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    MULTI-SAMPLE FILTER PLATE ASSEMBLING DEVICE
    81.
    发明专利
    MULTI-SAMPLE FILTER PLATE ASSEMBLING DEVICE 失效

    公开(公告)号：JPH04227032A

    公开(公告)日：1992-08-17

    申请号：JP12094191

    申请日：1991-05-27

    Applicant: BIO RAD LABORATORIES

    Inventor： JIYOOJI JII FUAANUTSUDO ,  UIRIAMU EE PENARUUNA ,  JIYANETSUTO GEISERUSODAA

    IPC: B01D35/02 ,  B01D29/01 ,  B01D61/18 ,  B01D63/08 ,  B01L3/00 ,  C12M1/12

    Abstract: PURPOSE: To guide and force an extremely small amount of substance on a membrane sheet into collection wells without diluting it by providing the membrane sheet under each sample well formed on an upper plate and providing a drop guide plate between a collection plate with individual wells placed underneath the membrane sheet and the membrane sheet. CONSTITUTION: Sample wells are formed on an upper plate 11 in a plate assembly for performing multiple filtrations with the use of vacuum. A collection plate 19 with individual wells is placed underneath a membrane sheet 13 forming a floor of each sample well. A small quantity of liquid is guided to the collection wells from the bottom of the membrane 13 through a drop guide plate 15 between the collection plate 19 and the membrane sheet 13. As a result, very small quantities of materials on the membrane sheet 13 can be drawn into the collection wells without dilution, and avoiding cross contamination between the collection wells.

    BIOTIN CROSSLINKING AND IMMUNOASSAY UTILIZING UNIVERSAL SOLID PHASE
    82.
    发明专利
    BIOTIN CROSSLINKING AND IMMUNOASSAY UTILIZING UNIVERSAL SOLID PHASE 失效

    公开(公告)号：JPH02145967A

    公开(公告)日：1990-06-05

    申请号：JP4840389

    申请日：1989-02-28

    Applicant: BIO RAD LABORATORIES

    Inventor： SHIYASHIDARA EICHI EMU MAASHII ,  SUUZAN II BUREGURIO ,  BINSENTO II FUIRITSUPUSU

    IPC: G01N33/53 ,  A61K39/395 ,  G01N33/543 ,  G01N33/74

    Abstract: PURPOSE: To increase the ligand capturing site allowable capacity of a solid phase and to expand a ligand detection range in a sample by causing a biotin binding substance to react to a solid phase made of a solid support where antibiotin antibody is immobilized on the surface. CONSTITUTION: A binding species made into a biotinyl that is considered to form ligand specifical binding site is cultivated by performing immunity binding with ligand along with anti-biotin antibody that is immobilized on a solid support in a method for detecting ligand in a sample. More specifically, the solid, support is cultivated along with the sample and is cultivated along with a binding species that is considered to be immunity-binding with the ligand and a species that preserves a labeled substance that is selected out of ligand similar bodies and can be selected. Then, the labeled substance that is selected from a solution and the solid support and exists in phase is detected, thus increasing the ligand acquiring site allowable capacity of the solid phase and increasing the ligand detection range in the sample.

    BIOLOGICAL SPECIFICITY ASSAY USING INDUCED GLASS SURFACE
    83.
    发明专利
    BIOLOGICAL SPECIFICITY ASSAY USING INDUCED GLASS SURFACE 失效

    公开(公告)号：JPH0212062A

    公开(公告)日：1990-01-17

    申请号：JP4840289

    申请日：1989-02-28

    Applicant: BIO RAD LABORATORIES

    Inventor： NIIRU II DESHIN ,  BAABARA JIEI RASUBAN ,  BAABARA PII REGAN

    IPC: G01N33/547 ,  G01N33/552 ,  G01N33/569

    Abstract: PURPOSE: To detect a specific connection reaction between a virus antigen and a complementary connection material by a method wherein a total absorption quantity of the virus antigen is increased by using a solid carrier treated by a sililation agent. CONSTITUTION: Firstly, a sample is placed on a melting condition to break all of the herpes viruses. The sample is brought into contact with a solid carrier which is derived from silane, then all of the broken herpes viruses are fixed to the solid carrier only by hydrophobic interaction. This product is brought into contact with a primary antibody which is specific to the broken viruses to form an immune antibody composite body. This product is brought into contact with a secondary antibody to which a mark is stuck to form a marked immune composite body and the marked immune composite body is detected.

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