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    82.
    发明专利
    未知

    公开(公告)号：DK433689A

    公开(公告)日：1990-03-03

    申请号：DK433689

    申请日：1989-09-01

    Applicant: BASF AG

    Inventor： PAUST JOACHIM ,  ERNST HANSGEORG

    IPC: C07D239/42

    Abstract: In an improved process for the preparation of 2-n-propyl-4-amino-5-methoxymethyl-pyrimidine of the formula I I by reacting butyramidine II II with alpha -methoxymethyl- beta -methoxyacrylonitrile III III the butyramidine II is reacted with a 0.4-5 molar excess of alpha -methoxymethyl- beta -methoxyacrylonitrile III at from -10 DEG to +20 DEG C.

    SUBSTITUTED HEXATRIENE DERIVATIVES, THEIR PREPARATION AND USE
    83.
    发明专利
    SUBSTITUTED HEXATRIENE DERIVATIVES, THEIR PREPARATION AND USE 未知

    公开(公告)号：CA1262910A

    公开(公告)日：1989-11-14

    申请号：CA497801

    申请日：1985-12-17

    Applicant: BASF AG

    Inventor： WUEST HANS-HEINER ,  FRICKEL FRITZ-FRIEDER ,  PAUST JOACHIM ,  SCHMIEDER KLAUS ,  NUERRENBACH AXEL

    IPC: C07C63/04 ,  C07D257/04 ,  C07C175/00 ,  A61K31/00

    Abstract: Substituted hexatriene derivatives of the formula (I): (I) where R1 is methyl, nitrile, C2-C10-ketal, tetrazolyl, -CH2OR2, -CH2NR3R4 or -COR5, where R2 is hydrogen, C1-4-alkyl, C1-20-alkanoyl or unsubstituted benzoyl or benzoyl substituted by methyl, methoxy, halogen or nitro, R3 and R4 are hydrogen, C1-6-alkanoyl or unsubstituted benzoyl or benzoyl substituted by methyl, methoxy, halogen or nitro, and R5 is hydrogen, C1-4-alkyl, halogen, -OR6 or -NR7R8, where R6 is hydrogen, unsubstituted or hydroxyl-substituted C1-6-alkyl, phenyl or aralkyl, and R7 and R8 are hydrogen, unsubstituted or hydroxyl-substituted C1-6-alkyl, phenyl or aralkyl, and, where relevant, their physiologically tolerated salts are descrobed, together with a process for their preparation. These compounds are useful in the topical and systemic therapy of acne, psoriasis and other dermatological disorders associated with pathologically modified keratinization. They may also be used for topical and systemic therapy, and for prophylaxis, of precanceroses and carcinomas of the skin, the mucous membranes and internal organs, as well as for the treatment of rheumatic disorders, especially disorders of an inflammatory or degenerative nature which affect the joints, muscles, sinews and other parts of the locomotor apparatus.

    85.
    发明专利
    未知

    公开(公告)号：DK10886A

    公开(公告)日：1986-08-16

    申请号：DK10886

    申请日：1986-01-10

    Applicant: BASF AG

    Inventor： PFAFF KLAUS-PETER ,  PAUST JOACHIM ,  HARTMANN HORST

    IPC: C07H1/00 ,  B01J31/00 ,  C07B61/00 ,  C07H9/04 ,  C07H

    Abstract: Sugar ketals are prepared by reacting a sugar with a ketone in the presence of an acid catalyst by a process in which A. a molecular boron trifluoride compound or trifluoromethanesulfonic acid is used in an amount of only from 0.01 to 10% by weight, based on the sugar used, B. up to a 30-fold molar excess of the ketone is used and C. the water formed during the reaction is removed continuously from the reaction mixture. In a particularly advantageous embodiment of the process, the boron trifluoride is used in the form of boron trifluoride etherate and, when the reaction is complete, this compound or the trifluoromethanesulfonic acid is rendered ineffective under non-aqueous conditions, after which the ketone is evaporated off and the reaction mixture is then subjected to fractional distillation. The process is particularly important for the reaction of L-sorbose with acetone to obtain 2,3:4,6-di-O-isopropylidene-L-sorbofuranose, which is required for the synthesis of ascorbic acid.

    87.
    发明专利
    未知

    公开(公告)号：DK527283D0

    公开(公告)日：1983-11-17

    申请号：DK527283

    申请日：1983-11-17

    Applicant: BASF AG

    Inventor： PAUST JOACHIM ,  LEININGER HARTMUT

    IPC: C07D307/33 ,  C07D307/60 ,  C07D307

    Abstract: Dihydro-4,4-dimethylfuran-2,3-dione is prepared by oxidation of racemic dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone by a process in which the oxidation is carried out by gradually adding powdered calcium oxide to a solution of racemic dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone and chlorine in the inert organic solvent.

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