公开(公告)号：AU2005226756B2

公开(公告)日：2008-08-28

申请号：AU2005226756

申请日：2005-02-18

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： OWEN WILLIAM F JR ,  KUNZLER JACQUELINE A ,  MONGOVEN JAMES W ,  PATEL MEHUL ,  GIERTYCH JOSEPH A ,  MARTIS LEO

IPC: C12Q1/26 ,  C12Q1/04 ,  C12Q1/37

Abstract: Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

公开(公告)号：DE69330189T3

公开(公告)日：2007-05-03

申请号：DE69330189

申请日：1993-12-10

Applicant: BAXTER INT

Inventor： MARTIS LEO ,  FAICT DIRK ,  BURKE RON

IPC: A61K9/08 ,  A61K38/00 ,  A61K31/70 ,  A61K33/00 ,  A61K38/01 ,  A61K38/02 ,  A61K47/26 ,  A61K47/42 ,  A61M1/14 ,  A61M1/18 ,  A61M1/28 ,  A61P7/08

Abstract: The solution contains as osmotic agents both dectrose and polypeptides. The polypeptides are synthetic and are 4 to 10 amino acids long.

公开(公告)号：DE60030682D1

公开(公告)日：2006-10-26

申请号：DE60030682

申请日：2000-07-27

Applicant: BAXTER INT

Inventor： DUPONCHELLE ANNICK ,  FAICT DIRK ,  BALTEAU PATRICK ,  HARTMAN JEAN-PIERRE ,  MARTIS LEO ,  PELUSO FRANCESCO

IPC: A61J3/00 ,  A61K33/10 ,  A61J1/05 ,  A61J1/10 ,  A61J1/20 ,  A61K33/14 ,  A61M1/14 ,  A61M1/16 ,  A61M1/28 ,  A61P13/12

公开(公告)号：CA2555209A1

公开(公告)日：2005-10-06

申请号：CA2555209

申请日：2005-02-18

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： PATEL MEHUL ,  GIERTYCH JOSEPH A ,  KUNZLER JACQUELINE A ,  MONGOVEN JAMES W ,  OWEN WILLIAM F JR ,  MARTIS LEO

IPC: C12Q1/37 ,  C12Q1/04 ,  C12Q1/26

Abstract: Methods and compositions for detection of microbial contaminants in peritone al dialysis solutions are provided. A novel cause of aseptic peritonitis is provided--aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilize d to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

公开(公告)号：AU2005226756A1

公开(公告)日：2005-10-06

申请号：AU2005226756

申请日：2005-02-18

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： OWEN WILLIAM F JR ,  KUNZLER JACQUELINE A ,  MONGOVEN JAMES W ,  PATEL MEHUL ,  GIERTYCH JOSEPH A ,  MARTIS LEO

IPC: C12Q1/26 ,  C12Q1/04 ,  C12Q1/37

Abstract: Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

公开(公告)号：CA2510788A1

公开(公告)日：2004-07-15

申请号：CA2510788

申请日：2003-12-18

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： CHOO CAROLYN ,  ZIESKE PAUL ,  MARTIS LEO

IPC: A61K31/718 ,  A61K31/724 ,  A61M1/28

Abstract: Glucose polymer-based solutions and methods of making same that can be used during medical therapy, such as dialysis therapy are provided. The glucose polymer-based solution preferably includes a first solution containing icodextrin at a pH ranging from about 1.5 to about 5.0 and a buffer solution at a pH ranging from about 7.0 to about 12.0 that are so constructed and arranged allowing the glucose polymer-based solution to be mixed prior to infusion into a patient. The glucose polymer-based solutions of the present invention can be made at physiologic pH and with minimal glucose degradation products.

公开(公告)号：DE69531426T2

公开(公告)日：2004-06-09

申请号：DE69531426

申请日：1995-01-23

Applicant: BAXTER INT

Inventor： MARTIS LEO ,  BURKE RON ,  SHOCKLEY TY ,  HENDERSON LEE W ,  FALLER BERNARDETTE

IPC: A61K31/715 ,  A61K33/14 ,  A61M1/28 ,  A61M1/14

Abstract: The method relates to providing an osmotic agent for a peritoneal dialysis solution containing sodium chloride and optionally lactate, bicarbonate, calcium and magnesium ions. The osmotic agent added comprises a first composition with a weight average molecular weight of ≥ 10,000 daltons and 0.25 to 2.0 (% w/v) of a second composition with a weight average molecular weight of ≤ 300 daltons.

公开(公告)号：AU2003249296A8

公开(公告)日：2004-02-09

申请号：AU2003249296

申请日：2003-07-16

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： CHILDERS ROBERT W ,  BROWN DAVID S ,  WARIAR RAMESH ,  KAROOR SUJATHA ,  DIN SHAHID ,  MARTIS LEO ,  BUCHMANN CODY ,  SOLTYS PAUL

IPC: A61M1/14 ,  A61M1/16 ,  A61M1/28

Abstract: A system for dialysis is disclosed. An example peritoneal dialysis system includes a peritoneal dialysis machine including a pumping mechanism, and a sensor configured to measure a property of peritoneal dialysis fluid. The peritoneal dialysis system also includes a disposable cassette operable with the peritoneal dialysis machine. The disposable cassette includes a fluid source inlet for accepting fluid from a fluid source and a fluid flow path in fluid communication with the fluid source inlet. The fluid flow path includes a pump chamber operable with the pumping mechanism to pump fluid through the fluid flow path. The disposable cassette also includes a concentrate inlet for fluidly communicating concentrate to the fluid flow path, and a sensor chamber located along the fluid flow path and operable with the sensor. The sensor is configured to provide feedback to the peritoneal dialysis machine for mixing the concentrate for forming peritoneal dialysis fluid.

公开(公告)号：AU2003225160A1

公开(公告)日：2003-12-02

申请号：AU2003225160

申请日：2003-04-23

Applicant: BAXTER INT

Inventor： MARTIS LEO ,  HOLMES CLIFF ,  CHILDERS ROBERT ,  DIN SHAHID ,  PAN LI ,  WARIAR RAMESH

IPC: A61M1/16 ,  B01D61/32

Abstract: A biosensor capable of monitoring a number of different constituents of a dialysate solution used during dialysis therapy is provided. The biosensor of the present invention includes an integrated array of reactive elements and sensing elements that can be hydraulically coupled to the dialysate solution. In this regard, the biosensor can be utilized to provide on-line monitoring of total solutes removed from a patient during dialysis therapy, infection levels and/or other desirable parameters such that an overall assessment of dialysis therapy can be readily evaluated.

公开(公告)号：DE69332433T2

公开(公告)日：2003-08-14

申请号：DE69332433

申请日：1993-12-10

Applicant: BAXTER INT

Inventor： MARTIS LEO ,  JONES MICHAEL R

IPC: A61K31/195 ,  A61K31/198 ,  A61K31/40 ,  A61K31/405 ,  A61K31/415 ,  A61K33/10 ,  A61K33/14 ,  A61M1/28 ,  A61P13/00 ,  A61P13/02 ,  A61P15/00 ,  A61K9/08 ,  A23J1/14

Abstract: The present invention provides a dialysis solution that contains amino acids for treating and/or preventing malnutrition in a peritoneal dialysis patient. The amino acid composition is optimized to minimize metabolic acidosis while normalizing amino acid plasma profiles.