公开(公告)号：KR1020130000219A

公开(公告)日：2013-01-02

申请号：KR1020110060796

申请日：2011-06-22

Applicant: 삼성전자주식회사

Inventor： 심저영 ,  전태한 ,  이동호 ,  정희정 ,  조성호

IPC: G01N27/02 ,  C12Q1/68

CPC classification number: G01N27/44791 ,  G01N33/48721 ,  C12Q1/6825 ,  C12Q1/6869

Abstract: PURPOSE: A nano sensor and a manufacturing method thereof are provided to form an insulating layer, in which a metallic electrode pad and nano pore are formed, on graphenes by using protective layers or a sacrificial layer. CONSTITUTION: A nano sensor(100) comprises a substrate(10), a first insulating layer(20), first and second electrodes(40,45), first and second electrode pads(50,55), and protective layers(60). A hole(15) is formed on the substrate. The first insulating layer is arranged on the substrate and a first nano pore(23) is formed at a position corresponding to the hole. The first and second electrodes are arranged on the first insulating layer and spaced from each other around the first nano pore. The first and second electrode pads are arranged on the first and second electrodes respectively. The protective layers are arranged on the first and second electrode pads.

Abstract translation: 目的：提供纳米传感器及其制造方法，通过使用保护层或牺牲层，在石墨烯上形成金属电极焊盘和纳米孔的绝缘层。 构造：纳米传感器（100）包括衬底（10），第一绝缘层（20），第一和第二电极（40,45），第一和第二电极焊盘（50,55）以及保护层（60） 。 在基板上形成孔（15）。 第一绝缘层布置在基板上，并且在与孔对应的位置处形成第一纳米孔（23）。 第一和第二电极布置在第一绝缘层上并且围绕第一纳米孔彼此间隔开。 第一和第二电极焊盘分别布置在第一和第二电极上。 保护层布置在第一和第二电极焊盘上。

公开(公告)号：KR1020120031740A

公开(公告)日：2012-04-04

申请号：KR1020100093301

申请日：2010-09-27

Applicant: 삼성전자주식회사

Inventor： 유창은 ,  안태진 ,  이규상 ,  심저영 ,  김기은 ,  김명순 ,  홍성우 ,  전태한 ,  김진국 ,  박세훈 ,  손인석 ,  정신호

IPC: C12Q1/68 ,  G01N33/15 ,  G06F17/18

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/15 ,  G06F17/18

Abstract: PURPOSE: A method for predicting sensitivity of an anticancer agent for a patient with gastric cancer is provided to effectively predict the sensitivity of a biological sample. CONSTITUTION: A kit for predicting sensitivity of an anticancer agent for a patient with gastric cancer contains a polynucleotide of sequence numbers 1-59 including the 27th base SNP. A method for predicting sensitivity of the anticancer agent comprises: a step of preparing the biological sample from a patient with gastric cancer; a step of identifying the presence of SNP contained in the kit from the sample; and a step of determining sensitivity of the anticancer agent by statistic classification. The biological sample is a gastric cancer tissue.

Abstract translation: 目的：提供一种预测胃癌患者抗癌药敏感性的方法，以有效预测生物样品的敏感性。 构成：用于预测抗癌剂对胃癌患者的敏感性的试剂盒含有序列号1-59的多核苷酸，包括第27位碱基SNP。 用于预测抗癌剂敏感性的方法包括：从患有胃癌的患者制备生物样品的步骤; 从样品中鉴定试剂盒中所含的SNP的存在的步骤; 以及通过统计分类来确定抗癌剂的敏感性的步骤。 生物样品是胃癌组织。

公开(公告)号：KR1020090052227A

公开(公告)日：2009-05-25

申请号：KR1020070118826

申请日：2007-11-20

Applicant: 삼성전자주식회사

Inventor： 이주원 ,  이영선 ,  남궁각 ,  박진성 ,  심저영

IPC: C12Q1/68

CPC classification number: C12Q1/6844 ,  C12Q2531/113 ,  C12Q2537/161

Abstract: 본 발명은 경쟁적 증폭 반응을 이용하여 표적 핵산을 검출하는 방법에 관한 것이다.
경쟁적 증폭반응, PCR, 프로브

公开(公告)号：KR100785029B1

公开(公告)日：2007-12-12

申请号：KR1020060111239

申请日：2006-11-10

Applicant: 삼성전자주식회사

Inventor： 정원석 ,  유규태 ,  심저영 ,  남궁각

IPC: C12Q1/00 ,  C12Q1/68 ,  G01N33/48

CPC classification number: B01L3/502746 ,  C12Q1/6825 ,  C12Q2565/629 ,  C12Q2565/631 ,  G01N33/48

Abstract: A device and a method for controlling flow are provided to allow various kinds of fluids flowing through many channels to flow in one channel in sequence and continuity using capillary force. A device for controlling flow(100) comprises inlet holes(106,108) in which fluid flows; a plurality of divergence channels(105,107) formed to allow the fluid flown-in through the inlet hole to flow; a confluence channel(112) where the plurality of divergence channels are extended by being flown together and an outlet hole(113) is formed at the end to discharge the fluid; and a porous material(130) located to be adjacent to the outlet hole and is characterized in that capillary force of the confluence channel is bigger than that of each of the divergence channels. A method for controlling flow comprises the steps of: (a) injecting fluid into the plurality of divergence channels except one of them up to a confluence point of the confluence channel through the inlet hole and then closing the inlet hole; (b) injecting fluid into the one remaining divergence channel through the inlet hole and then discharging the fluid passing through the confluence channel through the outlet hole as a porous material; and (c) after closing the inlet hole of the one remained divergence channel, opening one of the closed inlet holes and then discharging the fluid remaining at the open divergence channel through the outlet after passing through the confluence channel as a porous material.

Abstract translation: 提供一种用于控制流量的装置和方法，以允许流过许多通道的各种流体在一个通道中依次使用毛细管力顺序流动和连续。 用于控制流量的装置（100）包括流体流动的入口孔（106,108） 多个发散通道（105,107）形成为允许流体通过入口孔流入; 汇合通道（112），其中所述多个发散通道通过一起流动而延伸，并且在末端形成出口孔（113）以排出流体; 以及位于与出口孔相邻的多孔材料（130），其特征在于，汇流通道的毛细管力大于每个分支通道的毛细管力。 一种控制流量的方法包括以下步骤：（a）将流体注入多个发散通道中，除了其中一个，通过入口孔至汇流通道的汇合点，然后关闭入口孔; （b）通过入口孔将流体注入一个剩余的分流通道，然后将通过汇流通道的流体作为多孔材料排出出口孔; 并且（c）在关闭一个剩余分支通道的入口孔之后，打开其中一个封闭的入口孔，然后在通过作为多孔材料的汇合通道之后，通过出口排出残留在开口发散通道的流体。

公开(公告)号：KR1020070099151A

公开(公告)日：2007-10-09

申请号：KR1020060030170

申请日：2006-04-03

Applicant: 삼성전자주식회사

Inventor： 유규태 ,  이규상 ,  정원석 ,  심저영 ,  조연자

IPC: G01N33/48 ,  G01N33/483

CPC classification number: G01N33/54373 ,  G01N33/48707 ,  G01N27/4145 ,  G01N27/4146

Abstract: A method for detecting bio-molecules is provided to detect a plurality of different bio-molecules continuously using a field effect transistor(FET) with rapid speed of the bio-molecule detection reaction, use a used FET continuously without throwing it away and significantly lower the distribution of performance among FETs since the bio-molecules do not use a fixed FET. A method for detecting existence or concentration of target bio-molecules such as nucleic acids and proteins using a field effect transistor comprises the steps of: (a) providing a first sample including a first target bio-molecules to a gate electrode of the field effect transistor; and (b) measuring the electrical signal change of the transistor, wherein the field effect transistor comprises a substrate(21) consisting of a semiconductor material, a source region(22a) and a drain region(22b), each of which is respectively formed in the substrate with being spaced apart from each other and doped with polarity opposite to that of the substrate, a channel region displaced between the source and drain regions, an insulation layer(23) placed on the channel region and consisting of an electrically insulation material and a gate electrode(24) displaced on top of the insulation layer with being spaced apart therefrom. The method further comprises a step of providing a second sample including a second target bio-molecule to the gate electrode of the transistor, and a step of providing a solution not including a bio-molecule to the gate electrode of the field effect transistor to wash it before the step (b).

Abstract translation: 提供了一种用于检测生物分子的方法，使用具有生物分子检测反应快速的场效应晶体管（FET）连续地检测多种不同的生物分子，连续使用所用的FET，而不会将其丢弃并显着降低 由于生物分子不使用固定的FET，FET之间的性能分布。 使用场效应晶体管检测目标生物分子如核酸和蛋白质的存在或浓度的方法包括以下步骤：（a）向场效应的栅电极提供包含第一靶生物分子的第一样品 晶体管; 和（b）测量晶体管的电信号变化，其中场效应晶体管包括由半导体材料，源极区（22a）和漏极区（22b）组成的衬底（21），每个分别形成 在衬底中彼此间隔开并且掺杂有极性与衬底相反的极性，在源极和漏极区之间移位的沟道区，设置在沟道区上并由电绝缘材料构成的绝缘层（23） 以及在绝缘层的顶部上与之隔开的栅电极（24）。 该方法还包括向晶体管的栅电极提供包括第二目标生物分子的第二样品的步骤，以及向场效应晶体管的栅电极提供不包括生物分子的溶液以洗涤 它在步骤（b）之前。

公开(公告)号：KR1020070099150A

公开(公告)日：2007-10-09

申请号：KR1020060030169

申请日：2006-04-03

Applicant: 삼성전자주식회사

Inventor： 유규태 ,  이규상 ,  심저영 ,  정원석 ,  조연자

IPC: G01N33/48 ,  G01N33/483

CPC classification number: G01N33/54373 ,  G01N27/4145

Abstract: A method for detecting bio-molecules is provided to detect the bio-molecules accurately and easily and prepare a field effect transistor(FET) simply and lower the distribution of performance among FETs significantly since the bio-molecules do not use a fixed FET. A method for detecting target bio-molecules such as nucleic acids and proteins using a field effect transistor comprises the steps of: (a) providing a first sample including a first target bio-molecule to a gate electrode of the field effect transistor and measuring the first electrical signal change of the transistor; (b) providing a second sample including a second sample to the gate electrode of the same field effect transistor and measuring the second electrical signal change of the transistor; and (c) comparing the first electrical signal and the second electrical signal by calculating the ratio of the first electrical signal to the second electrical signal, wherein the field effect transistor comprises a substrate(21) consisting of a semiconductor material, a source region(22a) and a drain region(22b), each of which is respectively formed in the substrate with being spaced apart from each other and doped with polarity opposite to that of the substrate, a channel region displaced between the source and drain regions, an insulation layer(23) placed on the channel region and consisting of an electrically insulation material and a gate electrode(24) displaced on top of the insulation layer with being spaced apart therefrom. The method is further comprises a step of supplying a solution not including a bio-molecule to the gate electrode of the transistor to wash it before the step (b).

Abstract translation: 提供了一种用于检测生物分子的方法，可以准确，容易地检测生物分子，并且由于生物分子不使用固定的FET，因此简单地制备场效应晶体管（FET）并显着降低FET之间的性能分布。 使用场效应晶体管检测目标生物分子例如核酸和蛋白质的方法包括以下步骤：（a）向场效应晶体管的栅电极提供包含第一靶生物分子的第一样品，并测量 晶体管的第一个电信号变化; （b）向同一场效应晶体管的栅电极提供包括第二样品的第二样品，并测量晶体管的第二电信号变化; （c）通过计算第一电信号与第二电信号的比率来比较第一电信号和第二电信号，其中场效应晶体管包括由半导体材料构成的衬底（21），源区（ 22a）和漏极区域（22b），每个漏极区域分别形成在衬底中彼此间隔开并掺杂有极性与衬底相反的极性，在源极和漏极区之间移位的沟道区，绝缘体 层（23）放置在沟道区上并由电绝缘材料和在绝缘层的顶部上移位的栅电极（24）构成。 该方法还包括向晶体管的栅电极提供不包括生物分子的溶液以在步骤（b）之前进行洗涤的步骤。

公开(公告)号：KR100738081B1

公开(公告)日：2007-07-12

申请号：KR1020050111975

申请日：2005-11-22

Applicant: 삼성전자주식회사

Inventor： 심저영 ,  이규상 ,  유창은 ,  황규연 ,  김영아 ,  조연자 ,  유규태

IPC: G01N33/50 ,  C12Q1/68

CPC classification number: G01N33/54373 ,  B01J2219/00529 ,  B01J2219/00596 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00722 ,  G01N27/4145

Abstract: 본 발명은 기판, 상기 기판의 양측에 형성되고 상기 기판과 반대 극성으로 각각 도핑된 소스 및 드레인, 상기 소스 및 드레인과 접촉하고 상기 기판 상에 형성된 게이트를 포함하는 FET 기반 바이오 센서에 있어서, 상기 게이트 표면에 생분자가 결합 가능한 무기막이 구비되는 것을 특징으로 하는 FET 기반 바이오 센서를 제공한다. 또한, 본 발명은 상기 FET 기반 바이오 센서의 제조 방법 및 상기 FET 기반 바이오 센서를 이용한 생분자 검출 방법을 제공한다. 본 발명에 따른 무기막을 구비하는 FET 기반 바이오 센서는 별도의 추가적인 공정 없이 반도체 제조 공정만으로 제조가 가능하므로 패터닝이 가능하다. 따라서 하나의 FET에 있어서 게이트 표면에만 무기막을 선택적으로 증착하거나 복수의 FET에 있어서 일부의 게이트 표면에만 무기막을 선택적으로 증착할 수 있다. 또한, 본 발명에 따르면 미량의 타겟 생분자도 효과적으로 검출할 수 있고, 상기 무기막의 두께는 매우 얇게 조절될 수 있어 FET의 검출 가능 거리인 debye length 내에 생분자가 결합할 수 있다.
FET, 바이오 센서, 무기막, 게이트, 보에마이트(boehmite)

公开(公告)号：KR1020070026719A

公开(公告)日：2007-03-08

申请号：KR1020070012800

申请日：2007-02-07

Applicant: 삼성전자주식회사

Inventor： 심저영 ,  정성욱 ,  남궁지나 ,  유규태 ,  마장석

IPC: H04N1/00 ,  H04N1/03 ,  G01N21/64

CPC classification number: C03C17/28 ,  C03C2218/111 ,  C03C2218/365 ,  G01N21/278 ,  G01N21/6452

Abstract: An apparatus for calibrating an optical scanner, a method for manufacturing the apparatus, and a method for calibrating an optical scanner using the apparatus are provided to easily manufacture the optical scanner and obtain a stabilized fluorescent signal. An apparatus for calibrating an optical scanner includes a substrate onto which molecules capable of forming excimer are fixed. The apparatus includes a blank space where the excimer molecules are not fixed. The optical scanner includes at least one light source, a scanning unit, and a detector. The light source generates at least one coherent light beam at a specific wavelength. The scanning unit scans the coherent light beam on the surface of the substrate. The detector detects light generated from a sample region on the surface of the substrate.

Abstract translation: 提供了一种用于校准光学扫描仪的装置，用于制造该装置的方法以及使用该装置校准光学扫描仪的方法，以便容易地制造光学扫描器并获得稳定的荧光信号。 用于校准光学扫描仪的装置包括其上固定有能够形成准分子的分子的基底。 该装置包括其中准分子分子不固定的空白空间。 光学扫描器包括至少一个光源，扫描单元和检测器。 光源产生特定波长的至少一个相干光束。 扫描单元扫描基板表面上的相干光束。 检测器检测从衬底表面上的样品区域产生的光。

公开(公告)号：KR1020070003481A

公开(公告)日：2007-01-05

申请号：KR1020050059489

申请日：2005-07-02

Applicant: 삼성전자주식회사

Inventor： 심저영 ,  이수석 ,  박진성 ,  황규연

IPC: C12Q1/68

CPC classification number: B01L3/50857 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0819 ,  B82Y10/00 ,  G01N27/4145 ,  H01L21/823828 ,  H01L51/0093 ,  H01L51/0545 ,  Y10T436/2575 ,  G01N27/414 ,  H01L51/0512

Abstract: A method for manufacturing a DNA chip for detecting genes is provided to reduce the manufacturing costs by using no further devices, and to prevent lowering of organic film and DNA probe activities by completely removing the photosensitive film from the organic film and DNA probe in a development process because the organic film and DNA probe do not contact with the photosensitive film. The method for manufacturing a DNA chip for detecting genes containing a plurality of transistors on a substrate wherein the organic films(160) and DNA probes(164) are accumulated on gate electrodes(156) of the transistors sequentially comprises the steps of: forming an interlayer insulating layer(150) for covering the transistor on a substrate and planarizing its surface; forming at least two contact holes(158) through which the gate electrodes of the transistors are exposed to the interlayer insulating layer; selectively forming the organic film on the gate electrode within the contact hole; attaching the first DFR(dry film resist) film(162) for covering the contact hole in the top surface of the interlayer insulating layer; removing a part of the first DFR film for covering the first contact hole; attaching the first DNA probe on the organic film within the first contact hole; and removing the first DFR film.

Abstract translation: 提供了用于检测基因的DNA芯片的制造方法，通过不再使用其他装置来降低制造成本，并且通过在显影中从有机膜和DNA探针中完全除去感光膜来防止有机膜和DNA探针活性的降低 因为有机膜和DNA探针不与感光膜接触。 制造用于检测在基板上含有多个晶体管的基因的DNA芯片的方法，其中有机膜（160）和DNA探针（164）依次堆积在晶体管的栅电极上，其顺序包括以下步骤： 层间绝缘层（150），用于覆盖基板上的晶体管并使其表面平坦化; 形成至少两个接触孔（158），晶体管的栅电极通过该接触孔暴露于层间绝缘层; 在接触孔内的栅电极上选择性地形成有机膜; 安装用于覆盖层间绝缘层的顶表面中的接触孔的第一DFR（干膜抗蚀剂）膜（162） 去除用于覆盖第一接触孔的第一DFR膜的一部分; 将第一DNA探针附着在第一接触孔内的有机膜上; 并去除第一个DFR膜。

公开(公告)号：KR100634505B1

公开(公告)日：2006-10-16

申请号：KR1020040044505

申请日：2004-06-16

Applicant: 삼성전자주식회사

Inventor： 심저영 ,  남궁지나 ,  황규연

IPC: C12Q1/68 ,  G01N33/68

CPC classification number: G01N21/6428 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00385 ,  B01J2219/00432 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01L2300/0636 ,  B01L2300/0819 ,  B82Y30/00 ,  G01N21/45 ,  G01N21/6452

Abstract: 본 발명은 기판상에 패턴화된 박막층을 갖는 마이크로어레이 기판으로서, 상기 기판과 상기 박막층 물질은 서로 다른 굴절율을 가지며, 상기 패턴화된 박막층은 조사된 여기광이 상기 기판으로부터 반사되는 제1 반사광과 상기 박막층으로부터 반사되는 제2 반사광이 보강 간섭을 일으키는 두께를 갖는 스팟 영역과 조사된 여기광이 상기 기판으로부터 반사되는 제1 반사광과 상기 박막층으로부터 반사되는 제2 반사광이 상쇄 간섭을 일으키는 두께를 갖는 여백 영역을 포함하는 마이크로어레이 기판을 제공한다.
마이크로어레이, 패턴