Abstract:
본 발명은 바닐로이드 수용체(바닐로이드 수용체 1; VR1; TRPV1) 길항물질로서의 신규 화합물, 이의 이성체 또는 이의 약학적으로 허용가능한 염, 및 이를 함유하는 약학 조성물에 관한 것이다. 본 발명은 통증, 편두통, 관절통, 신경통, 신경병, 신경 손상, 피부 질환, 방광 과민증, 과민성 장 증후군, 긴급 배변, 호흡기 장애, 피부, 눈 또는 점막의 자극, 위-십이지장 궤양, 염증성 질환, 귀 질환, 또는 심장 질환과 같은 질환을 예방하거나 치료를 위한 약학 조성물을 제공한다.
Abstract:
PURPOSE: A cosmetic material stabilizing composition containing a polyol compound with 4 or more hydroxyl groups is provided to ensure a moisturizing effect without dust and convenience in distribution, and to prevent a separation phenomenon. CONSTITUTION: A cosmetic material stabilizing composition contains a polyol compound with 4 hydroxy groups. A cosmetic composition contains a polyol compound with 4 hydroxy groups. The polyol compound is pentaerythritol and a derivative thereof. The composition contains 5-40% of the polyol compound. The cosmetic composition is manufactured in the form of a skin softener, an astringent, a nutrition lotion, nutrition cream, massage cream, eye cream, an eye essence, an essence, cleansing cream, a cleansing lotion, cleansing foam, cleansing water, a pack, powder, a body lotion, body cream, a body essence, a body cleanser, a hair dyeing agent, a shampoo, a rinse, toothpaste, an oral cleanser, a lotion, an ointment, a gel, cream, a patch, or a spray. [Reference numerals] (AA) 37°C stability; (BB) 25°C stability; (CC) 45°C stability; (DD) Cycle stability; (EE) 4°C stability
Abstract:
PURPOSE: A composition for skin whitening is provided to show pigmentation suppression, and to have an excellent skin whitening effect by having a deterrent effect on tyrosinase which is an apoenzyme of melanogenesis and by containing an extract of acanthopanax. CONSTITUTION: A composition for skin whitening comprises an enzymatically treated extract of acanthopanax as an active ingredient. Acanthopanax is more than one of species selected from the group of Acanthopanax senticosus, Eleutherococcus senticocus, Acanthopanax senticosus for. Inermis, Acanthopanax sessilitlorus, Eleutherococcus divaricatus var. chiisanensis, Acanthopanax seoulense, Eleutherococcus divaricatus, Eleutherococcus gracilistylus, and Acanthopanax siebololianum. An enzyme is a cell wall degrading enzyme or proteinase. The cell wall degrading enzyme comprises cellulose. The proteinase comprises pectinase. The cellulase comprises celluclast. [Reference numerals] (AA) Voltage[mV]; (BB) Time(minutes)
Abstract:
PURPOSE: A composition containing a fermentation of a Fraxinus rhynchophylla Hance extract is provided to suppress tyrosinase activation and melanogenesis and to ensure excellent skin whitening effect. CONSTITUTION: A composition for skin whitening contains 0.001-20 wt% of a fermentation of a Fraxinus rhynchophylla Hance as an active ingredient. The extract is prepared using water, an organic solvent, or a mixture thereof. The fermentation is preparing by fermenting the extract with yeast such as Saccaromyces sp., Schizosaccharomyces sp., Torulopsis sp., Rhodotorula sp., or Candida ap. The composition is a cosmetic or pharmaceutical composition.
Abstract:
A pharmaceutical composition for prevention or treatment of diseases is provided to offer antagonism about vanilloid receptor or transient receptor potential vanilloid. The compound is used for prevention or treatment of the diseases related to activity of TRPV1. A pharmaceutical composition is manufactured by reacting a compound indicated as the chemical formula IIIa with the compound indicated as the chemical formula IIIb under presence of a coupling agent indicated as a chemical formula III. The coupling agent is N,N - dicyclohexylcarbodiimide, EDCl or DMTMM. The pharmaceutical composition includes an antagonist compound of vanilloid receptor and a carrier and salt can be allowed to a pharmaceutical range.
Abstract:
본 발명은 바닐로이드 수용체 길항제로서 하기 화학식 1로 표시되는 티오우레아 유도체 또는 약제학적으로 허용가능한 그의 염, 또는 그의 수화물 또는 용매화물과 약제학적으로 허용가능한 담체를 함유하는 소양성 또는 자극성 피부질환의 예방 또는 치료용 조성물에 관한 것이다.
1 상기 화학식 중 R은 수소, 탄소수 1 내지 5의 알킬, 탄소수 2 내지 5의 알케닐, 탄소수 1 내지 5의 알콕시, 하이드록시, 할로겐, 니트로, 시아노, 메톡시카르보닐 또는 카르복실기를 나타낸다. 바닐로이드 수용체 길항제, 티오우레아 유도체, 피부질환, 소양증, 피부자극