公开(公告)号：KR1020140123033A

公开(公告)日：2014-10-21

申请号：KR1020140124117

申请日：2014-09-18

Applicant: (주)아모레퍼시픽 ,  서울대학교산학협력단

Inventor： 안수선 ,  김수정 ,  이은영 ,  노민수 ,  이태룡 ,  문성준 ,  김한곤 ,  은희철 ,  정진호 ,  김은주 ,  최원우

IPC: C12Q1/68 ,  G01N33/53

CPC classification number: C12Q1/6844 ,  C12Q1/6813

Abstract: Disclosed is a biomarker of which gene expression levels are specifically increased or reduced for sensitive skin. The biomarker specific to sensitive skin is used in such a diagnostic kit for sensitive skin and a screening method of an abirritant. The biomarker for diagnosis of sensitive skin according to the present invention contains one or more gene selected from a group consisting of HLA-C, TCEA1, IGHA1, TFRC, S100A8, LOC652128, SERPINB13, EHF, FLJ10781, TP63, CDH1, TNFRSF19, GM2A, FKBP5, PI3, PSPH, HORMAD1, SPRR2G, and ACTR2 or a group consiting of KBTBD10, TTN, ACTA1, MYBPC1, MB, MYOZ1, TPM1, CA3, CASQ1, ENO3, RBP4, GYG2, PPP1R1A, PYGM, G0S2, NEB, H19, LIPE, PLIN, H19, GPAM, FABP4, CIDEC, LPL, PCK1, ADIPOQ, PDE3B, ACVR1C, LPL, FABP4, DKFZP761N09121, TNMD, ATP6V1B1, C8orf22, and CRISP3.

Abstract translation: 公开了一种生物标志物，其敏感性皮肤基因表达水平被特异地增加或降低。 敏感皮肤特异性的生物标志物用于敏感皮肤的诊断试剂盒和刺激物的筛选方法。 根据本发明的敏感性皮肤诊断用生物标志物含有选自HLA-C，TCEA1，IGHA1，TFRC，S100A8，LOC652128，SERPINB13，EHF，FLJ10781，TP63，CDH1，TNFRSF19，GM2A ，FKBP5，PI3，PSPH，HORMAD1，SPRR2G和ACTR2或KBTBD10，TTN，ACTA1，MYBPC1，MB，MYOZ1，TPM1，CA3，CASQ1，ENO3，RBP4，GYG2，PPP1R1A，PYGM，G0S2，NEB， H19，LIPE，PLIN，H19，GPAM，FABP4，CIDEC，LPL，PCK1，ADIPOQ，PDE3B，ACVR1C，LPL，FABP4，DKFZP761N09121，TNMD，ATP6V1B1，C8orf22和CRISP3。

公开(公告)号：KR1020140123031A

公开(公告)日：2014-10-21

申请号：KR1020140124110

申请日：2014-09-18

Applicant: (주)아모레퍼시픽 ,  서울대학교산학협력단

Inventor： 안수선 ,  김수정 ,  이은영 ,  노민수 ,  이태룡 ,  문성준 ,  김한곤 ,  은희철 ,  정진호 ,  김은주 ,  최원우

IPC: C12Q1/68 ,  G01N33/53

CPC classification number: C12Q1/6844 ,  C12Q1/6813

Abstract: 민감성 피부에 대해서 특이적으로 유전자 발현량이 증가 또는 억제되는 바이오 마커가 개시된다. 상기 민감성 피부에 특이적인 바이오 마커를 이용하여 민감성 피부 진단 키트 및 자극감 완화제의 스크리닝 방법 등에 활용할 수 있다.

Abstract translation: 公开了具有针对敏感皮肤特异性增加或降低的基因表达量的生物标志物。 敏感皮肤特异性的生物标志物用于敏感皮肤的诊断试剂盒和刺激物的筛选方法。 根据本发明的敏感性皮肤诊断用生物标志物，选自HLA-C，TCEA1，IGHA1，TFRC，S100A8，LOC652128，SERPINB13，EHF，FLJ10781，TP63，CDH1，TNFRSF19，GM2A， FKBP5，PI3，PSPH，HORMAD1，SPRR2G和ACTR2或由KBTBD10，TTN，ACTA1，MYBPC1，MB，MYOZ1，TPM1，CA3，CASQ1，ENO3，RBP4，GYG2，PPP1R1A，PYGM，G0S2，NEB，H19组成的组 ，LIPE，PLIN，H19，GPAM，FABP4，CIDEC，LPL，PCK1，ADIPOQ，PDE3B，ACVR1C，LPL，FABP4，DKFZP761N09121，TNMD，ATP6V1B1，C8orf22和CRISP3。

公开(公告)号：KR1020120058687A

公开(公告)日：2012-06-08

申请号：KR1020100116410

申请日：2010-11-22

Applicant: (주)아모레퍼시픽

Inventor： 김형준 ,  오택진 ,  이명렬 ,  이종석 ,  박창훈 ,  김한곤 ,  이태룡 ,  노민수 ,  신동욱

IPC: A61K8/37 ,  A61K8/368 ,  A61K8/36 ,  A61K8/49 ,  A61K8/89 ,  A61Q17/04 ,  A61K31/41 ,  A61K31/192 ,  A61K31/215 ,  A61K31/60

CPC classification number: A61K8/37 ,  A61K8/36 ,  A61K8/368 ,  A61K8/4966 ,  A61K8/89 ,  A61K31/192 ,  A61K31/215 ,  A61K31/41 ,  A61K31/60 ,  A61Q17/04

Abstract: PURPOSE: A composition containing cinnamic acid derivatives, triazine derivatives, and methoxy phenyl acrylate derivatives is provided to remarkably reduce chemical decomposition in case of irradiating with light. CONSTITUTION: A composition for sun screening contains cinnamic acid derivatives, triazine derivatives, and methoxy phenyl acrylate derivatives as an active ingredient. The triazine derivative includes bis-ethyl hexcyloxyphenyl methoxy phenyl triazine, tris(diisobutyl-aminobenzalmalonate)triazine, or combination thereof. The methoxyphenyl acrylate derivative is ethyl hexyl methoxy crylene. The composition further contains salicylic acid derivatives and benzalonate derivatives.

Abstract translation: 目的：提供含有肉桂酸衍生物，三嗪衍生物和甲氧基苯基丙烯酸酯衍生物的组合物，以显着减少在照射光时的化学分解。 构成：防晒组合物含有肉桂酸衍生物，三嗪衍生物和甲氧基苯基丙烯酸酯衍生物作为活性成分。 三嗪衍生物包括二乙基己氧基苯基甲氧基苯基三嗪，三（二异丁基 - 氨基苯甲醛丙二酸）三嗪或其组合。 甲氧基苯基丙烯酸酯衍生物是乙基己基甲氧基二烯丙基。 该组合物还含有水杨酸衍生物和苯甲酸酯衍生物。

公开(公告)号：KR1020120002964A

公开(公告)日：2012-01-09

申请号：KR1020110137404

申请日：2011-12-19

Applicant: (주)아모레퍼시픽

Inventor： 신동욱 ,  송민정 ,  노민수 ,  이형호 ,  이상민 ,  양승하 ,  김한곤

IPC: A61K36/49 ,  A61K36/898 ,  A61K36/537 ,  A61P17/00

CPC classification number: A61K36/49 ,  A61K8/97 ,  A61K36/537 ,  A61K36/898 ,  A61Q19/08

Abstract: PURPOSE: A composition for promoting differentiation of human mesenchymal stem cells into adipocytes is provided to enhance skin volume. CONSTITUTION: An external use skin composition for enhancing skin elasticity contains 0.0001-30 wt% of extract of Castaneae Semen, Selaginella tamariscina, Aloe vera L., Mentha arvensis var. piperascens Makinv., Pinellia ternata (Thunb.) Breit., Triticum aestivum L., Saururus chinensis Baill., Polygala tenuifolia Willd., or Gleditsia sinensis Lam. as an active ingredient. The composition promotes differentiation of mesenchymal stem cells into adipocytes. The mesenchymal stem cells are derived from human. A pharmaceutical composition for promoting differentiation of adipocytes contains the extract as an active ingredient.

Abstract translation: 目的：提供用于促进人间充质干细胞分化为脂肪细胞的组合物，以增强皮肤体积。 构成：用于增强皮肤弹性的外用皮肤组合物含有0.0001-30重量％的蓖麻精，卷柏，芦荟提取物， （Piellens Makinv。），Pinellia ternata（Thunb。）Breit。，Triticum aestivum L.，Saururus chinensis Baill。，Polygala tenuifolia Willd。或Gleditsia sinensis Lam。 作为活性成分。 该组合物促进间充质干细胞分化为脂肪细胞。 间充质干细胞来源于人。 用于促进脂肪细胞分化的药物组合物含有提取物作为活性成分。

公开(公告)号：KR1020120002482A

公开(公告)日：2012-01-05

申请号：KR1020110064247

申请日：2011-06-30

Applicant: (주)아모레퍼시픽

Inventor： 김규한 ,  심중현 ,  신동욱 ,  최현 ,  노민수 ,  이태룡

IPC: A61K38/16 ,  A61K31/7105 ,  A61P17/00

CPC classification number: A61K31/7105 ,  A61K8/64 ,  A61K31/7115 ,  A61K38/005 ,  A61K48/005 ,  A61Q19/08

Abstract: PURPOSE: A composition containing an oligonucleotide or mimic acting as an inhibitor of miRNA-526b is provided to control collagen generation and to prevent or treat aging. CONSTITUTION: A composition for controlling collagen contains 15-23 serial nucleotides of sequence number 1. The collagen is controlled by regulating the expression of matrix metalloproteinase 1(MMP1). The oligonucleotide reduces or suppresses the expression of MMP1 by hybridization with MMP1 mRNA. The composition is used for anti-aging.

Abstract translation: 目的：提供含有作为miRNA-526b抑制剂的寡核苷酸或模拟物的组合物，以控制胶原蛋白的产生和预防或治疗老化。 构成：用于控制胶原的组合物含有序列1的15-23个连续核苷酸。通过调节基质金属蛋白酶1（MMP1）的表达来控制胶原蛋白。 寡核苷酸通过与MMP1 mRNA杂交降低或抑制MMP1的表达。 该组合物用于抗衰老。

公开(公告)号：KR1020110000715A

公开(公告)日：2011-01-05

申请号：KR1020100117490

申请日：2010-11-24

Applicant: (주)아모레퍼시픽

Inventor： 박선미 ,  신동욱 ,  이상민 ,  송민정 ,  김신형 ,  노민수 ,  김한곤

IPC: A61K8/97 ,  A61K36/54 ,  A61Q19/00

Abstract: PURPOSE: A composition containing medicinal herb extract for skin care or plasty is provided to promote differentiation of mesenchymal stem cells to adipocytes. CONSTITUTION: A composition for promoting adipocyte differentiation contains Linderae Radix extract as an active ingredient. The composition increases fat tissue and promotes differentiation of mesenchymal stem cells to adipocytes. The mesenchymal stem cells are derived from human bone marrow.

Abstract translation: 目的：提供含有用于护肤或整形的药草提取物的组合物，以促进间充质干细胞向脂肪细胞的分化。 构成：用于促进脂肪细胞分化的组合物含有紫草提取物作为活性成分。 组合物增加脂肪组织并促进间充质干细胞向脂肪细胞的分化。 间充质干细胞衍生自人骨髓。

公开(公告)号：KR1020100120585A

公开(公告)日：2010-11-16

申请号：KR1020090039462

申请日：2009-05-06

Applicant: (주)아모레퍼시픽 ,  서울대학교산학협력단

Inventor： 손의동 ,  최현정 ,  김지현 ,  노민수 ,  김한곤 ,  정진호 ,  김은주 ,  김지영

IPC: A61K31/202 ,  A61P17/16 ,  A61K8/36 ,  A61Q19/08

Abstract: PURPOSE: A composition of external use skin formulation for anti-aging and moisturizing is provided to suppress MMP(matrix metalloprotease) increase. CONSTITUTION: A composition of external use skin formulation contains 0.001-10 weight% of 11,14,17-Eicosatrienoic acid(ETA) as an active ingredient. ETA is contained in oil phase. The composition is used for preventing aging through reduction of collagenase expression. The composition is also used for skin moisturizing by suppressing skin barrier damage.

Abstract translation: 目的：提供抗老化和保湿的外用皮肤制剂组合物，以抑制MMP（基质金属蛋白酶）增加。 构成：外用皮肤制剂的组合物含有作为活性成分的11,14,17-二十碳三烯酸（ETA）的0.001-10重量％。 ETA含在油相中。 该组合物用于通过降低胶原酶表达来预防老化。 该组合物还可用于通过抑制皮肤屏障损伤来进行皮肤保湿。

公开(公告)号：KR1020100060752A

公开(公告)日：2010-06-07

申请号：KR1020080119483

申请日：2008-11-28

Applicant: (주)아모레퍼시픽

Inventor： 최현 ,  여현주 ,  노민수 ,  김한곤

IPC: C12Q1/68 ,  A61K36/58

CPC classification number: G01N33/5023 ,  A61K36/58 ,  C12Q1/6844 ,  C12Q2600/136 ,  G01N33/15

Abstract: PURPOSE: A method for screening a material which relieves skin irritation by environmental harmful factor is provided to manufacture an external use formulation and to detoxify. CONSTITUTION: A method for screening a material which relieves skin irritation by environmental harmful factor comprises: a step of treating candidates which regulates intracellular factor in vitro; a step of treating the environmental harmful factor to test cells to induce overexpression of the factor; and a step of measuring expression level. The test cells are keratinocytes. The environmental harmful factor is pollen or yellow sand. The overexpressed factor is interleukin 6 or 8, GSTT1, NQ01, or hBD3. The screened material is Melia azedarach L. var. japonica Makino or Tussilago farfara L. extract.

Abstract translation: 目的：提供一种用于筛选由环境有害因素减轻皮肤刺激的物质的方法，以制造外用制剂和解毒。 构成：通过环境有害因子筛选缓解皮肤刺激的材料的方法包括：处理体外调节细胞因子的候选物的步骤; 治疗环境有害因素以测试细胞以诱导因子过表达的步骤; 以及测量表达水平的步骤。 测试细胞是角质形成细胞。 环境有害因素是花粉或黄沙。 过表达因子是白细胞介素6或8，GSTT1，NQ01或hBD3。 筛选的材料是Melia azedarach L. var。 粳稻或东方龙草L.提取物。

公开(公告)号：KR1020100059042A

公开(公告)日：2010-06-04

申请号：KR1020080117680

申请日：2008-11-25

Applicant: (주)아모레퍼시픽 ,  고려대학교 산학협력단

Inventor： 최현 ,  여현주 ,  노민수 ,  신화영 ,  김한곤 ,  도성재 ,  김원년

IPC: A61K31/195 ,  C12Q1/68 ,  A61K31/352

CPC classification number: A61K31/195 ,  A61K31/352 ,  C12Q1/6844 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/15 ,  G01N33/5023

Abstract: PURPOSE: A method for screening a material which induces skin irritation by yellow dust is provided to reduce skin irritative factor expression and to reduce skin irritation by yellow dust. CONSTITUTION: A method for screening a material which induces skin irritation by yellow dust comprises: a step of treating yellow dust to keratinocytes; and a step of screening a gene of which expression level is significantly changed comparing with the expression of normal keratinocytes through RT-PCR. The material which induces skin irritation by yellow dust is AhR or CYP. A method for screening a material which relieves skin irritation by yellow dust comprises: a step of treating yellow dust to test cells to induce overexpression of an irritative factor; a step of treating a candidate material to the overexpressed cells; a step of measuring expression level of the irritative factor by RT-PCR. The material which relieves skin irritation by yellow dust is Trichosanthis semen. An external use skin composition for relieving skin irritation contains 0.001-1 weight% of Trichosanthis semen.

Abstract translation: 目的：提供一种筛选黄色粉尘引起皮肤刺激的材料的方法，以减少皮肤刺激因子的表达，并减少黄色粉尘的皮肤刺激。 构成：用于筛选黄色粉尘引起皮肤刺激的材料的方法包括：将黄色粉末处理成角质形成细胞的步骤; 与通过RT-PCR的正常角质化细胞的表达相比，筛选其表达水平显着变化的基因的步骤。 黄色粉尘引起皮肤刺激的物质是AhR或CYP。 用于筛选减轻黄色粉尘对皮肤刺激的材料的方法包括：处理黄色粉尘以测试细胞以诱导刺激性因子的过度表达的步骤; 将候选材料处理到过表达细胞的步骤; 通过RT-PCR测定刺激因子的表达水平的步骤。 减轻黄色粉尘的皮肤刺激性的物质是Trichosanthis精液。 用于缓解皮肤刺激的外用皮肤组合物含有0.001-1重量％的Trichosanthis精液。

公开(公告)号：KR1020100010916A

公开(公告)日：2010-02-02

申请号：KR1020090067159

申请日：2009-07-23

Applicant: 한국과학기술원 ,  (주)아모레퍼시픽

Inventor： 나용주 ,  노민수 ,  김한곤 ,  신현정 ,  김미나

IPC: C12Q1/68 ,  G01N33/50

CPC classification number: C12Q1/6883 ,  C12Q2600/158

Abstract: PURPOSE: A method for screening dynamic stimulation for improving skin function is provided to measure biochemical change against external stimulation and screen kind, form, size, intensity, and time of dynamic stimulation. CONSTITUTION: A method for screening dynamic stimulation for improving skin function comprises: a first step of performing repeatitive dynamic stimulation to skin; a second step of measuring biochemical change of skin by dynamic stimulation; and a third step of selecting useful dynamic stimulation based on biochemical change. The measurement is performed by measuring mRNA expression level of fibroblast-derived gene. In the third step, nerve growth factor, neurotrophin 3, TIMP 1, TrkA, TrkC, TGF alpha, TGF beta1, TGF beta2 or TGF beta3 gene is selected as dynamic stimulation.

Abstract translation: 目的：提供一种用于筛选动态刺激以改善皮肤功能的方法，以测量对外部刺激和屏幕种类，形态，大小，强度和动态刺激时间的生物化学变化。 构成：用于筛选动态刺激以改善皮肤功能的方法包括：对皮肤进行重复动态刺激的第一步骤; 通过动态刺激测量皮肤生化变化的第二步; 以及基于生物化学变化选择有用的动态刺激的第三步。 通过测量成纤维细胞衍生基因的mRNA表达水平进行测量。 在第三步中，选择神经生长因子，神经营养因子3，TIMP1，TrkA，TrkC，TGFα，TGFβ1，TGFβ2或TGFβ3基因作为动态刺激。