公开(公告)号：KR1020120014512A

公开(公告)日：2012-02-17

申请号：KR1020100076635

申请日：2010-08-09

Applicant: 삼성전자주식회사

Inventor： 손대순 ,  이규상 ,  안태진 ,  김진석 ,  박창이 ,  손인석 ,  정신호

IPC: G06N3/12 ,  G06F17/00 ,  G06F9/44

CPC classification number: G06N3/126 ,  G06F9/448 ,  G06F9/4494 ,  G06F9/453 ,  G06F17/60 ,  G06N3/123

Abstract: PURPOSE: A prognosis prediction model creation method using a SNP(Single Nucleotide Polymorphism) method and apparatus thereof are provided to create a prognosis prediction model by collecting information for a dominant model, a recessive model, and an additive model. CONSTITUTION: An SNP determination unit(1102) determines the SNP of a test target person by using hereditary models which statistically examine the hereditary feature of the SNP. A hereditary model determination unit(1103) determines similar hereditary model for the SNP. A standardization unit(120) standardizes coding values of SNP hereditary types based on the determined hereditary model. A model creation unit(130) creates a prognosis evaluation model which displays a correlation by analyzing a statistical evaluation algorithm.

Abstract translation: 目的：提供使用SNP（单核苷酸多态性）方法及其装置的预后预测模型创建方法，通过收集主导模型，隐性模型和附加模型的信息来创建预测预测模型。 构成：SNP确定单元（1102）通过使用统计学检查SNP的遗传特征的遗传模型来确定测试对象人的SNP。 遗传模型确定单元（1103）确定SNP的类似遗传模型。 基于确定的遗传模型，标准化单元（120）对SNP遗传型的编码值进行标准化。 模型创建单元（130）创建通过分析统计评估算法来显示相关性的预后评估模型。

公开(公告)号：KR1020120031740A

公开(公告)日：2012-04-04

申请号：KR1020100093301

申请日：2010-09-27

Applicant: 삼성전자주식회사

Inventor： 유창은 ,  안태진 ,  이규상 ,  심저영 ,  김기은 ,  김명순 ,  홍성우 ,  전태한 ,  김진국 ,  박세훈 ,  손인석 ,  정신호

IPC: C12Q1/68 ,  G01N33/15 ,  G06F17/18

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/15 ,  G06F17/18

Abstract: PURPOSE: A method for predicting sensitivity of an anticancer agent for a patient with gastric cancer is provided to effectively predict the sensitivity of a biological sample. CONSTITUTION: A kit for predicting sensitivity of an anticancer agent for a patient with gastric cancer contains a polynucleotide of sequence numbers 1-59 including the 27th base SNP. A method for predicting sensitivity of the anticancer agent comprises: a step of preparing the biological sample from a patient with gastric cancer; a step of identifying the presence of SNP contained in the kit from the sample; and a step of determining sensitivity of the anticancer agent by statistic classification. The biological sample is a gastric cancer tissue.

Abstract translation: 目的：提供一种预测胃癌患者抗癌药敏感性的方法，以有效预测生物样品的敏感性。 构成：用于预测抗癌剂对胃癌患者的敏感性的试剂盒含有序列号1-59的多核苷酸，包括第27位碱基SNP。 用于预测抗癌剂敏感性的方法包括：从患有胃癌的患者制备生物样品的步骤; 从样品中鉴定试剂盒中所含的SNP的存在的步骤; 以及通过统计分类来确定抗癌剂的敏感性的步骤。 生物样品是胃癌组织。

公开(公告)号：KR1020120031734A

公开(公告)日：2012-04-04

申请号：KR1020100093292

申请日：2010-09-27

Applicant: 삼성전자주식회사

Inventor： 손대순 ,  이규상 ,  정성욱 ,  지성민 ,  박경희 ,  정원석 ,  정종석 ,  김동환 ,  김진국 ,  손인석 ,  정신호

IPC: C12Q1/68 ,  G01N33/15 ,  G06F17/18

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/15 ,  G06F17/18

Abstract: PURPOSE: A method for predicting cytarabine sensitivity is provided to effectively predict sensitivity to cytarabine in a biological sample. CONSTITUTION: A kit for predicting cytarabine sensitivity of a patient with acute leukemia contains a polynucleotide of sequence numbers 1-38 including the 27th base SNP. The polynucleotide is fixed on a microarray. A method for predicting cytarabine sensitivity of the patient comprises: a step of preparing a biological sample from the patient; a step of confirming the presence of SNP contained in the kit from the sample; and a step of determining the sensitivity to cytarabine.

Abstract translation: 目的：提供一种预测阿糖胞苷敏感性的方法，以有效预测生物样品中阿糖胞苷的敏感性。 构成：用于预测急性白血病患者的阿糖胞苷敏感性的试剂盒含有序列号1-38的多核苷酸，包括第27位碱基SNP。 将多核苷酸固定在微阵列上。 用于预测患者的阿糖胞苷敏感性的方法包括：从患者制备生物样品的步骤; 从样品中确认试剂盒中含有的SNP的存在的步骤; 并确定对阿糖胞苷敏感性的步骤。