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    83.
    发明专利
    未知

    公开(公告)号：BRPI0409929A

    公开(公告)日：2006-04-25

    申请号：BRPI0409929

    申请日：2004-04-29

    Applicant: BAXTER INT

    Inventor： RABINOW BARRETT E ,  WHITE RANDY ,  SUN CHONG-SON ,  WONG JOSEPH CHUNG TAK ,  KIPP JAMES E ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  PAPADOPOULOS PAVLOS

    IPC: A61K9/50 ,  A61K9/51 ,  A61K31/496 ,  A61K9/14

    Abstract: The present invention relates to compositions of submicron- to micron-size particles of antimicrobial agents. More particularly the invention relates to a composition of an antimicrobial agent that renders the agent potent against organisms normally considered to be resistant to the agent. The composition comprises an aqueous suspension of submicron-tomicron-size particles containing the agent coated with at least one surfactant selected from the group consisting of: ionic surfactants, non-ionic surfactants, biologically derived surfactants, and amino acids and their derivatives. The particles have a volume-weighted mean particle size of less than 5 µm as measured by laser diffractonetry.

    METHOD FOR PREPARING SMALL PARTICLES
    89.
    发明专利
    METHOD FOR PREPARING SMALL PARTICLES 未知

    公开(公告)号：CA2517589A1

    公开(公告)日：2004-09-30

    申请号：CA2517589

    申请日：2004-02-25

    Applicant: BAXTER INT

    Inventor： WONG JOSEPH CHUNG TAK ,  KIPP JAMES E ,  WERLING JANE ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN ,  DOTY MARK J

    IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

    Abstract: The present invention is concerned with the formation of small particles or organic compounds by precipitating the organic compounds in an aqueous mediu m to form a pre-suspension followed by adding energy to stabilize a coating of the particle or to alter the lattice structure of the particle. The process includes the steps of: (i) dissolving the organic compound in the water- miscible first solvent to form a solution; (ii) mixing the solution with the second solvent to define a presuspension of particles; and (iii) adding ener gy to the presuspension to form a suspension of particles having an average effective particle size of less than about 100 .mu.m. The process is preferably used to prepare a suspension of small particles of a poorly water - soluble, pharmaceutically active compound suitable for in vivo delivery by a n administrate route such as parenteral, oral, pulmonary, nasal, buccal, topic al ophthalmic, rectal, vaginal, transdermal or the like.

    Method for preparing small particles
    90.
    发明专利
    Method for preparing small particles 未知

    公开(公告)号：AU2004222362A1

    公开(公告)日：2004-09-30

    申请号：AU2004222362

    申请日：2004-02-25

    Applicant: BAXTER INT

    Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  WERLING JANE ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN

    IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

    Abstract: The present invention is concerned with the formation of small particles of organic compounds by precipitating the organic compounds in an aqueous medium to form a pre-suspension followed by adding energy to stabilize a coating of the particle or to alter the lattice structure of the particle. The process includes the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution; (ii) mixing the solution with the second solvent to define a presuspension of particles; and (iii) adding energy to the presuspension to form a suspension of particles having an average effective particle size of less than about 100 mum. The process is preferably used to prepare a suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrate route such as parenteral, oral, pulmonary, nasal, buccal, topical ophthalmic, rectal, vaginal, transdermal or the like.

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