公开(公告)号：KR1020100089549A

公开(公告)日：2010-08-12

申请号：KR1020090008855

申请日：2009-02-04

Applicant: 한국과학기술연구원

Inventor： 노주원 ,  판철호 ,  정상훈 ,  김철영 ,  엄병헌 ,  이샛별 ,  강경수 ,  유지혜 ,  차광현 ,  구송이 ,  송대근 ,  이은하 ,  이희주 ,  윤지호 ,  김명수 ,  안수용 ,  김종환 ,  강석우

IPC: A23L1/30 ,  A61P35/00 ,  A61K36/282 ,  A23L2/38

CPC classification number: A61K36/28 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/308 ,  A23V2250/21 ,  A23V2300/14 ,  A23V2300/18

Abstract: PURPOSE: A composition containing extract and portions of southernwood wild plants as an active ingredient is provided to activate quinone reductase which is an indicator enzyme for preventing cancer and to activate an antioxidant response element by including extracts and portions of the southernwood wild plants including Adenocaulon himalaicum or Artemisia dubia. CONSTITUTION: A composition for preventing cancers contains extracts and portions of southernwood wild plants including Adenocaulon himalaicum and Artemisia dubia as an active ingredient. The extracts are obtained by extracting dried Adenocaulon himalaicum or Artemisia dubia using alcohol having a carbon number of 1-4 or a mixed solvent. The portions are n-hexane portions, ethylacetate portions, n-butanol portions, or water portions.

Abstract translation: 目的：提供一种含有提取物和南部野生植物部分作为活性成分的组合物，用于活化醌还原酶，该还原酶是预防癌症的指示酶，并通过包括南木野生植物的提取物和部分，包括喜马拉松（Adenocaulon himalaicum） 或艾蒿（Artemisia dubia）。 构成：用于预防癌症的组合物含有南木野生植物的提取物和部分，其中包括Adenocaulon himalaicum和Artemisia dubia作为活性成分。 通过使用碳数为1-4的醇或混合溶剂提取干燥的Adenocaulon himalaicum或艾蒿，得到提取物。 这些部分是正己烷部分，乙酸乙酯部分，正丁醇部分或水部分。

公开(公告)号：KR1020080107049A

公开(公告)日：2008-12-10

申请号：KR1020070054855

申请日：2007-06-05

Applicant: 한국과학기술연구원

Inventor： 정상훈 ,  이은하 ,  판철호 ,  김철영 ,  엄병헌 ,  이동언 ,  송대근 ,  이주영

IPC: A61K36/22 ,  A61P3/10

CPC classification number: A61K36/22 ,  A61K31/34

Abstract: An agent for preventing and treating diabetes complication, and a health food are provided to inhibit the activity of the final sugar product and the aldose reductase. An agent for preventing and treating diabetes complication contains an extract of a lacquer tree (Rhus verniciflua) obtained by using water, an alcohol or their mixture as a solvent. Preferably the agent contains further an organic solvent fraction extracted by using an organic solvent. Preferably the organic solvent is n-hexane, methylene chloride, ethyl acetate or n-butanol.

Abstract translation: 提供了用于预防和治疗糖尿病并发症的药剂和保健食品以抑制最终糖产品和醛糖还原酶的活性。 用于预防和治疗糖尿病并发症的药剂含有通过使用水，醇或其混合物作为溶剂获得的漆树（Rhus verniciflua）的提取物。 优选地，该试剂还含有通过使用有机溶剂提取的有机溶剂级分。 有机溶剂优选为正己烷，二氯甲烷，乙酸乙酯或正丁醇。

公开(公告)号：KR100856486B1

公开(公告)日：2008-09-04

申请号：KR1020070032294

申请日：2007-04-02

Applicant: 한국과학기술연구원

Inventor： 김철영 ,  이희주 ,  정상훈 ,  이동언 ,  엄병헌 ,  판철호 ,  함정엽 ,  차광현 ,  이은하

IPC: A61K36/88

Abstract: A method for extraction of tectoridin and tectorigenin from the rhizomes of Belamcanda chinensis is provided to reduce the extraction time, improve the extraction yield and enhance environment and human affinity by using only water and ethanol as solvent under high temperature and high pressure. The tectoridin and tectorigenin are extracted from the rhizomes of Belamcanda chinensis through SWE(subcritical water extraction) by heating the rhizomes of Belamcanda chinensis in a mixed solvent containing water and 30-100 vol.% of ethanol to high temperature such as 80 deg. C or more, preferably 80-200 deg. C under high pressure condition such as 1-15 MPa.

Abstract translation: 提供了一种从中华白兰地根茎提取t idin素和t ector素的方法，通过在高温高压下仅使用水和乙醇作为溶剂，减少提取时间，提高提取产率，增强环境和人亲和力。 通过SWE（亚临界水提取），通过在含有水和30-100体积％乙醇的混合溶剂中加热中华白兰地根茎至80度的高温，从枸杞子根茎中提取鸢尾苷和t ector素。 ℃以上，优选为80〜200度。 C在高压条件下，如1-15MPa。

公开(公告)号：KR100850474B1

公开(公告)日：2008-08-07

申请号：KR1020080046221

申请日：2008-05-19

Applicant: 한국과학기술연구원

Inventor： 판철호 ,  이샛별 ,  김민철 ,  엄병헌 ,  이은하 ,  이주영 ,  노주원 ,  정상훈

IPC: A61K36/25 ,  A61P35/00

Abstract: A pharmaceutical composition comprising the extract of Cutleria cylindrical is provided to induce activity of quinone reductase, lead no an activity of phase 1 detoxification enzyme system but an activity of phase 2 detoxification enzyme system, inhibit cytotoxicity, and suppress increase carcinogenic and procarcinogenic materials and promote their release. A pharmaceutical composition for cancer chemoprevention comprises 0.001-99.9 wt.% of the extract of Cutleria cylindrical which is prepared by washing Cutleria cylindrical collected with water to remove foreign substances and salt, drying the Cutleria cylindrical, extracting the dried Cutleria cylindrical with solvent, preferably ethanol, filtering the extract of Cutleria cylindrical, and vacuum-concentrating and drying the filtered Cutleria cylindrical extract, and is formulated as powder, granule, tablet, capsule, suspension, emulsion, syrup, aerosol, ointment, cream, suppository or sterile injection solution, wherein the daily dosage of the Cutleria cylindrical extract is 0.001-1000 mg/kg.

Abstract translation: 提供包含圆锥形切片提取物的药物组合物以诱导醌还原酶的活性，不含相1脱毒酶系统的活性，但是第二阶段解毒酶体系的活性，抑制细胞毒性并抑制增加致癌和致癌物质并促进 他们的释放。 用于癌症化学预防的药物组合物包含通过洗涤用水收集的Cutleria圆柱体以除去外来物质和盐，干燥圆锥状切片，用溶剂提取干燥的Cutleria圆柱形的Cutleria圆柱形提取物的0.001-99.9重量％ 乙醇，过滤圆锥形切片提取物，真空浓缩和干燥过滤的西葫芦圆柱形提取物，配制成粉末，颗粒，片剂，胶囊，悬浮液，乳剂，糖浆，气溶胶，软膏，霜剂，栓剂或无菌注射溶液 其中，圆锥形提取物的日剂量为0.001〜1000mg / kg。

公开(公告)号：KR100824365B1

公开(公告)日：2008-04-22

申请号：KR1020060119768

申请日：2006-11-30

Applicant: 한국과학기술연구원

Inventor： 엄병헌 ,  정상훈 ,  김철영 ,  이희주 ,  이은하 ,  이정민

IPC: A61K36/899 ,  A61P3/10

Abstract: A composition comprising an extract of Phyllostachys nigra MUNRO, a fraction thereof or a compound isolated from the fraction is provided to inhibit accumulation of sorbitol, a fundamental cause of nephropathy and neuropathy shown as diabetic complications, by inhibiting aldose reductase, thereby being used as a pharmaceutical composition or a health food for preventing diseases related to the diabetic complications. A method for isolating a compound from Phyllostachys nigra MUNRO comprises the steps of: (a) extracting the Phyllostachys nigra MUNRO with ethanol and filtering the extract; (b) concentrating and freeze-drying the filtrate to obtain an extract; (c) fractionating an ethylacetate layer from the extract using a separation funnel; and (d) subjecting the fraction to silica gel column chromatography using CH2Cl2-MeOH as a solvent to obtain orientin, luteolin 6-C-(6''-O-transcaffeoylglucoside), tricetin 3',4',5'-trimethyl ether 7-O-b-D-glucopyranoside, tricine, p-coumaric acid or cis-coumaric acid. A pharmaceutical composition for preventing or treating diabetic retinopathy, diabetic neuropathy or diabetic nephropathy comprises the obtained compound as an effective ingredient.

Abstract translation: 提供了包含黑曲霉MUNRO提取物，其级分或从该级分分离的化合物的组合物，通过抑制醛糖还原酶来抑制山梨糖醇的积累，其是糖尿病并发症所示的肾病和神经病变的根本原因，因此被用作 药物组合物或用于预防与糖尿病并发症相关的疾病的保健食品。 一种从黑胫虫MUNRO中分离化合物的方法，包括以下步骤：（a）用乙醇萃取黑曲霉MUNRO，过滤提取物; （b）浓缩和冷冻滤液以获得提取物; （c）使用分液漏斗从提取物中分出乙酸乙酯层; 和（d）使用CH 2 Cl 2 -MeOH作为溶剂使级分进行硅胶柱色谱法，得到orientin，木犀草素6-C（6“-O-过氧基葡萄糖苷），三黄素3'，4'，5'-三甲基醚 7-ObD-吡喃葡萄糖苷，tricine，对香豆酸或顺式香豆酸。 用于预防或治疗糖尿病性视网膜病变，糖尿病性神经病变或糖尿病性肾病的药物组合物包含获得的化合物作为有效成分。