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    END-OF-DOSE DETECTION IN NEBULIZERS
    81.
    发明申请
    END-OF-DOSE DETECTION IN NEBULIZERS 审中-公开
    NEBULIZERS中的终端检测

    公开(公告)号：WO2017055166A1

    公开(公告)日：2017-04-06

    申请号：PCT/EP2016/072541

    申请日：2016-09-22

    Applicant: STAMFORD DEVICES LIMITED

    Inventor： GREHAN, Joseph ,  CASEY, Michael ,  PORTER, Shaun ,  SMITH, Niall

    IPC: B05B17/06 ,  A61M11/00

    CPC classification number: B05B17/0646 ,  A61M11/005 ,  A61M2205/3317 ,  A61M2205/3386 ,  B05B12/081 ,  B05B15/14 ,  B05B17/0669 ,  B06B1/0253 ,  B06B2201/77

    Abstract: A digital processor of a nebulizer controller controls and monitors drive current (I) applied to an aperture plate. The drive current is detected as a series of discrete values at each of multiple measuring points, each having a particular drive frequency The processor in real time calculates a slope or rate of change of drive current with frequency and additionally determines a minimum value for drive current leading up to the peak value. The processor uses both the value of the minimum drive current during the scan and also the maximum slope value to achieve reliable prediction of end of dose, when the aperture plate becomes dry.

    Abstract translation: 喷雾器控制器的数字处理器控制和监视施加到孔板的驱动电流（I）。 驱动电流被检测为多个测量点中的每一个的一系列离散值，每个测量点具有特定的驱动频率。处理器实时地计算驱动电流与频率的斜率或速率，并另外确定驱动电流的最小值 导致峰值。 处理器在扫描期间使用最小驱动电流的值，并且当孔板变干时也使用最大斜率值来实现剂量结束的可靠预测。

    AN AEROSOL DELIVERY SYSTEM WITH HUMIDIFICATION
    82.
    发明申请
    AN AEROSOL DELIVERY SYSTEM WITH HUMIDIFICATION 审中-公开
    具有湿度的气溶胶输送系统

    公开(公告)号：WO2015189290A1

    公开(公告)日：2015-12-17

    申请号：PCT/EP2015/062972

    申请日：2015-06-10

    Applicant: STAMFORD DEVICES LIMITED

    Inventor： POWER, Patrick

    IPC: A61M11/00 ,  A61M11/02 ,  A61M11/06 ,  A61M16/00 ,  A61M16/16

    CPC classification number: A61M11/02 ,  A61M11/00 ,  A61M11/06 ,  A61M16/00 ,  A61M16/024 ,  A61M16/16 ,  A61M16/161

    Abstract: An aerosol delivery system (1) has a nebulizer (2) and a humidifier (7) providing a gas flow to the nebulizer. A controller varies humidity level of the gas flow to the nebulizer (2) so that if the nebulizer is not operating it has about 100% humidity and it is operating the value is less to allow for the humidification effect of the nebulizer. The control may be achieved by dynamically varying proportions of flow through a dry branch (10, 11) and a humidification branch (8, 7).

    Abstract translation: 气雾剂输送系统（1）具有雾化器（2）和加湿器（7），其向雾化器提供气流。 控制器改变到雾化器（2）的气流的湿度水平，使得如果喷雾器不工作，则其具有约100％的湿度，并且其运行的值较小以允许雾化器的加湿效果。 控制可以通过动态变化通过干燥分支（10,11）和加湿分支（8,7）的流量的比例来实现。

    NEBULIZER VIBRATING APERTURE PLATE DRIVE FREQUENCY CONTROL AND MONITORING
    83.
    发明申请
    NEBULIZER VIBRATING APERTURE PLATE DRIVE FREQUENCY CONTROL AND MONITORING 审中-公开
    NEBULIZER振动孔板驱动频率控制和监测

    公开(公告)号：WO2015010809A1

    公开(公告)日：2015-01-29

    申请号：PCT/EP2014/060723

    申请日：2014-05-23

    Applicant: STAMFORD DEVICES LIMITED

    Inventor： GREHAN, Joseph ,  SMITH, Niall

    IPC: B05B17/06 ,  B05B12/08

    CPC classification number: A61M11/005 ,  A61M11/001 ,  A61M2205/33 ,  A61M2205/3317 ,  B05B12/004 ,  B05B12/081 ,  B05B15/14 ,  B05B17/0646 ,  B05B17/0669 ,  B06B1/0253 ,  G01N29/22 ,  G01N29/42 ,  G06F19/00 ,  G06F19/3456 ,  G16H20/13

    Abstract: A nebulizer has an aperture plate, a mounting, an actuator, and an aperture plate drive circuit (2- 4). A controller measures an electrical drive parameter at each of a plurality of measuring points, each measuring point having a drive frequency; and based on the values of the parameter at the measuring points makes a determination of optimum drive frequency and also an end-of-dose prediction. The controller performs a short scan at regular sub-second intervals at which drive current is measured at two measuring points with different drive frequencies. According to drive parameter measurements at these points the controller determines if a full scan sweeping across a larger number of measuring points should be performed. The full scan provides the optimum drive frequency for the device and also an end of dose indication.

    Abstract translation: 喷雾器具有孔板，安装件，致动器和孔板驱动电路（2-4）。 控制器测量多个测量点中的每一个的电驱动参数，每个测量点具有驱动频率; 并且基于测量点处的参数的值来确定最佳驱动频率以及剂量结束预测。 控制器以规定的次秒间隔执行短扫描，在两个间隔，在具有不同驱动频率的两个测量点处测量驱动电流。 根据这些点的驱动参数测量，控制器确定是否应执行扫描更大数量的测量点的全扫描。 全扫描可为设备提供最佳的驱动频率，同时也为剂量指示结束。

    A NEBULISER SYSTEM
    84.
    发明申请
    A NEBULISER SYSTEM 审中-公开
    NEBULISER系统

    公开(公告)号：WO2010035252A2

    公开(公告)日：2010-04-01

    申请号：PCT/IE2009/000068

    申请日：2009-09-28

    Applicant: STAMFORD DEVICES LIMITED ,  POWER, John ,  DUFFY, Conor ,  SMITH, Niall ,  CLANCY, Dermot, Joseph ,  HYLAND, Kieran

    Inventor： POWER, John ,  DUFFY, Conor ,  SMITH, Niall ,  CLANCY, Dermot, Joseph ,  HYLAND, Kieran

    IPC: A61M11/00 ,  A61M15/00

    CPC classification number: A61M11/005 ,  A61M15/0028 ,  A61M15/003 ,  A61M15/0031 ,  A61M15/0035 ,  A61M15/0085 ,  A61M2205/6045 ,  B05B12/081 ,  B05B17/0646

    Abstract: A nebuliser 1 particularly for home use comprises a housing 2 having an aerosol generator 3 mounted therein. The housing is closed by a hinged cap 4 and has an outlet 5 through which aerosol generated by the generator 3 is delivered. A suitable connector such as a mouthpiece 6 may be connected to the outlet 5. The housing 2 has a receiver for receiving a nebule 8. The receiver comprises a slot 7 which is sized and/or shaped to accommodate only a nebule 8 of predetermined shape and/or size. The nebuliser cap 4 has a nebule opening means which may be in the form of a puncture pin 10 projecting therefrom to pierce the nebule 8 when the cap is moved to the closed position. The pin 10 is hollow or splined to regulate flow from the nebule. The nebuliser 1 also has a switch means for enabling operation of the aerosol generator 3 when the nebule 8 is opened. The switch means comprises a microswitch 12 on the housing which is engageable by a trigger 13 on the cap 4 when the cap is moved to the closed position. Aerosol generated by the aerosol generator 3 is delivered into a chamber defined by the nebuliser housing 2. Air passes into the chamber through air inlets 30. The air entrains the aerosolised medicament and the entrained aerosolised medicament is delivered from the nebuliser through the outlet 5.

    Abstract translation: 特别用于家庭使用的雾化器1包括其中安装有气溶胶发生器3的壳体2。 壳体由铰接盖4封闭，并且具有出口5，由发生器3产生的气雾通过该出口5被输送。 诸如接口管6的合适的连接器可以连接到出口5.壳体2具有用于接收氖8的接收器。接收器包括槽7，槽7的尺寸和/或形状仅适于具有预定形状的氖8 和/或尺寸。 雾化器盖4具有ne形开口装置，其可以是当帽移动到关闭位置时从其突出的穿刺销10的形式刺穿氖8。 销10是中空的或花键的，以调节来自星云的流动。 雾化器1还具有开关装置，用于当氖8打开时能使气溶胶发生器3工作。 开关装置包括壳体上的微型开关12，当盖子移动到关闭位置时，该开关装置可由盖子4上的触发器13接合。 由气溶胶发生器3产生的气雾剂被输送到由雾化器壳体2限定的室中。空气通过空气入口30进入室。空气夹带雾化的药物，并且夹带的雾化的药物从喷雾器通过出口5输送。

    Gas therapy system for delivery of medicament
    86.
    发明授权
    Gas therapy system for delivery of medicament 有权

    公开(公告)号：US12290637B2

    公开(公告)日：2025-05-06

    申请号：US18061564

    申请日：2022-12-05

    Applicant: STAMFORD DEVICES LIMITED

    Inventor： Ronan MacLoughlin ,  Shaun Porter ,  Conor Duffy ,  John Power

    IPC: A61M16/14 ,  A61M11/00 ,  A61M11/02 ,  A61M16/00 ,  A61M16/06 ,  A61M16/16

    Abstract: A gas therapy system (1) has a flow line (3, 2), a coupler (6) to a gas source, and an aerosol generator (4) for aerosol delivery, and a patient interface such as a nasal interface (2). A controller (10) is configured to modulate gas flow and aerosol delivery in real time. The controller changes gas flow rate and dynamically reduces aerosol delivery during upper gas flow rates such as 60 LPM, and activates aerosol delivery during lower gas flow rates of for example 10 LPM. The control may also include sensors to detect breathing, so that there is a bias towards increased aerosol delivery during inhalation in addition to during lower level gas flow.

    Nebulizer aperture plate drive frequency control and monitoring
    87.
    发明授权
    Nebulizer aperture plate drive frequency control and monitoring 有权

    公开(公告)号：US12186477B2

    公开(公告)日：2025-01-07

    申请号：US18304854

    申请日：2023-04-21

    Applicant: Stamford Devices Limited

    Inventor： Joseph Grehan ,  Niall Smith

    IPC: A61M11/00 ,  B05B15/14 ,  B05B17/00 ,  B05B17/06 ,  B06B1/02 ,  G01N29/22 ,  G01N29/42 ,  G16H20/10 ,  G16H20/13 ,  B05B12/00 ,  B05B12/08

    Abstract: A nebulizer has an aperture plate, a mounting, an actuator, and an aperture plate drive circuit (2-4). A controller measures an electrical drive parameter at each of a plurality of measuring points, each measuring point having a drive frequency; and based on the values of the parameter at the measuring points makes a determination of optimum drive frequency and also an end-of-dose prediction. The controller performs a short scan at regular sub-second intervals at which drive current is measured at two measuring points with different drive frequencies. According to drive parameter measurements at these points the controller determines if a full scan sweeping across a larger number of measuring points should be performed. The full scan provides the optimum drive frequency for the device and also an end of dose indication.

    PROTECTION OF APERTURE PLATE DURING AEROSOL GENERATION
    88.
    发明公开
    PROTECTION OF APERTURE PLATE DURING AEROSOL GENERATION 审中-公开

    公开(公告)号：US20240066542A1

    公开(公告)日：2024-02-29

    申请号：US18495066

    申请日：2023-10-26

    Applicant: STAMFORD DEVICES LIMITED

    Inventor： Joseph GREHAN ,  Noel COYLE ,  Russell GREANEY ,  Stephen THORNTON

    IPC: B05B12/08 ,  A61M11/00 ,  A61M15/00 ,  B05B17/00 ,  B05B17/06

    CPC classification number: B05B12/081 ,  A61M11/005 ,  A61M15/0085 ,  B05B17/0646 ,  B05B17/0669 ,  A61M2205/3317 ,  A61M2205/50

    Abstract: An aerosol delivery system has an aerosol generator with a vibrating aperture plate (10) and an actuator (11, 16, 17, 19), a controller (18, 19). The controller in real time monitors (201) the aerosol generator as it is driven for vibration of the aperture plate, and detects (202) a change in an electrical characteristic in response to a transition from a wet state to a dry state of the aperture plate. It automatically modifies (203, 205, 206), during the transition, operation of the aerosol generator in response to the detected change. The modification includes reducing applied power (203). The controller continues (204) to monitor during the transition, including monitoring the aperture plate for presence of residual liquid on the aperture plate first surface. The controller monitors at a number of drive frequencies and maintains data representing trends in a combination of the electrical characteristic signals at the different frequencies, and identifies a start of a transition if a calculated value rises above a threshold. There is one threshold for triggering a check scan for residual volume and a higher threshold to trigger an immediate shut down.

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