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    호랑나비 유충에서 분리한 항균펩타이드 유전자 및 항균펩타이드
    81.
    发明公开
    호랑나비 유충에서 분리한 항균펩타이드 유전자 및 항균펩타이드 有权
    抗菌肽基因和抗巨噬细胞分离自白藜芦醇

    公开(公告)号：KR1020100100246A

    公开(公告)日：2010-09-15

    申请号：KR1020090019022

    申请日：2009-03-05

    Applicant: 대한민국(농촌진흥청장)

    Inventor： 김성렬 ,  황재삼 ,  박관호 ,  이광길 ,  강석우

    IPC: C07K14/00

    Abstract: PURPOSE: A novel antibacterial peptide gene and antibacterial peptide isolated from Papilio xuthus larva are provided to ensure antibacterial activity against fungi causing candidiasis. CONSTITUTION: An antibacterial peptide gene isolated from Papilio xuthus larva has a base sequence of sequence number 1. An antibacterial peptide encoded by the gene of sequence number 1 has an amino acid sequence of sequence number 2. A pharmaceutical composition contains the antibacterial peptide of sequence number 2 or 3 as an active ingredient.

    Abstract translation: 目的：提供从Papilio xuthus幼虫分离的新型抗菌肽基因和抗菌肽，以确保对引起念珠菌病的真菌的抗菌活性。 构成：从Papilio xuthus幼虫分离的抗菌肽基因具有序列号1的碱基序列。由序列号1的基因编码的抗菌肽具有序列号2的氨基酸序列。药物组合物含有序列的抗菌肽 2或3为有效成分。

    곤충유래 글라이코자미노글라이칸 및 그 제조방법
    82.
    发明授权
    곤충유래 글라이코자미노글라이칸 및 그 제조방법 有权
    从内部衍生的糖蛋白酶体及其纯化方法

    公开(公告)号：KR100847889B1

    公开(公告)日：2008-07-25

    申请号：KR1020070020818

    申请日：2007-03-02

    Applicant: 대한민국(농촌진흥청장)

    Inventor： 안미영 ,  지상덕 ,  황재삼 ,  윤은영 ,  김영식

    IPC: C12P21/00 ,  C07K1/14 ,  C07K1/02

    CPC classification number: C12P19/04 ,  A23L33/10 ,  A23V2002/00 ,  A23V2200/318 ,  A23V2200/326 ,  A23V2200/332 ,  A61K31/726 ,  C08B37/0063

    Abstract: Glycosaminoglycans derived from insect are provided to maintain the systolic blood pressure be normal level in a hypertension patient by reducing blood pressure, regulate excessive growth of vascular endothelial cell and inhibit inflammation without excess of heart and pulse pressure. A method for producing glycosaminoglycans derived from insect comprises the steps of: (1) dipping a dried insect in an organic solvent selected from acetone, hexane, ethylacetate, methylalcohol, ethylalcohol, propanol, butanol, acetonitrile and dichloromethane to remove lipids and drying it; (2) degrading the dried insect of step (1) with alcalase in sodium bicarbonate solution(pH 9.0); (3) removing degraded proteins with 5 wt.% of trichloroacetic acid(TCA), and precipitating the protein removed solution with ethanol, cetylpyridinium and ethanol, sequentially; and (4) dialyzing the precipitates produced from the step (3) with distilled water.

    Abstract translation: 提供衍生自昆虫的糖胺聚糖以通过降低血压，调节血管内皮细胞的过度生长并抑制炎症而不会过多的心脏和脉搏压力，使高血压患者的收缩压维持正常水平。 一种生产来自昆虫的糖胺聚糖的方法，包括以下步骤：（1）将干燥的昆虫浸入选自丙酮，己烷，乙酸乙酯，甲醇，乙醇，丙醇，丁醇，乙腈和二氯甲烷的有机溶剂中以除去脂质并干燥; （2）用碳酸氢钠溶液（pH9.0）中的alcalase降解步骤（1）的干燥昆虫; （3）用5重量％的三氯乙酸（TCA）除去降解的蛋白质，并依次用乙醇，十六烷基吡啶和乙醇沉淀除去蛋白质的溶液; 和（4）用蒸馏水透析步骤（3）产生的沉淀物。

    애기뿔소똥구리 유충으로부터 분리한 신규한 항균펩타이드유전자 및 항균 펩타이드
    83.
    发明授权
    애기뿔소똥구리 유충으로부터 분리한 신규한 항균펩타이드유전자 및 항균 펩타이드 有权
    一种抗菌碱基对和从DUNG BEETLE分离的抗细菌肽，三叶草

    公开(公告)号：KR100790807B1

    公开(公告)日：2008-01-04

    申请号：KR1020060124569

    申请日：2006-12-08

    Applicant: 대한민국(농촌진흥청장)

    Inventor： 황재삼 ,  윤은영 ,  안미영 ,  황석조 ,  방혜선 ,  강희윤 ,  김연주 ,  김익수 ,  구태원 ,  강석우

    IPC: C07K14/00

    Abstract: A novel sequence and an antibacterial peptide isolated from larvae of Copris tripartitus are provided to be usefully used as a prophylactic and therapeutic agent of bacterial diseases of human and plant and show antibacterial activity against various pathogenic bacteria. A sequence of an antibacterial peptide isolated from larvae of Copris tripartitus(SEQ ID : NO. 3) is represented by the following : AACGGTTCTG AATTCTTAAC CAGTTCATAC CCAGCTATAA TTTGAATTAC 50 GTCTTTTAAA AAGATGGCAA AATTAATTGC TTTTGCATTA GTAGCTTCGT 100 TATGCCTGTC TATGGTGTTG TGCAATCCGT TACCAGAAGA AGTCCAAGAA 150 GAGGGACTTG TCAGACAAAA AAGGGTAACC TGTGACGTGT TAAGTTTCGA 200 AGCCAAAGGA ATAGCTGTAA ATCATTCGGC TTGTGCGCTA CATTGTATTG 250 CCTTACGTAA AAAAGGTGGT TCTTGTCAAA ATGGTGTGTG TGTTTGTAGA 300 AATTAATTAA CAAGCTGATT GTCCTTTTTT TTAATTGTGG CCGGATGATA 350 TTATTTTCAG TGTAATAAGA ACAAAAATAA AGATTTATAA CTATTAAAAA 400 AAAAAAAAAA AA 412. A novel antibacterial peptide(SEQ ID : NO. 4) is encoded by the sequence and consists of an amino acid sequence of Met Ala Lys Leu Ile Ala Phe Ala Leu Val Ala Ser Leu Cys Leu 15 Ser Met Val Leu Cys Asn Pro Leu Pro Glu Glu Val Gln Glu Glu 30 Gly Leu Val Arg Gln Lys Arg Val Thr Cys Asp Val Leu Ser Phe 45 Glu Ala Lys Gly Ile Ala Val Asn His Ser Ala Cys Ala Leu His 60 Cys Ile Ala Leu Arg Lys Lys Gly Gly Ser Cys Gln Asn Gly Val 75 Cys Val Cys Arg Asn 80.

    Abstract translation: 提供从Copris triartae的幼虫分离的新的序列和抗菌肽，有效地用作人和植物的细菌性疾病的预防和治疗剂，并且对各种致病菌具有抗菌活性。 （SEQ ID：NO 3）从Copris tripartitus的幼虫中分离的抗菌肽的序列：AACGGTTCTG AATTCTTAAC CAGTTCATAC CCAGCTATAA TTTGAATTAC 50 GTCTTTTAAA AAGATGGCAA AATTAATTGC TTTTGCATTA GTAGCTTCGT 100 TATGCCTGTC TATGGTGTTG TGCAATCCGT TACCAGAAGA AGTCCAAGAA 150 GAGGGACTTG TCAGACAAAA AAGGGTAACC TGTGACGTGT TAAGTTTCGA 200由下式表示 AGCCAAAGGA ATAGCTGTAA ATCATTCGGC TTGTGCGCTA CATTGTATTG 250 CCTTACGTAA AAAAGGTGGT TCTTGTCAAA ATGGTGTGTG TGTTTGTAGA 300 AATTAATTAA CAAGCTGATT GTCCTTTTTT TTAATTGTGG CCGGATGATA 350 TTATTTTCAG TGTAATAAGA ACAAAAATAA AGATTTATAA CTATTAAAAA 400 AAAAAAAAAA AA 412的新型抗菌肽（SEQ ID：NO：4）是由序列编码，由一个氨基的 Met Ala Lys Leu的氨基酸序列Ile Ala Phe Ala Leu Val Ala Ser Leu Cys Leu 15 Ser Met Val Leu Cys Asn Pro Leu Pro Glu Glu Val Gln Glu Glu 30 Gly Leu Val Arg Gln Lys Arg Val Thr Cys Asp Val Leu Ser Phe 45 Glu Ala Lys Gly Ile Ala Val Asn His Ser Ala Cys Ala Leu His 60 Cys Ile Ala Leu Arg Lys Lys Gly Gly Ser Cys Gln Asn Gly Val 75 Cys Val Cys Arg Asn 80。

    누에 배양세포로부터 분리한 프로테인 디설피드이소머레이즈를 코딩하는 ｃＤＮＡ 유전자의 염기서열 및그의 연역 아미노산
    84.
    发明公开
    누에 배양세포로부터 분리한 프로테인 디설피드이소머레이즈를 코딩하는 ｃＤＮＡ 유전자의 염기서열 및그의 연역 아미노산 有权
    从SILKWORM的培养细胞中分离的CDNA编码蛋白质半胱氨酸异构酶的核苷酸序列及其氨基酸序列

    公开(公告)号：KR1020030002924A

    公开(公告)日：2003-01-09

    申请号：KR1020010039221

    申请日：2001-07-02

    Applicant: 대한민국(농촌진흥청장)

    Inventor： 구태원 ,  윤은영 ,  황재삼 ,  강석우 ,  권오유

    IPC: C12N15/10

    Abstract: PURPOSE: Provided are a nucleotide sequence of cDNA coding protein disulfide isomerase(PDI) isolated from the cultured cell of a silkworm, and an amino acid sequence thereof, thereby increasing the expression of useful proteins and consequently mass-producing them economically. CONSTITUTION: The nucleotide sequence of cDNA coding protein disulfide isomerase(PDI) isolated from the cultured cell of a silkworm, is represented by the SEQ ID NO:1, and its amino acid sequence is represented by the SEQ ID NO:2.

    Abstract translation: 目的：提供从蚕的培养细胞分离的cDNA编码蛋白质二硫键异构酶（PDI）的核苷酸序列及其氨基酸序列，从而增加有用蛋白质的表达，从而经济地批量生产它们。 构成：从蚕的培养细胞分离的cDNA编码蛋白质二硫键异构酶（PDI）的核苷酸序列由SEQ ID NO：1表示，其氨基酸序列由SEQ ID NO：2表示。

    미세 유리주사침을 이용한 ＤＮＡ의 누에알 주입방법
    86.
    发明公开
    미세 유리주사침을 이용한 ＤＮＡ의 누에알 주입방법 有权
    使用微光玻璃针对蚕丝蛋白的DNA的微观方法

    公开(公告)号：KR1020010054147A

    公开(公告)日：2001-07-02

    申请号：KR1019990054812

    申请日：1999-12-03

    Applicant: 대한민국(농촌진흥청장)

    Inventor： 김근영 ,  서동상 ,  황재삼 ,  이상몽 ,  강석우

    IPC: C12N15/00

    Abstract: PURPOSE: A microinjection method of DNA into silkworm eggs using micro glass needle is provided, of which processes are easy to perform and which has superior transformation rate. Therefore, a transformed silkworm is mass-produced. CONSTITUTION: The micro glass needle is produced by cutting and grinding the end of a capillary glass tube. Thereby, DNA solution containing a foreign gene is injected into a silkworm egg with maintaining a certain angle between the egg and the needle, at once, in order to directly express the foreign gene in a reproductive cell. Wherein, the angle between the egg and the needle is preferably 30-50 degree.

    Abstract translation: 目的：提供使用微玻璃针将DNA引入蚕卵的显微注射方法，其工艺简单，转化率高。 因此，转化的蚕是大量生产的。 构成：微型玻璃针是通过切割和研磨毛细管玻璃管的末端来生产的。 由此，将含有外来基因的DNA溶液一次注入到具有一定角度的蚕卵中，以便在生殖细胞中直接表达外源基因。 其中，鸡蛋与针之间的角度优选为30-50度。

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