in the presence of a competitor molecule. The SPR injection provides a dispersion gradient of two or more samples to a SPR flow cell and detector.
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公开(公告)号：EP1631829A1
公开(公告)日：2006-03-08
申请号：EP04736157.1
申请日：2004-06-04
Applicant: Biacore AB
Inventor： ANDERSSON, Karl , WASS, Christina
IPC: G01N35/08
CPC classification number: G01N21/05 , G01N21/553 , G01N35/08 , G01N2021/0162 , G01N2021/1723 , G01N2035/0097 , G01N2201/122
Abstract: The invention relates to a method of characterizing interaction between two species in a liquid environment, wherein a liquid comprising said at least one species is passed as a flow through a measurement system, and wherein the interaction takes place within said measurement system. The method comprises generating a concentration gradient of at least a first one of said species or of at least one other species having an influence on the interaction or on interacted components. The flow of liquid is passed through a sensor device, and a result of interaction between said at least two species is detected. The flow of liquid is intersected at least once with a further liquid before the flow is passed through said sensor, so as to create at least two separated liquid segments having different concentrations of at least one of said species forming the concentration gradient.
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80.发明授权
公开(公告)号：EP0551507B1
公开(公告)日：2000-10-18
申请号：EP92917851.5
申请日：1992-08-05
Applicant: MOSCETTA, Pompeo
Inventor： MOSCETTA, Pompeo
CPC classification number: G01N35/1097 , G01N35/08 , G01N2201/122 , Y10T436/11 , Y10T436/2575
Abstract: An apparatus for the determination of analytes in liquid samples is disclosed. The apparatus comprises in fluid connection a positive-displacement pump (18), a chamber (16) in which the reagents specific for the analytes to be determined can be delivered, a detector (23), a second chamber (43) and a device (4) for the introduction of sample within the circuit and for the discharge. The apparatus also provides for controlling flow means and means (7) for the control of the operation of each component. A process for the determination of said analytes is also disclosed.
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